Chao Ma

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Verified

Chao verified their affiliation via an institutional email.

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• Doctor of Medicine (Dr. med.)
• Attending Physician at Zhengzhou University

Background: Ribonucleoside-diphosphate reductase subunit M2 (RRM2) is the catalytic subunit of ribonucleotide reductase and modulates the enzymatic activity, which is essential for DNA replication and repair. However, the role of RRM2 in lung adenocarcinoma (LUAD) remains unclear. Methods: In this study, we explored the expression pattern and progn...

Background: Lung cancer has become the most common cancer type and caused the most cancer deaths. Lung adenocarcinoma (LUAD) is one of the major types of lung cancer. Accumulating evidence suggests the tumor microenvironment is correlated with the tumor progress and the patient’s outcome. This study aimed to establish a gene signature based on tumo...

Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have symptoms and signs of HF with normal or near-normal left ventricular ejection fraction (LVEF ≥50%). Roughly half of all patients with HF worldwide have an LVEF ≥50% and nearly half have an LVEF <50%. Thanks to the increased scientific attention...

A high level of difficulty is associated with the surgical procedure of total thoracoabdominal aortic aneu-rysm repair (tTAAAR), widespread clinical use has not been attained due to high demands of the procedure on the skill level of vascular surgeons, high incidence of complications and high mortality rates are often encountered in tTAAAR with dee...

Research indicates that there are links between m6A, m5C and m1A modifications and the development of different types of tumours. However, it is not yet clear if these modifications are involved in the prognosis of LUAD. The TCGA‐LUAD dataset was used as for signature training, while the validation cohort was created by amalgamating publicly access...

Background The tumor microenvironment (TME) is created by the tumor and dominated by tumor-induced interactions. Long-term survival of lung adenocarcinoma (LUAD) patients is strongly influenced by immune cell infiltration in TME. The current article intends to construct a gene signature from LUAD ICI for predicting patient outcomes. Methods For th...

Background Recent research has shown that lysosomes play a critical role in the onset and progression of malignancy by regulating tumor cell death through several mechanisms. Nevertheless, the involvement of lysosome-associated genes (LSAGs) in lung adenocarcinoma (LUAD) is still not well understood. Methods LSAGs were identified in malignant lung...

Background: Disulfidptosis, a recently identified type of regulated cell death, plays critical roles in various biological processes of cancer; however, whether they can impact the prognosis of lung adenocarcinoma (LUAD) remains to be fully elucidated. We aimed to adopt this concept to develop and validate a lncRNA signature for LUAD prognostic pre...

Background: Copper homeostasis and cuproptosis play critical roles in various biological processes of cancer; however, whether they can impact the prognosis of lung adenocarcinoma (LUAD) remain to be fully elucidated. We aimed to adopt these concepts to create and validate a lncRNA signature for LUAD prognostic prediction. Methods: For this study,...

Background: Cuproptosis is a newly discovered non-apoptotic form of cell death that may be related to the development of tumors. Nonetheless, the potential role of cuproptosis-related lncRNAs in tumor immunity formation and patient-tailored treatment optimization of lung adenocarcinoma (LUAD) is still unclear. Methods: RNA sequencing and survival d...

Background: There is a rapid increase in lung adenocarcinomas (LUAD), and studies suggest associations between cuproptosis and the occurrence of various types of tumors. However, it remains unclear whether cuproptosis plays a role in LUAD prognosis. Methods: Dataset of the TCGA-LUAD was treated as training cohort, while validation cohort consisted...

Background We aimed to investigate the effects of high on-treatment platelet reactivity (HPR) and antiplatelet therapy adjustment on high-risk radiomic features in patients with antiplatelet therapy adjustment on acute silent cerebral infarction (ASCI) who had unruptured intracranial aneurysms (UIA) after stent placement. Methods This single-insti...

Background: Chloride channel 3 (CLCN3) is regulated by transcription-coactivator, however, it is unclear which core transcription factor regulates CLCN3. The role of CLCN3 in lung adenocarcinoma (LUAD) is unexplored and the relationship between CLCN3 and tumor microenvironment is unknown. Methods: A 5′-biotin-labeled promoter probe of CLCN3 was us...

