Chandana Barua

• Professor (Full) at CVSc

Background: The anthelmintic activity of Butea frondosa seed extract as an alternative to the synthetic anthelmintic against GIPs in goats was undertaken by studying EPG, body weight and hemato-biochemical parameters in the infested goats. Methods: Goats (n=18) found positive for parasitic infection by screening at Goat Research Station (GRS), AAU,...

Colorectal cancer (CRC) is among the leading three diseases with higher death rates worldwide, with an expected 2.2 million new cases continuously in 2030. The expanding utilization of common plant-inferred parts, investigating the counter proliferative impacts of phytochemicals is progressively picking up significance in planning anticancer medica...

Introduction: The functions of the endoplasmic reticulum (ER) are important, particularly in the proteins' synthesis, folding, modification, and transport. Based on traditional medicine and our previous studies on Zanthoxylum alatum in lipopolysaccharide-induced depressive behavior and scopolamine-induced impaired memory, the present study explore...

Background: Alzheimer’s disease (AD) is a major form of dementia among neurodegenerative diseases, which results in memory deficits. There is no report of the memory enhancing activity of Entada phaseoloides, however we reported its potential as a memory enhancing compound and based on this study, its isolated compound Phaseoloidin is taken up for...

Objective: Conyza bonariensis is an ornamental medicinal weed. This experiment was planned to explore the outcome of petroleum ether extract of C. bonariensis (PECB) leaves on scopolamine-induced amnesia in rats. Materials and methods: For impairing memory, 0.4 mg/kg (i. p.) of scopolamine was given. Fifty to 200 mg/kg of PECB was fed orally to...

The pharmacodynamic effect of methanolic extract of seeds of Entada phaseoloides (MEEP) on cholinergic, histaminergic and serotonergic receptors using isolated tissue of rat ileum, guinea pig ileum and rat fundus preparation are presented in this paper. The concentration response curve (CRC) of standard agonist Ach, histamine, 5-HT and the test dru...

Background Entada phaseoloides (Linn.) Merr. (Family: Fabaceae), is a well-known traditional medicinal plant and has been extensively used in Ayurvedic system of medicine for centuries to combat wide range of ailments. Objective The goal of this work was to investigate the bioactive constituents from n-butanol extracts of Entada phaseoloides and f...

Background Entada phaseoloides is a well-known medicinal plant traditionally used in Ayurvedic medicine for centuries. Objective To evaluate the anti-stress activity of seeds of E. phaseoloides in endoplasmic reticulum stress during chronic restrain stress in mice, based on our preliminary screening. Materials and Methods Mice (n = 6/group) were...

Objective: The present study investigates the protective effects of crude extract from seeds of Entada phaseoloides and isolated compounds in enhancing cognition in Scopolamine induced learning and memory impairments in the radial arm maze model.Methods: Two doses (100 and 200 mg/kg) of the crude methanolic extract of Entada phaseoloides (MEEP) wer...

Context: Depression is an inflammatory, commonly occurring and lethal psychiatric disorder having high lifetime prevalence. Zanthoxylum alatum Roxb. (Rutaceae), commonly called Timur, has high medicinal value and is used ethnomedicinally for the treatment of various diseases. Objective: To evaluate the effect of hexane extract of Z. alatum seeds (Z...

Cisplatin is a regularly employed effective chemotherapeutic agent for the treatment of many types of cancer. The main drawback of cisplatin treatment is kidney toxicity which affects 25–35% of treated patients. Many mechanisms are believed to be involved in this kidney damage, but inflammation plays a significant role in this event. Curcumin is a...

The present study was carried out to investigate the diagnostic potential of gamma interferon (IFN-ã) assay and single intradermal comparative tuberculin test (SICTT), including species specification of bovine tuberculosis infection in different livestock farms of Assam and Meghalaya. A total of 199 animals (cattle and buffalo) were examined for bo...

http://www.cdb.riken.jp/sympo2017/programposter-e.html

The study was conducted to evaluate the adaptogenic activity of hydroethanolic extract of Elsholtzia communis (Collett & Hemsl.) Diels. by estimation of neurobiological and biochemical changes associated with acute and chronic stress. Adult male Wistar rats were given forced swimming induced acute and chronic stress for 3 and 7 days, respectively....

