Chantal M A M van der Horst

Academisch Medisch Centrum Universiteit van Amsterdam | AMC · Department of Plastic and Reconstructive Surgery

Background: Chronic pelvic sepsis mostly originates from complicated pelvic surgery and failed interventions. This is a challenging condition that often requires extensive salvage surgery consisting of complete debridement with source control and filling of the dead space with well-vascularized tissue such as an autologous tissue flap. The abdomin...

Background A congenital melanocytic naevus (CMN) is a rare skin condition that can be associated with abnormalities of the central nervous system (CNS). These anomalies can sometimes cause severe complications, and rarely death. Adequate information about aetiology and management is therefore crucial. To identify how to monitor patients with CMN, w...

Background : Treatment indications of congenital melanocytic naevi (CMN) have shifted from prevention of malignant transformation towards improvement of appearance and psychosocial health. Surgical excision is often preferred. However, its safety and effectiveness remain unclear. Objective : To assess the outcomes of surgical excision of medium-to...

the Science of Variation Groupk Purpose To determine whether simplification of the EatoneGlickel (E-G) classification of trape-ziometacarpal (TMC) joint arthrosis (eliminating evaluation of the scaphotrapezial [ST] joint) and information about the patient's symptoms and examination influence interobserver reliability. We also tested the null hypoth...

Background Peripheral vascular malformations (VMs) may lead to disfigurement of the body and face, potentially impairing aesthetic appearance. Yet, data on appearance in this population is limited. This study aimed to examine appearance-related concerns and their impact on health-related quality of life (HR-QoL) in patients with VMs. Methods In th...

Background: There is limited evidence on the best available treatment options for capillary malformations (CMs), mainly due to the absence of uniform outcome measures in trials on therapies. A Core Outcome Set (COS) enables standard reporting of trial outcomes, which facilitates comparison of treatment results. Objectives: To develop a core outc...

Introduction: Medium-to-giant congenital melanocytic nevi (CMN) can have a severe impact on life, due to their abnormal appearance, and association with melanoma and neurological complications. During the last decade, treatment has shifted from prevention of malignant transformation towards improvement of appearance and psychosocial health. To ena...

Background: Treatment indications of congenital melanocytic nevi (CMN) have shifted from prevention of malignant transformation towards improvement of appearance and psychosocial health. Surgical excision is often preferred. However, its safety and effectiveness remain unclear. Objective: To assess the outcomes of surgical excision of medium-to-...

Background Madelung deformity is a rare congenital hand difference with little known regarding the patient perspective. In this cross-sectional survey study, we harnessed the global reach of social media to understand the clinical spectrum of Madelung deformity and its impact on physical, mental, and social health. Methods A survey was developed b...

Objective Vascular malformations can negatively impact the patient’s quality of life. Pain is a common problem in these patients. The aim of this study was to investigate risk factors associated with pain and to assess how pain affects quality of life. Methods This prospective cross-sectional study was conducted in a tertiary vascular anomaly expe...

Background Macrodactyly is a rare congenital disorder of overgrowth affecting the digits of the upper or lower extremity. Mostly, patients are surgically treated during childhood to reduce the digit or to stop growth. There are no standardized guidelines for treatment and follow-up of macrodactyly. Consequently, follow-up may not be regularly sched...

Background and aim: Arteriovenous malformations (AVM) are defined as being quiescent vascular masses composed of mature vessels. However, recent studies reported areas of microvascular proliferation (MVP) in AVM, indicating a process of angiogenesis. As this finding questions the previous definition, the primary objective of this review was to eva...

Background Capillary malformations of the head and neck region often cause psychological and physical burden. As the effectiveness of modern laser and light therapies is still suboptimal, patients often seek different therapeutic strategies. Other recognized, but not routinely proposed therapies include cosmetic camouflage, surgery, and medical tat...

Background: Due to a large variety in treatment outcomes reported in therapeutic trials and lacking patient-relevant outcomes, it is hard to adequately compare and improve current therapies for patients with capillary malformations (CMs). The Core Outcome Set for Capillary Malformations (COSCAM) project aims to develop a core outcome set (COS) for...

Introduction: Patients with congenital vascular malformations often suffer from an impaired quality of life (QoL) because of pain and functional disabilities. Previous studies have shown that the mTOR inhibitor sirolimus can reduce complaints and improve QoL in some patients. High target levels of sirolimus of 10-15 ng/ml were well tolerated; howe...

Background: Congenital melanocytic naevi (CMN) can have a great impact on patients' lives due to perceived stigmatization and the risk of melanoma development and neurological complications. Development of a core outcome set for care and research of CMN will allow standard reporting of outcomes. This will enable comparison of outcomes, allowing pr...

