Catherine Amiel

Institute of Chemistry and Materials · Systemes Polymeres Complexe Team

This study examines the structures of soft surfactant-based biomaterials which can be tuned by temperature. More precisely, investigated here is the behavior of stearic acid (SA) and 12-hydroxystearic acid (12-HSA) aqueous mixtures as a function of temperature and the 12-HSA/SA molar ratio (R). Whatever R is, the system exhibits a morphological tra...

Here, we describe the behavior of mixtures of stearic acid (SA) and its hydroxylated counterpart 12-hydroxystearic acid (12-HSA) in aqueous mixtures at room temperature as a function of the 12-HSA/SA mole ratio R. The morphologies of the self-assembled aggregates are obtained through a multi-structural approach that combines confocal and cryo-TEM m...

We describe the behavior of mixtures of stearic acid (SA) and its hydroxylated counterpart 12-hydroxystearic acid (12-HSA) in aqueous mixtures at room temperature, as function of the 12-HSA/(fatty acid) mole ratio R. The morphologies of the self-assembled aggregates are obtained by a multi-structural approach that combines confocal and cryo-TEM mic...

Poly (methacrylic acid) (PMAA) solutions are known to exhibit a lower critical solution temperature (LCST). A temperature-composition phase diagram of PMAA has been constructed by standard cloud point determination through transmittance measurements, and also by studying the steady states reached under phase separation. This allows us to reconstruc...

A recent challenge in polymer self-assembly is the utilization of double hydrophilic graft copolymers (DHGC) in view of biomedical applications. Here we describe, for the first time, a platform of biocompatible DHGC fully based on poly(2-alkyl-2-oxazoline) leading to stimuli-responsive self-assemblies. This original DHGC platform was composed of ba...

This work aims at gaining a comprehensive picture of the interactions between three differently functionalized silica nanoparticles and a polyacid – PMAA namely – in aqueous media. Native silica nanoparticles and silica nanoparticles functionalized with amine or quaternary amine groups are either negatively or positively charged with various charge...

This study aims to design and characterize the layer-by-layer assembly of core-corona nanoarchitecture for novel surface-modified solid lipid nanoparticles. Oppositely charged β-cyclodextrin polymers were used to build corona structure onto lipid core, and the particle size, polydispersity index, and zeta potential of SLN with polymer layers were e...

Hypothesis Dispersions of Laponite in water may form gels, the rheological properties of which being possibly tuned by the addition of polymer chains. Laponite-based hydrogels with poly(ethylene oxide) (PEO) were the most widely investigated systems and the PEO chains were then found to reduce the elastic modulus. Experiments Here, hydrogels based...

In order to reveal the influence of the guest molecular structure, the interactions between 4-sulfonatocalix[n]arene (SCXn) cavitands (n = 4 or 6) and two series of quinolinium derivatives were studied in neutral aqueous solutions at 298 K. For this, the long alkyl chain of the quinoliniums was attached either to the heterocyclic nitrogen (CmC1OQ⁺...

Methylimidazolium side groups were grafted via ether linkage to dextran and the self-assembly of these polymers with 4-sulfonato-calix[n]arenes (SCXn) was studied in aqueous solutions. Dynamic light scattering and zeta potential measurements revealed the mixing ratio ranges of the constituents where stable nanoparticles could be created. The macroc...

Synthesis of novel host-guest functionalized polymers is presented along with structural characterization using small-angle X-ray scattering (SAXS) of the resulting nanoparticles. Mono-6-deoxy-mono-6-azidoβCD (N 3 βCD) was grafted onto alkyne-functionalized pullulan via the “click” reaction copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) and...

A range of amphiphilic diblock and triblock copolymers based on poly (2-methyl-2-oxazoline) (PMeOx) and poly (D,L-lactide) (PLA) with various compositions and molecular masses were prepared combining cationic ring-opening polymerization and click chemistry. Their hydrophilic weight ratios (f) covered a wide range of composition (21–77%). In water,...

The effect of the chain length of the alkyl and alkoxy substituents on the binding characteristics of 1-alkyl-6-alkoxy-quinolinium cations was studied using 4-sulfonatocalix[4]arene (SCX4) and 4-sulfonatocalix[6]arene (SCX6) in neutral aqueous solutions at 298 K. Isothermal calorimetric titrations showed enthalpy-controlled inclusion with 1:1 stoic...

