Celine Frochot

• University of Lorraine

In this work, we aimed at photocaging the well‐known anticancer agents dasatinib, ceritinib, gemcitabine, and combretastatin A4 with red‐light activatable 4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY)‐based cages using a carbonate/carbamate linking strategy. Due to the synthetic challenges discussed in this article, we only obtained two targe...

In this work, we describe the synthesis of three new meso-arylporphyrins, named meso-tetrakis [4-(nicotinoyloxy)phenyl] porphyrin (H2TNPP), meso-tetrakis [4-(picolinoyloxy)phenyl] porphyrin (H2TPPP), and meso-tetrakis [4-(isonicotinoyloxy) phenyl] porphyrin (H2TIPP). These new synthesized meso-arylporphyrins are characterized using spectroscopic an...

Phthalocyanine derivatives have attracted significant attention due to their unique chemical properties and applications in various fields, including photodynamic therapy. However, the synthesis and purification of phthalocyanines remain challenging. Among these derivatives, zinc(II) tetra, tert-butyl phthalocyanine (tert-ZnPc(II)) is noteworthy fo...

Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anti-cancer therapies. Here, a small series of osmium(II) polypyridyl complexes were synthesized and their biological activity in the dark and upon light irradiation against various cancer cell lines was studied. The com...

PDT has gained growing interest as a prospective approach for cancer therapy, thanks to its minimal invasiveness and low systemic toxicity, making it a promising therapeutic option. Nevertheless, type II PDT is significantly influenced by the oxygen levels in the tumoral microenvironment. Consequently, the weak oxygen pressure encountered in hypoxi...

Despite advances achieved in the health field over the last decade, infections caused by resistant bacterial strains are an increasingly important societal issue that needs to be addressed. New approaches have already been developed to overcome this problem. Photodynamic antimicrobial chemotherapy (PACT) could provide a promising alternative method...

The quantum-chemical method is a crucial area of innovation for photodynamic therapy. Density Functional Theory can be used to investigate the electronic structures, excited states, and other photochemical properties of a photosensitizer. In the present study, the intensities and energies of electronic transitions are calculated, and absorption and...

Dans le cadre d’un projet de recherche destiné à améliorer les techniques d’analyse d’imagerie médicale, notamment employées pour repérer ou suivre certains cancers, nous avons mené une étude de recherche création. Celle-ci s’est focalisée sur la création d'un jeu de société sérieux visant à aborder de manière ludique les bénéfices et les limites d...

Light‐activated treatments, such as photodynamic therapy (PDT), provide temporal and spatial control over a specific cytotoxic response by exploiting toxicity differences between irradiated and dark conditions. In this work, a novel strategy for developing near infrared (NIR)‐activatable Ru(II) polypyridyl‐based photosensitizers (PSs) was successfu...

Photodynamic therapy (PDT) is a medical technique for the treatment of cancer. It is based on the use of non-toxic molecules, called photosensitizers (PSs), that become toxic when irradiated with light and produce reactive oxygen specious (ROS) such as singlet oxygen (¹O2). This light-induced toxicity is rather selective since the physician only ta...

Graphene is a form of carbon allotrope that has received tremendous attention from researchers in various fields. Graphene oxide (GO) has unique characteristics that have proven to be useful in many areas, including biomedical and pharmaceutical applications. Its large surface area and richness in oxygen-containing functional groups enable the load...

Trisubstituted porphyrin derivatives [(TriMPyP)M][Formula: see text](Cl[Formula: see text] (where M = 2H, Zn[Formula: see text] or Pd[Formula: see text] containing three [Formula: see text]-methyl-4-pyridyl ([Formula: see text]-MePy[Formula: see text] groups were synthesized and characterized electrochemically and spectroscopically in DMSO containi...

Neuropilin 1 (NRP1), a cell-surface co-receptor of a number of growth factors and other signaling molecules, has long been the focus of attention due to its association with the development and the progression of several types of cancer. For example, the KDKPPR peptide has recently been combined with a photosensitizer and a contrast agent to bind N...

Photodynamic therapy (PDT) has shown improvements in cancer treatment and in the induction of a proper anti-tumor immune response. However, current photosensitizers (PS) lack tumor specificity, resulting in reduced efficacy and side effects in patients with intraperitoneal ovarian cancer (OC). In order to target peritoneal metastases of OC, which o...

