Cesar A. Catalan

Cesar A. Catalan
  • Ph.D.
  • Professor Emeritus at National University of Tucumán

About

299
Publications
94,847
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
8,146
Citations
Introduction
Cesar A. Catalan currently works at the Organic Chemistry Institute, School of Chemistry Biochemistry and Pharmacy, National University of Tucuman. Cesar does research in Phytochemistry, Organic Chemistry and Medicinal Plants native to South America, mainly those used in Andean folk medicine. His current projects are devoted to the isolation and structural elucidatios of bioactive metabolites, mainly sesquiterpene lactones, from native plants belonging to the family Asteraceae (Compositae); identification of antifungal, antiparasitic, antioxidant and cytotoxic compounds as well as the chemical composition of essential oils from native aromatic plants.
Current institution
National University of Tucumán
Current position
  • Professor Emeritus
Additional affiliations
December 1983 - August 2015
National University of Tucumán
Position
  • Full Professor of Organic Chemistry
January 1982 - March 1983
Stanford University
Position
  • Professor
Description
  • - Biosynthetic studies of marine sterols with extended side chain. - Isolation and structural elucidation of sterols from marine organisms (sponges).
January 2005 - present
INQUINOA-CONICET and Facultad de Bioquimica Quimica y Farmacia, Universidad Nacional de Tucuman
Position
  • Bioactive metabolites from native plants. Search of leader compounds for their optimization as agents of pharmacological and agricultural utility. Studies on plant - plant, plant - soil and plant - microorganism interactions.
Education
March 1973 - April 1977
National University of Tucumán
Field of study
  • Organic Chemistry

Publications

Publications (299)
Article
Full-text available
Leishmaniasis is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. An estimated 700,000 to 1 million new cases occur annually. Current therapies are limited by high toxicity, cost, prolonged treatment period, and rising resistance in endemic regions. The Asteraceae family has emerged as a promising source of bioact...
Article
Many plant-derived compounds, mostly of mid-to-high molecular weight, exert alexiteric properties. However, some small phenolic molecules, such as 2-hydroxy-4-methoxybenzoic acid, are also known to be alexiteric by their ability to bind to snake venom proteins. This study presents the in vitro alexiteric activity of 2-isopropenyl-3-methylphenol [ca...
Article
Full-text available
Cestodes are etiological agents of neglected diseases such as echinococcosis and cysticercosis, which are major public health problems. Antiparasitic treatment relies on a small number of approved drugs, which are often only partially effective, poorly tolerated and require prolonged administration. Thus, the discovery of novel potential treatments...
Technical Report
Full-text available
Publication of science popularization. Journal "A Flora", Brazilian Society of Pharmacognosy. Vol. 12: 46-47.
Preprint
Full-text available
Cestodes are etiological agents of neglected diseases such as echinococcosis and cysticercosis, which are major public health problems. Antiparasitic treatment relies on a small number of approved drugs, which are often only partially effective, poorly tolerated and require prolonged administration. Thus, the discovery of novel potential treatments...
Article
Full-text available
Morphoanatomy and histochemistry of Baccharis palustris: insights into a highly endangered endemic species from Southeastern America. The phenotypic plasticity of the Baccharis genus makes species identification difficult, even at the flowering stage. In this context, morphoanatomical studies are a powerful tool for botanical authentication, mainly...
Article
Fusarium graminearum causes destructive ear rot diseases in maize and wheat. New antifungals are essential to combat this pathogen, and aerial parts of Justicia species (Acanthaceae) are a potential source. We investigated the antifungal activity of extracts from stems and leaves of five Justicia species native to Northwest Argentina. The aerial pa...
Article
Full-text available
Chagas disease, caused by the protozoan Trypanosoma cruzi, affects 6–7 million people worldwide. The dichloromethane extract obtained from the aerial parts of Gymnocoronis spilanthoides var subcordata showed trypanocidal activity in vitro. The fractionation of the dewaxed organic extract via column chromatography led to the isolation of three diter...
