Chantal W B Boonacker

Chantal W B Boonacker
University Medical Center Utrecht | UMC Utrecht · Julius Center for Health Sciences and Primary Care

PhD

About

33
Publications
3,361
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845
Citations

Publications

Publications (33)
Article
Background: Prior to introducing pneumococcal conjugate vaccines (PCVs), Streptococcus pneumoniae was most commonly isolated from middle ear fluid of children with acute otitis media (AOM). Reducing nasopharyngeal colonisation of this bacterium by PCVs may lead to a decline in AOM. The effects of PCVs deserve ongoing monitoring since studies from...
Article
Full-text available
Objectives: The prenatal diagnosis of oral clefts (OCs) by ultrasound can pose an ethical dilemma. The purpose of this study was to obtain insight into the psychosocial and moral considerations of prospective parents concerning OCs, the burden of OCs and parents' attitude toward possible termination of pregnancy (TOP) in order to improve counselin...
Article
Full-text available
Background No consensus exists on the optimal treatment protocol for orofacial clefts or the optimal timing of cleft palate closure. This study investigated factors influencing speech outcomes after two-stage palate repair in adults with a non-syndromal complete unilateral cleft lip and palate (UCLP). Methods This was a retrospective analysis of a...
Data
Test form for the evaluation of speech in patients with an orofacial cleft according to the Dutch national protocol (translated into English)
Article
Objective: To identify early factors associated with disease course in patients with juvenile idiopathic inflammatory myopathies (JIIM). Methods: Univariable and multivariable multinomial logistic regression analyses were performed in a large JIIM registry (n=365), including demographics, early clinical features, serum muscle enzyme levels, myos...
Article
To introduce and validate a new oral cleft classification system based on prenatal ultrasound for use by professionals in daily practice. During a three-year period (2011-2014), all cases of prenatal oral cleft diagnosed by ultrasound were retrospectively reviewed. A new prenatal ultrasound classification system was introduced. For the purpose of v...
Article
Full-text available
To assess the opinion of obstetric care providers who perform prenatal ultrasounds to screen for anomalies and who advise women about their options, including termination of pregnancy, when an oral cleft is detected. We compared providers' opinions about pregnancy termination for isolated oral cleft in the Netherlands, where the number of terminati...
Article
Background Serum thymus and activation-regulated chemokine (sTARC) levels reflect disease severity of atopic dermatitis (AD) in small study populations. It remains unclear whether sTARC is a reliable outcome measurement for AD severity in heterogeneous AD populations in daily practice. Objective We sought to assess the utility of sTARC as a biomar...
Article
Childhood immune thrombocytopenia (ITP) is a rare autoimmune bleeding disorder. Most children recover within 6 to 12 months, but individual course is difficult to predict. We performed a systematic review and meta-analysis to identify predictors of chronic ITP. We found 1399 articles; after critical appraisal, 54 studies were included. The followin...
Article
Background Hazelnut allergy in adults is often birch pollen-related, whereas in children non-pollen-related hazelnut allergy is more frequent.Objective To compare the differences in hazelnut allergy between children and adults with regard to severity, aetiology and diagnostic value of routinely available data.Methods Adults (n=120) who underwent a...
Article
Acute otitis media (AOM) is a very common respiratory infection in early infancy and childhood. The marginal benefits of antibiotics for AOM in low-risk populations in general, the increasing problem of bacterial resistance to antibiotics and the huge estimated direct and indirect annual costs associated with otitis media (OM) have prompted a searc...
Article
Background/Purpose:Three disease courses can be distinguished in patients with juvenile idiopathic inflammatory myopathies (JIIM): monocyclic (M), polycyclic (P), and chronic continuous (CC). Predictors of disease course could result in improved therapy and help focus research efforts. We examined the association of immunogenetic and environmental...
Article
Full-text available
Otitis media (OM) is a leading cause of medical consultations, antibiotic prescription and surgery in children. The surgical procedures offered to children with recurrent or persistent OM are insertion of grommets, adenoidectomy or a combination of the two. There is clear National Institute for Health and Care Excellence guidance for the use of gro...