A novel Ru(II) cyclometalated photosensitizer (PS), Ru‐NH2, for photodynamic therapy (PDT) of formula [Ru(appy)(bphen)2]PF6 (where appy=4‐amino‐2‐phenylpyridine and bphen=bathophenanthroline) and its cetuximab (CTX) bioconjugates, Ru‐Mal‐CTX and Ru‐BAA‐CTX (where Mal=maleimide and BAA=benzoylacrylic acid) were synthesised and characterised. The pho...

One of the most pressing environmental problems worldwide is sewage sludge (SS) management. Every year, wastewater volume increases and thus, the amount of SS produced increases as well. The disposal of SS in landfills, as practiced in many countries, is not a sustainable solution. Instead, SS, rich in organic matter and other nutrients, can be use...

Rose Bengal is a well-known photosensitizer used in the treatment of several diseases [1, 2]. This photosensitizer produces a large amount of singlet oxygen upon specific illumination, which allows its use in photodynamic therapy [3]. The work to be presented highlights the passive tumor targeting by coupling Rose Bengal to nanoparticles in clinica...

A novel symmetric tetra-imidazolium-bis-heterocycle, called C7, was designed and synthesized in a quick two-step pathway, with the objective to synthesize biologically active supramolecular assembly. The synthesized compound was then analyzed for its photophysical properties, for a potential application in theragnostic (fluorescence) or phototherap...

New heterogeneous porous materials based on 5,10,15,20-(tetraphenyl)porphyrin (H 2 TPP), 5,10,15,20-(tetra-N-methyl-4-pyridyl)porphyrin tetrachloride (H 2 TNMPyP), zinc(II) 5,10,15,20-(tetra-N-methyl-4-pyridyl)porphyrin tetrachloride (ZnTNMP y P), 5,10,15,20-(tetra-4-carboxyphenyl)porphyrin (H 2 TCPP) and zinc(II)5,10,15,20-(tetra-4-carboxyphenyl)p...

Targeting vascular endothelial growth factor receptor (VEFGR) and its co–receptor neuropilin–1 (NRP–1) is an interesting vascular strategy. tLyp–1 is a tumor–homing and penetrating peptide of 7 amino acids (CGNKRTR). It is a truncated form of Lyp–1 (CGNKRTRGC), which is known to target NRP–1 receptor, with high affinity and specificity. It is media...

Rose Bengal (RB) is a photosensitizer (PS) used in anti-cancer and anti-bacterial photodynamic therapy (PDT). The specific excitation of this PS allows the production of singlet oxygen and oxygen reactive species that kill bacteria and tumor cells. In this review, we summarize the history of the use of RB as a PS coupled by chemical or physical mea...

Despite conventional treatment combining complete macroscopic cytoreductive surgery (CRS) and systemic chemotherapy, residual microscopic peritoneal metastases (mPM) may persist as the cause of peritoneal recurrence in 60% of patients. Therefore, there is a real need to specifically target these mPM to definitively eradicate any traces of the disea...

Photodynamic therapy (PDT) is a method of treating precancerous diseases and malignant neoplasms. The efficacy of PDT depends on different parameters such as light dosimetry, oxygen availability, and photophysical and physical‐chemical properties of the photosensitizer. In PDT, a photosensitizer is activated using light to promote oxygen photosensi...

Folate receptor α (FRα) is overexpressed on numerous tumorous cell types such as ovarian or endometrial cancer cells. Moreover, FRα is absent from most healthy tissues as it is normally expressed only on the surface of proximal tubules cells of kidneys and choroid plexus. Thus, folate-based radiopharmaceuticals have emerged this last two decades as...

This paper is devoted to recent works developed on the heterogeneous photocatalysis and the different parameters affecting the catalysis efficiency in the adsorption capacity of the organic pollutants for the wide applications in water treatment. The heterogeneous photocatalysis based on titanium dioxide is increasing and growing. The choice of tit...

The reaction of the [meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II) complex ([Cd(TClPP)]) with an excess of 2-aminopyridine results in the formation of the corresponding axially ligated (2- aminopyridine)[meso-tetra(p-chlorophenyl)porphyrinato]cadmium(II)with the formula [Cd(TClPP)(2-NH2Py)] (I). This five-coordinated metalloporphyrin was chara...

The physicochemical characterization of nanomaterials and photocatalysts by is of vital importance. One of the most interesting technique to do this is the inverse gas chromatography (IGC) at infinite dilution. A section will be devoted to results obtained by using IGC technique to determine the surface and interface properties of materials and nan...

