Charikleia Stefanaki

Charikleia Stefanaki
National and Kapodistrian University of Athens | uoa · U.R.I (University Research Institute for the Study of Genetic & Malignant Disorders in Childhood)

M.D.; M.Sc; PhD
Researcher C Level

About

68
Publications
16,337
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Introduction
Pediatrician, with interest in Endocrinology, Metabolism, and Diabetes. MSc in Reproductive Endocrinology and Stress. PhD in Microbiome. Currently exploring the GI tract from the endocrinologic point of view.
Additional affiliations
October 2021 - present
U.R.I (University Research Institute for the Study of Genetic & Malignant Disorders in Childhood)
Position
  • Researcher
June 2016 - September 2021
General Hospital of Nikaia, Piraeus "Agios Panteleimon ''
Position
  • Medical Doctor
January 2015 - April 2017
National and Kapodistrian University of Athens, Medical School
Position
  • Research Associate

Publications

Publications (68)
Chapter
Osteosarcopenia, either in the simple phenotype of itself, or osteosarcopenic obesity are underacknowledged entities by the clinicians. These conditions usually start in the young age, however, the lack of consensus and statements by official scientific societies for the young populations does not help in providing early identification and proper c...
Article
Background: Chronic stress is a recognized risk factor for poor health, body composition disequilibrium, impaired mental health, and deterioration of quality of life. Chronic stress-related cortisol oversecretion and circadian dysregulation and associated systemic low grade, injurious inflammation ("para-inflammation") contribute to steatosis in v...
Chapter
Diabesity is a common denominator of mortality and morbidity, due to noncommunicable diseases, and it affects populations of different ages, race, and sex. Low-grade, subclinical inflammation derives from diabesity, resulting in deterioration of health status. Human gut microbiome, consisting of bacteriome, virome, and mycobiome, is a complex and s...
Chapter
Diabesity is a common denominator of mortality and morbidity, due to noncommunicable diseases, and it affects populations of different ages, race, and sex. Low-grade, subclinical inflammation derives from diabesity, resulting in deterioration of health status. Human gut microbiome, consisting of bacteriome, virome, and mycobiome, is a complex and s...
Chapter
The gastrointestinal (GI) tract contains its own autonomic “enteric nervous system”, which is in dynamic homeostasis with the central nervous system of the organism, forming with it the so-called gut-brain axis. The GI tract, however, contains the gut microbiome, a remarkable “organ”, irrevocably connected to its function and hence also to that of...
Article
Given the heterogeneity of Attention-Deficit Hyperactivity Disorder (ADHD), there is a constant need for proper diagnosis, employing more accurate, efficient, patient-friendly, and clinician-friendly tools. We developed a Greek version of the National Institute for Children’s Health Quality (NICHQ) Vanderbilt ADHD Diagnostic Parent Rating Scale (VA...
Article
Obesity and thus, lipotoxicity, is a major health risk factor. Modern exposure to environmental chemicals has contributed significantly to the obesity epidemic. The purpose of this study was to assess, via telemedicine and using bioelectrical impedance analysis (BIA) in schools, the levels of adiposity and other body composition parameters of Greek...
Article
Full-text available
Prediabetes in the form of impaired fasting glucose, impaired glucose tolerance, or both is considered as a preliminary stage for the onset of diabetes and diabetic complications. Hormonal fluctuations in adolescence are accompanied by body composition modifications, which are associated with insulin resistance and subclinical inflammation. Bioimpe...
Article
Full-text available
Purpose To investigate the association of the hypothalamic-pituitary-testicular (HPT) axis with pro- and anti- oxidation, in relation to puberty and obesity in boys, before and after an aerobic exercise bout. Methods This is a cross-sectional human observational study of 92 healthy normal-weight, obese pre- and early- pubertal boys that underwent...