Aim/Background: Chemoprevention is regarded as one of the most promising and realistic approaches in the prevention of lung cancer. Several bioactive compounds present in diet such as fruits and vegetables have their beneficial effect on lung cancer. Luteolin is one such naturally occurring dietary phytochemical possesses anti-oxidative, anti-infla...

Lung cancer is the major cause of cancer-related mortality and is a growing economic burden worldwide. Chemoprevention has emerged as a very effective preventive measure against carcinogenesis and several bioactive compounds in diet have shown their cancer curative potential on lung cancer. Naringenin (NRG), a predominant flavanone found in citrus...

Cancer Gene Therapy is the essential gene therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest developments in gene therapy for cancer.

Dementia is a syndrome of progressive nature, characterized by impairment of memory and loss of intellectual ability. Subsequently, allopathic system of medicine is yet to provide a fundamental cure; it is meaningful to look for novel directions, which would curtail the memory loss seen in elderly patients. We have screened few plants for enhanceme...

Background: Chemoprevention is considered as one of the most promising and realistic approaches in the prevention of lung cancer. Chrysin, a naturally occurring dietary flavone widely found in Passiflora family of plants and honey, has been studied extensively for its chemopreventive properties. The objective of present study is to divulge the che...

Introduction: Lung cancer is the major cause of overall cancer deaths, and chemoprevention is a promising strategy to control this devastating condition. Honokiol, a lignan phytochemical has been studied widely for its chemopreventive properties. Objectives: The aim of the present study is to explore the anti-tumor activity of honokiol against benz...

Cancer is the second largest leading cause of death worldwide and breast cancer is the most prevailing causes of mortality among all cases of malignant neoplastic disease in adult females. The incidence rate of breast malignant neoplastic disease is predominantly higher in Western women, when compared to women in Asian nations. The definitive reaso...

Lung cancer is the major cause of overall cancer deaths, and chemoprevention is a promising strategy to control this disease. Benzo(a)pyrene [B(a)P], a polycyclic aromatic hydrocarbon, is one among the principal constituents of tobacco smoke that plays a key role in lung carcinogenesis. The B(a)P induced lung cancer in mice offers a relevant model...

The present study investigates the effect of oral administration of chlorpyrifos (CPF) in indigenous chicken. The birds were divided into two groups I and II. Group I served as control and group II was treated with CPF (0.36 mg/kg) orally daily up to 12 weeks. Blood samples were assayed for hemoglobin (Hb), total erythrocyte count (TEC), total leuk...

Anxiety disorders are commonly occurring co-morbid neuropsychiatric disorders with chronic inflammatory conditions such as live damage. Numerous studies revealed that peripheral inflammation, oxidative stress and brain derived neurotrophic factor (BDNF) play important roles in the pathophysiology of anxiety disorders. Honokiol (HNK) is a polyphenol...

In recent era, the researchers and scientists from the developing as well as Western countries move on their research on plant and herbal products due to immense popularity. The Gnetum gnemon is an evergreen and perennial tree, native of the place from Northeast (NE) India to Fiji which is used in several traditional medicines to cure various disea...

Background: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous mutagenic and carcinogenic environmental pollutants. Benzo(a)Pyrene [B(a)P] is one of the PAH, a classified carcinogen to humans by International Agency for Research on Cancer (IARC). Since B(a)P is an omnipresent environmental pollutant and is believed to be a risk factor for human...

Cancer is the second largest leading cause of death worldwide and breast cancer is the most prevailing cause of mortality among all cases of malignant neoplastic disease in adult females. The incidence rate of breast malignant neoplastic disease is predominantly higher in Western women, when compared to women in Asian nations. The definitive reason...