In this work, host-guest supramolecular hydrogels were prepared from poly(N-isopropylacrylamide) (pNIPAm) microgels utilizing electrostatic and host/guest self-assembly. First, pNIPAm microgels bearing a poly(acrylic acid) (pAAc) shell were coated with positively charged β-cyclodextrin polymers. Addition of adamantane-substituted dextrans (Dex-Ada)...

The effect of headgroup variation on the association of supramolecular amphiphiles composed of 4-sulfonatocalix[6]arene (SCX6) and cationic surfactant possessing tetradecyl substituent was studied in aqueous solutions at pH 7. When the surfactant contained hydrophilic trimethylammonium, pyridinium, or 1-methylimidazolium headgroup, highly reversibl...

Stealth nanocarriers are a promising technology for the treatment of diseases. However preparation and characterization of well-defined soft nanoparticulate systems remains challenging. Here is described a platform of amphiphilic graft copolymers leading to nanoparticles with multiple morphologies and the role of the hydrophilic backbone in their i...

Host-guest nanoassemblies made from spontaneous self-association of host and guest polymers in aqueous solutions have been studied. The specific motivation behind this work was to clarify the impact of the molecular design of the polymers on the interactions between them and on the inner structure of the resulting nanoassemblies. The polymers were...

Concentrated aqueous solutions of poly(methacrylic acid) (PMAA) display a sharp increase of their viscosity over time under a shear. This phenomenon known as antithixotropy is studied as a function of the polymer concentration and ionization degree. Both shear and oscillatory shear experiments are used to characterize rheological behavior of PMMA s...

Spontaneous formation of positively charged nanoparticles was observed upon mixing more than stoichiometric amount of chitosan with 4-sulfonatocalix[8]arene (SCX8) in acidic solution. The particle size did not change with SCX8 concentration, polymer chain length, and the degree of deacetylation at 0.002 ≤ SCX8/chitosan ≤0.043 molar ratios in 0.01 M...

The effect of macrocycle size on the association of supramolecular amphiphiles composed of 4-sulfonatocalix[n]arene and 1-methyl-3-tetradecylimidazolium (C14mim⁺) was studied in aqueous solutions at pH 7. When the cavitand contained four sulfonatophenol units (SCX4), formation of spherical nanoparticles (NPs) was observed. By contrast, both supramo...

In this article, is reported for the first time the preparation of nanoparticles from graft copolymer composed of a hydrophilic backbone made of poly(2-methyl-2-oxazoline-co-2-pentyl-2-oxazoline) and hydrophobic poly(d,l-lactide) grafts. The copolymers were synthesized by the grafting-onto approach through the Huisgen 1,3-dipolar cycloaddition reac...

Hierarchical self-assembly exploits various non-covalent interactions to manufacture sophisticated organized systems at multiple length scales with interesting properties for pharmaceutical industry such as possibility of spatially controlled drug loading and multiresponsiveness to external stimuli. Cyclodextrin (CD)-mediated host-guest interaction...

The effect of temperature and NaCl concentration variations on the self-assembly of 1-methyl-3-tetradecylimidazolium (C14mim+) and 4 sulfonatocalix[6]arene (SCX6) was studied by dynamic light scattering and isothermal calorimetric methods at pH 7. Inclusion complex formation promoted the self-assembly to spherical nanoparticles (NP), which transfor...

Novel (S)-camptothecin-dextran polymers were obtained by "click" grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin between 3.1 and 10.2%. The binding properties with β-cyclodextrin and β-cyclodextrin polymers were m...

The aim of this study was to highlight the properties of novel phosphorus-containing β-cyclodextrin polymers (CDP) and mainly their dual complexing abilities toward hydrophobic guests and (bio)minerals. Affinity of CDP toward divalent metal cations, calcium, magnesium and zinc, has been investigated by isothermal titration microcalorimetry (ITC). T...

The objective of this work was to synthesize a new type of dextran-based host polymer in which beta-cyclodextrin (beta CD) moieties are linked to the dextran backbone via flexible hydrophilic poly (ethylene glycol) (PEG) spacer. Short PEG-acrylate (M(n similar to)375) was coupled with 5-hexynoic acid and grafted to the thiolated dextran using thiol...

The present invention relates to a method for preparing a cyclodextrin polymer and/or a hydrophilic polymer emulsion having cyclodextrins as well as lipophilic compounds, the emulsions having a remarkable stability. In particular, the method includes: (i) adding a lipophilic compound into an aqueous solution of a cyclodextrin unit polymer or hydrop...

