
Céline Falentin-DaudréUniversité Sorbonne Paris Nord · BEST - CB3S
Céline Falentin-Daudré
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Publications (62)
Myelomeningocele (MMC) is a congenital defect of the spine characterized by meningeal and spinal cord protrusion through open vertebral archs, and its exposure to the amniotic fluid. Given that the progression of neuronal loss begins early in fetal life, an early coverage of the defect is required to improve the neurological outcomes. Several studi...
Melt‐blown, an environmentally friendly technique, is widely used to create high‐quality non‐woven fabrics by extruding molten polymer resins into interlaced fibers. In the realm of biomedical textiles, its unique microstructure makes it ideal for filtration and wound dressings. Our study focuses on modifying the surfaces of polypropylene melt‐blow...
Abstact
Myelomeningocele (MMC) is a congenital defect of the spine characterized by meningeal and spinal cord protrusion through the open vertebral arches. This defect causes progressive prenatal damage of the spinal cord, leading to lifelong handicap. Although midtrimester surgical repair may reduce part of the handicap, an earlier and less invasi...
Poly(dimethyl siloxane) (PDMS) is one of the most widely used materials in the biomedical field. Despite its numerous advantages, its hydrophobic character promotes bacterial adhesion and biofilm formation. For breast implants, biocompatibility is challenged due to the biofilm formed around the implant that can degenerate to severe capsular contrac...
In this study, the characteristics of nanocrystalline diamond films synthesized at low surface temperature on Ti-6Al-4V (TA6V) substrates using a distributed antenna array microwave reactor aiming at biomedical applications were investigated. The surface roughness of the TA6V substrates is varied by scratching with emery paper of 1200, 2400, 4000 p...
The modification of the surface of pure titanium (Ti) implant by grafting biomimetic polymer offers the possibility of camouflaging the synthetic origin of the implant to bone cells. In our previous studies, we have shown that with ultraviolet irradiation (UV) technology, polymers such as poly(methyl methacrylate) (PMMA) and poly(sodium styrene sul...
Background:
Bacterial biofilm can occur on all medical implanted devices and lead to infection and/or dysfunction of the device. In this study, artificial biofilm was formed on four different medical implants (silicone, piccline, peripheral venous catheter and endotracheal tube) of interest for our daily clinical and/or research practice. We inves...
[This corrects the article DOI: 10.1021/acsomega.0c00376.].
Proteins adsorption occurs spontaneously on biomaterial upon insertion within the body. The resulting protein layer influences biomaterial biocompatibility through enhanced bio-integration or, on the contrary, adverse reactions. Furthermore, upon adsorption, proteins can undergo modifications of their structure and, ultimately, their physicochemica...
Titanium (Ti) and its alloys are the most effective metals for structural implantable device applications. However, Ti-based materials are passively integrated into the bone, resulting in a purely mechanical attachment. Consequently, the loss of osseointegration often leads to implant failure. Therefore, enhancing bone formation surrounding the imp...
Prior to its commercialization, a biomaterial must fulfill the regulation in place. The International Organization for Standardization outlines the requirements needed for a material in order to guarantee safety and quality. In previous work, we have successfully grafted a bioactive polymer known as poly(styrene sodium sulfonate) – (polyNaSS) on si...
Background
Bacterial biofilm can occur on all medical implanted devices and lead to infection and/or dysfunction of the device.
In this study, artificial biofilm was formed on four different medical implants (silicone, piccline, peripheral venous catheter and endotracheal tube) of interest for our daily clinical and/or research practice. We investi...
The world of biomaterials has been continuously evolving. Where in the past
only mono-material implants were used, the growth in technology and col-
laboration between researchers from different sectors has led to a tremendous
improvement in implant industry. Nowadays, composite materials are one of
the leading research areas for biomedical applica...
Objective
The publication aims to characterize the particularities of breast implant outer shells' structure and roughness. Then, it seeks to study the implication of the topography and the type of silicone on the grafting of the bioactive polymer under UV irradiations.
Material & methods
PolyNaSS was grafted on silicone surfaces via a radical pol...
Titanium (Ti) is the most commonly used material for cranial prostheses. However, this material does not exhibit the same mechanical properties as the bone. Incorporating polymers onto Ti by combining both their properties is a solution to overcome this issue. Thus, sandwich materials made of two Ti skin sheets and a poly(methyl methacrylate) (PMMA...
A challenge in contractile restoration of myocardial scars is one of the principal aims in cardiovascular surgery. Recently, a new potent biological tool used within healing processes is represented by exosomes derived from mesenchymal stem cells (MSCs). These cells are the well-known extracellular nanovesicles released from cells to facilitate cel...
Objectives
To improve the hydrophilicity of cyclic olefin copolymer, a simple and rapid method using two-stage with ultraviolet irradiation was developed in order to graft a bioactive polymer on the surface of these polymers.
Materials and Methods
A bioactive polymer, poly(sodium styrene sulfonate) was grafting in two step on the cyclic olefin cop...