Due to their very poor prognosis and a fatal outcome, secondary brain tumors are one of the biggest challenges in oncology today. From the point of view of the early diagnosis of these brain micro- and macro-tumors, the sensitivity and specificity of the diagnostic tools constitute an obstacle. Molecular imaging, such as Positron Emission Tomograph...

X-ray-induced Photodynamic Therapy (X-PDT) is an alternative strategy to improve Photo Dynamic Therapy (PDT) for cancer treatment1 PDT consists in the transfer of light-photon to a photosensitizer which in turn produces singlet oxygen and reactive species. The photo reactions depend mainly on the photosensitizer, light and the presence of molecular...

Cancer is the second leading cause of death worldwide after cardiovascular disease. Depending on the type and the location of the tumor, several cancer treatments are implemented. Among these, the three most conventional therapies are surgery, radiotherapy and chemotherapy. However, there are other therapeutic approaches such as photodynamic therap...

Anti-cancer therapies (radiotherapy, chemotherapy, etc.) are limited by their significant drawbacks. Today, photodynamic therapy (PDT) represents a real revival and success in the world of cancer therapy. Nevertheless certain limitations remain. One of those limitations is the lack of selectivity of most of the photosensitizers. Our teams have deve...

The combination of photodynamic therapy and chemotherapy is a promising strategy to enhance cancer therapeutic efficacy and reduce drug resistance. In this study two zinc(II) phthalocyanine-tin(IV) conjugates linked by a triethylene glycol chain were synthesized and characterized. In these complexes, the zinc(II) phthalocyanine was used as a potent...

X-ray-induced photodynamic therapy is based on the energy transfer from a nanoscintillator to a photosensitizer molecule, whose activation leads to singlet oxygen and radical species generation, triggering cancer cells to cell death. Herein, we synthesized ultra-small nanoparticle chelated with Terbium (Tb) as a nanoscintillator and 5-(4-carboxyphe...

Self-aggregation of Curcumin (Cur) in aqueous biological environment decreases its bioavailability and in vivo therapeutic efficacy, which hampers its clinical use as candidate for reducing risk of neurodegenerative diseases. Here, we focused on the design of new Cur- β-Cyclodextrin nanoconjugates to improve the solubility and reduce cell toxicity...

Despite advances achieved over the last decade, infections caused by multi-drug-resistant bacterial strains are increasingly becoming important societal issues that need to be addressed. New approaches have already been developed in order to overcome this problem. Photodynamic antimicrobial chemotherapy (PACT) could provide an alternative to fight...

Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS). Depending on the medium, photophysical properties of the PS can change leading to increase or decrease in fluorescence emission and formation of...

Photodynamic therapy (PDT) is a promising technique to treat different kinds of disease especially cancer. PDT requires three elements: molecular oxygen, a photoactivatable molecule called the photosensitizer (PS), and appropriate light. Under illumination, the PSs generate, in the presence of oxygen, the formation of reactive oxygen species includ...

Photodynamic therapy (PDT) is a promising therapeutic strategy for cancers where surgery and radiotherapy cannot be effective. PDT relies on the photoactivation of photosensitizers, most of the time by lasers to produced reactive oxygen species and notably singlet oxygen. The major drawback of this strategy is the weak light penetration in the tiss...

Background Local recurrences of glioblastoma (GBM) after heavy standard treatments remain frequent and lead to a poor prognostic. Major challenges are the infiltrative part of the tumor tissue which is the ultimate cause of recurrence. The therapeutic arsenal faces the difficulty of eradicating this infiltrating part of the tumor tissue while incre...

1H-Phenalen-1-one is a very efficient and easy-to-synthesize photosensitizer. Many substitutions have been previously described, but most of them significantly reduce the singlet oxygen quantum yield. The chloromethyl derivative described elsewhere is a good starting point for the synthesis of many useful derivatives because of the methylene bridge...

BACKGROUND most serious games and other game-based tools are designed as digital games or escape games. They are designed for learning or sometimes in the field of medicine as an aid to care. However, they can also be seen as an aid to research, in our case, to evaluate the advantages and disadvantages of imaging techniques for cancer detection. O...