The preparation of novel nanoparticles is described, which consist of a poly(lactic acid) (PLA) core obtained by the nanoprecipitation method with a shell made of oppositely charged -cyclodextrin polymer (poly--CD) assembled using the layer-by-layer technique. Characterization of these nanoparticles is accomplished through dynamic light scattering,...

Inclusion of 6-methoxy-1-methylquinolinium (C1MQ) in the cavity of cucurbit[7]uril (CB7) was studied by absorption, fluorescence, NMR and isothermal calorimetric methods in aqueous solution at 298 K. The free C1MQ exhibited dual-exponential fluorescence decay kinetics due to the two torsional isomers differing in the orientation of the methoxy moie...

Novel phosphorous-containing β-cyclodextrin (βCD) polymers (CDP) were synthesized easily under "green chemistry" conditions. A simple polycondensation between the hydroxyl groups of βCD and non-toxic sodium trimetaphosphate (STMP) under basic conditions led to soluble, non-reticulated CDPs with molecular weights (Mw) higher than 10(4)gmol(-1), the...

A new monomer (2-(5-azidopentyl)-2-oxazoline) bearing an azido group was synthesized. The cationic ring-opening copolymerization of this monomer with 2-methyl-2-oxazoline resulted in a well-defined linear polymer backbone with pendant azido groups. Alkynyl-poly(D,L-lactide) was grafted onto the azido groups of poly(oxazoline) via a Huisgen 1,3-dipo...

The interaction of 4-sulfonatocalix[6]arene (SCX6) macrocycle with 1-alkyl-3-methylimidazolium type of ionic liquids possessing dodecyl, tetradecyl or hexadecyl substituent was studied in aqueous solution at 298 K. Host-guest complexation promoted the spontaneous self-assembly into nanoparticles of 7:1 ionic liquid:SCX6 stoichiometry. Positively ch...

The inclusion of 1-alkyl-3-methylimidazolium ions (Cnmim+) in 4-sulfonatocalix[8]arene was studied by isothermal titration calorimetry in aqueous solution at 298 K. Sequential formation of 1:1 and 2:1 complexes occurred in enthalpy driven reactions. The alteration of the molecular structure of the guest barely affected the driving force of the conf...

Nanoassemblies are spontaneously formed in dilute aqueous solutions by mixing of two dextrans modified with lauroyl and β-cyclodextrin moieties, respectively. This association process is mainly driven by host/guest interactions between the two polymers. The nanoassemblies' size depends on the substitution degrees of the polymers, and on the total c...

The aim of this work was to incorporate a hydrophobic compound benzophenone (BP) into core-shell nanoparticles (NPs) and to study its release. The core of these NPs is based on polylactic acid (PLA) and serves as a nanocontainer to accommodate BP. The shell is constituted of a β-cyclodextrin polymer (Poly-β-CD) which ensures the control of BP relea...

The inclusion complex forming properties and aggregation of novel dextran-based cyclodextrin (CD) polymers were investigated using hydrocortisone as a model drug. The long term aim of the project is to produce nanoparticles of self-assembled CD polymers that possess sufficient stability for parenteral administration and drug targeting. Previous st...

The segmental dynamics of poly(ethylene glycol) (PEG) chains adsorbed on the clay platelets within nanocomposite PEG/Laponite hydrogels was investigated over the tens of microseconds time scale, using combined solution and solid-state NMR approaches. In a first step, the time evolution of the molecular mobility displayed by the PEG chains following...

The purpose was to prepare triclosan-loaded polylactic acid nanoparticles containing β-cyclodextrin polymer shell, evaluate triclosan release from the particles using Franz diffusion cells and to study the stability of the particles in presence of a model protein, bovine serum albumin. The nanoparticles were prepared by a solvent displacement proce...

The main goal of this work was to develop two strategies for stabilization of nanoassemblies made of β-cyclodextrin polymer and amphiphilic dextran associated through host-guest complexes. The first strategy was to coat the nanoassemblies with a dextran derivative bearing adamantyl anchoring groups and hydrophilic poly(ethylene oxide-co-propylene o...

The objective of this work is to develop an original method of polyoxazoline brush generation based on supramolecular chemistry onto silica nanoparticles. A first layer is realized by adsorption of a polymer bearing β-cyclodextrin units (PβCD). This allows the anchoring of a second layer made of alkyl end-capped poly(2-methyl-2-oxazoline) (POXZ-C(n...

