Cesar Augusto Cuba Cuba

Cesar Augusto Cuba Cuba
University of Brasília | UnB · Núcleo de Medicina Tropical (NMT)

Dr Sc. PhD

About

188
Publications
11,858
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Introduction
Cesar Augusto Cuba Cuba, Emeritus Professor. Unversity of Brasilia, Brazil.Currently works as Senior Research at the Núcleo de Medicina Tropical (NMT) , University of Brasília. Cesar does research in Entomology and Protozoology. Their current project is 'Epidemiology of Leishmaniasis'and Vector related to Trypanosomiasis and Leishmaniasis.
Additional affiliations
January 2000 - December 2012
Universidade de Brasília
March 1987 - July 1989
London School of Hygiene and Tropical Medicine
Position
  • Senior Researcher
July 1981 - October 1981
Harvard Medical School
Position
  • Lecturer on Medicine

Publications

Publications (188)
Article
Rhodnius ecuadoriensis (Hemiptera, Reduviidae) is an important vector of both Trypanosoma hemoflagellates, Trypanosoma cruzi and Trypanosoma rangeli, in Ecuador and Peru. Ecotopes of sylvatic and domestic/peridomestic habitats have been reported in Ecuador. Meanwhile in Peru, to the best of our knowledge, findings of sylvatic populations in their d...
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Vector-borne pathogens threaten human health worldwide. Despite their critical role in disease prevention, routine surveillance systems often rely on low-complexity pathogen detection tests of uncertain accuracy. In Chagas disease surveillance, optical microscopy (OM) is routinely used for detecting Trypanosoma cruzi in its vectors. Here, we use re...
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A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Introduction: Chagas disease surveillance requires current knowledge on synanthropic triatomines. We analyzed the occurrence and Trypanosoma cruzi infection rates of triatomine bugs in central Brazil, during 2012-2014. Methods: Triatomines were collected inside or around houses, and T. cruzi infection was determined by optical microscopy and con...
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Neotropical primates are important sylvatic hosts of Trypanosoma cruzi, the etiological agent of Chagas disease. Infection is often subclinical, but severe disease has been described in both free-ranging and captive primates. Panstrongylus megistus, a major T. cruzi vector, was found infesting a small-primate unit at Brasília zoo (ZooB), Brazil. Zo...
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T4 is the Acanthamoeba genotype most related to cases of granulomatous amoebic encephalitis (GAE) in immunocompromised patients and of keratitis in contact lens wearers. The determination of the pathogenic potential of Acanthamoeba clinical and environmental isolates using experimental models is extremely important to elucidate the capacity of free...
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Objective: To evaluate whether the inoculation of contaminated cultures in the peritoneal cavity of mice could implement decontamination of Acanthamoeba cultures. Methods: Suspensions of Acanthamoeba, Acanthamoeba polyphaga ATCC 30461, or Acanthamoeba spp. isolated from soil (UnB13 strain) were inoculated in the peritoneal cavity of Swiss mice (n =...
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Trypanosoma cruzi has been classified into six Discrete Typing Units (DTUs), designated as TcI-TcVI. In order to effectively use this standardized nomenclature, a reproducible genotyping strategy is imperative. Several typing schemes have been developed with variable levels of complexity, selectivity and analytical sensitivity. Most of them can be...
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Specific host-parasite a ssociations have been detected experimentally and suggest that triatomines of the genus Rhodnius act as biological filters in the transmission of Trypanosoma rangeli . To analyze the susceptibility of four Rhodnius species ( Rhodnius robustus , Rhodnius neglectus , Rhodnius nasutus and Rhodnius pictipes ) to a Brazilian str...
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Introducción. Se han detectado asociaciones biológicas huésped-parásito específicas que sugieren que los triatominos del género Rhodnius podrían actuar como filtros biológicos en la transmisión de Trypanosoma rangeli. Objetivo. Estudiar la sensibilidad de cuatro especies de Rhodnius (Rhodnius robustus, Rhodnius neglectus, Rhodnius nasutus y Rhodni...
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Se ha estudiado el proceso del desarrollo de Parogonimus peruvianus Miyazaki, Ibóñez y Miranda, 1969 en el gato doméstico, Felis cati L. infectado experimentalmente mediante la administración oral de metacercarias del parasito extraídas de ejemplares de Pseudothelphusa chilensis Milne Edwards, 1843 procedentes de áreas endémicas.
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Se ha estudiado el índice de infección natural y la intensidad del parasitismo en cangrejos recolectados en tres provincias del Departamento de Cajamarca, Perú, habiéndose encontrado metacercarias de Paragonimus Braun, 1899 en el 43.97% de 539 especímenes de Pseudothelphusa chilensis Milne Edwards, 1843, único cangrejo hallado en la zona. El órgano...
