Cecilia Guariglia

Cecilia Guariglia
Sapienza University of Rome | la sapienza · Department of Psychology

PhD

About

217
Publications
45,238
Reads
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6,134
Citations
Citations since 2016
94 Research Items
3144 Citations
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
Additional affiliations
January 1992 - present
Foundation Santa Lucia
Position
  • Senior Researcher

Publications

Publications (217)
Article
Full-text available
Background: Based on studies of children with motor disabilities on topographic working memory (TWM), no influence of age was reported. The only differences were in the degree of mobility and exploration of the environment. The more active a child was in exploring the environment, the less his/her TWM was poor. However, in typically developing chil...
Article
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The Developmental Topographical Disorientation (DTD) is a pathological condition that impairs an individual’s ability to orient in space, even in the most familiar environments. It is a lifelong selective condition in individuals without brain damage or without impaired general cognitive functions. Here, we aimed at characterizing 54 individuals wi...
Article
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Alzheimer’s disease (AD) diagnosis often requires invasive examinations (e.g., liquor analyses), expensive tools (e.g., brain imaging) and highly specialized personnel. The diagnosis commonly is established when the disorder has already caused severe brain damage, and the clinical signs begin to be apparent. Instead, accessible and low-cost approac...
Article
The game of chess is a valuable extracurricular activity for children, with positive effects on their cognitive skills and academic achievements. We investigated the extent to which the Giant Chess Game (GCG) played on a giant chessboard enhances working memory in “navigational-vista” space and “reaching” space. We also assessed if the GCG enhances...
Article
Full-text available
In the last decade, several cases affected by Developmental Topographical Disorientation (DTD) have been described. DTD consists of a neurodevelopmental disorder affecting the ability to orient in the environment despite well-preserved cognitive functions, and in the absence of a brain lesion or other neurological or psychiatric conditions. Describ...
Article
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Visual hallucinations (VH) in Lewy body disease (LBD) have a heterogenous phenomenology classified into minor phenomena (MVH) and complex hallucinations (CVH). Mechanisms underpinning VH and their temporal aspects are largely unknown. According to the hodotopic model, we investigated whether changes in distinct cognitive domains and neural networks...
Article
Slowness of information processing (SIP) is frequently reported after traumatic brain injury (TBI). Previous studies point toward a pivotal role of white matter damage on speed of information processing. However, little is known about the more comprehensive and ecological assessment of SIP in TBI. Here, we combined an ecological assessment of SIP w...
Article
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Global navigation satellite systems (GNSS) can provide better data quality for different purposes; however, some age groups might lie outside its use. Understanding the barriers to its adoption is of interest in different fields. This work aims at developing a measurement instrument of the adoption attitudes towards this technology and examining th...
Article
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The cerebellum has a homogeneous structure and performs different computational functions such as modulation/coordination of the communication between cerebral regions, and regulation/integration of sensory information. Albeit cerebellar activity is generally associated with motor functions, several recent studies link it to various cognitive funct...
Article
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The acquisition of information on the timing of events or actions (temporal learning) occurs in both the subsecond and suprasecond range. However, although relevant differences between participants have been reported in temporal learning, the role of dimensions of individual variability in affecting performance in such tasks is still unclear. Here...
Article
Background: Detecting the beginning of cognitive decay is crucial to guarantee good management and the possible prevention of dementia progression. The present study arises from observations collected during an educational event to promote mental and physical health in which incidental neuropsychological data gathered on 290 citizens showed the im...
Article
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Background: In children with myelomeningocele (MMC) and arthrogryposis multiplex congenital (AMC), adequate rehabilitation measures are accessible with the goal of attaining the utmost motor development. However, there is a lack of knowledge as to how children develop navigation utilizing their locomotion abilities. The aim of the present study was...
Article
Slowness of Information Processing (SIP) is frequently experienced after traumatic brain injury (TBI); however, the impact of SIP on everyday functioning may be underestimated by standard neuropsychological tests. Objective: we aimed to adapt two ecological instruments assessing SIP in Italian patients with moderate-to-severe TBI, as formerly pro...