The synthesis of two well-defined 2,2,5-trimethyl-4-phenyl-3-azahexane-3-nitroxide-terminated poly(2-methyl-2-oxazoline) with narrow dispersity (Mw/Mn = 1.1) has been achieved for the first time. The insertion of the alkoxyamine end groups at one or both ends of poly(2-methyl-2-oxazoline) (PMEOX) chains has been successfully done using a method bas...

Nanoassemblies formed by host/guest interactions between two polymers in aqueous media are studied. Two types of polymers with the same dextran backbone are modified with adamantyl or βCD groups. The sizes of the spontaneously formed nanoassemblies depend on the βCD:Ada ratio and on the total concentration and composition of the mixtures. The resul...

Neutral β-cyclodextrin polymers (polyβCD) associated with cationic adamantyl derivatives (Ada) can be used to deliver plasmid DNA into cells. In absence of an endosomolytic agent, transfection efficiency remains low because most complexes are trapped in the endosomal compartment. We asked whether addition of an imidazole-modified Ada can increase e...

The purpose of this study was to conceive novel nanoparticles (NPs) designed for drug delivery applications. The NPs were based on a hydrophobic poly (lactic acid) (PLA) core and a hydrophilic β-cyclodextrin polymer (Poly-β-CD) shell. The PLA NPs were prepared by the nanoprecipitation method. The Poly-β-CD shell was obtained by adsorption from Poly...

In this work, amphiphilic pH sensitive dextrans have been designed to elaborate complex systems with β-cyclodextrin polymers. The synthesized di-substituted dextrans bear purely hydrophobic groups (either dodecyl, C12, or adamantyl, Ada) and cyclohexancarboxylic acid groups (CHX). The assemblies formed by simply mixing the di-substituted dextrans a...

In pharmaceutical formulations cyclodextrins (CDs) are used to improve the aqueous solubility, stability, dissolution rate, bioavailability and/or local tolerance of drugs. Moreover, water-soluble polymers can be used to stabilize drug/CD complexes through formation ternary complexes. Alternative approach is to use CD-polymers, which can both enhan...

IntroductionSystems Based on CD DerivativesSystems Based on Polypseudorotaxanes and PolyrotaxanesSystems Based on CD Oligomers and PolymersConclusions References

CROP has been used to synthesize well-defined POXZ with a monofunctional (iodomethane) or a bifunctional (1,3-diiodopropane) initiator. POXZ has been functionalized with an azido group at one (alpha-azido-POXZ, (M) over bar (n) = 3.58 x 10(3) g.mol(-1)) or both ends (alpha,omega-azido-POXZ, (M) over bar (n) = 6.21 x 10(3) g.mol(-1)) of the macromol...

The influence of the gravity on fluids and mixtures near critical points or on heterogeneous materials are well known. In the present paper, we show that gravity also affects gelling systems. We report unexpected results on weakly concentrated gels which find their origin in the deformation under its own weight of the polymer network.

The permeability of tenuous porous objects such as gels or aggregates formed by flocculation or on a filter surface must be measured in the presence of sufficiently weak flows not to perturb the solid structure. We have developed of differential permeability technique which we apply to the study of the formation of a chemical gel in time. La perméa...

Water-soluble calixarenes are promising macrocyclic compounds which have found numerous applications in chemistry and biology. However, these compounds have been less studied in regard to their behavior in aqueous solutions and mechanisms of drug solubilization. The present work is devoted to the evaluation of the solubilizing properties and estima...

Polymeric cyclodextrins (CDs) derivatives combine the complex forming properties of CDs and properties of polymers such as high molecular weight and high solubility, justifying the increasing interest for its use in biomedical science. In this paper, a series of water-soluble epichlorohydrin/γ-CD polymers were synthesized and the influences of the...

Three series of novel water-soluble beta-cyclodextrin-dextran polymers have been prepared by "click" chemistry. The polymers were synthesized from alkyne-modified dextrans (AMDs) onto which mono-6-O-deoxy-monoazido-betaCD (N3betaCD) was grafted by a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The polymers have been characterized by NMR...

The α,ω-end-capped poly(2-methyl-2-oxazoline) (Cn-POXZ-Cn) have been synthesized by a one-pot process using cationic ring-opening polymerization with an appropriate initiator and terminating agent. The polymers bearing different alkyl groups C12 and C18 have molecular weight in the range of 2.4 × 103 to 14 × 103 with a small polydispersity index. T...

