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Celia Fortuna R.

Celia Fortuna R.
TOXRUN @ CESPU and LEPABE @ FEUP

PharmD, PhD

About

101
Publications
28,149
Reads
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1,316
Citations
Introduction
Pharmacist with a PhD in Chemical and Biological Engineering. Research focused on biofilms, AMR, Candida spp. infections, pathogens detection, FISH,microfluidics, alternative therapies, probiotics, and biomaterials @TOXRUN-CESPU and @ LEPABE-FEUP. Invited Assistant Professor @ IUCS-CESPU. http://www.rodriguescf.pt https://pt.linkedin.com/in/celiafrodrigues
Additional affiliations
October 2019 - present
Letters to a Pre-Scientist
Position
  • Mentor
Description
  • Mentor for Letters to a Pre-Scientist, an organization that brings science closer to young children from minorities (www.prescientist.org).
January 2019 - present
Cooperativa de Ensino Superior, Politécnico e Universitário
Position
  • Professor (Assistant)
November 2018 - present
University of Porto
Position
  • PostDoc Position
Description
  • Project: Integration of fluorescence in situ hybridization with microfluidics for the quasi real-time detection of food pathogens
Education
December 2017 - December 2017
Nature Research
Field of study
  • Focus on Peer Review - Nature Masterclasses Online Course
December 2016 - December 2016
Engineering School - University of Minho
Field of study
  • Proteome 2 Gene 2 Protein - Hands-on-Course
February 2016 - February 2016
Life and Health Sciences Research Institute - University of Minho
Field of study
  • Laboratory Animal Science Certification by DGV and FELASA, Category C

Publications

Publications (101)
Article
Full-text available
One of the most prevalent healthcare-associated infection is the urinary tract infection (UTI), caused by opportunistic pathogens such as Candida albicans or non-albicans Candida species (NACS). Urine culture methods are routinely used for UTI diagnostics due to their specificity, sensitivity and low-cost. However, these methods are also laborious,...
Article
Full-text available
Atypical Candida spp. infections are rising, mostly due to the increasing numbers of im-munocompromised patients. The most common Candida spp. is still Candida albicans; however, in the last decades, there has been an increase in non-Candida albicans Candida species infections (e.g., Candida glabrata, Candida parapsilosis, and Candida tropicalis)....
Article
Full-text available
Candida albicans is still the major yeast causing human fungal infections. Nevertheless, in the last decades, non-Candida albicans Candida species (NCACs) (e.g., Candida glabrata, Candida tropicalis, and Candida parapsilosis) have been increasingly linked to Candida sp. infections, mainly in immunocompromised and hospitalized patients. The escalade...
Poster
Full-text available
Urinary tract infections (UTI) represent one of the most common healthcare- associated infections across EU countries, accounting for 18.9% of all cases [1]. These infections are caused by microbial pathogens, either bacteria or fungi, such as Candida species. Candiduria – is defined as presence of Candida species in urine, which diagnostics relies...
Article
Full-text available
Oral fungal infections are a worldwide healthcare problem. Although Candida albicans is still the most common yeast involved in the infections of oral cavity, non-Candida albicans Candida species (NCACs) have been highly related to these infections, particularly in older, immunosuppressed or patients with long exposure to antimicrobial drugs. The g...
Article
Full-text available
Citation: Abedini, F.; Mohammadi, S.R.; Dahmardehei, M.; Ajami, M.; Salimi, M.; Khalandi, H.; Mohsenzadegan, M.; Seif, F.; Shirvan, B.N.; Yaalimadad, S.; et al. Enhancing of Wound Healing in Burn Patients through Candida albicans β-Glucan.
Presentation
Full-text available
Candida tropicalis is the second most prevalent Candida species in urinary tract infections (UTIs). However, urine cultures take from 18 to 48 h to completely identify the microorganism, which may be sufficient for the progression of the UTI. New developments in molecular biology, automation, and micro-electro-mechanical systems, could be transferr...
Article
Full-text available
Patients with severe COVID-19, such as individuals in intensive care units (ICU), are exceptionally susceptible to bacterial and fungal infections. The most prevalent fungal infections are aspergillosis and candidemia. Nonetheless, other fungal species (for instance, Histoplasma spp., Rhizopus spp., Mucor spp., Cryptococcus spp.) have recently been...
