Celso Eduardo Olivier

Instituto Alergoimuno de Americana | ALERGOAME · Allergy and immunology

Background: Several publications report that tartrazine is responsible for IgE-mediated and non-IgE-mediated hypersensitivity reactions. There is no standardized lab exam to endotype non-IgE-mediated immunoreactivity against tartrazine besides in vivo provocation tests. Aim: To evaluate the potential of the Tube Titration of Precipitins (TTP) and t...

Background: Spices from the Allium genus season food worldwide, and their widespread use may produce allergic reactions by contact or ingestion. However, the Non-IgE-mediated immunoreactivity against these allergens has not yet been adequately investigated. Aim: To evaluate the potential of the Tube Titration of Precipitins (TTP) and the Leukocyte...

Sinus headache, sinusitis, and migraine are phenotypic diagnoses frequently elaborated by otolaryngologists, neurologists, and primary care general practitioners under different perspectives. These conditions present with very similar phenotypes that are investigated, diagnosed, and treated according to the physician's perspective. Some patients pr...

Background: Several publications report that aluminum is responsible for hypersensitivity reactions. There is no standardized lab exam that can endotype (determine the pathophysiology responsible for the phenotype) hypersensitivity to aluminum. Aim: To evaluate the potential of the Tube Titration of Precipitins (TTP) and the Leukocyte Adherence Inh...

Background: Several publications report polyethylene glycols (PEGs) and PEGylated therapeutics as responsible for non-IgE-mediated allergic reactions. There is no standardized lab exam that can endotype (quantify the participation of these mechanisms inside each patient's pattern of symptoms) besides in vivo provocation tests. Objective and Aim: To...

Background: Several publications report Dermatophagoides farinae allergens as responsible for several types of non-IgE-mediated allergic reactions. There is no standardized lab exam to endotype (quantify the participation of these mechanisms) in the context of allergic disease pathophysiology. Aims: To evaluate the potential of the Leukocyte Adhere...

Background: Several publications report benzoic acid as responsible for non-IgE-mediated allergic reactions. No standardized lab exam identifies these reactions besides in vivo provocation tests. Aim: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) to discriminate non-IgE-mediated immunoreactivity against benzoic acid in...

Aim: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) to evaluate immunoreactivity against peanut proteins in patients with a clinical diagnosis of non-IgE-mediated Atopic Dermatitis (AD). Study Design: We retrospectively examined the medical charts of a population of 51 children (0 to 56 17 years) and 275 adults (18 to 9...

Aims: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) to discriminate non-IgE-mediated immunoreactivity against Aspergillus fumigatus in patients with non-IgE-mediated Allergic Rhinitis and/or Asthma. Study Design: We retrospectively examined the medical charts of 100 patients diagnosed with respiratory allergy with clin...

Aims: The study aims to evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) to discriminate non-IgE-mediated immunoreactivity against Staphylococcus aureus in patients with Intrinsic Atopic Dermatitis (IAD). Study Design: We retrospectively examined the medical charts of 200 patients diagnosed with IAD who were investigated wit...

Aims: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) to discriminate Non-IgE-mediated immunoreactivity against Candida albicans in Atopic Dermatitis () patients with clinical suspicion of hypersensitivity reactions to fungal allergens. Study Design: We retrospectively examined the medical charts of 100 patients diagnose...

Aims: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) to discriminate innate immunoreactivity against Alternaria alternata in patients with clinical suspicion of allergic reaction to fungal allergens. Study Design: We retrospectively examined the medical charts of 100 patients diagnosed with Allergic Rhinitis and/or Asth...

Aims: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) to discriminate non-IgE-mediated innate immunoreactivity against Saccharomyces cerevisiae in patients with clinical suspicion of allergic reaction to fungal allergens. 235 Study Design: We retrospectively examined the medical charts of 200 allergic outpatients with ur...

Aims: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) for evaluating immunoreactivity against cochineal dye (E120) in patients with clinical suspicion of symptomatic hypersensitivity to this food additive. 186 Study Design: We retrospectively examined the medical charts of a population of 82 patients diagnosed with Atopi...

Aims: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) as a tool for evaluating immunoreactivity against cobalt in patients with clinical suspicion of cobalt hypersensitivity. Study Design: We retrospectively examined the medical charts of a population of 97 patients diagnosed with Allergic Contact Dermatitis (ACD) and/or...

Aims: To evaluate the contribution of non-IgE-mediated hypersensitivity mechanisms in Papular Urticaria produced by Aedes spp and Culex spp bites in patients diagnosed with Intrinsic Atopic Dermatitis coming from an urban (not beachy) Brazilian region. Study Design: To better understand the relationship between Papular Urticaria and Atopic Dermatit...