Summary Background The symptoms and appearance of vascular malformations can severely harm a patient’s quality of life. The aim of treatment of vascular malformations generally is to improve condition‐specific symptoms and/or appearance. Therefore, it is highly important to start testing treatment effects in clinical studies from the patient’s pers...

Background: Surgical treatment of peripheral vascular malformations is widely performed as primary and secondary treatments. Excellent results have been reported; however, it is thought that complications are likely to occur because of damage to adjacent structures. This systematic review aimed to elucidate the indications and outcomes of surgical...

Background: Wide excision (WE) is generally considered to be the most common treatment for recurrent hidradenitis suppurativa. When performed, excision is followed by decisions regarding best options for management of the surgical defect. Different reconstructive strategies (RSs) have been used, with varying rates of recurrence. Objective: To pr...

Background The OVAMA (Outcome Measures for VAscular MAlformations) project determined quality of life (QoL) as a core outcome domain for evaluating treatment effect in vascular malformations. To correctly evaluate treatment effect on QoL, patient-reported outcome measures (PROMs) are needed that are responsive to changes. In children with vascular...

Background: Treatment recommendations for trapeziometacarpal (TMC) arthrosis are highly variable from surgeon to surgeon. This study addressed the influence of viewing radiographs on a decision to offer surgery for TMC arthrosis. Methods: In an online survey, 92 hand surgeons viewed clinical scenarios and were asked if they would offer surgery t...

Background: An appropriate reconstruction strategy after wide excision for severe cases of anogenital hidradenitis suppurativa (aHS) is important to optimize outcomes, but there is no consensus on which reconstruction strategy should be preferred. Objective: Evaluate which reconstruction strategy after wide excision in patients with severe aHS i...

Background: A plethora of outcome measurement instruments (OMIs) are being used in port wine stain (PWS) studies. It is currently unclear how valid, responsive, and reliable these are. Objectives: The aim of this systematic review was to appraise the content validity and other measurement properties of OMIs for PWS treatment to identify the most a...

Background Medium, large and giant congenital melanocytic nevi (CMN) can impose a psychosocial burden on patients and families, and are associated with increased risk of developing melanoma or neurological symptoms. Lack of consensus on what outcomes to measure makes it difficult to advise patients and families about treatment and to set up best pr...

Background Valid and reliable outcome measures are needed to determine and compare treatment results of port wine stain (PWS) studies. Besides, uniformity in outcome measures is crucial to enable inter-study comparisons and meta-analyses. This study aimed to assess the heterogeneity in reported PWS outcome measures by mapping the (clinical) outcome...

Vascular malformations are a group of rare congenital (present at birth) vessel anomalies. Mostly visible as a bumpy mass different in colour from normal skin, they can cause disfigurement of the face or body. Patients often experience pain, physical impairment, bleeding, and psycho‐social problems, leading to an overall poor quality of life. Thus,...

Background: Surgery is considered to be the best treatment for recurrent hidradenitis suppurativa (HS). Varying recurrence rates have been reported in the literature. Objective: To provide an up-to-date systematic review of the complete literature for different excision strategies and their recurrence rates in HS. Methods: A systematic literat...

Purpose The Outcome measures for vascular malformation (OVAMA) group reached consensus on the core outcome domains for the core outcome set (COS) for peripheral vascular malformations (venous, lymphatic and arteriovenous malformations). However, it is unclear which instruments should be used to measure these domains. Therefore, our aims were to ide...

Background: Congenital melanocytic naevi (CMN) can have a great impact on patients' lives due to the remarkable appearance and the risk of developing melanoma and neurocutaneous melanosis. Comparison of treatment efficacy is currently hindered by the lack of standard and uniform outcome reporting; this impedes guidance on optimal management policy...

Introduction: The OVAMA (Outcome measures for vascular malformations) project determined quality of life (QoL) as a core outcome domain for patients with vascular malformations. In order to measure how current therapeutic strategies alter QoL in these patients, a patient-reported outcome measurement (PROM) responsive to changes in QoL is required....

Background: Bleomycin sclerotherapy is ineffective for treating capillary malformations (CMs) because bleomycin cannot adequately be injected into the small-diameter capillary lumina. Electrosclerotherapy (EST) might be a new treatment modality for CMs, as it combines bleomycin sclerotherapy and "electroporation"-an electric field applied to the t...

Background: Having large congenital melanocytic nevi (CMN) is associated with a psychosocial burden on patients and their parents because of its remarkable appearance and the extra care it may require. Large CMN also pose an increased risk of malignant melanoma or neurocutaneous melanosis. There is a lack of international consensus on what importa...

The aim was to evaluate if motion between the scaphoid bone fragments is related to the position of the fracture line and if a scaphoid nonunion results in the uncoupling of the proximal and distal carpal row during wrist motion. The influence of dorsal intercalated segment instability on interfragmentary motion was also analysed. In this study, 12...