Article
Full-text available
Fungal infections are an important and increasing global threat, carrying not only high morbidity and mortality rates, but also extraordinary healthcare costs. Without an effective response, it is predicted that 10 million people will die per year because of multidrug-resistant pathogens. A high percentage of the mortalities caused by fungi are kno...
Article
Full-text available
The current coronavirus disease (COVID-19) outbreak is a significant threat to human health and the worldwide economy. Coronaviruses cause a variety of diseases, such as pneumonia-like upper respiratory tract illnesses, gastroenteritis, encephalitis, multiple organ failure involving lungs and kidneys which might cause death. Since the pandemic star...
Article
Full-text available
Biofilms are highly-organized microbial communities attached to a biotic or an abiotic surface, surrounded by an extracellular matrix secreted by the biofilm cells. The majority of fungal pathogens contribute to biofilm formation within tissues or biomedical devices, leading to serious and persistent infections. The clinical significance of biofilm...
Article
Full-text available
Mint and ginger are rich sources of phenolic compounds, and thus the present study aimed to assess the impact of different extraction techniques on their polyphenolic yield and antioxidant activity, and to develop a ginger-mint drink. Conventional, ultrasonic and supercritical fluid extraction techniques were used, and ethanol, methanol and distill...
Article
Periodontitis is an inflammatory condition causing a severe infection in the gum, leading to tooth loss and related serious health hazards. Severe periodontitis is the sixth most prevalent medical condition, globally affecting about 743 million individuals. Resveratrol (3,5,4′-trihydroxystilbene) is a plant polyphenol, extensively popularized durin...
Article
Candidiasis (e.g., oral, gastrointestinal, vaginal, urinary tract, systemic) is a worldwide growing problem, since antifungal resistance and immunosuppression states are rising. To address this problem, very few drugs are available for the treatment of Candida spp. infections. Therefore, novel therapeutic strategies are urgently required. Probiotic...
Article
Full-text available
Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has m...
Article
Full-text available
Biofilms are the major way of life for both bacteria and fungi [...]
Article
The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been...
Chapter
Suitable molecular methods for a faster microbial identification in food and clinical samples have been explored and optimized during the last decades. However, most molecular methods still rely on time-consuming enrichment steps prior to detection, so that the microbial load can be increased and reach the detection limit of the techniques.In this...
Article
Oral candidiasis are among the most common noncommunicable diseases, related with serious local and systemic illnesses. Although these infections can occur in all kinds of patients, they are more recurrent in immunosuppressed ones such as patients with HIV, hepatitis, cancer or under long antimicrobial treatments. Candida albicans continues to be t...
Article
A crucial factor in the pathogenesis of orthopedics associated infections is that bacteria do not only colonize the implant surface but also the surrounding tissues. This study aimed to engineer an antimicrobial release coating for stainless steel (SS) surfaces, to impart them with the ability to prevent Staphylococci colonization. Chlorhexidine (C...
Chapter
Anthocyanins (ACNs) have a widespread spectrum of biological activities, such as antioxidant, anti-inflammatory, or chemopreventive features, which support human health, although their low bioavailability and extensive biotransformation interfere with these advantages. This chapter underlines the various ACN bioactivities, their bioavailability and...
Article
Natural products interest is gradually increasing worldwide. Plant-food-derived bioactives have a long history of use as a good source of ingredients for valuable medical usages. Plant-based foods consist of micro and macronutrients, and bioactive components, with health-promoting benefits. The handling of complex mixtures of plants has been method...
Article
Natural products interest is gradually increasing worldwide. Plant-food-derived bioactives have a long history of use as a good source of ingredients for valuable medical usages. Plant-based foods consist of micro and macronutrients, and bioactive components, with health-promoting benefits. The handling of complex mixtures of plants has been method...
Article
Full-text available
When living in biological and interactive communities, microorganisms use quorum-sensing mechanisms for their communication. According to cell density, bacteria and fungi can produce signaling molecules (e.g., secondary metabolites), which participate, for example, in the regulation of gene expression and coordination of collective behavior in thei...
Article
Full-text available
Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery dis...
Article
Full-text available
Medical devices are a typical and important part of health care for both diagnostic and therapeutic purposes. Nonetheless, these devices (e.g., catheters, implants, dentures, or prostheses) recurrently lead to the appearance of several types of infections. In fact, there is a high rate of colonization of abiotic surfaces (such as biomaterials from...
