Chandima Edirisinghe

• Western University

Background Accurate segmentation of the clinical target volume (CTV) corresponding to the prostate with or without proximal seminal vesicles is required on transrectal ultrasound (TRUS) images during prostate brachytherapy procedures. Implanted needles cause artifacts that may make this task difficult and time‐consuming. Thus, previous studies have...

Purpose: The purpose of this study was to evaluate and clinically implement a deformable surface-based magnetic resonance imaging (MRI) to three-dimensional ultrasound (US) image registration algorithm for prostate brachytherapy (BT) with the aim to reduce operator dependence and facilitate dose escalation to an MRI-defined target. Methods and ma...

Purpose: To measure the accuracy and variability of manual high-dose-rate (HDR) prostate brachytherapy (BT) needle tip localization using sagittally reconstructed three-dimensional (3D) transrectal ultrasound (TRUS) augmented with live two-dimensional (2D) sagittal TRUS. Methods and materials: Ten prostate cancer patients underwent HDR-BT during...

Purpose: Sagittally reconstructed 3D (SR3D) ultrasound imaging shows promise for improved needle localization for high-dose-rate prostate brachytherapy (HDR-BT); however, needles must be manually segmented intraoperatively while the patient is anesthetized to create a treatment plan. The purpose of this article was to describe and validate an auto...

Ultrasound-guided high-dose-rate prostate brachytherapy (HDR-BT) needle segmentation is performed clinically using live-2D sagittal images. Organ segmentation is then performed using axial images, introducing a source of geometric uncertainty. Sagittally-reconstructed 3D (SR3D) ultrasound enables both needle and organ segmentation, but suffers from...

Background: High-dose-rate brachytherapy (HDR-BT) is a prostate cancer treatment option involving the insertion of hollow needles into the gland through the perineum to deliver a radioactive source. Conventional needle imaging involves indexing a trans-rectal ultrasound (TRUS) probe in the superior/inferior (S/I) direction, using the axial transduc...

Purpose: Conventional transrectal ultrasound guided high-dose-rate prostate brachytherapy (HDR-BT) uses an axially acquired image set for organ segmentation and 2D sagittal images for needle segmentation. Sagittally reconstructed 3D (SR3D) transrectal ultrasound enables both organ and needle segmentation and has the potential to reduce organ-needl...

An apparatus for determining a distribution of a selected therapy in a target volume is provided. A three-dimensional ultrasound transducer captures volume data from the target volume. A computing device is in communication with the three-dimensional ultrasound transducer for receiving the volume data and determining the distribution of the selecte...

Ultrasound imaging has improved the treatment of prostate cancer by producing increasingly higher quality images and influencing sophisticated targeting procedures for the insertion of radioactive seeds during brachytherapy. However, it is critical that the needles be placed accurately within the prostate to deliver the therapy to the planned locat...

The purpose of this study was to create a phantom to validate the Low Dose Rate Prostate Brachytherapy (LDRPB) plans using oblique (angled) needles delivered using robotic guidance in overcoming pubic arch interference for large prostates. Five patient 3D Trans?rectal Ultra Sound (TRUS)images were selected. The images were required to show a maximu...

Purpose: To validate the dosimetric benefits of Low Dose Rate Prostate Brachytherapy (LDPB) plans using oblique (angled) needles delivered using robotic guidance in overcoming pubic arch interference (PAT) for large prostates. Methods and Materials: Five patient 3D Trans?rectal Ultra Sound (TRUS)images that showed a maximum pubic arch interference...

An integrated system for minimally invasive robot-assisted image-guided lung brachytherapy has been developed. The system incorporates an experimental setup for accurate radioactive seed placement with commercially available dosimetry planning software. The end result is a complete system that allows planning and executing a brachytherapy procedure...

A confocal image understanding system was developed which uses the blackboard model of problem solving to achieve computerized identification and characterization of confocal fluorescent images (serial optical sections). The system is capable of identifying a large percentage of structures (e.g., cell nucleus) in the presence of background noise an...

Thesis (Ph. D.)--State University of New York at Buffalo, 1996. Includes bibliographical references (leaves 86-92). Photocopy of typescript.