Catherine Crofts

Auckland University of Technology | AUT · School of Public Health and Interdisciplinary Studies

Electronic medical records (EMRs) help in identifying disease archetypes and progression. A very important part of EMRs is the presence of time domain data because these help with identifying trends and monitoring changes through time. Most time-series data come from wearable devices monitoring real-time health trends. This review focuses on the ti...

Background: Pathological insulin resistance in pregnancy is associated with an increased risk for complications such as gestational diabetes mellitus and pre-eclampsia. Individuals with pathological insulin resistance also exhibit hyperinsulinaemia. Currently, there are no diagnostic criteria for pathological hyperinsulinaemia in pregnancy that may...

Aim: This study aimed to investigate New Zealand health professionals' views and experiences around the dietary and lifestyle management of gestational diabetes. Methods: Semi-structured interviews were conducted remotely with health professionals; sessions were recorded and transcribed. Core themes were extracted using inductive thematic analys...

In utero diet may be directly related to the risk of fetal hyperinsulinaemia and offspring metabolic health. This review examines the relationship between maternal dietary exposures and sub-clinical fetal hyperinsulinaemia and neonatal adiposity. Articles were identified in MEDLINE, Web of Science, Cochrane Controlled Register of Controlled Trials,...

Unlike bolus insulin secretion mechanisms, basal insulin secretion is poorly understood. It is essential to elucidate these mechanisms in non-hyperinsulinaemia healthy persons. This establishes a baseline for investigation into pathologies where these processes are dysregulated, such as in type 2 diabetes (T2DM), cardiovascular disease (CVD), certa...

Aim: Hyperinsulinemia is a known underlying driver of metabolic disease; however, its role in pregnancy complications is less understood due to insulin measurement not being a part of standard clinical assessments. This study aimed to characterize hyperinsulinemia in pregnancy by gestational diabetes (GD) status using Kraft methodology. Methods:...

Risk factors for COVID-19 patients with poorer outcomes include pre-existing conditions: obesity, type 2 diabetes mellitus, cardiovascular disease (CVD), heart failure, hypertension, low oxygen saturation capacity, cancer, elevated: ferritin, C reactive protein (CRP) and D-dimer. A common denominator, hyperinsulinaemia, provides a plausible mechani...

Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5minutes). It is theorised that c-peptide levels (half-life 20–30minutes) would be a better proxy for insulin due to both horm...

Background: Ascertaining Kraft dynamic insulin response patterns following a 3-h 100 g oral glucose tolerance test seems to be the most reliable method for diagnosing hyperinsulinaemia. However, this test may be too resource-intensive for standard clinical use. Aim: This study aims to see if Kraft patterns can be accurately predicted using fewer b...

Background: Hyperinsulinaemia is emerging as an independent risk factor for metabolic disease, but diagnostic measures are limited. It is plausible that insulin resistance measures, such as homeostatic model assessment (HOMA) type 2 variants, may model hyperinsulinaemia, but repeatability data are limited. Kraft and Hayashi insulin response pattern...

Background Low-carbohydrate, high-fat (LCHF) diets are useful for treating a range of health conditions, but there is little research evaluating the degree of carbohydrate restriction on outcome measures. This study compares anthropometric and cardiometabolic outcomes between differing carbohydrate-restricted diets. Objective Our hypothesis was th...

R data file showing baseline and completion and change from baseline for outcome measures described in this paper.

CONSORT checklist for the study presented here.

Title: Aristotle in action: How we made our Team stronger than the sum of its parts. Oral presentation Subtheme: Context Background: Take a pharmacist with an interest in reducing polypharmacy and a mechanical engineer with an interest in breathing and body rhythms. How did they combine to form the nucleus of a strong interdisciplinary and interfac...

Background: The global pandemic of metabolic disease is worsening. The metabolic theory of obesity proposes that hormonal changes, especially hyperinsulinaemia, precede metabolic disease development. Although quality sleep is recognised as a key factor for good health, less is known about disrupted sleep as a risk factor for hyperinsulinaemia. Aim...

p> Background: Insulin resistance is commonly assessed using the homeostasis model assessment (HOMA) variants. HOMA is potentially insensitive to change because of its high coefficient of variation. The repeatability coefficient is an alternative means of assessing test repeatability. To be confident of clinical change, rather than biological varia...

Nutrition & Diabetes is a peer-reviewed, open access online journal publishing clinical, metabolic, genetic and epidemiological studies that describe methodologies, mechanisms, and associations in relation to diabetes and nutrition-related diseases

Objective: Hyperinsulinaemia is associated with development of chronic metabolic disease and is emerging as a health risk independent to that of insulin resistance. However, little is known to what extent hyperinsulinaemia occurs with normal glucose tolerance in lean subjects. Method: Oral glucose tolerance tests with concurrent insulin assay we...

Chronic hyperinsulinemia associated with insulin resistance is directly and indirectly associated with many metabolic disorders that contribute to significant morbidity and mortality. Because hyperinsulinemia is not widely recognised as an independent health risk, there are few studies that assess management strategies. Medication management may no...

Globally, there is an increasing prevalence of non-communicable diseases. The morbidity and mortality from these conditions confer a greater economic societal burden. Epidemiological research associates insulin resistance in the etiology of these diseases, but there is limited evidence for the mechanism of damage. Emerging research suggests that hy...

There is little evidence supporting the claim that mass participation sporting events (MPSE) increase the population's physical activity (PA). This research aimed to identify the demographic, motivational and PA profile of participants in a women-only non-elite triathlon race series. It also aimed to identify whether PA in previously insufficiently...

Little is known about the long-term physical activity (PA) behaviours of women after participating in a non-elite mass participation sporting event (MPSE). Three months post-event, 95 women reported their intentions to participate in: 1) the same event the following year; 2) other triathlons and/or other MPSE. The results suggest a strong associati...

The main objective of this thesis is to determine if the 2009 Triwoman series could attract insufficiently active women and encourage them to sustain a sufficient level of physical activity three months after the event. A further objective was to explore the role of the psychological connection model as a means of modelling behaviour change in the...