Aims: To evaluate the potential of the Leukocyte Adherence Inhibition Test (LAIT) as a diagnostic tool for nickel sensitization in patients with clinical suspicion of Nickel Hypersensitivity (NiH). Study Design: We retrospectively examined the medical charts of a population of 102 patients diagnosed with chronic extensive dermatitis that prevented...

Aims: Medical literature defines the diagnosis of "selective IgE deficiency" (sIgEd) as the individuals able to produce, at normal amounts, all antibodies' classes, and subclasses, with exception of the IgE, which is not found by the laboratory detection method (usually below 2.0 kIU/L). Patients with sIgEd may present non-IgE-mediated allergies/hy...

Background: The ancient concept of “intrinsic” and “extrinsic” asthma has evolved in line with growing scientific knowledge and the use of new clinical diagnostic tools. Objective: The present study aims to evaluate the non-IgE-mediated immunoreactivity against common allergens, in asthmatic patients without evidence of IgE-mediated hypersensitivit...

Background: The presence of anti-Saccharomyces cerevisiae antibodies (ASCA) has been reported in the serum of patients with several immune-inflammatory diseases. Objective: To evaluate the presence of ASCA in patients with non-IgE-mediated hypersensitivity. Methods: A group of 222 patients with non-IgE-mediated hypersensitivity was divided into thr...

Background: The non-IgE-mediated immunoreactivities against common allergens are little understood conditions, especially in patients suffering from allergic respiratory disorders such as persistent rhinitis. Objective: The present study aims to evaluate the non-IgE-mediated immunoreactivity against common allergens, in allergen-reactive patients c...

Food Allergy is a chronic systemic immuno-inflammatory condition that depends on several factors, but, above all, the gastrointestinal epithelial barrier. The rupture of this intestinal barrier results in a deleterious increase in intestinal permeability allowing the paracellular permeation of molecules greater than 150 Da into the bloodstream, pro...

Background: The non—IgE-mediated food allergy syndromes are a group of conditions diagnosed mostly by clinical criteria and Oral Food Challenge tests (OFC). Objective: To evaluate the feasibility of the Leukocyte Adherence Inhibition Test (LAIT) to discriminate antigen-specific immunoreactivity in a group of patients with non—IgE-mediated cow’s mil...

Background: The Non-Celiac Gluten Sensitivity (NCGS) is a category inside the Gluten-Related Disorders (GRD) that groups the patients with unidentified mechanisms responsible for their symptoms. Objective: To evaluate the opportunity of an ex vivo challenge immunoassay, the Leukocyte Adherence Inhibition Test (LAIT), to discriminate non—IgE-mediate...

Background: Due to the lack of standardized laboratory procedures able to demonstrate specific non—IgE-mediated immune responses against latex allergens, these conditions are diagnosed mostly by clinical criteria based on empiric exclusion prescriptions monitored by in vivo challenge tests. Objective: To evaluate the opportunity of an ex vivo chall...

Levels of specific IgG and IgE against Bos d 5 (bovine beta-lactoglobulin) in routine analyses of asymptomatic Brazilian children

Background: Due to the lack of standardized laboratory procedures able to demonstrate specific immune responses against the culprit allergens, the non—IgE-mediated allergy syndromes are a group of conditions diagnosed mostly by clinical examination and exclusion criteria. Objective: To evaluate the opportunity of the Leukocyte Adherence Inhibition...

Background: Due to the lack of standardized laboratory procedures able to demonstrate specific immune responses against the culprit allergens, the non—IgE-mediated allergy syndromes are a group of conditions diagnosed mostly by clinical examination and exclusion criteria. Objective: To evaluate the opportunity of the Leukocyte Adherence Inhibition...

Background: The diagnosis of non-IgE mediated food allergies may be a complex puzzle when there is no start point to establish an elimination diet to allow a clear clinical field to initiate diagnostic Oral Food Challenges tests. Objective: To evaluate the opportunity of the tube titration of precipitins to select food allergens to proceed with eli...

Background: The diagnosis of non-IgE mediated food allergy is done mainly by in vivo Oral Food Challenge (OFC) tests that depend on well-succeeded previous exclusion diets.

Citation: Olivier CE (2021) Sublingual allergen immunotherapy is safe and effective when precisely prescribed. The three decades of the Brazilian experience. J Allergy Ther. 12(7): 256.

