Celso Eduardo Olivier

Celso Eduardo Olivier
Instituto Alergoimuno de Americana | ALERGOAME · Allergy and immunology

MD PhD Allergist
Clinical investigation and treatment of allergic diseases

About

31
Publications
15,851
Reads
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185
Citations
Citations since 2016
18 Research Items
121 Citations
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20162017201820192020202120220102030
20162017201820192020202120220102030
Additional affiliations
June 2007 - July 2012
University of Campinas
Position
  • Researcher
January 1999 - present
Instituto Alergoimuno de Americana
Position
  • Senior Researcher

Publications

Publications (31)
Article
Full-text available
Food Allergy is a chronic systemic immuno-inflammatory condition that depends on several factors, but, above all, the gastrointestinal epithelial barrier. The rupture of this intestinal barrier results in a deleterious increase in intestinal permeability allowing the paracellular permeation of molecules greater than 150 Da into the bloodstream, pro...
Article
Full-text available
Background: The non—IgE-mediated food allergy syndromes are a group of conditions diagnosed mostly by clinical criteria and Oral Food Challenge tests (OFC). Objective: To evaluate the feasibility of the Leukocyte Adherence Inhibition Test (LAIT) to discriminate antigen-specific immunoreactivity in a group of patients with non—IgE-mediated cow’s mil...
Article
Full-text available
Background: The Non-Celiac Gluten Sensitivity (NCGS) is a category inside the Gluten-Related Disorders (GRD) that groups the patients with unidentified mechanisms responsible for their symptoms. Objective: To evaluate the opportunity of an ex vivo challenge immunoassay, the Leukocyte Adherence Inhibition Test (LAIT), to discriminate non—IgE-mediate...
Article
Full-text available
Background: Due to the lack of standardized laboratory procedures able to demonstrate specific non—IgE-mediated immune responses against latex allergens, these conditions are diagnosed mostly by clinical criteria based on empiric exclusion prescriptions monitored by in vivo challenge tests. Objective: To evaluate the opportunity of an ex vivo chall...
Article
Full-text available
Background: Due to the lack of standardized laboratory procedures able to demonstrate specific immune responses against the culprit allergens, the non—IgE-mediated allergy syndromes are a group of conditions diagnosed mostly by clinical examination and exclusion criteria. Objective: To evaluate the opportunity of the Leukocyte Adherence Inhibition...
Article
Background: Due to the lack of standardized laboratory procedures able to demonstrate specific immune responses against the culprit allergens, the non—IgE-mediated allergy syndromes are a group of conditions diagnosed mostly by clinical examination and exclusion criteria. Objective: To evaluate the opportunity of the Leukocyte Adherence Inhibition...
Article
Full-text available
Background: The diagnosis of non-IgE mediated food allergies may be a complex puzzle when there is no start point to establish an elimination diet to allow a clear clinical field to initiate diagnostic Oral Food Challenges tests. Objective: To evaluate the opportunity of the tube titration of precipitins to select food allergens to proceed with eli...
Article
Full-text available
Background: The diagnosis of non-IgE mediated food allergy is done mainly by in vivo Oral Food Challenge (OFC) tests that depend on well-succeeded previous exclusion diets.
Article
Full-text available
Citation: Olivier CE (2021) Sublingual allergen immunotherapy is safe and effective when precisely prescribed. The three decades of the Brazilian experience. J Allergy Ther. 12(7): 256.
Article
Full-text available
Allergen Immunotherapy is not a conventional “treatment” that may be recommended (or discouraged) by experts panels to treat symptoms such as asthma, but a personalized approach used by Precision Medicine as part of a tolerance-inducing strategy that supports the establishment of the allergen avoidance, minimizing the risk of anaphylaxis, and, in t...
Article
Full-text available
Background: The Precision Medicine’s approach employs the endotype concept as a central feature to personalize medical treatment. Individual immunoreactivity, alongside characteristics such as genetics, environment, and diet, is one of the factors that differentiates the therapeutic-driven endotypes. Objective: To evaluate the opportunity of the Le...
Article
Full-text available
Background: The Leukocyte Adherence Inhibition Test (LAIT) is an ex vivo challenge test used to testimony specific immunoreactivity. Despite numerous studies had been performed to elucidate the interactions involved in the assay, there are yet several questions about its mechanisms and how to translate its results into the medical practice. Objecti...
Article
Full-text available