Article
Full-text available
Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of dichloromethane and methanolic extracts prepared f...
Article
Chagas disease, African trypanosomiasis and Leishmaniasis are neglected parasitic diseases which affect millions of people worldwide. In a previous work, we report the antiprotozoal activity of the dichloromethane extract of Mikania periplocifolia Hook. & Arn. (Asteraceae). The aim of this work was to isolate and identify the bioactive compounds pr...
Article
Chagas disease is an infection caused by the protozoan Trypanosoma cruzi, affecting 6-8 million people worldwide. Only two drugs are available for its treatment, having a limited efficacy and adverse side-effects. Estafietin is a sesquiterpene lactone isolated from Stevia alpina with in vitro activity against T. cruzi and low cytotoxicity against m...
Article
Full-text available
Stevia species (Asteraceae) have been a rich source of terpenoid compounds, mainly sesquiterpene lactones, several of which show antiprotozoal activity. In the search for new trypanocidal compounds, S. satureiifolia var. satureiifolia and S. alpina were studied. Two sesquiterpene lactones, santhemoidin C and 2-oxo-8-deoxyligustrin, respectively, we...
Book
Fusarium verticillioides y F. graminearum son los principales agentes etiológicos de podredumbres de mazorca de maíz en Argentina. Reducen los rendimientos y contaminan los granos con micotoxinas. La disponibilidad de fungicidas es limitada y encarece costos de producción por lo que se requiere el desarrollo de nuevos antifúngicos. Para ello se tra...
Book
Allelopathy is a new field of science, as the term ´Allelopathy´ was coined in 1937. However, researchers are not using the standard methods due to lack of compendium on the Techniques, hence, the results obtained are not easily comparable with each others. Current research on allelopathy emphasizes not only on Plant–Plant Interactions but also int...
Book
Especies del complejo Fusarium graminearum generan podredumbres de espiga en maíz del noroeste y en trigo del centro de Argentina. Estos patógenos reducen el rendimiento en granos y los contaminan con tricotecenos, especialmente deoxinivalenol (DON) y nivalenol (NIV), cuya ingestión puede generar intoxicaciones en humanos y animales. La ecofisiolog...
Book
The discovery of new bioactive compounds from natural products/secondary metabolites has played a major role in the development of organic chemistry. The ecological role of these allelochemicals as herbicides, insecticides and fungicides for ecological/organic sustainable agriculture has recently drawn great attention, due to increasing public conc...
Article
Neglected tropical diseases are a group of infectious diseases that mainly affect the poorest populations. Among them, Chagas disease, African trypanosomiasis and Leishmaniasis affect millions of people worldwide. Mikania periplocifolia (Asteraceae) is a medicinal species that has been used as alexipharmac, febrifuge and as antirheumatic. Our previ...
Chapter
Monoterpenes are frequently the most common and distinctive components of essential oils. Most of them (the so-called regular monoterpenes) obey the Ruzicka’s Isoprene Biogenetic Rule, which means that the assembly of the bioactive isoprene building blocks (IPP and DMAPP) takes place in a head-to-tail fashion. However, in some cases, the occurrence...
Conference Paper
Full-text available
Polyacetylenes, a group of specialized bioactive metabolites potentially useful in therapy as antitumorals, are present in plants mostly from the Asteraceae family. Baccharis L. is a known source of C10 and C17-polyacetylenes, despite so far, their presence in essential oils is extremely rare. Previously we studied the unusual composition of B. pal...
Article
The essential oil composition of the aerial parts from Baccharis palustris Heering (Asteraceae), a highly endangered species, was analyzed by GC/qMS, GC/HRMS-TOF, FT-IR, UV–vis and NMR spectroscopy using 1D and 2D techniques. To our knowledge, this is the first report on the essential oil composition of B. palustris, as well as the first phytochemi...