Article
Full-text available
Oral diseases are considered the most common noncommunicable diseases and are related to serious local and systemic disorders. Oral pathogens can grow and spread in the oral mucosae and frequently in biomaterials (e.g., dentures or prostheses) under polymicrobial biofilms, leading to several disorders such as dental caries and periodontal disease....
Article
Full-text available
Chronic pelvic pain syndrome (CPPS) can be triggered by a various types of gynecological, gastrointestinal, urological, and musculoskeletal disorders. Recently, the role of the central nervous system has proven to be an integral part on the development of any chronic pain syndrome, including CPPS. However, owing to the complex and heterogeneous eti...
Article
Full-text available
Candida glabrata is an important human fungal pathogen known to trigger serious infections in immune-compromised individuals. Its ability to form biofilms, which exhibit high tolerance to antifungal treatments, has been considered as an important virulence factor. However, the mechanisms involving antifungal resistance in biofilms and the impact of...
Article
Full-text available
Isolation of metallo-lactamase-producing, carbapenem-resistant, Pseu-domonas aeruginosa strains is increasingly being documented worldwide; their presence constitutes a public health threat. Here, we report draft genome sequences of two New Delhi metallo-lactamase-1-producing, multidrug-resistant, P. aeruginosa strains of sequence type 235 that wer...
Article
Full-text available
The ability to form biofilms is a common feature of microorganisms, such as bacteria or fungi. These consortiums can colonize a variety of surfaces, such as host tissues, dentures, and catheters, resulting in infections highly resistant to drugs, when compared with their planktonic counterparts. This refractory effect is particularly critical in po...
Article
Silymarin is a complex extract isolated from the plant Silybum marianum, widely known for its prominent antioxidant and hepatoprotective effects, although increasing evidences have reported extraordinary antiproliferative and apoptotic abilities. As a result, several signaling pathways involved in cell cycle control, cell proliferation, and cell de...
Poster
Full-text available
Here, we explore the use of microfluidic devices for on-chip magnetic capture of Escherichia coli O157:H7 based on Immiscible Filtration Assisted by Surface Tension (IFAST), followed by detection, visualization and characterization of the isolated E. coli with a Fluorescence in situ Hybridization (FISH) assay in the same chip. Preliminary experimen...
Article
Stevia rebaudiana Bertoni, a plant from South America and indigenous of Paraguay, has shown several biological effects and healthy properties, although it is especially used in South America and some Asiatic regions. In addition, it is a natural sweetener, almost 300 times sweeter than sucrose, being attributed to its phytoconstituents prominent an...
Chapter
Candida species belong to the normal human microbiota and are commonly responsible for several clinical manifestations from mucocutaneous overgrowth to severe bloodstream infections. Candida albicans is the predominant species involved in disease conditions. Nevertheless, in the last decade, the number of infections due to nonalbicans Candida (NAC)...
Chapter
The presence of fungal infections continue to grow worldwide, mostly in immunosuppressed patients, and in individuals with continued antimicrobial treatments. Candida spp. are the most common yeasts involved in these disorders, being associated with a high rate of antifungal resistance and an increased ability to form biofilms, which make the treat...
Article
Full-text available
Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and...
Article
Full-text available
Microbial colonization of urinary catheters remains a serious problem for medicine as it often leads to biofilm formation and infection. Among the approaches reported to deal with this problem, surfaces functionalization to render them with antimicrobial characteristics, comprises the most promising one. Most of these strategies, however, are desig...
Article
Full-text available
Cucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical...
Article
Full-text available
Biofilms, which are the predominant mode of microbial growth, are described as attached and structured microbial communities enclosed by an exopolymeric matrix. Biofilms may be composed of a single-species population or a multiple-species community, but, in both cases, they provide ecologic advantages such as protection from the environment , nutri...
Article
Multiple attempts have been conducted to correlate milk keeping quality with chemical, physical or bacteriological parameters. These methods only measure the chemical changes in milk produced by bacteria. Headspace solid-phase micro-extraction (HS-SPME) is an economic and recent method used to measure both volatile compounds and microbial load in m...
Poster
Full-text available
Here, we explore the use of microfluidic devices for on-chip magnetic capture of E. coli O157:H7 based on Immiscible Filtration Assisted by Surface Tension (IFAST), followed by detection, visualisation and characterisation of the isolated E. coli with a Fluorescence in situ Hybridisation (FISH) assay in the same chip. Preliminary experiments confir...