Article
Full-text available
Dysbiosis of intestinal ecology could be implicated in prediabetes. The aim of this pilot randomized controlled trial (RCT) was to collect preliminary data on the effects of probiotic supplementation (Vivomixx©) on markers of glucose metabolism, intestinal microbiome composition, and intestinal health indices, of prediabetic adolescents. The interv...
Article
Full-text available
Scarce data exist on the body composition of lean women with polycystic ovary syndrome (PCOS) on treatment with metformin and oral contraceptives (OCs). Thirty-four lean (body mass index 18.5–24.9 kg/m2) women (17 with PCOS on metformin and OCs treatment for six months and 17 controls) aged 18–40 years were assessed for body composition parameters...
Article
Full-text available
Scarce data exists about the hemostatic status of small for gestational age (SGA) neonates. We aimed at evaluating the hemostatic profile of SGA neonates, using thromboelastometry (TEM). This is an observational study performed in a Greek tertiary General Hospital during an 18-month period. Ninety-three neonates were included in the study: 48 appro...
Chapter
Human gut microbiome is the combined genetic material of the microorganisms in the gut. Bacteriome, virome and mycobiome are its principal constituents. Numerous studies have connected the bacteriome with metabolic, neoplastic, gastrointestinal, and even mental disorders. Few studies have focused on the virome, and mycobiome. It seems that a stron...
Poster
Full-text available
serial number: 691 Poster Number: P1-P210 Introduction: Puberty is a maturation period characterized by changes of the dynamically regulated HPG axis. Obesity in childhood and especially after the onset of puberty is a relatively hypogonadal state. Oxidative stress is a state of imbalance between pro-and anti-oxidation within the cell. Pro-oxidatio...
Article
Full-text available
Purpose: The aim of this study was to examine the relationship between disordered eating attitudes and emotional/behavioral adjustment in Greek adolescents as well as the moderating role of gender and body mass index (BMI) in this relationship. Methods: Ninety adolescents, 11-18 years old, were assessed using anthropometric measurements; demogra...
Article
Full-text available
Background: Recent studies have demonstrated that a significant proportion of adolescents exhibit abdominal obesity in early–middle adolescence, and impaired glucose metabolism. Dysregulation of glucose metabolism is aggravated by the existing osteosarcopenia not only in obese but also in overweight youth. Biochemical inflammation, derived from glu...
Article
Recent studies have suggested that body composition is key to health and disease. First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine, metabolic, an...
Poster
Full-text available
Context: Circulating brain-derived neurotrophic factor (BDNF) in adolescents with polycystic ovary syndrome (PCOS). Objective: To evaluate potential differences in BDNF concentrations between overweight/obese adolescents and adolescents of normal weight with PCOS. Methods: Serum levels of LH, E2, testosterone and BDNF were measured in each particip...
Poster
Full-text available
Background: Increasing studies show that immigrants have different perinatal health outcomes when compared to native women. Perinatal outcomes have been extensively studied among immigrant women, with conflicting results while few studies were carried out in the Greek population. Objective:.Τhis study aims at evaluating possible effects of the migr...
Poster
Full-text available
Introduction: Perinatal hypoxia is associated with increased risk of coagulation disorders. Hypoxia, among other effects, has an impact on hepatic and bone marrow function, resulting in further derangement of the immature production of coagulation factors and platelets. Hypoxic neonates may present with hemorrhagic disorders. The prevention and tim...
Poster
Full-text available
Background. Hemostasis is a dynamic process which gradually evolves during development from fetal stage into adulthood. Healthy neonates are born with an intrinsic hemostatic deficit directly dependent on gestational age, birth weight, and maturation of hepatic function. All factors of the coagulation- fibrinolysis system differ in neonates. Howeve...
Poster
Full-text available
Background:Hypothyroidism is a quite common disorder during pregnancy. Untreated maternal hypothyroidism is associated with both pregnancy and neonatal complications. Recent studies have shown that there is a strong correlation between maternal hypothyroidism and neurodevelopmental outcome of the newborn. Objective: To identify the adverse effects...