Bone properties and especially its microstructure around implants are crucial to evaluate the osseointegration of prostheses in orthopaedic, maxillofacial and dental surgeries. Given the intrinsic heterogeneous nature of the bone microstructure, an ideal probing tool to understand and quantify bone formation must be spatially resolved. X-ray imagin...
Scaffold-guided viral gene therapy is a novel, powerful tool to enhance the processes of tissue repair in articular cartilage lesions via the delivery and overexpression of therapeutic genes in a non-invasive, controlled release manner based on a procedure that may protect the gene vehicles from undesirable host immune responses. In the present stu...
Les biomatériaux polymères entrent pour une bonne part dans l’allongement toujours croissant de l’espérance de vie et dans la préservation d’une bonne qualité de vie des patients, tous âges confondus. Malgré cela, l’implantation d’un biomatériau dans les tissus induit une série de réactions appelée « réponse de l’hôte » qui, si elle est contrôlée,...
Silicone implants are widely used in the medical field for plastic or reconstructive surgeries for the purpose of soft tissue issues. However, as with any implanted object, healthcare-associated infections are not completely avoidable. The material suffers from a lack of biocompatibility and is often subject to bacterial/microbial infections charac...
This study highlights recent advances in the synthesis of nanoconjugates based on gold (Au(III)) complex with a bioactive polymer bearing sulfonate groups called thiol-poly(sodium styrene sulfonate) (PolyNaSS-SH) with various molecular weights (5, 10, and 35 kDa). The three nanomaterials differ substantially in shape and structure. In particular, f...
Background:
The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while protecting the cargos from detrimental immune responses, particularly when targeting chondroreparative bone marrow-derived mesenchymal stromal...
In this paper, the microstructure and biological properties through osteoblast cell viability and morphology study of Nano Crystalline Diamond (NCD) films deposited on Ti and TiAl6V4 substrates using a Distributed Antenna Array (DAA) microwave system are investigated. The morphology, purity and microstructure of such NCD coatings are comparable to...
Silicone-based materials are largely used in plenty of fields, especially in the biomedical field as implantable devices for surgery purposes. However, due to recent issues, the safety of the material has been reconsidered. In this work, we aim to graft a bioactive polymer on silicone breast implants shell surface to allow better integration of the...
This study is part of a new trend in the metallic biomaterials field that searches to use the titanium beta alloys with recognized bulk and surface properties for better biological response. Ti15Mo alloy (wt%) had it surface modified by TiO2 nanotubes growth using the anodic oxidation method and grafted with poly(sodium styrene sulfonate) (PNaSS)....
Scaffold-guided gene transfer offers strong systems to develop non-invasive, convenient therapeutic options for the treatment of articular cartilage defects, especially when targeting bone marrow aspirates from patients containing chondroregenerative mesenchymal stromal cells in a native microenvironment. In the present study, we examined the feasi...
The purpose of this study is to present the poly(caprolactone) (PCL) functionalization by the covalent grafting of poly(sodium styrene sulfonate) on electrospun scaffolds using the "grafting from" technique and evaluate the effect of the coating and surface wettability on the biological response. The "grafting from" technique required energy (therm...
Implanted biomaterials play a key role in the current success of orthopedic and dental procedures. Pure titanium and its alloys are the most commonly used materials for permanent implants in contact with bone. However, implant-related infections remain among the leading reasons for failure. The most critical pathogenic event in the development of i...
Background: Polycaprolactone (PCL) is a biodegradable polymer which is used in tissue engineering applications thanks to its many favorable characteristics. However, PCL surfaces are known as hydrophobic leading to a lack of favorable cell response. To overcome this problem, PCL surfaces will undergo a surface functionalization by grafting bioactiv...
Articular cartilage supports joint loading and motion but has a limited ability for self-healing. Gene transfer using the clinically relevant recombinant adeno-associated viral (rAAV) vectors is a powerful tool to enhance cartilage repair [1]. Here, we tested the ability of various poly(sodium styrene sulfonate) grafted poly(epsilon-caprolactone) s...
Injuries occurring in orthopedic tissues do not completely heal if left untreated due to their imperfect self abilities for spontaneous repair. As most of the current clinical treatments often fail to fully restore the damaged tissues, there is a critical need to develop potent alternatives to activate the processes of repair in sites of orthopedic...
The goal of this report is to provide a versatile one step method based on UV irradiation in order to graft a bioactive polymer bearing sulfonate groups called poly(sodium styrene sulfonate) (polyNaSS) onto titanium nanoparticles (TiO 2 NPs) through covalent bond. The synthetic approach consists in two steps: (1) fabrication of TiO 2 nanocrystals w...
The aim of this article is to present three different techniques of poly(sodium styrene sulfonate) (polyNaSS) covalent grafting onto titanium (Ti) surfaces and study the influence of their architecture on biological response. Two of them are “grafting from” techniques requiring an activation step either by thermal or UV irradiation. The third metho...
Titanium based materials slowly induce the formation of a fibrous layer after several years of implantation, compromising the quality of bone/implant interface and leading progressively to an aseptic loosening of the implants. The functionalization of Titanium based materials by bioactive polymers bearing ionic groups has been shown to be an excell...