In this work, a new cadmium(II) complex namely the (1,4-diazabicyclo[2.2.2]octane)(meso-tetrakis(4-tert-methoxyphenyl)porphyrinato)cadmium(II) with the formula [Cd(TMPP)(DABCO)] (I) (DABCO = 1,4-diazabicyclo[2.2.2]octane) was successfully synthetized. The structure of (I) have been characterized by FT-IR, 1HNMR, UV-visible, fluorescence spectroscop...

In this work, we exploit the versatile function of cationic phosphonium-conjugated polythiophenes to develop multifunctional platforms for imaging and combined therapy (siRNA delivery and photodynamic therapy). The photophysical properties (absorption, emission and light-induced generation of singlet oxygen) of these cationic polythiophenes were fo...

Triphenylamines (TPAs) were previously shown to trigger cell death under prolonged one- or two-photon illumination. Their initial subcellular localization, before prolonged illumination, is exclusively cytoplasmic and they translocate to the nucleus upon photoactivation. However, depending on their structure, they display significant differences in...

Often discovered at an advanced stage, ovarian cancer progresses to peritoneal carcinoma, which corresponds to the invasion of the serosa by multiple tumor implants. The current treatment is based on the combination of chemotherapy and tumor cytoreduction surgery. Despite the progress and standardization of surgical techniques combined with effecti...

Surgical management of peritoneal metastases raises the problem of the theoretical spread of the entire peritoneal surface. Intraperitoneal photodynamic therapy (IntraPDT) has been limited by the lack of specificity of photosensitizers (PS) and difficulties to bring light into the abdominal cavity. Recent data in ovarian cancer may give development...

Multidrug resistance (MDR) and the spread of cancer cells (metastasis) are major causes leading to failure of cancer treatment. MDR can develop in two main ways, with differences in their mechanisms for drug resistance, first drug-selected MDR developing after chemotherapeutic treatment, and metastasis-associated MDR acquired by cellular adaptation...

To date, pancreatic adenocarcinoma (ADKP) is a devastating disease for which the incidence rate is close to the mortality rate. The survival rate has evolved only 2–5% in 45 years, highlighting the failure of current therapies. Otherwise, the use of photodynamic therapy (PDT), based on the use of an adapted photosensitizer (PS) has already proved i...

Abstract The objective of this chapter is to describe our work in developing various strategies of surface modification in order to (i) enhance the adsorption capacity of the organic pollutants, (ii) accelerate the kinetic of degradation, (iii) shift the light activation towards visible and solar light, and (iv) facilitate the catalyst recovery to...

Self-aggregation of hydrophobic porphyrin-based photosensitizers (PSs) in aqueous biological environment decreases their bioavailability and in vivo therapeutic efficacy, which hampers their clinical use in photodynamic therapy (PDT). In the current study, we explore three new supramolecular systems based of hydrophobic PSs (i.e. 5,10,15,20-tetraki...

This study describes the employment of gold nanorods (AuNRs), known for their good reputation in hyperthermia-based cancer therapy, in a hybrid combination of photosensitizers (PS) and peptides (PP). We report here, the design and the synthesis of this nanosystem and its application as a vehicle for the selective drug delivery and the efficient pho...

Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for oxygen to induce a photodynamic effect. Tumours often have low oxygen concentrations, related to the abnormal structure of the microvessels leading to an ineffective...

Porphyrins and phthalocyanines are photosensitizers (PS) that are used in clinical imaging, detection of cancer cells and are particularly applied in photodynamic therapy (PDT). Many scientists have been focused on the design of different porphyrin compounds. However, similar to other anti-cancer agents, they cannot recognize selectively tumor tiss...

Recently, gold(III) porphyrins have gained great interest as anticancer drugs not only for the stability of gold(III) but also for the functionalization of the porphyrin to allow bridging with another metal such as platinum(II). We report here, for the first time, the synthesis of three new bimetal compounds containing a gold(III) porphyrin conjuga...

Photodynamic therapy (PDT) is a cancer therapy modality. After excitation of a photoactivable molecule (called photosensitizer) and its energy transfer to oxygen, reactive oxygen species are produced leading to photooxidation reactions. New improvements in the field of PDT concern the development of nanoparticles as delivery carriers for anticancer...

In this work, we describe a novel cadmium(II) complex based on the insertion of the Cd(II) metal ion into the meso-tetrakis(4-tert-butylphenyl)porphyrin (TBPP) ring, followed by the coordination of the 2-methylimidazole (2-MeHIm) N-donor axial ligand. Single crystal X-ray diffraction of [Cd(TBPP)(2-MeHIm)] (I) revealed that the Cd(II) metal ion ind...