Article
Full-text available
A new dimeric sesquiterpene lactone named parodiolide was isolated from Mikania parodii Cabrera. Its structure and relative stereochemistry were established by HR-MS, 1 Hand 13 C-NMR spectroscopy using 1D and 2D experiments in combination with the use of FT-IR, FT-Raman and UV-Visible spectroscopies. The combination of B3LYP/6-31G* calculations wit...
Chapter
Baccharis L. (Asteraceae) contains more than 440 species of exclusively American distribution, from USA to Argentina, concentrated mostly in the highland areas of southern Brazil and throughout the Andes. Besides its ethnopharmacological/medicinal importance, Baccharis volatile fractions (VFs) are important sources of bioactive compounds for flavor...
Conference Paper
Full-text available
Introducción: Baccharis trimera (Less.) DC. (Asteraceae) (Bt, “carqueja”), es una de las plantas medicinales icónicas de Sudamérica, empleada en infusiones y/o decocciones para tratar malestares hepato-gástricos [1]. Su potencial farmacológico validado incluye propiedades antioxidantes, antiinflamatorias, digestivas, alexitéricas, antimicrobianas y...
Article
Artemisia copa var. copa, popularly known as “copa”, “copa-copa”, “coa”, “copal” or “tola”, is an aromatic shrub that inhabits the high Andean peaks and the Puna region of Chile, Bolivia, and Argentina. Its aerial parts are sold in the local markets as a sedative, for the treatment of digestive disorders, hypertension, fever, urinary, respiratory i...
Article
Full-text available
The Stevia genus (Asteraceae) comprises around 230 species, distributed from the southern United States to the South American Andean region. Stevia rebaudiana, a Paraguayan herb that produces an intensely sweet diterpene glycoside called stevioside, is the most relevant member of this genus. Apart from S. rebaudiana, many other species belonging to...
Article
Full-text available
Baccharis dracunculifolia DC. and Baccharis microdonta DC. (Asteraceae) are woody species morphologically similar growing in Uruguay, where not taxonomists people often confuse them in field conditions. As the essential oil of B. dracunculifolia (‘vassoura’ oil) is highly prized by the flavor and fragrance industry, the correct differentiation of t...
Chapter
Xenophyllum poposum (Philippi) V.A. Funk (syn. Werneria poposa Philippi) is a creeping sub-shrub, 3–5 cm tall with an unpleasant smell, commonly known as “poposa” or “pupusa”. It is widely used in Andean traditional medicine to treat hypertension, altitude sickness (mountain sickness), hepatic diseases and digestive disorders. Mono- and sesquiterpe...
Chapter
Aspidosperma quebracho-blanco Schltdl. is a tree that - at maturity - can reach up to 25 m in height. It has a straight trunk that can reach 0.8–1 m in diameter. It is commonly known as “quebracho blanco” and widely used in the Chaco region as medicine to treat fever, malaria, swellings, stomach upsets, cough, headaches, syphilis, impotence, benign...
Chapter
Lippia turbinata Griseb. is a native aromatic shrub commonly known as “poleo”, “té del país”, “té criollo” or “poleo fino”. It is widely used in traditional medicine of Northern and central Argentina. Infusions of aerial parts are used as diuretic, tonic, emmenagogue, for dysmenorrhea, as a regulator of the menstrual cycle and as abortifacient. Its...
Chapter
The aerial parts of Cyclolepis genistoides, commonly called “palo azul” or “matorro negro”, are widely used in folk medicine in Paraguay, Northern and central Argentina, as a diuretic and for the treatment of kidney diseases, urinary tract irritation, kidney pain, bone pain (analgesic). It is also used as an antipyretic, as a blood purifier, agains...