Staging disease when the patient comes for their consultation is an important part of estimating the disease's subsequent course (prognosis) and the likely effectiveness of any treatment. Staging means formally assessing the disease's severity including its extent, such as how much of the skin is affected. Hidradenitis suppurativa (HS) is a chronic...

在患者就诊时疾病分级是估计疾病的后续病程(预后)及任何治疗的可能疗效的一个重要部分。分级是指正式评估疾病的严重性, 包括程度(例如, 受影响皮肤的面积)。化脓性汗腺炎(HS)是一种在身体褶皱部位出现的慢性皮肤炎症(如腹股沟或腋窝),在这些部位出现脓疮和脓疱, 因此可能导致结疤。至少有4种不同评分方法用于疾病分级, 其中最常用的是Hurley分级法。本研究是德国、丹麦和波兰不同科室间的一次国际合作, 旨在审查不同皮肤科医生(包括实习医生)在两种不同情况下对5名不同患者HS分级评定的一致性。测验显示在不同医生间及同一医生在不同情况下都很难获得一致评估。在不同医生间或同一医生在不同情况下一致性都最高的评分方法是国际化脓性汗腺炎评分系统及HS医师整体评估量表。作者强调了培训医生对如何使用这些评分系统...

An appropriate reconstruction strategy after wide excision for severe cases of axillary hidradenitis suppurativa (HS) is important to optimize outcomes, but no consensus exists on which reconstruction strategy should be preferred. Objective: Evaluate which reconstruction strategy after wide excision in patients with severe axillary HS is associat...

There is a variety of outcome reporting in the clinical research on peripheral vascular malformations including capillary, venous, lymphatic, arteriovenous and combined malformations. Without harmonization of outcome measures, treatments cannot be properly compared. This hampers the development of evidence‐based treatment guidelines, urgently neede...

https://onlinelibrary.wiley.com/doi/10.1111/jdv.15599 Background Since the early ‘80s the pulsed dye laser has been the standard treatment for port wine stains (PWS). In the last three decades, a considerable amount of research has been conducted to further improve clinical outcomes, given that a fraction of PWS patients proved recalcitrant to lase...

Objectives: The aim of this retrospective study was to compare subcuticular sutures and Steri-Strip™ S in closing median sternotomy incisions in children with regard to wound healing and scar formation. Methods: Fifty-three children and adolescents were enrolled in this study who all underwent a median sternotomy at age 0-18 years and had their...

Background Hidradenitis suppurativa (HS) is a chronic, inflammatory and recurrent skin disease. Different staging instruments have been suggested, but none has achieved universal acceptance. Despite the fact that the Hurley staging is one of the most widely applied HS disease severity staging instruments, it has not been validated. Objective To de...

Background: Micrognathia occurs isolated and as part of entities like Robin sequence (RS). An objective measurement of mandible size and growth is needed to determine the degree of micrognathia and enable a comparison of treatment outcomes. A pilot study was conducted to investigate the usability of 3-dimensional (3D) facial photogrammetry, a fast...

Purpose: There is paucity of data on patient-perceived outcomes of bleomycin sclerotherapy for low-flow vascular malformations. In this study, the long-term outcomes of bleomycin sclerotherapy were investigated in terms of quality of life (QoL) and patient-perceived changes in health. Materials and methods: A cohort of Dutch patients with vascul...

Introduction A scaphoid fracture is the most common carpal fracture. When healing of the fracture fails (nonunion), a specific pattern of osteoarthrosis occurs, resulting in pain, restricted wrist motion and disability. Scaphoid fracture classification systems recognize fragment displacement as an important cause of nonunion. The fracture is consid...

We present a case of a 67-year-old man with episodes of extreme pain of the right lower extremity that prevented him from walking and sleeping. The patient had a history of varices in both legs. Physical examination showed a pretibial varix of the right leg inferiorly from a painful spot. X-ray of the right lower leg showed a cortex disruption at t...

Vascular malformations are congenital anomalies of the vascular and/or lymphatic system that affect the head and neck region. The most common treatment options are sclerotherapy, laser therapy, surgery, and embolization. Because vascular malformations are variable in type, size, extent, and location, it is a challenge to select methods for evaluati...

外周血管畸形(VM)是指由在胚胎中形成的血管发育缺陷而导致的胎记或肿胀。不同的类型可根据其主要组成部分来分类:分为淋巴管(LM)、血管(VM)或结合动脉和血管(AVM)。目前难以评估现有的各种医疗和外科手术治疗方法,因为医学界尚没有衡量结果指标的统一方法。该国际组织针对医务人员和患者开展了一项在线调查,以决定未来的临床试验中需要重点记录的因素。他们首先列出了病情及其疗法的各种方面,涉及36个领域共97个具体项目。随后,他们邀请了167名医生和134名患者及患者父母对这些项目进行打分,从0(不重要)到4(至关重要)。经过3轮调查和共识会议之后,选项范围逐渐缩小。最终达成一致的“核心指标集”涵盖:扫描结果;医生对由VM压力引起的问题的评估;患者或父母对症状、疼痛和生活质量的评估;以及他们对治疗、...