Objective : The main objective of the present study was to explore the antitumor activity of the ethyl acetate extract of the Alternanthera brasiliana (EAAB) and its antioxidant status against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Materials and Methods: Based on the preliminary in vitro cytotoxicity studies, EAAB was selected for an...

Piper longum, belonging to the family Piperaceae, have been reported to have pharmacological and clinical importance. The present study was undertaken to compare the in vitro antioxidant and antimycobacterial activity of chloroform, ethyl-acetate, hexane, ethanol, hydro-ethanol and aqueous extracts of seeds of Piper longum in order to establish the...

Natural products particularly of plant origin with antistress property and nutraceutical value have become the focus of scores of scientific investigation in recent times. Against this background the present study was carried out to analyse the phytochemical components and adaptogenic activity of Rhododendron arboreum which grow in high altitudes....

Cancer chemoprevention is a strategy taken to block, reverse or retard the multistep process of carcinogenesis, including the blockage of its vital morphogenetic milestones viz. normal-preneoplasia-neoplasia-metastasis. Naturally occurring phytochemicals are becoming increasingly popular over synthetic drugs for several reasons, including safety, e...

Cancer chemoprevention is a strategy taken to block, reverse or retard the multistep process of carcinogenesis, including the blockage of its vital morphogenetic milestones viz. normal-preneoplasia-neoplasia-metastasis. Naturally occurring phytochemicals are becoming increasingly popular over synthetic drugs for several reasons, including safety, e...

Objectives: The present study was designed to investigate the potential role of hydroethanolic root extracts were Rhus mysurensis (HERM) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin induced diabetes in Wistar rats. Methods: In this study, the anti-diabetic, hypolipidemic and an...

ABSTRACT Clerodendron indicum, a widely dis tributed plant in South Eas t As ia, has been reported for its various therapeutic properties . The aim of our s tudy was to determine the phytochemicals pres et there in both qualitatively and quantitatively and their antioxidant potentials . The ethanolic extract (EE) and hydroethanolic extract (HE) of...

Ethanolic extract of Homalomena aromatica root was selected to evaluate their in vitro antioxidant potential. Antioxidant potential of the plant part was estimated by different in vitro antioxidant assay procedures and their EC50 values were calculated. Screening of phytochemical constituents and high performance thin layer chromatography and high...

Piper longum, belonging to the family Piperaceae, have been reported to have pharmacological and clinical importance. The present study was undertaken to compare the in vitro antioxidant and antimycobacterial activity of chloroform, ethyl-acetate, hexane, ethanol, hydro-ethanol and aqueous extracts of seeds of Pip- er longum in order to establish t...

Acorus calamus Linn. (Acoraceae) is a medicinal plant widely distributed in India and other eastern countries. The root, rhizome extracts and aromatic oil from the plant has been previously screened for its antioxidant potential. But whole plant extract is yet to be screened for its possible bioactivity and antioxidant property to the best of our k...

Ethanolic extract of Homalomena aromatica root was selected to evaluate their in vitro antioxidant potential. Antioxidant potential of the plant part was estimated by different in vitro antioxidant assay procedures and their EC50 values were calculated. Screening of phytochemical constituents and high performance thin layer chromatography and high...

The global threat of tuberculosis (TB) demands for the search for alternative antimycobacterial drugs. Present study dealt with the antimycobacterial potential of methanolic extracts of seeds of Mucuna imbricata and its synergistic effect with rifampicin against M. tuberculosis by molecular identification of mycobacterium in the lung tissue of mice...

Two species of coccidian viz. Eimeria arloingi and Eimeria ninakohlyakimovae were detected out of 414 goat faecal samples examined in Kamrup district of Assam with overall 26.57% prevalence. The prevalence was found to be highest in the age group of 0-3 months (32.86%) and lowest in 7-9 months (16.19%). The female (27.22%) goats exhibited higher pr...