Allergen Immunotherapy is not a conventional “treatment” that may be recommended (or discouraged) by experts panels to treat symptoms such as asthma, but a personalized approach used by Precision Medicine as part of a tolerance-inducing strategy that supports the establishment of the allergen avoidance, minimizing the risk of anaphylaxis, and, in t...

Background: The Precision Medicine’s approach employs the endotype concept as a central feature to personalize medical treatment. Individual immunoreactivity, alongside characteristics such as genetics, environment, and diet, is one of the factors that differentiates the therapeutic-driven endotypes. Objective: To evaluate the opportunity of the Le...

Background: The Leukocyte Adherence Inhibition Test (LAIT) is an ex vivo challenge test used to testimony specific immunoreactivity. Despite numerous studies had been performed to elucidate the interactions involved in the assay, there are yet several questions about its mechanisms and how to translate its results into the medical practice. Objecti...

Background: The Precision Medicine's approach employs the endotype concept as a central feature to personalize medical treatment. Individual immunoreactivity, alongside characteristics such as genetics, environment, and diet, is one of the factors that differentiates the therapeutic-driven endotypes. Objective: To evaluate the opportunity of the Le...

This is a historical review about the use of allergoids and adjuvants in Allergen Immunotherapy.

Objectives: To study the IgE-mediated immunoreactivity of genetically improved farmed Nile tilapia (Oreochromis niloticus) proteins in human subjects with occasional allergy to fish. Methods: Total protein extract and pepsinized extracts of the genetically improved farmed Nile tilapia (Oreochromis niloticus) were tested for their IgE-binding proper...

Background: Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. Objective: The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines...

Background Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. Objective The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines...

The leukocyte adherence inhibition (LAI) test was designed to evaluate the presence of cellular immunoreactivity against specific antigens and is highly sensitive to analytical interference. To compare the performance of the LAI test among plasmas obtained with different anticoagulants, 36 blood samples of allergic subjects were divided into three...

Background: The treatment of polysensitized allergic patients continues to represent a challenge and is a matter for debate amongst allergists who preferentially use allergen-specific immunotherapy. Objective: To study the effect of group-specific sublingual/swallow immunotherapy on quality of life of polysensitized human subjects with allergic rhi...

Vocal cord dysfunction (also called paradoxical vocal cord motion) or paradoxical vocal fold motion (PVFM) is an event elicited by specific and nonspecific triggers in which its diagnosis is limited by the restricted number of available functional tests. This study was designed to appreciate the contribution of the spirometric changes elicited by t...

Background Skin testing is a mainstay in allergology, and its importance is increasing in several fields. The ability to choose the most suitable technique according to the clinical setting is an advantage for the medical team. Objectives To describe in detail an alternative technique of the coetaneous allergy test (skin scrape test) conceived as...

Adverse reactions to food may be produced by several mechanisms and present a great diversity of symptoms, which may be reproducible or not reproducible (occasional adverse food reactions). The reproducible adverse food reactions to minimal or usual amounts of food are classified as hypersensitivity reactions, which may be derived from immune disor...

To explore the use of β-lactoglobulin polymerized using microbial transglutaminase and heating to identify whether protein polymerization could reduce in vivo allergenicity and maintain in vitro and ex vivo immunoreactivity for use in tolerance-induction protocols. Based on previous protocols applied in mice and children, we performed in vivo chall...

Acquired delayed-onset hypolactasia is a common autosomal recessive condition. Cow's milk allergies, conversely, are less common conditions that may manifest with equivalent symptoms and are able to simulate and/or aggravate lactose intolerance. This study was designed to evaluate the contribution of IgE-mediated cow's milk sensitization to the sym...

Background: Cow's milk allergy in pediatric patients is an unresolved issue. Among the proteins in milk, bovine whey beta-lactoglobulin (Bos d 5) is the most commonly allergenic. Allergenicity to native cow's milk proteins in humans is a well-studied issue, but very little is known about the allergenicity of cross-linked proteins found in bioproces...

OBJECTIVES: To identify the main clinical manifestations, triggers, and treatment of severe allergic reactions (SAR) in children and adolescents (n=191, up to 18 years of age) seen by allergologists and registered in the Online Latin American Survey of Anaphylaxis (OLASA). RESULTS: 53.0% of the patients were males and the aetiological agent was ide...

In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible t...

The susceptibility of the MAP Brazilian strain (F1 to F5 progenies) of S. mansoni to four antischistosomal drugs has been reported in a previous study. In the present investigation, progeny F14 of the same strain, was tested for stability to the same 4 drugs. A new medication, Oltipraz (35,972 RP), was added to the study. Five groups of 12 mice inf...