Introduction The current state-of-the-art treatment modality for hypertrophic capillary malformations (CMs), laser therapy, has a considerable rate of non-responders and recurrence. Intralesional bleomycin injections (or ‘sclerotherapy’) are commonly used to treat venous and lymphatic malformations with an excellent effect, but these intravascular...

Background: An important limitation in vascular malformation research is the heterogeneity in outcome measures used for the evaluation of treatment outcome. Objective: The Outcome measures for VAscular MAlformations (OVAMA) project aimed to reach international consensus on a core outcome set (COS) for clinical research on peripheral vascular mal...

Introduction: Venous malformations (VMs) are ubiquitous, low-flow vascular anomalies known to be occasionally painful due to thrombotic episodes within the lesion. The prevalence of superficial or deep vein thrombosis is unclear. Methods: A cross-sectional study among outpatients aged ≥ 12 years with pure VMs was performed, quantifying the preva...

Objective: To evaluate complications of pregnancy, including thromboembolism, in women with extensive vascular malformations associated with Klippel-Trenaunay Syndrome (KTS). Design: Nationwide cross-sectional study. Setting: Two tertiary expert centers and the Dutch Klippel-Trenaunay patient organization. Sample: Adult women with KTS. Meth...

Background: In shared decision-making, clinicians and patients arrive at a joint treatment decision, by incorporating best available evidence and the patients' personal values and preferences. Little is known about the role of shared decision-making in managing patients with congenital vascular malformations, for which preference-sensitive decisio...

Introduction Low-flow vascular malformations are congenital abnormalities of the veins, capillaries or lymphatic vessels or a combination of the previous. Compressive garments are frequently used as a first-line treatment option for low-flow vascular malformations of the extremities with the purpose of relieving symptoms. Yet, the benefits and harm...

Objectives: Polyhydramnios is suggested to be associated with oral clefts (OC) due to swallowing problems. This study assessed incidence and outcome of idiopathic polyhydramnios in isolated OC pregnancies. Methods: This was a retrospective cohort study of prenatally diagnosed OC. The incidence of idiopathic polyhydramnios in isolated OC pregnanc...

Vascular Malformations on soft tissue: Clinical versus Histological Diagnosis Objective The International Society for the Study of Vascular Anomalies (ISSVA) classification, is based on histopathological findings. In daily practice, diagnosis are made clinically. For effective therapeutic decision-making and research, correct diagnoses are necessa...

This patient-reported outcome (PRO) study reports on 102 children with Robin sequence (RS) and their parents. There has been differentiated between those with isolated RS and those with RS as part of a syndrome, and take various treatments into account. All RS families from an earlier described cohort were invited to participate. Parents and RS chi...

Patients with extensive lymphatic malformations associated with tissue overgrowth syndromes (such as Klippel-Trenaunay syndrome and CLOVES) often pose a therapeutic challenge for physicians. In recent years, it has been suggested that oral sildenafil therapy might be used to treat congenital lymphatic malformations. However, this possible new thera...

Introduction: Craniosynostosis represents premature closure of cranial sutures. Prevalence is approximately 3.1-6.4 in 10.000 live births, which is reportedly rising. This epidemiologic study aims to provide insight into this rise through an accurate description of the prevalence, exploring regional variation and change over time. Methods: The D...

We present a case of a 7 week old baby girl with a rapidly involuting congenital hemangioma (RICH), presenting as an ulcerating erythematous plaque on the sole of the foot. We discuss the clinical aspects of RICH.

We present the case of a young girl with a large segmental facial infantile hemangioma and a combination of a Dandy-Walker malformation and dysplasia of the internal carotid artery. This meets the diagnostic criteria for PHACE syndrome. PHACE syndrome is defined by large (segmental facial) infantile hemangiomas associated with posterior fossa anoma...

Background: Considerable advances have already been made in the treatment of deep thoracic wound infections following a median sternotomy for cardiac surgery. Further improvement in diagnosis, treatment, and outcome will require a targeted approach by multidisciplinary teams. Clear communication and synergy between the various clinical and support...

Beckwith–Wiedemann syndrome (BWS) is an overgrowth disorder in which macroglossia is one of the main signs. We investigated the long-term outcome of tongue surgery reduction (TRS) on taste and speech in patients with BWS who were more than 5 years of age and had undergone surgical anterior wedge resection of the tongue. A questionnaire was used to...