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In vitro and in vivo experimental infection of Rhodnius robustus salivary glands by Trypanosoma rangeli: An ultrastructural approach of the initial process of invasion ABSTRACT The mechanism of invasion of triatomine salivary glands by Trypanosoma rangeli remains little known. To promote further information on the initial process of parasite invasi...
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In vitro and in vivo experimental infection of Rhodnius robustus salivary glands by Trypanosoma rangeli: An ultrastructural approach of the initial process of invasion ABSTRACT The mechanism of invasion of triatomine salivary glands by Trypanosoma rangeli remains little known. To promote further information on the initial process of parasite invasi...
Article
Species of Acanthamoeba can cause keratitis and brain infections. The characterization of environmental isolates is necessary to analyze the risk of human infection. We aimed at identifying and genotyping Acanthamoeba isolates from soil, swimming pools, and water features in Brasília, Federal District, Brazil, as well as determining their physiolog...
Article
Species of Acanthamoeba can cause keratitis and brain infections. The characterization of environmental isolates is necessary to analyze the risk of human infection. We aimed at identifying and genotyping Acanthamoeba isolates from soil, swimming pools, and water features in Brasília, Federal District, Brazil, as well as determining their physiolog...
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Dipetalogaster maxima (Uhler, 1894) is a species typical of the south of the Baja Californa peninsula, Mexico. The adaptability of Argentine strains of Trypanosoma cruzi to vectors of other latitudes could be of relevance to epidemiology as well as to xenodiagnosis. The purpose of the present study was thus to investigate whether or not there is go...
Article
To determine the infestation and trypanosome infection of triatomines captured in Mauritia flexuosa palm trees across its geographic distribution in the Brazilian savanna (Cerrado), we sampled 42 localities in eight states and in the Federal District, Brazil, between July 2005 and January 2010. Overall, 2154 specimens of the species Rhodnius neglec...
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In the present work, we investigated whether it is possible to detect morphometric changes in Rhodnius neglectus Lent, 1954 (a candidate vector of Chagas disease in Central Brazil) populations in the transition from sylvatic to laboratory conditions. We analyzed size and shape variation in wings of sylvatic parents and their laboratory descendents...
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The vector competence of triatomine insects is determined by studying their biology and feeding behavior under field and/or laboratory conditions. Factors including the number of bites, the amount of blood ingested and defecation time have implications for trypanosome transmission. The biological and behavioral parameters of Rhodnius neglectus and...
Article
Spliced leader intergenic region (SL-IR) sequences from 23 Trypanosoma rangeli strains isolated from the salivary glands of Rhodnius colombiensis, R. ecuadoriensis, R. pallescens and R. prolixus and two human strains revealed the existence of 4 genotypes with CA, GT, TA, ATT and GTAT microsatellite repeats and the presence of insertions/deletions (...
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Psammolestes tertius Lent & Jurberg, 1965 is a sylvatic triatomine bug species that occurs in thornbird nests in Brazil. We studied infestation of 527 nests of Phacellodomus rufifrons Wied, 1821 and Phacellodomus ruber Vieillot, 1817 by P. tertius in eight Brazilian states across the Cerrado and Caatinga ecoregions. Psammolestes tertius occurred in...
Article
The intergenic region of spliced-leader (SL-IR) genes from 105 Trypanosoma cruzi I (Tc I) infected biological samples, culture isolates and stocks from 11 endemic countries, from Argentina to the USA were characterised, allowing identification of 76 genotypes with 54 polymorphic sites from 123 aligned sequences. On the basis of the microsatellite m...
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Rhodnius neglectus is frequently found in palm trees and bird nests in sylvatic environments. However, adult specimens infected by Trypanosoma cruzi have been invading houses in central Brazil. Analyzing and predicting the geographical distribution of this species may improve vector surveillance strategies for Chagas disease. Ecological niche model...
Article
Sylvatic triatomines of the genus Rhodnius commonly fly into houses in Latin America, maintaining the risk of Chagas disease transmission in spite of control efforts. In the recent past, adult bugs collected inside houses in central Brazil were identified as R. prolixus, a primary disease vector whose natural geographical range excludes this region...
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; *** ABSTRACT The development of strategies for the adequate control of the vector transmission of Chagas disease depends on the availability of updated data on the triatomine species present in each region, their geographical distribution, natural infections by Trypanosoma cruzi and/or T. rangeli, eco- biological characteristics and synanthropic...