This contribution reports on grafting of bioactive polymers such as poly(sodium styrene sulfonate) (polyNaSS) onto titanium (Ti) surfaces. This grafting process uses a modified dopamine as an anchor molecule to link polyNaSS to the Ti surface. The grafting process combines reversible addition-fragmentation chain transfer polymerization, postpolymer...
Background:
Osseointegration of implant materials with surrounding tissues is crucial for their long-term success.
Objective:
The aim of the present study was to investigate the extent of physisorption of polymers on a titanium alloy (Ti6Al4V) surface. In addition, the water contact angles on the physisorbed coatings were measured to compare the...
The anchorage failure of titanium implants in human body is mainly due to biointegration problems. The use of bioactive polymers bearing anionic groups (such as sulfonates) in combination with titanium-based materials has been shown to be an excellent solution. We have checked and confirmed the positive effect of grafted sulfonate groups onto titan...
The anchorage failure of titanium implants in the human body is mainly due to biointegration problems. The
use of bioactive polymers bearing anionic groups (such as sulfonates) in combination with titanium-based
materials has been shown to be an excellent solution. In this paper, we report the grafting of an ionic
polymer poly(sodium styrene sulfon...
This paper describes the reversible addition−fragmentation chain transfer (RAFT) polymerization of mussel-inspired acetonide-protected dopamine (meth)acrylamide monomers (ADA and ADMA) and its implementation to the synthesis of innovative ambivalent block copolymers. They consist in a hydrophobic poly((meth)acrylamide) block functionalized by catec...
Bacterial adhesion, biocompatibility and biointegration on implanted prosthetic materials represent major problems for public health. The use of bioactive polymers has been shown to be an excellent solution. Several techniques for covalently tethering well-defined polymer brushes onto surfaces have been developed, including the covalent attachment...
Mesomorphic properties of S-alkylthiopentonolactones (d-ribono, d-arabinono and d-xylono) and corresponding alditol derivatives with the general formula Su-SR (R=CnH2n+1; n=5-12) are studied. It was shown that the thermotropic and lyotropic phase transition temperatures are influenced by the following structural parameters: alkyl chain length, cycl...
Catechols represent an important and versatile building block for the design of mussel-inspired synthetic adhesives and coatings. Indeed, their ability to establish large panoply of interactions with both organic and inorganic substrates has promoted catechol as a universal anchor for surface modifications. In addition to its pivotal role in adhesi...
In this work, longa term antibacterial, antiadhesion, and antibiofilm activities are afforded to industrial stainless steel surfaces following a green and bioa inspired strategy. Starting from catechol bearing synthetic polymers, the film crossa linking and the grafting of active (bio)molecules are possible under environmentally friendly conditions...
A bio-inspired durable anti-biofilm coating was developed for industrial stainless steel (SS) surfaces. Two polymers inspired from the adhesive and cross-linking properties of mussels were designed and assembled from aqueous solutions onto SS surfaces to afford durable coatings. Trypsin, a commercially available broad spectrum serine protease, was...
In this study, we report on the original synthesis and characterization of novel antimicrobial coatings for stainless steel by alternating the deposition of aqueous solutions of positively charged polyelectrolyte micelles doped with silver-based nanoparticles with a polyanion. The micelles are formed by electrostatic interaction between two opposit...
d-Ribono-1,4-lactone was treated with ethylamine in DMF to afford N-ethyl-d-ribonamide 8a in quantitative yield. Using this reaction procedure, N-butyl, N-hexyl, N-dodecyl, N-benzyl, N-(3-methyl-pyridinyl)-, N-(2-hydroxy-ethyl)-, and N-(2-cyano-ethyl)-d-ribonamides 8b-h were obtained in quantitative yield. Bromination of the amides 8a-e with acetyl...
d-Ribono-1,4-lactone was treated with ethylamine in DMF to afford N-ethyl-d-ribonamide 9a in quantitative yield. Bromination of amide 9a by the system SOBr2 in DMF or PPh3/CBr4 in pyridine led, after acetylation, to epoxide 7. However, treatment of amide 9a with acetyl bromide in dioxane followed by acetylation gave 2,3,4-tri-O-acetyl-5-bromo-5-deo...
The non-natural enantiomer of polyoxamic acid (1) and 3,4-diepipolyoxamic acid (2) was synthesized in four steps from d-lyxono-1,4-lactone (4). Regioselective bromination of unprotected d-lyxono-1,4-lactone with HBr/AcOH led to 2-bromo-2-deoxy-d-xylono-1,4-lactone (5). This intermediate was treated with NaN3 to give 2-azido-2-deoxy-d-lyxono and xyl...
Saponification of 5-azido-5-deoxy-D-pentonolactones (ribo-, arabino-, xylo-) with NaOH gave the corresponding 5-azido-5-deoxyaldonic acids sodium salts which, after regeneration of the acid form followed by catalytic reduction, led to the target compounds in 98% overall yields.
We describe a procedure to link two saccharides by click chemistry techniques. This methodology allows the generation of new molecules in which two carbohydrates are connected through a triazole ring. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)