Streptococcus suis infection, a zoonotic disease (Perch et al. 1968), causes arthritis, pneumonia, septicaemia, endocarditis, polyserositis, and abscesses in pigs with high economic losses. Subclinical carrier animals are important source as bacteria are transmitted to susceptible young pigs (Okwumabua et al. 2003). Detection of S. suis by standard...

Background: Anxiety or depressed mood is associated with low levels of serotonin in the brain. A hydroxycitric acid (HCA), constituent of Garcinia indica (GIA), increases serotonin release from isolated rat brain cortex. Aim: To evaluate the anxiolytic activity of aqueous extract of dried fruits of GIA in mice. Materials and Methods: The anxiolytic...

Alternanthera brasiliana Kuntze is a neotropical native species used against inflammation, cough and diarrhea etc. Traditionally it is used as hemostatic in north east India, but its excellent wound healing activity in excision, incision, aged, burn, immunocompromised wound were reported by us. Keeping in mind the delayed healing of wound in diabet...

An experiment was carried out to study the bhaemato-biochemical changes in paramphistomiasis affected cattle treated with oxyclozanide, rafoxanide and hydroethanolic extract of Melia azadirachta. Haematological and biochemical values from corresponding groups during pre-treatment and different post-treatment days were estimated as per the standard...

A study on prevalence of paramphistomiasis in respect to age, sex, breed, season and rearing system in cattle in Kamrup district of Assam showed overall 69.81% prevalence rate. The prevalence was found to be highest in the age group of 5-8 years (78.17%) and lowest in 9 years and above (48.95%). The male (74.55%) and local cattle (86.35%) exhibited...

Cisplatin is one of the most common chemotherapeutic drugs used against various solid, tumours. Despite of its therapeutic benefits, its use in clinical practice is often limited because of dose, related toxicity. The nephrotoxic potential of cisplatin has been ascribed to its accumulation in the, renal tubular cells generating reactive oxygen spec...

Anxiety related disorders are the most common mental illnesses and major cause of disability in man. Anxiolytic activity of methanol extract of leaves of A. brasiliana (L.) Kuntze (MEAB) was evaluated using hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration test (LDE) in mice. Its locomotor activity was studied us...

The neuromuscular system of helminths is an important area for target identification and drug development. Many anthelmintics, namely ivermectin, levamisole, piperazine, pyrantel, praziquantel and organophosphates, produce paralysis of helminths by affecting their neuromuscular systems. The neuromuscular system of helminths is also an important are...

Studies on prevalence of coccidiosis in kids was conducted during the period of one year (August, 2010 to July, 2011) at Goat Research Station, Assam Agricultural University, Burnihat and other private farms at Khanapara, Dolgaon, Kamalpur and Hajo in Kamrup district of Assam under natural feeding and management system. The prevalence of coccidiosi...

The methanol extract of Alternanthera brasiliana Kuntze (Family: Amaranthaceae) leaf was investigated for its wound healing effect by excision wound model (in vivo) in aged Sprague Dawley rats. In excision wound model, compared to the control group, percent contraction of wound was significantly (P < 0.01) higher in A. brasiliana-treated group (5%...

Alternanthera brasiliana (L.) Kuntze (Amaranthaceae) is a herbaceous plant used against inflammation, cough, and diarrhea in Brazilian popular medicine. In our preliminary study, promising wound healing activity of methanol extract of leaves of A. brasiliana (MEAB) was observed in normal excision and incision wound models. Therefore, the present st...

The floral richness of the North-East Indian region cannot be neglected in context to its medicinal importance. Achyranthes aspera Linn. (Amaranthaceae; Prickly Chaff flower) is an indigenous plant species of this region. Although the local traditional healers have ethnomedical knowledge on the use of this plant, there is no scientific study on wou...