Chapter
Smallanthus sonchifolius (Poepp.) H. Rob., (family Asteraceae) commonly known as “yacón” or “yakon”, is an herbaceous perennial species native to South America. Its tuberous roots have a sweet taste and are used as traditional food and eaten either raw alone or in fruit salads. They can be also boiled, baked or used to prepare beverages, syrup or j...
Chapter
Lippia integrifolia (Griseb.) Hieron. is a native aromatic shrub, commonly known as “incayuyo” or “inca tea”. It is widely used in traditional medicine in northern and central Argentina, where infusions of leaves and flowers are used as digestive, emmenagogue, antitussive, carminative, and against dyspepsia, stomachache, flu and indigestions. Its e...
Article
Full-text available
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of t...
Article
Differences in female/male plant metabolism for dioecious species are poorly understood but relevant if the economic exploitation of such resources is the objective. In this work, the composition of Baccharis tridentata Vahl essential oil from the flowering aerial parts of male and female plants was analysed separately by GC-MS (gas chromatography-...
Chapter
Sesquiterpene lactones are secondary metabolites mainly found in the Asteraceae family. The chemical structure of these compounds is based on a 15-carbon skeleton containing an α,β-unsaturated-γ-lactone moiety. Occasionally, a saturated γ-lactone or a closely related functionality can be found in place of a classical α,β-unsaturated-γ-lactone moiet...
Article
The antifungal activity of organic extracts from leaves, bark and hearthwood of the timber tree Prosopis nigra was investigated against fungi responsible for soybean late season diseases. Nine extracts were assayed by the disc diffusion test toward Septoria glycines and Cercospora kikuchii. The methanol extract of leaves was the most active with th...
Article
Full-text available
In this work, structural, electronic, topological, and electronic and vibrational spectra of antiepileptic and antiparkinsonian drug safinamide (two enantiomers and their mesylate salt) were investigated with the DFT/TD-DFT methodology in gas phase and PCM solvent model. The absorbance maximum of safinamide was found at 227 nm, and the computed max...
Article
Aims: This work aimed to identify secondary metabolites from aerial parts of Euphorbia species functional for control of toxigenic Fusarium species responsible of cereal grain rots. Methods and results: Aerial parts of Euphorbia serpens, E. schickendantzii and E. collina were sequentially extracted with hexane, ethyl acetate and methanol. The ex...
Article
Lippia integrifolia, commonly known as “incayuyo”, is a traditional aromatic and medicinal plant that grows wild in northwestern Argentina. Aqueous extracts of this species exert beneficial effects against affections of the gastrointestinal tract, mainly gastric inflammations. Across the wide distribution of L. integrifolia, there is a high variabi...
Article
The compound 3-(2,3-dihydroxy-isopentyl)-4-hydroxyacetophenone has been synthesized and characterized by ¹H Nuclear Magnetic Resonance (NMR), Infrared (IR) and Raman spectroscopies and its crystal structure was solved by single crystal X-ray diffraction. The molecular geometry of the compound was investigated theoretically by performing density fun...
Article
Full-text available
The sesquiterpene lactones eupatoriopicrin, estafietin, eupahakonenin B and minimolide have been isolated from Argentinean Astearaceae species and have been found to be active against Trypanosoma cruzi epimastigotes. The aim of this work was to evaluate the activity of these compounds by analyzing their effect against the stages of the parasites th...
Conference Paper
Full-text available
Baccharis trimera (Less.) DC. (Asteraceae) is a medicinal and aromatic herb from South America, known as “carqueja”, being included in the Brazilian Pharmacopeia (1). Besides its medicinal properties (digestive, analgesic and diuretic; among others), the essential oil of this species is employed by the fragrance industry for it reminiscence to rose...
Article
Full-text available
The essential oil composition of the aerial parts of Artemisia magellanica sch. bip. (Asteraceae), native to Patagonia, was analyzed by GC‐FID‐MS. This is the first report on the essential oil composition of A. magellanica. A total of 113 components were identified accounting for 95.6–95.7 % of the oil. The essential oil was characterized by a high...