La conception de cartes à des fins de communication ou, de manière plus générale, la visualisation de données est un champ de recherches relativement ancien qui a subi de profonds changements au cours de ces dernières années. Si de nombreuses recherches y sont consacrées, très peu d’entre elles s’intéressent à une autre tendance forte du moment : l...

Photodynamic therapy has become of interest in many European countries. Since, most of national authorities and all medical journals require the registration of the clinical study on the database ClinicalTrials. gov in order to be published, information regarding clinical studies are now available. This article aims to synthetize data gathered than...

AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulat...

Free access to this article online from the website of "The Conversation". https://theconversation.com/lutter-contre-le-cancer-avec-le-ciblage-moleculaire-101832

Photodynamic therapy (PDT) is mainly used to destroy cancerous cells; it combines the action of three components: a photoactivatable molecule or photosensitizer (PS), the light of an appropriate wavelength, and naturally occurring molecular oxygen. After light excitation of the PS, the excited PS then reacts with molecular oxygen to produce reactiv...

Photodynamic therapy is a therapeutic option to treat cancer and others diseases. PDT is used everyday in dermatology and recent developments in the treatment of glioblastoma, mesothelioma or prostate prove the efficacy of this modality. In order to improve the efficacy of PDT, different strategies are under development such as the use of targeted...

A new aminophosphonic acid was synthesized by condensation of 4,4'-(propane-2,2-diylbis(4,1-phenylene)bis(oxy)dianiline), phosphorous acid and formaldehyde, according to the Moedritzer-Irani reaction. The structure of the inhibitor was analyzed by ¹H and ³¹P NMR, FT-IR, mass spectrometry and thermogravimetry. The new inhibitor presented high effici...

Introduction Epithelial ovarian cancer (EOC) management is underlined by the high rate of peritoneal recurrence that may be related to microscopic peritoneal metastases ignored by conventional cytoreductive surgery. Intraperitoneal photodynamic therapy (PDT) could improve microscopic cytoreduction. In addition, immune response seems to be enhanced...

In this study, light-sensitive photosensitizers (Chlorin e6, Ce6) were linked to TiO2and SiO2nanoparticles (NPs) in order to develop new kinds of NP-based drug delivery systems for cancer treatment by PDT. the TiO2or SiO2NPs were modified either by the growth of a polysiloxane layer constituted of two silane reagents ((3-aminopropyl)triethoxysilane...

In the present study, β-cyclodextrin-grafted chitosan nanoparticles (β-CD-g-CS NPs) were prepared using a new ionic gelation strategy involving a synergistic effect of NaCl (150 mmol/L), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES, 10 mmol/L), and water bath sonication. This new strategy afforded smaller and more monodisperse β-CD-g-C...

Further improvements in Photodynamic therapy (PDT) necessitate that the dye targets more selectively tumour tissues or neovascularization than healthy cells. Different enzymes such as matrix metalloproteinases (MMPs) are overexpressed in tumour areas. Among these MMPs, gelatinases (MMP-2 and MMP-9) and its activator MMP-14 are known to play a key r...

In this study, light-sensitive photosensitizers are coupled to titanium dioxide and silicon dioxide nanoparticles in order to develop new kinds of visible light photocatalysts for water treatment applications. The influence of the mode of surface modification of the nanoparticles and the nature of the linked photosensitizer (PS) on the photocatalyt...

Objectives Epithelial ovarian cancer (EOC) management is underlined by the high rate of peritoneal recurrence that may be related to microscopic peritoneal metastases ignored by conventional cytoreductive surgery. Intraperitoneal photodynamic therapy (PDT) could improve microscopic cytoreduction. In addition, immune response seems to be enhanced af...

Nanoparticles (NPs) have been shown to have good ability to improve the targeting and delivery of therapeutics. In the field of photodynamic therapy (PDT), this targeting advantage of NPs could help ensure drug delivery at specific sites. Among the commonly reported NPs for PDT applications, NPs from zinc oxide, titanium dioxide, and fullerene are...

Despite combined treatments, glioblastoma outcome remains poor with frequent local recurrences, indicating that a more efficient and local therapy is needed. In this way, vascular-targeted photodynamic therapy (VTP) could help tumor eradication by destroying its neovessels. In this study, we designed a polysiloxane-based nanoparticle (NP) combining...