Article
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Several studies investigating environmental navigation require participants to navigate in virtual environments, in which the proprioceptive and vestibular components present during real environmental navigation are lost. Here, we aimed to provide a novel computerized ecological navigational battery, investigating whether the absence of propriocept...
Article
Psychosis is frequent in Alzheimer’s disease (AD) and it is associated with a worse disease course. AD psychosis may represent a distinct AD phenotype, though its specific neurobiological underpinnings have yet to be identified. This study investigated neural underpinnings of AD psychosis using surface-based-morphometry.Data from 32 AD patients, 17...
Article
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It is commonly acknowledged that visual imagery and perception rely on the same content-dependent brain areas in the high-level visual cortex (HVC). However, the way in which our brain processes and organizes previous acquired knowledge to allow the generation of mental images is still a matter of debate. Here, we performed a representation similar...
Article
It has been proposed that declarative memory evolved from spatial navigation, with episodic memory having its roots in mechanisms of egocentric navigation and semantic memory in those of allocentric navigation; however, whether these brain networks actually overlap is still unclear. Using Activation Likelihood Estimation, we assessed the correspond...
Article
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Background: Topographic memory is the ability to reach various places by recognizing spatial layouts and getting oriented in familiar environments. It involves several different cognitive abilities, in particular executive functions (EF), such as attention, working memory, and planning. Children with attention deficit hyperactivity disorder (ADHD)...
Article
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Background: Interoceptive information plays a pivotal role in building higher-order cognitive body representations (BR) that neuropsychological and neuroimaging evidence classifies as action-oriented (i.e., body schema) or non-action-oriented (i.e., visuo-spatial body map). This study aimed to explore the development of BR, considering the associa...
Article
Objective Systematic studies about the impact of unilateral brain damage on the different body representations (body schema, body structural representation, and body semantics) are still rare. Aim of this study was to evaluate body representation deficits in a relatively large sample of patients with unilateral brain damage and to investigate the i...
Article
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Interoceptive information plays a pivotal role in building body representations (BR), but the association between interoception and the different types of BR in healthy individuals has never been systematically investigated. Thus, this study aimed to explore the association between BR and interoceptive sensibility (IS) throughout adulthood. One hun...
Article
The phenomenology of visual hallucinations (VH) in Lewy Body Disease (LBD) is heterogenous including minor phenomena (passage, presence, illusions) and complex hallucinations. Underlying mechanisms are largely unknown and here we investigated whether distinct neural networks underpin minor (MVH) and complex VH (CVH). LBD patients (n=17 DLB, n=10 PD...
Article
Visual Mental Imagery (VMI), the ability of seeing with the mind eyes, has shown to be related with autobiographical memory deficits inAlzheimer's disease (AD) (El Haj et al., 2019). Hippocampus, affected by AD neuropathology since early stages, plays a pivotal contribution to the recollection of previous memories in service of VMI; however, little...
Article
Moral sense is important for determining human behaviour. Moral sense becomes crucial in operational environments in which choices must be made that have complex moral implications in highly stressful situations. Behavioural and neuroimaging findings have shown the existence of gender-related differences in moral reasoning. The present study aimed...
Article
The triadic taxonomy posits that three distinct types of body representations do exist, namely body schema (BS), which corresponds to the representation derived from multiple sensory and motor inputs, the body structural representation (BSR), which corresponds to the structural description of spatial relations among the body parts, and the body sem...
Article
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We constantly process top-down and bottom-up inputs concerning our own body that interact to form body representations (BR). Even if some evidence showed BR deficits in children with cerebral palsy, a systematic study that evaluates different kinds of BR in these children, taking into account the possible presence of a general deficit affecting non...
Article
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Background: Neuroimaging and neuropsychological studies have suggested that common features characterize both Gambling Disorder (GD) and Alcohol Use Disorder (AUD), but these conditions have rarely been compared. Methods: We provide evidence for the similarities and differences between GD and AUD in neural correlates of executive functions by pe...