Article
Full-text available
1) Background: Due to a high rate of antifungal resistance, Candida glabrata is one of the most prevalent Candida spp. linked to systemic candidiasis, which is particularly critical in catheterized patients. The goal of this work was to simulate a systemic infection exclusively derived from C. glabrata biofilm cells and to evaluate the effectivenes...
Article
Full-text available
Candidiasis has increased substantially worldwide over recent decades and is a significant cause of morbidity and mortality, especially among critically ill patients. Diabetes mellitus (DM) is a metabolic disorder that predisposes individuals to fungal infections, including those related to Candida sp., due to a immunosuppressive effect on the pati...
Article
Full-text available
Candidemia cases have been increasing, especially among immunosuppressed patients. Candida glabrata is one of the most resistant Candida species, especially to the azole drugs, resulting in a high demand for therapeutic alternatives. The minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), and minimum biofilm eradication...
Article
Full-text available
Candida glabrata biofilms are recognized to have high resistance to antifungals. In order to understand the effect of mannans in the resistance profile of C. glabrata mature biofilms, C. glabrata Dmnn2 was evaluated. Biofilm cell walls were analysed by confocal laser scanning microscopy (CLSM) and their susceptibility was assessed for fluconazole,...
Article
Background: Candida is the main human fungal pathogen causing infections (candidiasis), mostly in the elderly and immunocompromised hosts. Even though Candida is a member of the oral microbiota in symbiosis, in some circumstances, it can cause microbial imbalance leading to dysbiosis, resulting in oral diseases. Alternative therapies are urgently n...
Article
Candidiasis are the most recurrent fungal infections, especially among immunosuppressed patients. Although Candida albicans is still the most widespread isolated species, non-Candida albicans Candida species have been increasing. The goal of this work was to determine the susceptibility of C. glabrata biofilms to echinocandins and to evaluate their...
Article
Full-text available
(1) Background: Candida glabrata is one of the most significant Candida species associated with severe cases of candidiasis. Biofilm formation is an important feature, closely associated with antifungal resistance, involving alterations of gene expression or mutations, which can result in the failure of antifungal treatments. Hence, the main goal o...
Article
Full-text available
Background: candidiasis is the primary fungal infection encountered in patients undergoing prolonged hospitalization, and the fourth leading cause of nosocomial bloodstream infections. One of the most important Candida spp. virulence factors is the ability to form biofilms, which are extremely refractory to antimicrobial therapy and very difficult...
Article
Full-text available
Chronic wounds afford a hostile environment of damaged tissues that allow bacterial proliferation and further wound colonization. Escherichia coli is among the most common colonizers of infected wounds and it is a prolific biofilm former. Living in biofilm communities, cells are protected, become more difficult to control and eradicate, and less su...
Article
Full-text available
Candida albicans has the ability to adapt to different host niches, often glucose-limited but rich in alternative carbon sources. In these glucose-poor microenvironments, this pathogen expresses JEN1 and JEN2 genes, encoding carboxylate transporters, which are important in the early stages of infection. This work investigated how host microenvironm...
Poster
Full-text available
The incidence of Candida infections (Candidosis) has increased remarkably in the last years, being attributed to the rise in the elderly population, the increasing number of immunocompromised patients, and the widespread use of indwelling medical devices. Candida albicans remains as the most prevalent species of these infections, but a clear rise i...
Poster
Full-text available
Candidiasis have globally increased over the last years, being a major cause of morbidity and mortality, especially in immunosuppressed and hospitalized patients. Candida albicans remains to be the most common species responsible in candidiasis, but Candida glabrata has appeared as second most common Candida in the USA and the third in Europe. Biof...
Poster
Full-text available
Infections caused by Candida species have increased worldwide substantially over the latest decades, and are a significant cause of morbidity and mortality, mostly among critically ill patients. Candida glabrata is the second most common Candida responsible for these infections in the USA and the third in Europe, and is characterized by a high anti...
Poster
Chronic wounds afford a hostile environment of damaged tissues that allow bacterial proliferation and further wound colonization. Wound colonization by bacterial biofilms is one of the main obstacles of chronic wounds healing. Escherichia coli is among the most common colonizers of infected wounds and it is a prolific biofilm former. Living in biof...