Chandra Mohan

Shanmuga Centre for Medicinal Plants Research, TN, India · Phytochemistry

Sn doped zinc oxide (ZnO:Sn) thin films were deposited on to the ultrasonically cleaned pre-heated glass substrates by employing simplified spray pyrolysis technique using spray gun at a constant temperature 250oC. The films were deposited on the substrate for various solution volume by taking 0.05M of Zinc acetate as precursor concentration along...

In the present study the methanol extract of a novel polyherbal formulation (PHF) was studied for alpha (α)- amylase and alpha (α)-glucosidase inhibition using an in vitro antidiabetic model. The polyherbal extract were also examined for its antioxidant activity by using free radical 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging method. The stud...

Background Natural products are the rootstock for identifying new drugs since the ancient time. In comparison with synthetic drugs, they have abounding beneficial effects in bestowing protection against many diseases, including cancer. Cancer has been observed as a major threat in recent decades, and its prevalence is expected to increase over the...

Shorea robusta has been widely used for its various pharmacological activities including cancer studies. The present study was designed to evaluate the antioxidant defense system of red blood cells in DEN induced hepatocellular carcinoma rats. Wistar strain male albino rats, weighing 180-200 g/bw were selected for the study. Group I was served as c...

Background and Objective: Environmental pollution from human activities is a major challenge of civilization today. This study aimed to use Sn doped ZnO nanoaprticles for the purification polluted water from dye and heavy metal. Materials and Methods: The Sn doped ZnO nanoparticles have been synthesized using a simple chemical method and characteri...

Background and Objective: Antioxidants are involved in the prevention of cancer, aging and variety of diseases. The scientific community has begun to interest in the identification, recovery and enhanced performance of natural antioxidant principles from plant sources. The objective of this present study is also guide to the invention of new antiox...

A novel series of Biginelli type dihydropyrimidinones derivatives were synthesized and investigated for their antibacterial activity against Gram positive and Gram negative bacteria. The recorded data of zone of inhibition showed significant broad activity when compared with standard. The structure reactivity correlation of the compounds has been s...

Substituted 2-benzylidene-1,3-indandiones have been prepared and characterized by UV, IR, 1 H and 13 C NMR spectral analysis. The antimicrobial activities and structure reactivity correlation of the compounds have been studied.

Substituted 6-aryl-4-methyl-2-oxo-1, 2, 3, 6-tetrahydropyrimidine-5-(N-aryl) carboxamides have been prepared and characterized by 1H NMR spectral analysis. The antimicrobial activities and structure reactivity correlation of the compounds have been studied.

Background and Objectives: Mushrooms are potent source of biologically active substances which have beneficial effect on human health. Many mushrooms contain polysaccharides which may boost human immune system. In the present study, polysaccharides were extracted and purified from two edible mushroom species, Pleurotus florida and Agrocybe cylindra...

Objective: In the present study, the leaves of Canthium parviflorum were subjected to preliminary phyto chemical and GC MS analysis. Methods: GC-MS analysis was carried out on the instrument GC and MS JEOL GC mate equipped with secondary electron multiplier. Results: Gas chromatography-mass spectrometry results revealed presence of 8 phytoconstitue...

Objective:Canthium coromandelicum is a traditional medicinal plant used in various regions of India for treating many diseases. However, its anticancer effects on hepatocellular carcinoma (HCC) have not yet been studied. The aim of this study was to investigate the chemopreventive action and the possible mechanisms of Ethanolic extract of Canthium...

Objective: The objective of this study was to evaluate in vitro antioxidant, antimicrobial activity and characterize the chemical constituents of leaves and seeds of Abutilon indicum by using gas chromatography–mass spectrometry (GC–MS). In addition total phenolics and flavanoids were also estimated. Materials and Methods: GC-MS analysis of plant a...

The present study was undertaken to evaluate the Ethanolic Extract of Tecoma stans (EETS) flowers for its protective effect on gentamicin-induced nephrotoxocity in rats. Nephrotoxocity was induced in rats by intraperitoneal administration of gentamicin 80 mg kg-1 dayG1 for seven days. Effect of concurrent administration of EETS at a dose of 500 mg...

Plant sterols (i.e. phytosterols) are important agricultural products for health and nutrition industries. Various phytochemical, antimicrobial, antioxidant and wound healing studies have already been carried out with canthium coromandelicum leaf extract . In our search for biologically active compounds, three steroids have been isolated from the l...

The purpose of this study is to regulate the ROS (Reactive oxygen species) defense system in cardiac damage induced by CCl4(Carbon tetra chloride) in rats using Hybanthus enneaspermus. Administration of CCl4 induces damage in the heart of rats as proved by estimation of antioxidant enzymes such as, SOD (Superoxide dismutase), CAT (catalase), GPx (...