Article
Aim: The aim of the present study was to investigate topographical working memory in individuals with motor disabilities. Methods: Topographical working memory was investigated using the Walking Corsi Test in 89 participants with motor disability, mean age 11.5 years, of which 40 with cerebral palsy, 31 with spina bifida, and 18 with orthopaedic or...
Article
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Forty children with cerebral palsy (CP) and 120 typical developing children (TD) performed a topographic working memory (WalCT) test requiring to move their body in a walked vista-space and a visuo-spatial test (CBT) requiring just reaching movements. WalCT score was significantly higher in GMFCS II/III than in TD. CBT score was significantly lower...
Article
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The loss of sensorimotor and visual information that follows limb amputation is known to affect both the action-oriented (body schema, BS) and non-action oriented (NA) body representations. However, the neural underpinnings of these effects have not yet been fully understood. We investigated the neural correlates of body representations in a group...
Chapter
Background: This study investigated the effect of estradiol levels on spatial orientation skills. Method: Twenty-five healthy young women were asked to perform the Cognitive Map Test (CMT), a virtual environment test that assesses the formation and use of a mental representation of a virtual town , and a computerized version of the Mental Rotation...
Article
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Planning ability is fundamental for goal-directed spatial navigation. Preliminary findings from patients and healthy individuals suggest that travel planning (TP)-namely, navigational planning-can be considered a distinct process from visuospatial planning (VP) ability. To shed light on this distinction, two right brain-damaged patients without hem...
Article
Following the triadic taxonomy, three different body representations do exist, namely the body semantics, the body structural representation and the body schema. The development of these body representations has been widely investigated in toddlers, but several issues remain to be addressed in school age. To assess age- and gender-related changes i...
Article
Background: Interoception is the basic process enabling evaluation of one's own internal state of body, but its alteration in brain-damaged patients has not been adequately investigated. Our study aimed to investigate awareness of visceral and somatosensorial sensations in brain-damaged patients with unilateral stroke. Methods: Sixty patients (2...
Article
Episodic autobiographical memory (EAM) is pivotal for the development and maintenance of personal identity. However, a theoretical debate still exists about where EAMs are stored in our brain and about hippocampal unique contribution to their recollection. Here we disentangled this issue performing an Activation Likelihood Estimation (ALE) meta-ana...
Article
Environmental navigation entails the constant integration of information across space and time; however, the relation between spatial and temporal features involved in wayfinding has not been fully established yet. Here we investigated how two key spatio-temporal aspects of navigation – namely the processing of information concerning the order of l...
Article
Awareness of psychophysiological changes has been proposed to play a role in duration perception; however, evidence on whether interoceptive awareness affects timing is mixed, and it is not clear which task features favor the reliance on bodily changes to track time. Here we tested the hypothesis that interoceptive awareness is selectively involved...
Article
Full-text available
Neuropsychological studies on acquired topographical disorientation have provided useful insights into the contribution of different brain regions to human navigation. However, little is known about the possibility to restore navigational skills after brain damage. Here we describe the case of No Longer Lost (NLL), a 49-year-old man who complained...
Article
We investigated whether the gender differences in working memory are linked to the nature of the stimuli (verbal vs. visuo-spatial) or to the type of processing (active vs. passive). With this aim, we administered two well-known tests: Corsi Block-tapping test (CBT) and the Digit span (DS) using two versions: forward (fCBT and fDS) and backward (bC...
Article
Objectives: Psychosis of Alzheimer's disease (AD) may represent a distinct disease phenotype, however neuropsychological profile and neural basis linked to this phenotype have not yet been clarified. In this study, we aimed at detecting whether impairment in specific cognitive domains predicts the onset of psychosis in AD patients and what grey ma...
Article
Primary Objective: The primary aim of this study was to determine the frequency of severe impaired self-awareness (ISA) in patients with severe traumatic brain injury (TBI) and the correlates of selected clinical, neuropsychiatric and cognitive variables. The secondary aim of the study was to assess depression and apathy on the basis of their level...
