Chang-Jun Lan

North Sichuan Medical University · Department of Ophthalmology and Optometry

Purpose To evaluate and compare the effect of decentration and tilt on the optical quality of monofocal and trifocal intraocular lenses (IOL). Methods Optical quality of a monofocal IOL (AcrySof IQ SN60WF; Alcon Laboratories, Inc., USA) and a trifocal IOL (AcrySof IQ PanOptix; Alcon Laboratories, Inc., USA) was assessed using an in vitro optical b...

AIM: To propose an algorithm for automatic detection of diabetic retinopathy (DR) lesions based on ultra-widefield scanning laser ophthalmoscopy (SLO). METHODS: The algorithm utilized the FasterRCNN (Faster Regions with CNN features)+ResNet50 (Residua Network 50)+FPN (Feature Pyramid Networks) method for detecting hemorrhagic spots, cotton wool spo...

Background Retinal disorders cause substantial visual burden globally. Accurate estimates of the vision loss due to retinal diseases are pivotal to inform optimal eye health care planning and allocation of medical resources. The purpose of this study is to describe the proportion of visual impairment and blindness caused by major retinal diseases i...

Purpose To investigate the effect of the optional biometric parameters lens thickness (LT) and center corneal thickness (CCT) in the Kane formula on intraocular lens (IOL) power calculation. Methods A cross-sectional study included consecutive cataract patients who received uncomplicated cataract surgery with IOL implantation from May to September...

Aim: To investigate the effect of all-trans retinoic acid (ATRA) on retinol dehydrogenase 5 (RDH5), matrix metalloproteinase-2 (MMP-2) and transforming growth factor-β2 (TGF-β2) transcription levels, and the effect of RDH5 on MMP-2 and TGF-β2 in retinal pigment epithelium (RPE) cells. Methods: After adult RPE cell line-19 (ARPE-19 cells) interve...

Purpose: To identify the expression of the mechanosensitive ion channel Piezo1 in the retina of guinea pigs with form deprivation myopia (FDM) and to investigate mechanisms by which Piezo1 channels might regulate myopia. Method: Sixty 3-week-old guinea pigs were divided into four groups randomly: normal control, FDM, FDM + vehicle control (DMSO)...

Purpose To investigate whether our modified hydrodissection is safe and efficient in age related cataract surgery. Methods A prospective, randomized, single-blind clinical study was performed in Chongqing Bishan Old Town Hospital from May 16 to August 31, 2022. Age related cataract patients without any other ocular disease were included. They were...

•AIM: To systematically evaluate the effects of 0. 01%, 0.025% and 0.05% ophthalmic atropine on the change of spherical equivalent (SE) degree and axial length (AL) of myopic children. •METHODS: PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang Database, VIP and CBM were searched for all publications related to 0.01%, 0.025% and 0. 05...

Purpose To evaluate the repeatability of wavefront aberration measurements and the correlation between corneal aberration and pupil size in normal eyes using a wavefront-based autorefractor (i.ProfilerPlus; Carl Zeiss Vision, Germany). Methods A prospective cross-sectional study. Wavefront aberrations, including spherical aberration (SA) (Z4⁰), co...

Objective: To compare the difference of decentration and tilt among 4 kinds of aspherical intraocular lenses (IOLs), and to analyze their objective visual quality. Methods: Prospective non-randomized controlled clinical trial. Age-related cataract patients who planned to undergo phacoemulsification and IOL implantation in the Affiliated Hospital of...

Background To investigate the effect of all-trans retinoic acid (ATRA) on retinol dehydrogenase 5 (RDH5), matrix metalloproteinase-2 (MMP2) and transforming growth factor-β2 (TGF-β2) transcription levels, and the effect of RDH5 on MMP-2 and TGF-β2. Methods After ARPE-19 cells intervened with gradient concentrations of ATRA (0–20 µM) for 24 h, flow...

Purpose: To compare the binocular vision status of patients pre- and post-cataract surgery, and to investigate the risk factors for patients who develop binocular vision anomalies post-surgery. Methods: A prospective study of patients (≥50 years) who elected to undergo bilateral cataract surgery was implemented. A comprehensive binocular vision...

Background This study is the first part of the “Binocular Vision Anomalies after Cataract Surgery” study that aimed to investigate the impact of cataract surgery on binocular vision status in adults with age-related cataract. This study aimed to investigate the preoperative binocular vision status of participants with age-related cataract. Methods...

Purpose The retina is a highly energy-consuming tissue associated with visual development, and the reduced quality of retinal imaging can be related to myopia. Synthesis of cytochrome c oxidase 1 ( SCO1) and synthesis of cytochrome c oxidase 2 ( SCO2) are involved in ATP (adenosine triphosphate) synthesis and energy metabolism. This study aimed to...

