Chandrika Dinesh Nayak

Manipal Academy of Higher Education | MAHE

Objective: The present study was carried out to assess the effects of fenugreek seed extract on various biochemical and haematological parameters in high-fat diet (HFD)-fed rats. Methods: Female Wistar rats were allocated into five groups (n = 6): 1) control rats, 2) HFD-fed control rats 3) rats fed with HFD and fenugreek (FG) seed extract at do...

Introduction: Medical education today, encourages modification of traditional didactic lectures with innovations to promote active learning strategies to enhance integration of knowledge and critical thinking skills among students. Learning independently is challenging in year 1 of the undergraduate medical curriculum. However, defining the learnin...

Higher risk of infections, poor neurodevelopmental outcomes and morbidity is commonly associated with low birth weight (LBW) in neonates. Early identification of risk is an ongoing challenge for pediatricians. The current retrospective study screened 1232 neonates born over a period of one year in a secondary care hospital of south India. The study...

Convulsive status epilepticus (CSE) is a common pediatric neurological medical emergency associated with significant morbidity and mortality. The current study aimed to study the relation of age, sex, etiology and outcome in CSE. A total of 94 subjects aged 1month and above with CSE were included for the present study. Results were analyzed using C...

Objective: Fetus with intrauterine stress may exhibit programmed changes that can alter its metabolism and bear severe risk for diseases in adult life. The current study was designed to assess the correlation between cord blood lipid profile with the anthropometric data in neonates. Materials and methods: 146 newborn babies born at Dr. T M A Pai...

Thyroid hormone is crucial for growth and hence the current study is designed to correlate the cord blood thyroid stimulating hormone (TSH) levels with their anthropometry and maternal factors in 187 newborns. Statistical analysis was done by Mann Whitney-U test and Spearman correlation coefficient. TSH levels were significantly higher in males tha...

To determine the composition of non pathogenic microflora (NPM) and pathogenic microflora (PM) and the assessment of factors affecting their colonization in the oropharynx. Oropharyngeal swabs were obtained from 464 infants, aged 15 days to I year, with or without clinical signs and symptoms of upper respiratory tract infection (URTI), for the curr...

Epidemiologic works reveal that moderate head injury (MHI) is more frequent and a substantial number of these patients develop complications resulting in neurological disabilities. Reactive oxygen species (ROS) play a major role in post-traumatic neuronal damage following traumatic head injury. Thus, the current study analysed the post-traumatic ch...

Acute oxidative stress following a traumatic head injury (HI) has been implicated in inducing severe secondary brain damage and influencing the clinical outcome of HI patients. This study was performed to evaluate and compare the oxidative changes in patients with varying severity of HI in the early posttraumatic period using erythrocyte indicators...

Reactive oxygen species are indicated to play a prime role in the pathophysiology of brain damage following a severe head injury (SHI). The current study was designed to understand the time-relative changes and relationship between erythrocyte antioxidant enzyme activities and Glasgow Coma Scale (GCS) scores of SHI patients in the 21-day posttrauma...

Experimental data indicate that destructive oxidative events reach their peak within the first 24 h after trauma in head injury (HI) and that brain damage occurring due to this impact can be the cause of death or irreversible permanent disabilities in affected patients. Venous blood samples were obtained from 50 HI patients within 24 h of trauma on...

Oxidative stress is said to strongly influence the neurological recovery of patients following a severe head injury. Estimation of the markers of oxidative stress in the blood of such patients can hence aid in predicting the prognosis of head injury. Erythrocyte thiobarbituric acid-reactive substances (TBARS) and plasma ceruloplasmin (CP) levels we...