Article
Fusarium meridionale and F. boothii cause Gibberella Ear Rot (GER) in maize. This study determined the effects of temperature (5-35 °C) and water activity (0.90-0.995 aw) on the growth, and deoxynivalenol (DON) and nivalenol (NIV) production of F. meridionale and F. boothii strains in maize grains. Fusarium graminearum sensu stricto strains from wh...
Article
Full-text available
Sesquiterpene lactones are naturally occurring compounds mainly found in the Asteraceae family. These types of plant metabolites display a wide range of biological activities, including antiprotozoal activity and are considered interesting structures for drug discovery. Four derivatives were synthesized from estafietin (1), isolated from Stevia alp...
Article
Full-text available
Septoria brown spot and Cercospora leaf blight are late season diseases caused by Septoria glycines and Cercospora kikuchii, respectively. New antifungals are required against these diseases because the chemical controls currently used have detrimental impacts on wildlife and human health. In this work, 48 extracts originated from the leaves, bark,...
Article
Volatile organic compounds (VOCs) released by plants are generally involved in host recognition and host selection for many phytophagous insects. However, for leafhoppers and planthoppers, host recognition is mainly thought to involve a phototactic response, but it is not clear if a host plant could be selected based on the volatile cues it emits....
Article
Full-text available
The complete vibrational assignments for the alkaloid scopolamine as free base, quaternary scopolammonium cationic and hydrobromide species were reported for first time by using the internal coordinates, the scaled quantum mechanical force field (SQMFF) procedure and the experimental FT-IR, FT-Raman spectra of hydrobromide tri-hydrate. Hybrid B3LYP...
Article
Full-text available
Carquejyl acetate (CA), the main component of the essential oil from Baccharis trimera was isolated and characterized by using Fourier Transform infrared (FT-IR) and Raman (FT-Raman), Ultraviolet-Visible (UV-Visible), Electronic Circular Dichroism (ECD), Mass, Hydrogen and Carbon Nuclear Magnetic Resonance (1H-and 13C-NMR) and 2D 1H1H gCOSY, 1H-13C...
Article
Full-text available
Six native plants of South America traditionally consumed in the Patagonian region (southern Argentina and Chile), namely: Adesmia boronioides Hook. f., Apium australe Thouars, Buddleja globosa Hope, Drimys andina (Reiche) R. Rodr. & Quezada, Dysphania multifida L. and Solidago chilensis Meyen were investigated to determine the nutraceutical proper...
Chapter
The aim of this chapter is to provide an introduction to the current methods available for the analysis of plant material containing sesquiterpene lactones, delineate the most widely used extraction methods and provide a brief review of the literature on the subject. A general classification of sesquiterpene lactones, based on their carbocyclic ske...
Chapter
The most widely used spectroscopic methods for the identification of sesquiterpene lactones are discussed. The most distinctive and characteristic signals in the UV, IR, MS, ¹H-MNR and ¹³C-NMR spectra are discussed. In addition, some examples of the application of these techniques for the structure elucidation of some representative sesquiterpene l...
Article
Full-text available
In this work, 2-isopropenyl-3-methylphenol, hereafter referred to as carquejiphenol (CARP), a minor component of "carqueja" essential oil, was synthesized starting from carquejol and characterized by using Fourier Transform infrared (FT-IR) and Raman (FT-Raman) spectroscopies, Ultraviolet-Visible (UV-Visible) spectroscopy, Electron Impact Mass spec...
Article
Baccharis trimera (Less.) DC. (Asteraceae), ‘carqueja', is a medicinal plant native from South America employed as decoction or infusion for the treatment of low to moderate ailments, and included in the Brazilian Pharmacopeia. This plant is also a rich source of essential oil (EO) valuable in the fragrance industry, mainly owing to carquejyl aceta...
