Celina Dubin

• Resident at Icahn School of Medicine at Mount Sinai

Background In the SARS-CoV-2/COVID-19 pandemic, we need to understand the impact of immunomodulatory medications on COVID-19 symptom severity in patients with inflammatory diseases, including the Type 2/Th2 polarized skin disease, atopic dermatitis/AD. Objective Since it is believed that Type 1/Th1immunity controls viral infections, and that there...

Background Alopecia areata (AA) is characterized by immune dysregulation in both scalp and blood, but a large‐scale approach establishing biomarkers of AA incorporating both scalp tissue and serum compartments is lacking. We aimed to characterize the transcriptomic signature of AA lesional and nonlesional scalp compared to healthy scalp and determi...

Introduction Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier defects driving cutaneous inflammation and allergic symptomatology. The IL-4, IL-13, and IL-31 inflammatory pathways have been identified as hallmark features in the pat...

Background Atopic dermatitis/AD is a common disease, with particularly high prevalence seen in Africa. It is increasingly recognized that AD patients of different ethnic backgrounds have unique molecular signatures in skin, potentially accounting for treatment response variations. However, the skin profile of AD patients from Africa is unknown, hin...

Background Frontal fibrosing alopecia/FFA is a progressive, scarring alopecia of the frontotemporal scalp, and poses a substantial burden on quality of life. Largescale global profiling of FFA is lacking, preventing the development of effective therapeutics. Objective To characterize FFA compared to normal and alopecia areata/AA using broad molecu...

Dubin C, Del Duca E, Guttman-Yassky E. Ther Clin Risk Manag. 2020;16:1319– 1332. The authors have advised the drug, ARQ-252, was misnamed in the paper as roflumilast (which is called ARQ-151 and ARQ-154 by the manufacturer). The drug named ARQ-252 by the manufacturer should instead be classified as a JAK1 inhibitor in the paper. On page 1320, CHE T...

Chronic hand eczema (CHE) is a common and burdensome inflammatory skin condition seen in up to 10% of the population, more often in high-risk occupational workers. Topical therapeutics comprise the standard of care, but up to 65% of cases do not resolve after treatment, and moderate-to-severe cases are often resistant to topical therapeutics and re...

Context: Skin sensitivity may be best defined as self-reported intolerance to application of skincare products. It is commonly believed that individuals with darker skin are generally less sensitive, while those lighter skin are more sensitive. However, there is little objective data correlating sensitivity with skin type or with objective measures...

Background Although there is increased understanding of the alopecia areata/AA pathogenesis based on studies in scalp tissues, little is known about its systemic profile. Objective To evaluate the blood proteomic signature of AA and determine biomarkers associated with increased disease severity. Methods In a cross-sectional study, we assessed 35...

This is the first study that objectively compares the molecular cutaneous improvement with different treatments in AD and may facilitate personalized medicine by identifying the best treatments for individual phenotypes, based on immune/barrier profiles.

Background: Moderate-to-severe atopic dermatitis (AD) has been associated with significant disease burden and systemic abnormalities and often requires systemic treatments. Currently, safe and effective oral systemic treatments for moderate-to-severe AD are not yet available. ASN002 is an oral inhibitor of the Janus kinase/spleen tyrosine kinase s...