Article
Full-text available
In 2014, an association between biomarkers of chronic stress and inflammation, and bioimpedance (BIA) parameters, such as increased fat mass, and decreased skeletal muscle and bone masses measured by an advanced BIA-ACC© apparatus, and medically unexplained symptoms (MUS), was reported in a large population of adult men and women. We suggested that...
Article
Human gut microbiome is defined as the gene complement of the gut microbial community, measured via laboratory metagenomic techniques. It includes bacteriome, virome and mycobiome, which represent, respectively, the assemblages of bacteria, viruses and fungi, living in the human gut. Gut microbiota function as a living “organ” that interacts with t...
Article
Full-text available
Background-objectives: We aimed at evaluating the efficiency of a newly developed, advanced Bioimpedance Analysis (BIA-ACC®) device as a screening tool for determining the degree of obesity and osteosarcopenia in postmenopausal women with normal or decreased bone density determined by Dual-Energy X-Ray absorptiometry (DEXA) in a representative sam...
Article
Full-text available
Objective: The Humulus lupulus L. plant (hops) is used as a herbal medicinal product for anxiety/mood disorders. Our aim was to study the effects of a hops dry extract on self-reported depression, anxiety and stress levels in young adults. Design: Apparently healthy young adults from our university completed the Depression Anxiety Stress Scale-2...
Article
Full-text available
I ntermediate hyperglycemia, or prediabetes, is increasing worldwide, affecting people of all ages, including adolescents. Hormonal, physiological, psychological, and lifestyle changes in adolescence have been associated with disruptions in glucose homeostasis, such as decreased insulin sensitivity, insulin resistance, or the combination of both. A...
Article
Full-text available
Background: Osteosarcopenic obesity was recently described as a variant phenotype of obesity, mainly observed in old age. This nested case-control study was performed to detect the differences in body composition between young, healthy overweight/obese and healthy lean populations of both genders. Our null hypothesis was that except for the fat ma...
Conference Paper
Full-text available
Experimental animal, and human studies have associated gut “dysbiosis” with a subclinical, systematic inflammatory state, occuring in glucose intolerance disorders. This case-control study examined the differences in intestinal ecology, between prediabetic adolescents, and matched healthy controls, all aged 12-17 years. Our null hypothesis was that...
Article
Full-text available
To compare the prevalence of human papillomavirus (HPV) genital infection among prepubertal children, sexually active and not sexually active adolescents and assess potential risk factors for transmission. Prospective study. Outpatient adolescent health clinic. 95 girls aged 2-21 years; 38 sexually active adolescents (group A), 28 not sexually acti...
Article
Introduction: Half of subjects following a low-calorie dietary program cannot tolerate its nutritional restrictions and abandon it. A realistic approach to overcome this obstacle is the addition of low glycaemic index (GI), low glycaemic load (GL) snacks in their nutrition. Stevia, a potent, low calorie natural sweetener exerts anti-hyperglycaemic...
Conference Paper
Growth hormone is fundamental in skeletal growth during puberty, however detailed studies of body composition analyses in adolescents on growth hormone replacement therapy are scarce. In this case-control study, we aimed to investigate differences in body composition, based on the measurement of bio-impedance, between adolescents with idiopathic gr...
Conference Paper
Full-text available
Obesity, overweight and hypovitaminosis D are common in adolescents living in developed countries. Obesity is associated with low vitamin D plasma concentrations. This has been explained as a result of selective sequestration of vitamin D in subcutaneous and visceral adipose tissues. The aim of this study was to evaluate potential differences and p...
Article
This large cross-sectional, multi-center study evaluated the association of body composition measurements by a novel dual frequency bio-impedance device (BIA-ACC) with chronic stress/inflammation biomarkers and presence of Medically Unexplained Symptoms (MUS). Participants were adult Caucasians of both sexes and included 10416 lean subjects with no...