Article
Full-text available
Solidago chilensis Meyen (Asteraceae) is a medicinal and aromatic herb widely distributed in South America. From 2000 to the present numerous articles on this species have been published, mainly in the last decade where the pharmacological studies and articles on its secondary metabolites have risen sharply. S. chilensis has potential beneficial ef...
Article
Full-text available
Four sesquiterpene lactones, mikanolide, deoxymikanolide, dihydromikanolide and scandenolide, were isolated by a bioassay-guided fractionation of Mikania variifolia and Mikania micrantha dichloromethane extracts. Mikanolide and deoxymikanolide were the major compounds in both extracts (2.2% and 0.4% for Mikania variifolia and 21.0% and 6.4% for Mik...
Data
Trypanocidal activity of the reference drug benznidazol determined by in vitro assays against: epimastigotes (A), trypomastigotes (B) and amastigotes (C) of T. cruzi. In vivo treatment with benznidazol in a murine model of T. cruzi infection (D). Area under curve (AUC) was determined. *p<0.01, ***p<0.001. (TIF)
Data
Leishmanicidal in vitro activity of the reference drug amphotericin B against promastigotes of L. braziliensis. (TIF)
Article
Full-text available
The trees Schinopsis lorentzii and S. marginata produce alk(en)ylcatechols, also known as urushiols, which function in plant defense as antifungals, antifeedants and cause contact dermatitis in human beings. Here, we propose the use of the diazonium salts Fast Blue B ½ZnCl2 and Fast Blue RR ZnCl2 for the in situ histochemical localization of urushi...
Article
Carquejol and its acetate are monoterpenoids based on the rare o-menthane skeleton and distinctive components of the essential oil from Baccharis trimera. Carquejol was characterized by using Fourier Transform infrared (FT-IR) and Raman (FT-Raman), UltravioleteVisible (UVeVisible), Electronic Circular Dichroism (ECD), Mass, Hydrogen and Carbon Nucl...
Article
Epoxidation of 4HMBA, the main metabolite of the medicinal plant Sencecionutans, produces an unstable epoxide eventually giving rise to a mixture of four derivatives, three of them previously reported as natural products. The epoxide product easily undergoes an intra-molecular attack of the phenolic hydroxyl against the epoxide group carbons to pro...
Article
Full-text available
p>Caracterización morfo-anatomía y aceites esenciales de Tagetes terniflora y Tagetes minuta (Asteraceae) de Tucumán (Argentina). Se estudió la composición del aceite esencial y morfo-anatomía de Tagetes minuta coleccionada en “El Mollar” y de dos poblaciones diferentes de Tagetes terniflora de Tafí del Valle (Tucumán, Argentina). El aceite esencia...
Article
Full-text available
The essential oil composition and morpho-anatomy of Tagetes minuta, collected at "El Mollar" and two different populations of Tagetes terniflora collected in Tafí del Valle (Tucumán, Argentina) were studied. The essential oil of aerial parts (flowers and leaves) from both species was analyzed by gas chromatography-mass spectrometry. Qualitative and...
Article
Full-text available
The chemical composition, antioxidant and antimicrobial potentials of essential oils and oleoresins obtained from dill (Anethum graveolens L.) seeds and leaves have been studied. The isolated essential oils and oleoresins were analyzed by gas chromatography coupled with mass spectrometry. The antioxidant activity of essential oils and oleoresins in...
Article
Full-text available
The composition of essential oils from leaves of Kazakhstan medicinal plants was analysed by GC-MS. The major compounds identified were 1,8-cineole (34.2%), myrcene (19.1%) and α-pinene (9.4%) in Ajania fruticulosa; 1,8-cineole (21.0%), β-thujone (11.0%), camphor (8.5%), borneol (7.3%) and α-thujone (6.5%), in Achillea nobilis; camphor (47.3%), 1,8...