Background: The Precision Medicine's approach employs the endotype concept as a central feature to personalize medical treatment. Individual immunoreactivity, alongside characteristics such as genetics, environment, and diet, is one of the factors that differentiates the therapeutic-driven endotypes. Objective: To evaluate the opportunity of the Le...
Article
Full-text available
This is a historical review about the use of allergoids and adjuvants in Allergen Immunotherapy.
Article
Full-text available
Objectives: To study the IgE-mediated immunoreactivity of genetically improved farmed Nile tilapia (Oreochromis niloticus) proteins in human subjects with occasional allergy to fish. Methods: Total protein extract and pepsinized extracts of the genetically improved farmed Nile tilapia (Oreochromis niloticus) were tested for their IgE-binding proper...
Article
Full-text available
Background: Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. Objective: The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines...
Article
Full-text available
The leukocyte adherence inhibition (LAI) test was designed to evaluate the presence of cellular immunoreactivity against specific antigens and is highly sensitive to analytical interference. To compare the performance of the LAI test among plasmas obtained with different anticoagulants, 36 blood samples of allergic subjects were divided into three...
Article
Full-text available
Background: The treatment of polysensitized allergic patients continues to represent a challenge and is a matter for debate amongst allergists who preferentially use allergen-specific immunotherapy. Objective: To study the effect of group-specific sublingual/swallow immunotherapy on quality of life of polysensitized human subjects with allergic rhi...
Article
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Vocal cord dysfunction (also called paradoxical vocal cord motion) or paradoxical vocal fold motion (PVFM) is an event elicited by specific and nonspecific triggers in which its diagnosis is limited by the restricted number of available functional tests. This study was designed to appreciate the contribution of the spirometric changes elicited by t...
Article
Full-text available
Background Skin testing is a mainstay in allergology, and its importance is increasing in several fields. The ability to choose the most suitable technique according to the clinical setting is an advantage for the medical team. Objectives To describe in detail an alternative technique of the coetaneous allergy test (skin scrape test) conceived as...
Article
Full-text available
Adverse reactions to food may be produced by several mechanisms and present a great diversity of symptoms, which may be reproducible or not reproducible (occasional adverse food reactions). The reproducible adverse food reactions to minimal or usual amounts of food are classified as hypersensitivity reactions, which may be derived from immune disor...
Article
Full-text available
To explore the use of β-lactoglobulin polymerized using microbial transglutaminase and heating to identify whether protein polymerization could reduce in vivo allergenicity and maintain in vitro and ex vivo immunoreactivity for use in tolerance-induction protocols. Based on previous protocols applied in mice and children, we performed in vivo chall...
Article
Full-text available
Acquired delayed-onset hypolactasia is a common autosomal recessive condition. Cow's milk allergies, conversely, are less common conditions that may manifest with equivalent symptoms and are able to simulate and/or aggravate lactose intolerance. This study was designed to evaluate the contribution of IgE-mediated cow's milk sensitization to the sym...
Article
Full-text available
Background: Cow's milk allergy in pediatric patients is an unresolved issue. Among the proteins in milk, bovine whey beta-lactoglobulin (Bos d 5) is the most commonly allergenic. Allergenicity to native cow's milk proteins in humans is a well-studied issue, but very little is known about the allergenicity of cross-linked proteins found in bioproces...
Article
OBJECTIVES: To identify the main clinical manifestations, triggers, and treatment of severe allergic reactions (SAR) in children and adolescents (n=191, up to 18 years of age) seen by allergologists and registered in the Online Latin American Survey of Anaphylaxis (OLASA). RESULTS: 53.0% of the patients were males and the aetiological agent was ide...
Article
Full-text available
In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible t...
Article
Full-text available
The susceptibility of the MAP Brazilian strain (F1 to F5 progenies) of S. mansoni to four antischistosomal drugs has been reported in a previous study. In the present investigation, progeny F14 of the same strain, was tested for stability to the same 4 drugs. A new medication, Oltipraz (35,972 RP), was added to the study. Five groups of 12 mice inf...

Questions

Questions (3)
Question
I planning to use papain to cleave antibodies in a plasma ex vivo challenge study with live immune cells releasing cytokines. The proposition is to demonstrate the participation of specific antibodies in the reaction.

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Projects (3)