To study the anxiolytic activity of methanol extract of Achyranthes aspera Linn (Amaranthaceae). Male Swiss albino mice were used. Methanolic extract of Achyranthes aspera (MEAA) was administered in the doses of 100, 300 and 600 mg/kg p.o. Hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration (LDE) tests were used fo...

To study the analgesic and anti-nociceptive activity of hydroethanolic extract of Drymaria cordata Willd. Wistar rats and Swiss albino mice were used for studying analgesic and anti-nociceptive activity of Drymaria cordata hydroethanolic extract (DCHE) at doses 50, 100 and 200 mg/kg p.o. Various models viz. acetic acid induced writhing model (femal...

In the present study, comparative protein profile of granulation tissues of burn, diabetic and immunocompromised wounds treated with 5.0% (w/w) ointment of methanol extract of Achyranthes aspera was undertaken. Granulation tissue of A. aspera treated group showed expression of a protein with molecular weight 69.4 kD in burn wound and proteins rangi...

Plantago erosa ex Roxb (Plantaginaceae) locally known as "Singapat" is a perennial herb traditionally used in folk remedy as astringent, antitoxic, antimicrobial, demulcent, expectorant and diuretic, applied externally for insect bites, poison-ivy rashes, minor sores, boils and is also known to be able to cure snakebite. The present study involves...

The anti-inflammatory effects of Drymaria cordata methanolic extract (DCME) at the doses 300 to 900 mg/kg body wt. p.o was evaluated and compared with control and standard drug - Indomethacin (10 mg/kg body wt. p.o.). Carrageenaninduced paw oedema model in rats and mice, formalin-induced paw licking in mice were used for evaluation. Antiinflammator...

Leaves of Plantago erosa ex Roxb are used traditionally in Northeast India in different illnesses which include wounds, cuts, bruises, insect bites, poison-ivy rashes, minor sores and snakebite, etc. Plantago erosa is one of the commonly used medicinal plants in various inflammatory conditions in this region; however, due to paucity of scientific l...

Wound healing activity of methanolic extract of Achyranthes aspera Linn, was evaluated by excision and incision wound model (in vivo) in Sprague Dawley rats and by chorioallantoic membrane (CAM) model (in vitro) in 9-day-old embryonated chicken eggs. In excision wound, there was 82.23% wound contraction in control group on 21st day, whereas in A. a...

Antinociceptive activity of methanolic extract of leaves of A. aspera was studied by peripheral/non-narcotic model of nociception like acetic acid induced writhing syndrome test and central/narcotic models like hot plate and tail flick tests. The methanolic extract of the plant, administered orally (@ 300, 600 and 900 mg/kg, body weight) and the st...

Production of the antioxidant enzymes in M. habana vaccinated peritoneal exudates cells increased gradually. After 60 days of vaccination and 30 days booster all enzymes, SOD, CAT, GPx and MPO were significantly higher in comparison to control. The release declined after 90 days of vaccination and 30 days of 2nd booster. It appears that M .habana v...

Achyranthes aspera Linn is an annual biennial plant known as Prickly chaff flower. The present study is designed to investigate the antidepressant-like effect of the plant by using modified forced swimming test (MFST). The methanolic extract of A. aspera (MEAA) is used to investigate the putative psychotherapeutic effects of this plant as antidepre...

The floral richness of the North East region cannot be neglected in context to its medicinal importance and it is expected that screening and scientific evaluation of plant extracts for their pharmacological activity may provide new drug molecule that can combat various side effects of the commercially available drugs. Azadirachta indica A. Juss; l...

Drymaria cordata hydroethanolic extract (DCHE) at 25, 50 and 100 mg/kg (p.o.) was administered to study anxiolytic effect. Different models for anxiolytic activity viz. Hole board, Open field, Elevated plus maze, Light/dark exploration model were used. In the hole board model, there was dose dependent and significant increase in the numbers of head...

Wound healing activity of methanolic extract of leaves of Alternanthera brasiliana Kuntz was studied by excision and incision wound model (in vivo) in Sprague Dawley rats and by Chorioallantoic membrane (CAM) model (In vitro) in 9-day-old embryonated chicken eggs. In excision wound model, compared to the control group, per cent contraction of wound...