Article
Objective To compare the costs associated with 2 clinical strategies in children with recurrent upper respiratory tract infections (URTIs): immediate adenoidectomy vs an initial watchful waiting strategy. Design A cost-minimization analysis from a societal perspective including both direct and indirect costs, alongside an open randomized controlled...
Article
Full-text available
High rates of potentially pathogenic bacteria and respiratory viruses can be detected in the upper respiratory tract of healthy children. Investigating presence of and associations between these pathogens in healthy individuals is still a rather unexplored field of research, but may have implications for interpreting findings during disease. We sel...
Data
Full-text available
Bacterial colonization in relation to the co-occurrence with respiratory viruses. (PDF)
Data
Bacterial colonization in relation to the co-occurrence with other pathogenic bacteria. (PDF)
Article
To assess the effectiveness of adenoidectomy in children with recurrent upper respiratory tract infections. Open randomised prospective trial (Dutch Trial Register: 968; ISRCTN-register: ISRCTN03720485). The study was performed in 11 general and 2 academic hospitals. 111 children aged 1-6 years with recurrent upper respiratory tract infections sele...
Data
Appendix 1: Data from generic and disease specific health related quality of life questionnaires
Article
Full-text available
To assess the effectiveness of adenoidectomy in children with recurrent upper respiratory tract infections. Open randomised controlled trial. 11 general hospitals and two academic centres. 111 children aged 1-6 with recurrent upper respiratory tract infections selected for adenoidectomy. A strategy of immediate adenoidectomy with or without myringo...
Article
In this paper, the authors compare subgroup analyses as outlined in grant applications and their related publications. Grants awarded by the Netherlands Organization for Health Research and Development (ZonMw) from 2001 onward that were finalized before March 1, 2010, were studied. Of the 79 grant proposals, 50 (63%) were intervention studies, 18 (...
Article
While pneumococcal conjugate vaccines have shown to be highly effective against invasive pneumococcal disease, their potential effectiveness against acute otitis media (AOM) might become a major economic driver for implementing these vaccines in national immunization programmes. However, the relationship between the costs and benefits of available...
Article
To analyse which strategies are used to promote evidence based interventions in the management of children with upper respiratory tract infections (URTIs) in daily practice. To assess the effectiveness of these interventions, and when more are effective--which works best. And to analyse the costs associated with these interventions. We systematical...
Article
Background: Adenoidectomy, surgical removal of the adenoids, is a common ENT operation worldwide in children with otitis media. A systematic review on the effectiveness of adenoidectomy in this specific group has not previously been performed. Objectives: To assess the effectiveness of adenoidectomy versus non-surgical management or tympanostomy...
Article
Background: Adenoidectomy, surgical removal of the adenoids, is a common ENT operation worldwide in children with recurrent or chronic nasal symptoms. A systematic review on the effectiveness of adenoidectomy in this specific group has not previously been performed. Objectives: To assess the effectiveness of adenoidectomy versus non-surgical man...
Article
Full-text available
Both treatment guidelines and the amount of antibiotics used for acute otitis media (AOM) vary across western countries. Parental expectations and their awareness of antimicrobial use and resistance, which may also be influenced by the guidelines, are not yet completely known. To compare parental experiences and opinions regarding the management of...
Article
To study the cost-effectiveness of a 6- to 12-week course of high-dose oral trimethoprim-sulfamethoxazole in children with chronic active otitis media (COM). Cost-effectiveness study including both direct and indirect costs alongside a randomized placebo-controlled trial. Tertiary care university hospital in the Netherlands. One hundred one childre...
Article
Transfer of evidence into practice is often slow and therefore remains an important challenge. Factors influencing this process include awareness and agreement with available evidence, feelings about the applicability of the evidence to one’s own patients and pressure from patients to start or refrain from a particular treatment. The best chance of...

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