Article
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Herein, we investigate how the three types of mental spatial representation (landmark, route and survey) are reorganized to perform wayfinding and homing behaviour. We also investigate the contribution of visuo-spatial working memory in reaching and in vista space in performing the retracing of the path. For this purpose, we asked 68 healthy colleg...
Article
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Field dependence–independence (FDI) is a stable dimension of individual functioning, transversal to different cognitive domains. While the role of some individual variables in time perception has received considerable attention, it is not clear whether and how FDI influences timing abilities. In this study, we tested the hypothesis that FDI differe...
Article
Spatial navigation tasks reveal small differences between normal and pathological aging and may thus disclose potential neuropsychological predictors of neurodegenerative diseases. The aim of our study was to investigate which navigational skills are compromised in the early phase of pathological aging as well as the extent to which they are compro...
Article
Objective: It has been repeatedly hypothesized that at least 3 distinct types of body representations do exist: body schema, a representation derived from multiple sensory and motor inputs; topological map of the body, a structural description of spatial relations among the body parts; and body semantics, a lexical-semantic representation. Althoug...
Article
Mental imagery and visual perception rely on the same content‐dependent brain areas in the high‐level visual cortex (HVC). However, little is known about dynamic mechanisms in these areas during imagery and perception. Here we disentangled local and inter‐regional dynamic mechanisms underlying imagery and perception in the HVC and the hippocampus (...
Article
Full-text available
The ability of seeing with the mind’s eye, the visual mental imagery, is peculiarly compromised in patients with representational neglect. Representational neglect affects the processing of the left side of a mental image and may selectively concern the ability to imagine places and/or objects. Right-brain damaged patients with representational neg...
Article
Notwithstanding its well‐established role on high‐demanding spatial navigation tasks during adulthood, the effect of field dependence–independence during the acquisition of spatial navigation skills is almost unknown. This study assessed for the first time the effect of field dependence–independence on topographical learning (TL) across the life sp...
Article
Full-text available
Background Endogenous ovarian hormones as well as exogenous oestradiol and progesterone play an important role in cognitive processing. Specifically, these hormones play a role in different aspects of memory, both in terms of storage capacity and temporal duration of the mnemonic track. These hormones also have various effects on different types of...
Article
This study investigates prospective memory (PM) deficits as well as the interplay between performance in executive functions (EFs), speed of processing, episodic memory and PM in traumatic brain injury (TBI), differentiating between time based and event based tasks. The Memory for Intentions Screening Test was administrated to a sample of 19 partic...
Article
Full-text available
Objective: Following current model of body representations, we aimed to systematically investigate the association between brain modifications, in terms of grey matter loss, and body representation deficits, in terms of alterations of the body schema (BS) and of non-action oriented body representations (NA), in individuals with lower limb amputati...
Article
A dynamic interplay exists between Internally-Based (IBT) and Externally-Cued (ECT) time processing. While IBT processes support the self-generation of context-independent temporal representations, ECT mechanisms allow constructing temporal representations primarily derived from the structure of the sensory environment. We performed an activation l...
Article
The purpose of this study was to analyze the characteristics of individuals working in the field of neuropsychology in Italy, as part of a larger study examining the practice of neuropsychology across various countries. They were asked about their background, professional training, current work situation, types of assessment, preferred diagnostic p...
Data
Training task. (A) Example of a trial of the training task about position. Participants were instructed to decide whether the position they perceived in the square corresponded to the green wedge on the sketch. The label below the photograph (not shown to the participant) identifies the position from which the photograph is taken (first two letters...
Data
Box plots showing a more detailed distribution of position- and direction-related adaptation effects showed in Figure 3C.
Data
Correlations between neural signal and the amount of practice. Scatterplots show the correlations between the neural signal (repeated position minus no repeated) and the amount of practice (number of runs needed to reach at least 70% of accuracy in the position questions of the training task) in the bilateral PPA.
Data
Box plots showing a more detailed distribution of multivariate classification results showed in Figures 5A,B.
Data
Box plot showing a more detailed distribution of the left RSC decoding accuracy result as a function of navigational abilities as shown in Figure 6.