The azo base of 1-(4-amino phenyl) ethanone and their complexes were synthesized and well characterized by elemental analysis, spectral studies, conductivity and magnetic measurements. All the complexes have lower molar conductance values, indicating their non-electrolytic nature. The synthesized ligands, along with their metal complexes were scree...

To find out the phytochemical, GCMS, hypoglycemic and hypolipidemic activities of ethanolic leaf extract of Catharanthus roseus is the main objective of the present study. The acclimatized animals were injected with Alloxan for induce diabetic condition. Animals were treated with ethanol extract of Catharanthus roseus and standard drug glibenclamid...

For thousands of years, nature has been a rich source of medicinal agent. A remarkable number of potent drugs have been isolated from natural sources, particularly plants, many of which are well established in their use in traditional medicine. Phytochemicals like terpenoids, alkaloids, flavonoids and steroids have been used either in their natural...

Objective: In this study methanol extract of leaves of canthium coromandelicum (Family: Rubiaceae) was screened for the presence of phytochemical components by GC-MS analysis. In addition total phenolics and flavanoids were also estimated. Methods: GC-MS analysis of plant extract was performed using a Perkin-Elmer GC Clarus 500 system and Interpre...

In this study, a new metal complex of Cu (II) with N, N’-bis(benzoin)-1,4 butane diimine was synthesized and characterized by FT-IR, 1H-NMR and Scanning Electron Microscope. The antioxidant activity of this complex was studied and compared with the activity of ascorbic acid. Antioxidant study was carried out against the 2,2-diphenyl-1-picrylhydrazy...

This study aims to synthesis of silver nanoparticles using aqueous extract of Canthium comandelicum leaves and evaluates its antibacterial activity, as well as antioxidant activity. Characterizations of silver nano particles(AgNPs) were determined by using ultraviolet-visible (UV-Vis) spectrophotometry, scanning electron microscopy (SEM), and X-ray...

This study aims to synthesis of silver nanoparticles using aqueous extract of Canthium comandelicum leaves and evaluates its antibacterial activity, as well as antioxidant activity. Characterizations of silver nano particles (AgNPs) were determined by using ultraviolet-visible (UV-Vis) spectrophotometry, Scanning Electron Microscopy (SEM) and X-ray...

The objective of this study was to evaluate the wound healing1 potential of the ethonolic extract of Canthium coromandelicum. The study was done on male albino rats using1 excision model. The ethanolic extract, treated wounds were found to epithelize faster and the rate of wound contraction was significantly increased as compared to control and sta...

Acalypha indica distributed in the southern part of India particularly in Tamilnadu and it has potential medicinal properties and used as diuretic, anthelmintic and for respiratory problems such as bronchitis, asthma and pneumonia. The present work was designed to investigate the preliminary phytochemical, antibacterial and GCMS analysis of ethanol...

The main objective of the medicinal chemistry is to synthesize the compounds that show promising activity and therapeutic agents with lower toxicity. Thiazolidinone are very useful compound with well known biological activities. Notable among these are antibacterial, antiviral, analgesic, anti-inflammatory, antitubercular and anticonvulsant. In the...

The batch removal of copper(II) ions from aqueous solution under different experimental conditions using Brassice oleracea (Cabbage) has been studied. The copper(II) uptake was dependent on the initial pH and initial copper concentration, with the pH 4 being the optimum value. The equilibrium data were fitted using Langmuir and Freundlich isotherm...

Schiff base derived between the condensation of aldehyde and amine. The main objective of this research work ,trans aminocyclohexanol condensed with three different aromatic aldehydes such as Ethyl Vanillin, 4-hydroxy benzaldehyde, Vanillin to from a Schiff base. The main objective of the present work is to synthesis one of the Schiff base by O-alk...

The phytochemical analysis of the medicinal plant Kalonchoe pinnata was carried out to evaluate the antioxidant potential. Alcoholic extracts of the leaves was subjected to in vitro antioxidant activity screening models such as inhibition of lipid peroxidation, nitric oxide ,superoxide radical and hydroxyl radical scavenging activity. Ascorbic acid...

The synthetic dyes which are of wide commercial importance cause severe atmospheric and environmental pollution. Use of natural dye has increased several folds in the past few years due to ecofriendly approach of the people.The present investigation was carried out for dyeing with natural dye obtained from flowers of Tecoma stans belongs to bignoni...

The phytochemical analysis of the medicinal plant Kalanchoe pinnata was carried out to evaluate the antioxidant potential. Alcoholic extracts of the leaves was subjected to in vitro antioxidant activity screening models such as inhibition of metal ion chelating activity and hydrogen peroxide scavenging activity.EDTA is used as a standard for metal...

In this study , we analyzed the induced genetic variability in Rhizobium using azo dye (methyl orange) which are commercially used in textile industries. we isolated and characterized the Rhizobium from root nodules of Arachis hypogaea by using colonial, morphological and biochemical methods. Inoculation of Rhizobium strain in different concentrati...