KCNQ5 is suggestively associated with myopia, but its specific role in the myopic process has not been studied further. The aim of this study was to investigate the expression of potassium channel gene KCNQ5 and the changes of K⁺ microenvironment within the retina of form deprivation myopia (FDM) guinea pigs. A total of 60 guinea pigs were randomly...

Background: This study is the first part of the “Binocular Vision Anomalies after Cataract Surgery” study that aimed to investigate the impact of cataract surgery on binocular vision status in adults with age-related cataract. This study aimed to investigate the preoperative binocular vision status of participants with age-related cataract. Methods...

Congenital cataract is the most common cause of visual impairment and blindness in children worldwide, with about a quarter is related to genetics. To date, more than 100 gene mutations have been found in inherited congenital cataracts. As the most important component of the crystalline lens, the gene mutation of lens protein is closely related to...

AIM: To evaluate the repeatability of a swept-source optical coherence tomography (SS-OCT) based biometer-IOL Master 700 in ocular biometrics in cataract eyes, and to investigate its agreement with a partially coherent optical interference based biometer-IOL Master 500. This study was also designed to compare the detection rate of the axial length...

Purpose To evaluate the repeatability of wavefront aberration measurements and the correlation between corneal aberration and pupil size in normal eyes using a wavefront-based autorefractor (i.ProfilerPlus; Carl Zeiss Vision, Germany). Methods A prospective cross-sectional study. Wavefront aberrations, including SA (Z4⁰), coma (Z3 − 1, Z3¹), trefo...

In recent years, ocular biometers based on swept-source optical coherence tomography (SS-OCT) technology have emerged in ophthalmic practice. Compared with the earlier ocular biometers such as the partially coherent interference (PCI) based ones, the SS-OCT based devices have a higher signal-to-noise ratio, greater swept light wavelength, better ti...

Purpose: To investigate the impact of different sizes of steep meridian clear corneal incisions for phacoemul sification on anterior corneal higher-order aberrations. Methods: Medical records of patients who underwent 2.2-mm coaxial micro-incision cataract surgery or 2.75-mm coaxial small-incision cataract surgery were retrospectively reviewed....

With the advances in cataract phacoemulsification and intraocular lens implantation, more and more attention has been paid to the postoperative effects by both clinicians and patients. Meanwhile, the instruments for the preoperative measurements are also evolving. Various types of ocular biometers have emerged, which have evolved the principles fro...

Cataract surgery has become a refractive surgery, which has attracted much attention on postoperative functional vision and visual quality, and promoted the continuous development and improvement of intraocular lens (IOL) materials and design. The traditional presbyopia-correcting IOL has achieved distance and near visual acuity initially, while in...

AIM: To evaluate the repeatability and reproducibility of ocular biological measurements by a swept-source optical coherence tomography biometer IOL Master 700 in healthy eyes. METHODS: A diagnostic test study of 103 healthy subjects was implemented. The right eyes were selected for measurements. Ocular biological parameters including axial length...

This prospective cross-sectional study aimed to evaluate the agreement of two new biometers for measuring ocular biometric parameters in young healthy eyes. Ocular biometric parameters were measured using IOLMaster 700 and OA-2000. Power vector analyses of Cartesian (J0) and oblique (J45) components of corneal astigmatism were performed. The right...

Purpose To investigate whether optical quality could be improved by cylindrical correction for low astigmatic eyes with different amounts and axis orientations in patients with myopia up to − 3.00 diopters (D). Methods A cross-sectional study enrolling healthy young eyes with 0 to − 3.00 D myopia and − 0.50 to − 0.75 D myopic astigmatism was imple...

Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and lim...

BACKGROUND: To compare the postoperative optical quality in eyes with customized selection and random selection of aspheric intraocular lens (IOL) implantation. METHODS: A prospective, nonrandomized study was implemented in adult cataract patients who underwent unilateral phacoemulsification with aspheric IOL implantation. Patients were allocated...

Backgroud To compare the postoperative optical quality in eyes with customized selection and random selection of aspheric intraocular lens (IOL) implantation. Methods A prospective, nonrandomized study was implemented in adult cataract patients who underwent unilateral phacoemulsification with aspheric IOL implantation. Patients were allocated into...

Objective: To systematically compare the effects of Toric intraocular lens (IOL) implantation and corneal incisional procedures on the correction of astigmatism during cataract surgery. Methods: A peer-reviewed literature search was implemented in MEDLINE, EMBASE, EBSCO, ScienceDirect, Trip Database, Ovid, and the Chinese databases including CNKI a...

Backgroud To compare the postoperative optical quality in eyes with customized selection and random selection of aspheric intraocular lens (IOL) implantation. Methods A prospective, nonrandomized study was implemented in adult cataract patients who underwent unilateral phacoemulsification with aspheric IOL implantation. Patients were allocated into...

