Catia Laranjeira

• Doctor of Philosophy
• Manager at Fundação para a Ciência e a Tecnologia

The Portuguese Foundation for Science and Technology (FCT) has endorsed Plan-S since early 2021 and it is working towards implementing its obligations. To ensure an effective fulfillment of its open science policies, FCT is implementing a new monitoring and compliance tool, that will enforce the compliance with Plan-S as well as the new FCT's open...

Funding information is one of the pillars of the research information ecosystem. Despite this, it is still very challenging to associate scientific outputs to all the entities that financially support a project and all the stakeholders involved. To tackle such limitation, PTCRIS-a national integrated research information management ecosystem-develo...

Funding information is one of the pillars of the research information ecosystem. Despite this, it is still very challenging to associate scientific outputs to all the entities that financially support a project and all the stakeholders involved. To tackle such limitation, PTCRIS-a national integrated research information management ecosystem-develo...

Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examined centrosomes in Barrett’s esophagus tumorigenesis, a well-characterized multistep pathway of progression, from the premalignant condition to the metastatic disease. This hu...

Acknowledging the benefits associated with open access (OA) to scientific literature, the Foundation for Science and Technology (Fundação para a Ciência e Tecnologia - FCT), the national funding agency for science in Portugal, defined an OA policy that aims at ensuring free, online access to publications arising from FCT-funded research. Key to the...

In order to achieve such vision, PTCRIS has two main goals. The first one is to define a regulatory framework based on the best international standards and practices. The second is to foster the adoption of such framework in the various information systems, both national (including RCAAP) and local (at the institution level).

Background and aims: The enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not clear how cell diversity is created within the embryonic ENS-information required for development of cell-based therapies and models of enteric neuropathies. We aimed to i...

The generation of neurons from neural stem cells requires large-scale changes in gene expression that are controlled to a large extent by proneural transcription factors, such as Ascl1. While recent studies have characterized the differentiation genes activated by proneural factors, less is known on the mechanisms that suppress progenitor cell iden...

Document S1. Supplemental Experimental Procedures, Figures S1–S7, and Tables S7–S12

Table S1. Genes Deregulated 4 hr after MyT1 GoF in NS5 Cells, Related to Figure 3 Table S2. Genomic Coordinates of MyT1-HA BEs Determined by ChIP-Seq, Related to Figure 3 Table S3. Genes Bound and Repressed by MyT1 GoF, Related to Figure 3 Table S4. Identity of MyT1 Target Genes Associated with Enriched GO Terms, Related to Figure 3 Table S5. Expre...

The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be identified in the adult intestine using clonal cultures and in vivo transplantation assays. The identity of these neurogenic precursors in the adult gut and their relationsh...

The enteric nervous system (ENS) in vertebrates is derived from neural crest cells which emerge during embryogenesis from the hindbrain and, following stereotypical migratory pathways, colonize the entire gastrointestinal tract. Assembly of enteric ganglia and formation of functional neuronal circuits throughout the gut depends on the highly regula...

The enteric nervous system is the largest subdivision of the peripheral nervous system that plays a critical role in digestive functions. Despite considerable progress over the last 15 years in understanding the molecular and cellular mechanisms that control the development of the enteric nervous system, several questions remain unanswered. The pre...

Only 20-25% of families screened for BRCA1/2 mutations are found positive. Because only a positive result is informative, we studied the role of BRCA1/2 immunohistochemistry as an additional method for patient selection. From 53 high-risk-affected probands, 18 (34%) had available paraffin blocks of their tumors and were selected for this study. Mut...

Unlabelled: Barrett's esophagus is lined by columnar and goblets cells with gastric and intestinal characteristics. Despite the association between goblet elements and malignancy, it was not demonstrated that other columnar cells lineages are not related to neoplasia. Chromosomal abnormalities were described in metaplasia adjacent to Barrett's neo...

The purpose of this study was to compare the immunohistochemical profile of cell cycle inhibitors of G1/S phase transition (p21, p53 and pRb), Ki-67 proliferation marker and DNA ploidy in male (MBC) and female breast cancer (FBC). One hundred patients (50 non-consecutive cases of FBC and an equal number of MBC) were selected according to homogeneou...

The biological impact of cell cycle regulatory proteins on breast cancer progression is widely recognised, although mostly unclear. The aim of this preliminary study was to investigate the correlations of several cell cycle modulators (p53, p21, pRb, and mdm2) and c-erbB-2 expression with cell proliferation markers (S-phase fraction [SPF] and Ki-67...