Article
Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a significant psychological burden throughout the life course of affected women. Thus, use of mindful awareness may be beneficial as an adjunct to conventional medical management of women with PCOS. A randomized, controlled trial was conducted at the Evgenideion Hospital of the At...
Conference Paper
Limited data are available on the body composition of Polycystic Ovary Syndrome (PCOS) patients. In this case-control study, we aimed to elucidate the body composition differences between PCOS patients and their age- and weight- matched controls using Bio-Impedance (BIA) and BIA spectroscopy measures. Seventeen (17), lean PCOS patients and seventee...
Conference Paper
Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders in women, with a prevalence of about 7%. PCOS is associated with high incidence of anxiety and depressive symptomatology, which indicates stress system dysfunction in these patients. This reduces their quality of life and accelerates the development of chronic non-commun...
Conference Paper
Objective: The natural history of essential hypertension entails a sequence of neuro-endocrine alterations in the human body, which possibly result in body composition and compartment changes that can be detected using bio-impedance analyzers (BIA). Indeed, hypertension may be caused by chronically increased activity of the stress axis and/or renin...
Conference Paper
Study Design: This is a cross-sectional, multi-center study conducted in Italy and coordinated by Biotekna® in Venice, Italy, between September 2009 and September 2012. Objectives: To evaluate the association of body composition measurements using a novel, advanced bio-impedance device with chronic stress/inflammatory biomarkers in a large Caucasia...
Article
Full-text available
To investigate the way that family stress influences glycemic control among patients with diabetes who are younger than 18 years of age. PubMed and Scopus were searched for relevant studies published since 1990 using the following key words: diabetes type 1, glycemic control, family stress, family conflict, and family function. In total, 1478 paper...
Article
Full-text available
Objectif Examiner la façon dont le stress familial influence le contrôle glycémique chez les patients diabétiques de moins de 18 ans. Sources des données Une recherche des études pertinentes publiées depuis 1990 a été réalisée dans PubMed et Scopus à l'aide des mots-clés suivants en anglais: diabetes type 1, glycemic control, family stress, fami...
Article
Full-text available
Breast cancer is the second-leading cause of cancer death among women in the United States, alone. Many papers throughout the past and current medical literature have shown it is strongly associated with the reproductive axis and the growth hormone axis. Ghrelin is a pleiotropic 28-aminoacidic hormone and an integrated component of the GH axis, whi...
Article
Background Jaundice is the clinical manifestation of hyperbilirubinaemia, considered as a sign of either liver disease or, less often, a haemolytic disorder. It is classified as obstructive and non-obstructive, according to the increase of indirect (non-conjugated) or of direct (conjugated) bilirubin, respectively, but can also present as mixed typ...
Article
Gastrocolic Fistula is, in the majority of cases the pathological communication between stomach and transverse colon, because cases involved with the small intestine, pancreas and skin have been also documented, even though are rare. It occurs mostly in adults, but they can be present to infants, as well, as a result of congenital abnormalities or...
Article
Full-text available
Intracystic papillary carcinoma (IPC) of the breast in men is an extremely infrequent disease, and it appears to have a good prognosis. Because of this, histological findings are of great importance in the decision-making process regarding treatment. Clinical examination, radiological and histological assessments are required for early detection. A...
Article
Breast cancer continues to be the most common malignancy among women in the United States. Despite its high incidence, early detection and modern treatment have made long-term survival more common. One of the most important sequelae of the treatment of breast cancer is the development of lymphedema. There are many issues for women to deal with afte...
Article
It is interesting to assess the hitherto knowledge, on breast cancer in reproductive and young females, aged <35. Even if breast cancer is rare in this group, it is, also physically and emotionally devastating. It is characterized by worse prognosis and outcome, in a stage of life, which is delicate for the female patients. This rare subgroup of br...