Methanolic extract of leaves of Alternanthera brasiliana Kuntz. was studied for its antinociceptive activity in both peripheral and non-narcotic models like acetic acid induced writhing syndrome test and narcotic analgesic models like tail flick and hot plate test. The methanolic extract of Alternanthera brasiliana when administered @ 300, 600 and...

The antidepressant activity of methanolic extract of the leaves of Achyranthes aspera was studied using various animal models of depression viz. forced swimming test in mice, forced swimming test in rats and tail suspension test in mice. The methanolic extract of Achyranthes aspera at a dose rate of 100, 300 and 600 mg/kg, distilled water as contro...

The ectoparasiticidal effect of AAU-NW- EVM-1 and AAU-NW-EVM-2 was tested against clinically affected goats with scabies caused by Sarcoptes scabei var capris. Five percent ointment (w/w) of the plant extract was compared with standard drug ivermectin @ 200μg kg-1 body weight subcutaneously and numbers of mite sq.cm-1 were recorded till 28 days bas...

The methanol extract of Moringa pterygosperma (Moringaceae) was used to evaluate its analgesic, anti-inflammatory and local anaesthetic activity in the present study. Analgesic activity was tested in mice using various doses orally. Acetic acid-induced writhing episodes were significantly and dose-dependently reduced. At the same dose, its anti-inf...

The pharmacokinetic studies of enrofloxacin was investigated in yak ( Bos grunniens L.) after intravenous administration at 5 mg.kg-1 body weight. Blood samples were collected from the jugular vein at predetermined time intervals after drug administration. Plasma was separated and analysed for enrofloxacin by reverse-phase high performance liquid c...

The present study was undertaken to find out the pharmacokinetic disposition of enrofloxacin in yaks after intramuscular administration at the dose rate of 7.5 mg.kg -1 body weight. The various pharmacokinetic parameters of enrofloxacin were calculated as t 1/2 kβ, 2.535±0.491 h; AUC, 7.79±1.046 μg.h.ml -1; AUMC, 32.933±8.627 μg.h 2.ml -1; MRT, 4.0...

The pharmacokinetic disposition of enrofloxacin was studied in six zebu calves after intramuscular administration of enrofloxacin at the dose of 5 mg/kg -1 body weight. The various pharmacokinetic parameters of enrofloxacin were investigated. The result suggest that intramuscular route is suitable for administration in calves.

The pharmacokinetic studies of enrofloxacin were investigated in yak (Bos grunniens L.) after administra-tion of enrofloxacin by intramuscular route at 5 mg·kg-1 body weight. Blood samples were collected from the jugular vein at predetermined time intervals after drug administration. Plasma was separated and ana-lysed for enrofloxacin by reverse-ph...

The immunomodulatory effect of the bark of Albizzia lebbeck (Sirisha) was evaluated by studying humoral and cell mediated immune responses. The hot aqueous extract and its butanolic fraction were administered once daily for one week in mice, immunised previously with sheep red blood cells (SRBC). At the dose levels tested (6.25, 12.5 and 25 mg/kg,...

The immunomodulatory effect of the bark of Albizzia lebbeck (Sirisha) was evaluated by studying humoral and cell mediated immune responses. The hot aqueous extract and its butanolic fraction were administered once daily for one week in mice, immunised previously with sheep red blood cells (SRBC). At the dose levels tested (6.25, 12.5 and 25 mg/kg,...

Picroliv, a standardised iridoid glycoside fraction from the root and rhizome of Picrorhiza kurroa at a dose of 25 mg kg-1 p.o. inhibited passive cutaneous anaphylaxis in mice (82%) and rats (50-85%) and protected mast cells from degranulation (60-80%) in a concentration-dependent manner. Its effect was also studied in sensitised guinea pig ileum p...