Background Lung adenocarcinoma (LUAD) is the leading histological subtype of lung cancer worldwide, causing high mortality each year. The tumor immune cell infiltration (ICI) is closely associated with clinical outcome with LUAD patients. The present study was designed to construct a gene signature based on the ICI of LUAD to predict prognosis. Me...

Background: Esophageal squamous cell carcinoma (ESCC) is a life-threatening thoracic tumor with a poor prognosis. The tumor microenvironment (TME) mainly comprises tumor cells and tumor-infiltrating immune cells mixed with stromal components. The latest research has displayed that tumor immune cell infiltration (ICI) is closely connected with the...

Background: Lung adenocarcinoma (LUAD) is the most common form of lung cancer, accounting for 30% of all cases and 40% of all non-small-cell lung cancer cases. Immune-related genes play a significant role in predicting the overall survival and monitoring the status of the cancer immune microenvironment. The present study was aimed at finding an im...

Osteosarcoma (OS) is the most common type of primary malignant bone tumor. The high-throughput sequencing technology has shown potential abilities to illuminate the pathogenic genes in OS. This study was designed to find a powerful gene signature that can predict clinical outcomes. We selected OS cases with gene expression and survival data in the...

Background: The tumor microenvironment (TME) mainly comprises tumor cells and tumor-infiltrating immune cells mixed with stromal components. Latestresearch hasdisplayed that tumor immune cell infiltration (ICI) is associated with the clinical outcome of patients with osteosarcoma (OS). This work aimed to build a gene signature according to ICI in O...

Background: Lung cancer has been the focus of attention for many researchers in recent years due to its leading contribution to cancer-related death worldwide, with lung adenocarcinoma (LUAD) being the most common histological type. Ferroptosis, a novel iron-dependent form of regulated cell death, can be induced by sorafenib. Emerging evidence show...

Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from other forms of cell death in morphology, biochemistry, and genetics, and has played a vital role in cancer biology. This study aimed to identify a ferroptosis-related gene s...

Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors (PBT) that may lead to novel therapeutic strategies. Participants of the cohort Pediatric Brain Tumor Atlas: CBTTC (CBTTC cohort), were randomly divided into training and validation cohorts. In the training cohort, Kaplan-Meier analysis a...

Background: Uveal melanoma (UM) is the most common intraocular tumor in adults. Ferroptosis is a newly recognized process of cell death, which is different from other forms of cell death in terms of morphology, biochemistry and genetics, and has played a vital role in cancer biology. The present research aimed to construct a gene signature from fe...

Esophageal squamous cell carcinoma (ESCC) is the main type of esophageal cancer in most of sub-Saharan Africa and Asia, including China. Both genetic and epigenetic aberrations have been considered playing a crucial role in the initiation and progression of ESCC. Although the genetic aberrations in ESCC, including mutations in TP53, CDKN2A, and PIK...

Background Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Many previous studies have demonstrated that the infiltrating of immune and stromal cells in the tumor microenvironment contributes significantly to prognosis. Methods Dataset TCGA-UVM, download from TCGA portal, was taken as the training cohort, and GSE221...

Background. Glucosamine-Phosphate N-Acetyltransferase 1 (GNPNAT1) is a critical enzyme in the biosynthesis of uridine diphosphate-N-acetylglucosamine. It has many important functions, such as protein binding, monosaccharide binding, and embryonic development and growth. However, the role of GNPNAT1 in lung adenocarcinoma (LUAD) remains unclear. Met...

Background: Uveal melanoma (UM) is the most common primary intraocular cancer in adults. Genomic studies have provided insights into molecular subgroups and oncogenic drivers of UM that may lead to novel therapeutic strategies. Methods: Dataset TCGA-UVM, download from TCGA portal, were taken as the training cohort, and dataset GSE22138, obtained fr...

The microenvironment plays a vital role in the tumor recurrence of neuroblastoma. This research aimed at exploring prognostic genes that are involved in neuroblastoma microenvironment. We used "estimate"R package to calculate the immune/stromal/ESTIMATE scores of each sample of ArrayExpress dataset E-MTAB-8248 based on the ESTIMATE algorithm. Then...