Purpose: To evaluate the effects of different residual total ocular spherical aberration (SA) on objective and subjective visual quality in pseudophakic eyes. Methods: This prospective consecutive study comprised 171 patients with age-related cataract and undergone unilateral uneventful phacoemulsification. All participants were divided into four g...

Backgroud To improve the aspheric intraocular lens (IOL) selection strategy in cataract surgery. Methods A prospective, nonrandomized study was implemented in adult cataract patients who underwent unilateral phacoemulsification with aspheric IOL implantation. Patients were allocated into two treatment groups: a customized group and a control group....

Purpose: To compare the visual and optical quality of eyes implanted with three aspheric versus two spherical intraocular lenses (IOL) after cataract surgery. Methods: This prospective comparative study included 349 eyes of 349 patients with age-related cataract and undergone uneventful phacoemulsification. Implanted posterior monofocal IOLs have a...

Purpose: The aim of this study was to improve selection strategies among aspheric and spherical mono-focal intraocular lenses (IOLs) in cataract surgery. Methods: Peer-reviewed literature was searched in MEDLINE, Cochrane Library, EMBASE, EBSCO, ScienceDirect, Trip Database, Ovid, and ClinicalTrials.gov using keywords "Tec-nis", "Sensar", and "intr...

Aims/Introduction To investigate the protective effect of polygonati sibiricum polysaccharide (PSP) on the retina in diabetic rats. Materials and Methods A total of 120 SD rats were randomly divided into blank control (BC), model control meaning diabetic mellitus (DM), and DM with PSP intervention of high (H), medium (M) and low (L) doses groups....

Purpose: To compare objective optical quality, ocular scattering and aberrations of eyes implanted with an aspheric monofocal intraocular lens (IOL) or an aspheric apodized diffractive multifocal IOL three months after surgery. Methods: Prospective consecutive nonrandomized comparative cohort study. A total of 80 eyes from 57 cataract patients were...

As the results of both environmental and genetic factors, myopia is one of the most popular refractive errors in the world. In recent years, progressive achievements have been made in genome-wide association study (GWAS) of myopia and refractive error. A lot of susceptibility loci and regions have been found, which means the researches on genetic b...

Refractive error (RE) is a complex multifactorial disease. Genome-wide association studies (GWAS) have provided significant insight into the genetic architecture and identified plenty of robust genetic variations or single nucleotide polymorphisms (SNPs) associated with complex disease. A major current challenge is to convert those resources into c...

Aim: To investigate the possible association between CFH gene polymorphisms -543G>A (rs1410996), A473A (rs2274700), -257C>T (rs3753394), IVS15 (rs1329428) and AMD risk. Methods: We searched the published literature in the Medline and Scopus from inception to May 2015. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and t...

AIM: To evaluate the clinical effect and safety for diabetic macular edema (DME) with triamcinolone acetonide (TA) by intravitreous injection and retrobulbar injection combined with macular grid laser photocoagulation. METHODS: Fifty-two patients (sixty-two eyes) with DME were randomly divided into two groups: thirty-one eyes were treated with an i...

To investigate the association between lumican gene -1554 T/C polymorphism and high myopia susceptibility. We searched the published literature in the Medline, Embase, and CBM databases from inception to July 2013. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the odds ratio (OR) with 95% confidence interval (CI) was...

AIM: To investigate the cause and treatment of high intraocular pressure (IOP) after pars plana vitrectomy (PPV). METHODS: Totally, 482 patients (511 eyes) underwent PPV from January 2007 to March 2010, were reviewed to explore the mechanism and treatment of high IOP after PPV. RESULTS: High IOP occurred in 140 patients (141 eyes), the rate of IOP...

The purpose of this study was to elucidate the molecular basis of ocular albinism type I in a Chinese pedigree. Complete ophthalmologic examinations were performed on 4 patients, 7 carriers and 17 unaffected individuals in this five-generation family. All coding exons of four-point-one (4.1), ezrin, radixin, moesin (FERM) domain-containing 7 (FRMD7...

AIM: To investigate neuroprotective effects of Erigeron brevicapas hand mass (EBHM) on the optic nerve of chronic glaucoma model in rats. METHODS: Ninety adult Wistar rats were divided into three groups. The trabecular meshwork of both eyes of the 1st and 2nd group rats were performed photocoagulation with 532nm Krypton laser to establish chronic g...

AIM: To explore the clinical effect of pars plana vitrectomy(PPV) combined triamcinolone acetonide(TA) intravitreal injection for proliferative diabetic retinopathy(PDR). METHODS: The study included 90 patients with PDR was who underwent PPV: TA group included 50 eyes, control group included 48 eyes. The visual acuity, inflammation, intraocular pre...