Conference Paper
Intracystic papillary carcinoma (IPC) of the breast in men is an extremely infrequent disease, and it appears to have a good prognosis. Because of this, histological findings are of great importance in the decision-making process regarding treatment. Clinical examination, radiological and histological assessments are required for early detection. A...
Article
Breast cancer continues to be the most common malignancy among women in the United States. Despite its high incidence, early detection and modern treatment have made long-term survival more common. One of the most important sequelae of the treatment of breast cancer is the development of lymphedema. There are many issues for women to deal with afte...
Article
Full-text available
Medullary thyroid cancer is a type of thyroid cancer of neuroendocrine origin. It occurs in hereditary and sporadic forms, and its aggressive behavior is associated with the clinical presentation and type of RET mutation. Total thyroidectomy remains the ideal choice of treatment. Early diagnosis and treatment are the fundamental for a 100% cure rat...
Article
Several human breast cancer cell lines have been shown to contain mutational activation of Ras oncogenes. The goal of this review is to clarify the physiology and biochemical pathways of Ras family oncogenes in order to understand thoroughly the mechanisms behind Ras gene mutations. Ras genes are involved in the early stages of mammary oncogenesis...
Article
Full-text available
Walled-off pancreatic necrosis (WOPN), formerly known as pancreatic abscess is a late complication of acute pancreatitis. It can be lethal, even though it is rare. This critical review provides an overview of the continually expanding knowledge about WOPN, by review of current data from references identified in Medline and PubMed, to September 2009...
Article
Lymphatic mapping and sentinel lymphadenectomy have become an important tool for axillary lymph node staging in women with early-stage breast cancer. Many issues such as indications, usefulness, or best method of performing a sentinel node biopsy need to be addressed. Multiple studies now confirm that sentinel lymphadenectomy accurately stages the...
Article
Full-text available
Increased levels of cytokines or reactive oxygen species (ROS) in the bronchoalveolar lavage (BAL) fluid are associated with acute lung injury after ischemia/reperfusion. We investigated the correlation of these markers with the degree of lung injury in a rabbit model of hemorrhagic shock. Rabbits, maintained by mechanical ventilation, were left un...
Article
Full-text available
GISTs are a subset of mesenchymal tumors and represent the most common mesenchymal neoplasms of GI tract. However, GIST is a recently recognized tumor entity and the literature on these stromal tumors has rapidly expanded. An extensive review of the literature was carried out in both online medical journals and through Athens University Medical lib...
Article
Full-text available
Adenocarcinoid arising in the vermiform appendix is a rarity. The diagnosis of appendiceal adenocarcinoma has never been made preoperatively and is frequently an incidental finding at the time of operation for unrelated conditions. Because of the rarity of the disease, its natural history is poorly understood. Benefits from adjuvant radiation, chem...
Article
The main goal of the paper is to clarify anthelminthic treatment as an alternative hydatic cyst therapy, its indications and contraindications. Chemotherapy constitutes a non-invasive treatment and is less limited by the patient's status than surgery or PAIR. Many investigators have employed benzoimidazole carbonates for the management of human hyd...
Article
Full-text available
Ischemic colitis is the most common type of intestinal ischemia, and it represents the consequences of acute or, more commonly, chronic blockage of blood flow through arteries that supply the large intestine. Ischemic colitis is manifested through a continuum of injury and considered as an illness of the elderly. The incidence of ischemic colitis h...
Article
Full-text available
Superior mesenteric artery syndrome is extremely rare and is characterized by postprandial epigastric pain, nausea, vomiting and loss of appetite, with subsequent weight loss, which aggravates the condition of the patients. The syndrome is caused by compression of the third part of the duodenum in the angle between the aorta and the superior mesent...
Article
Full-text available
The main goal of this article is to update etiology, epidemiology, diagnosis, treatment and outcome of the various causes of mesenteric ischemia in order to elucidate its labyrinthine clinical riddle, by reviewing the current English medical literature. Mesenteric ischemia is a quite uncommon disorder, observed in the emergency department. It is a...

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