Article
An antifungal activity-directed fractionation of leaf constituents from Schinopsis balansae on Fusarium graminearum yielded a fraction mainly made of a mixture of four 3-n-heptadec(en)ylcatechols (PALK). The PALK fraction showed on macroconidia germination a MIC100 value of 500 μg/mL which was twofold higher than that required for prothioconazole (...
Article
Sesquiterpene lactones (STLs) are a large and structurally diverse group of plant metabolites generally found in the Asteraceae family. STLs exhibit a wide spectrum of biological activities and it is generally accepted that their major mechanism of action is the alkylation of the thiol groups of biological molecules. The guaianolides is one of vari...
Article
N-(3,4-dimethoxybenzyl)-hexadecanamide (DMH) was characterized by using Fourier Transform infrared (FT-IR) and Raman (FT-Raman), Ultraviolet- Visible (UV-Visible) and Hydrogen and Carbon Nuclear Magnetic Resonance (1H- and 13C-NMR) spectroscopies. The structural, electronic, topological and vibrational properties were evaluated in gas phase and in...
Article
Full-text available
According to theory, variation in plant secondary metabolism against herbivores is driven by variation in biotic and abiotic conditions interacting with plants genotype to determine the expression of resistance traits. Particularly, it has been long postulated that plants growing along latitudinal gradients experience changes in biotic and abiotic...
Article
Full-text available
Objective: To investigate the chemical compositions and antimicrobial potentials of the essential oils and oleoresins obtained from fresh and dried Mentha longifolia L. Methods: Gas chromatography and gas chromatography-mass spectrometer techniques were used to determine the profiling of the essential oils and oleoresins. In order to determine the...
Article
The aerial parts of Lippia integrifolia (incayuyo) are widely used in northwestern and central Argentina for their medicinal and aromatic properties. The essential oil composition of thirty-one wild populations of L. integrifolia covering most of its natural range was analyzed by GC and GC-MS. A total of one hundred and fifty two terpenoids were id...
Article
Full-text available
Essential oils from aerial parts of Acantholippia deserticola, Artemisia proceriformis, Achillea micrantha and Libanotis buchtormensis were analysed by GC-MS. The major compounds identified were β-thujone (66.5 ± 0.2%), and trans-sabinyl acetate (12.1 ± 0.2%) in A. deserticola; α-thujone (66.9 ± 0.4%) in A. proceriformis; 1,8-cineole (26.9 ± 0.5%),...
Article
The main secondary metabolite of Senecio nutans is 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone (4HMBA). The antifungal activity of this compound and three derivatives was assessed using Candida albicans. 4HMBA exhibited the highest antifungal activity among the assayed compounds. The Fractional Inhibitory Concentration (FIC = 0.133) indicated a sy...
Article
In the present work, the structural and vibrational properties of the sesquiterpene lactone onopordopicrin (OP) were studied by using infrared spectroscopy and density functional theory (DFT) calculations together with the 6-31G(∗) basis set. The harmonic vibrational wavenumbers for the optimized geometry were calculated at the same level of theory...
Article
Full-text available
The present study was designed to assess differences in chemical composition and antioxidant potential of essential oils and oleoresins from fresh and sun-dried Mentha longifolia L. Essential oils and oleoresins were obtained by hydrodistillation and solvent extraction (n-hexane and ethanol), respectively. The chemical profile was evaluated by usin...
Article
Full-text available
The ontogeny of the tuberous roots of yacon (Smallanthus sonchifolius), an ancient Andean crop, is described for the first time along with three other wild species of Smallanthus: S. connatus, S. macroscyphus and S. siegesbeckius. Tuberous storage roots are present in the four species. Tuberization results from unusual secondary thickening. A meris...
Article
Full-text available
The sesquiterpene lactones (STLs) content of glandular trichomes from the leaves of twenty-five yacon (Smallanthus sonchifolius, Asteraceae) accessions, obtained along a latitudinal gradient from Ecuador to northwest Argentina, was characterized by gas chromatography/mass spectroscopy (GC/MS). While accessions from Ecuador, Bolivia and Argentina pr...