Background Lung adenocarcinoma (LUAD) is the most common primary lung cancer, and increasing evidence indicates the clinical importance of the microenvironment in LUAD. Tumor-infiltrating immune cells play an important role in promoting or inhibiting tumor growth. This study aimed to identify immune-related prognostic genes that were associated wit...

Small cell lung cancer (SCLC) is one of the most lethal cancer, mainly attributing to its high tendency to metastasis. Mounting evidence has demonstrated that genes and microRNAs (miRNAs) are related to human cancer onset and progression including invasion and metastasis. An eligible gene dataset and an eligible miRNA dataset were downloaded from t...

Background MicroRNAs (miRNAs), which modulate the expression of their target genes, are commonly involved in stimulating and adjusting of many processes that result in cardiovascular diseases, contain cardiac ischemia/reperfusion (I/R) damage. However, the expression and role of miR-149 in pyroptosis mediated myocardial I/R damage remains unclear....

Abstract RATIONALE: Diabetic foot ulcer is a severe complication of diabetes, and most patients with diabetic foot ulcer require amputation. The incidence of Budd-Chiari syndrome is low; it is relatively rare. Diabetic foot ulcer combined with Budd-Chiari syndrome has not been reported so far. PATIENT CONCERNS: A 52-year-old man presented with unc...

Background: The ability to distinguish between a normal thymus, thymic hyperplasia, and thymoma should aid in clinical management and decision making for patients with myasthenia gravis (MG). We sought to determine the accuracy of routine radiological examinations in predicting thymic pathology. Methods: We retrospectively analyzed the records of p...

Objective To observe the effect of low energy laser irradiation (LLLI) on the expression of microRNA (miRNA, miR)-214 in the infarcted region and its peripheral tissues in rats and to explore its significance. Methods 110 SD rats were randomly divided into sham operation group and sham operation group. In the control group and treatment group, the...

Aim: To observe the effect and significance of low-level laser irradiation (LLLI) on myocardial infarct area and the edge of the organization miRNA (miR) -21 expression. Methods: 110 SD rats were randomly divided into sham group(30 rats), the control group(40 rats) and the treatment group(40 rats). The control and treatment groups by ligation of th...

Objective To observe the low level laser irradiation (LLLI) rats with myocardial infarction after vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) expression of the impact and significance. Methods 110 SD rats were divided into three groups: sham group, the control group and the treatment group. The control and t...

The acute type A aortic dissection is rapidly onset and is in critical condition. If no surgical treatment is performed, the prognosis is extremely poor. The mortality rate is 50% within 48 hours, 70% within 1 week, and 90% within 2 weeks. In recent years, with the popularization of CT angiography (CTA) and the awareness of disease prevention, many...

Objective This paper aims to investigate the medical students' recognition on the physician-patient relationship,its influencing factors and the influence on specialty thinking.Methods We used homemade questionnaire to investigate 810 medical students of medical col ege and the af iliated hospital of Zhengzhou University. Results Show that 77.81% o...

The use of ventilator-assisted breathing to make models of rat myocardial infarction is more effective, causing more animal damage, tedious procedures, longer time, and slower postoperative animal recovery. This study was designed to investigate the rapid and effective use of ventilator machines. Establish a rat myocardial infarction model.

Objective: To investigate the risk factors for severe neurological complications after coronary artery bypass grafting. Methods: Data were collected from 1 060 patients undergoing coronary artery bypass graft surgery. Postoperative neurological complications occurred in 57 patients. Logistic analysis was used. Regression Screening risk factors for...

Objective To investigate the effect and mechanism of nanoceria nanoparticles on oxidative damage of rat cardiomyocytes. METHODS: Rat cardiomyocytes cultured in vitro were randomly divided into experimental group, model group and blank group; 10 nmol/L Nanoceria culture medium was cultured for 24 hours. The model group and blank group were cultured...

Acute aortic dissection (AAD) is a disease in which the morbidity rate increases year by year in the cardiovascular system. Typical AAD patients have severe, sudden, chest-back, and tear-like pain. Severe sudden syncope, heart failure, and even sudden failure to rescue. It has been reported that the mortality rate of this disease is 1%~2% in early...