Article
Full-text available
The composition of the essential oils from leaves (Sal) and fruits of S. areira (Saf), and fruits of S. fasciculatus (Sff) and S. gracilipes (Sgf) were analyzed by GC/MS. The major compounds identified were sabinene (26.0 +/- 0.5%), bicyclogermacrene (14.5 +/- 0.4%), and E-citral (6.7+/- 0.2%) in Sal oil, limonene (27.7 +/- 0.7%), sabinene (16.0+/-...
Article
An experimental and theoretical investigation of cnicin is presented, combining the use of infrared, Raman, NMR and UV─visible spectroscopies with density functional theory (DFT) that employs hybrid B3LYP exchange correlation functional and a 6-31G∗ basis set. The molecular electrostatic potentials, atomic charges, bond orders, stabilization energi...
Article
The non-polar extract of the tubers of Lepidium meyenii Walpers yielded two benzylated alkamides (macamides), N-(3,4-dimethoxybenzyl)-hexadecanamide (1) and N- benzyltetracosanamide (2). The structure elucidation of the compounds was based on 1D and 2D NMR spectroscopic analyses, including H-1-H-1 COSY, H-1-C-13 HSQC, H-1-C-13 HMBC, H-1-N-15 HSQC a...
Article
Full-text available
The sesquiterpene lactones (STLs) are a large class of plant secondary metabolites that are generally found in the Asteraceae family and that have high diversity with respect to chemical structure as well as biological activity. STLs have been classified into different groups, such as guaianolides, germacranolides, and melampolides etc., based on t...
Article
Full-text available
Gas chromatography-mass spectrometry (GC-MS) analysis revealed the major components in black cumin essential oils which were thymoquinone (37.6%) followed by p-cymene (31.2%), α -thujene (5.6%), thymohydroquinone (3.4%), and longifolene (2.0%), whereas the oleoresins extracted in different solvents contain linoleic acid as a major component. The an...
Article
The purpose of this research was to identify antifungal compounds from leaves of Schinus and Schinopsis species useful for the control of toxigenic Fusarium species responsible of ear rot diseases. Leaves of Schinopsis (S. lorentzii and S. haenkeana) and Schinus (S. areira, S. gracilipes and S. fasciculatus) were sequentially extracted with dichlor...
Article
A 96-well plate micromethod was developed to measure 5-n-alkylresorcinols (5nARs) in cereal grains and food derived products. The 5nARs reacted in alkaline alcoholic medium with Fast Blue RR ½ZnCl2 salt to yield coloured azo-derivatives. The highest sensitivity for 5nARs was obtained at 490nm with 0.025% ethanolic Fast Blue RR and 5% K2CO3. This re...
Article
The aim of the present study was to analyze the in vivo hypoglycaemic effects of both decoction of Smallanthus macroscyphus leaves and pure crystalline polymatin A isolated from its leaves. Phytochemical analysis of the leaf decoction showed that its major constituents were caffeic, chlorogenic and three dicaffeoilquinic acids, together with the se...
Article
Full-text available
Twenty six isolates of Fusarium graminearum from grains of maize hybrids harvested in ±west Argentina were grown on autoclaved rice grain to assess their ability to produce type B trichothecenes. Chemical analysis indicated that 38% of isolates were nivalenol (NIV) producers only, 31% were major NIV producers with high DON(deoxynivalenol)/NIV ratio...
Article
Full-text available
Among the natural compounds, terpenoids play an important role in the drug discovery process for tropical diseases. The aim of the present work was to isolate antiprotozoal compounds from Ambrosia elatior and A. scabra. The sesquiterpene lactone (STL) cumanin was isolated from A. elatior whereas two other STLs, psilostachyin and cordilin, and one s...

Network

Cited By