A series of novel water soluble β-cyclodextrin (βCD) polymers has been synthesized from functionalized poly(ethylene glycol) (PEG). The chemical composition of the polymers has been characterized by 1H NMR and the βCD content is found to be between 48 and 33% (w/w). The molecular weight has been determined by Size Exclusion Chromatography (SEC) and...

The aim of this paper was to study the associations between a neutral β-cyclodextrin polymer and amphiphilic dextrans substituted with two kinds of groups able to make inclusion complexes with β-cyclodextrin. The first kind of substituent is purely hydrophobic (dodecyl C12 or adamantyl Ada groups) and the second one, cyclohexancarboxylic acid group...

Associative networks have been elaborated by mixing in aqueous media a cyclodextrin polymer to a dextran bearing adamantyl groups. The two polymers interact mainly via inclusion complexes between adamantyl groups and cyclodextrin cavities, as evidenced by the high complexation constants determined by isothermal titration microcalorimetry (approxima...

This paper presents a SANS study of hydrophobically end-modified poly(2-methyl-2-oxazoline) (POXZ-C(n)) micelles in aqueous solutions. Strong long-range repulsive interactions between the micelles are evidenced by correlation peaks present at concentrations as low as 0.5 wt %. Due to the dissymmetry in size between the hydrophobic and hydrophilic p...

A linear water soluble β-cyclodextrin terpolymer (P(MVE-AM)-g-βCD) was synthesized by grafting different amounts of βCD on the copolymer P(MVE-AM). The resulting terpolymer showed a pH sensitive behaviour in aqueous solution, due to the presence of carboxylic acid groups. Whatever the substitution degree in βCD, the terpolymer behaved like a polyac...

The entrapment of two hydrophobic molecules, benzophenone and tamoxifen, into self-assembling cyclodextrin (CD)-based nanogels has been studied. These nanogels formed spontaneously upon the association of a hydrophobically modified dextran (MD) and a cyclodextrin polymer (pbetaCD). The interactions of benzophenone and tamoxifen with MD and pbetaCD...

In this study, we investigated whether a cyclodextrin polymer (polybetaCD) complexed with cationic adamantyl derivatives (Ada) could be used as a vector for gene delivery. DNA compaction as a function of adamantyl/DNA phosphate ratio (A/P) by this new class of vector was demonstrated using surface enhanced Raman spectroscopy, zeta potential measure...

This study aims to investigate the rheological properties of self-assembling gels containing cyclodextrins with potential application as injectable matrix for the sustained delivery of poorly soluble drugs. The ability of these gels to entrap two hydrophobic molecules, benzophenone (BZ) and tamoxifen (TM), and to allow their in vitro sustained rele...

The self‐assembling properties of hydrophobically modified ( N ‐isopropylacrylamide) have been investigated by dynamic light scattering and rheological measurements. Size of the globules and transmission of the solutions vary strongly in the same range of temperature. The presence of hydrophobic groups leads to contraction of the globules' size com...

Macromolecular assemblies were elaborated by mixing in water hydrophobically modified dextrans (MDC(n)) and beta-cyclodextrin polymers (pbetaCD) interacting by inclusion complexation between the hydrophobic moieties of MDCn and the beta-cyclodextrin cavities of pbetaCD. Dextrans have been modified by grafting alkyl groups (C(n)) of varying chain le...

In aqueous solutions, beta-cyclodextrin (CD) and cyclodextrin-containing polymers (PolCD) associate with azobenzene-modified polyacrylate (AMP). Inclusion complexes in solution of CD (or PolCD) and AMP, and the viscosity of these mixtures, have been studied as a function of the composition of AMP and concentrations of samples. AMPs are random copol...

New nanoassemblies were instantaneously prepared by mixing two aqueous solutions, one containing a beta-cyclodextrin polymer (pbetaCD), and the other a hydrophobically modified by alkyl chains dextran (MD). The formation mechanism and the inner structure of these nanoassemblies were analysed using surface tension measurements and (1)H NMR spectrosc...

Macromolecular assemblies are elaborated by mixing beta-cyclodextrin-containing polymer (polybetaCD), dextran sulfate polyanion (NaDxS), and cationic amphiphiles which are adamantane derivatives (Ada1 or Ada2) in aqueous medium. These components are assembled via coupled inclusion complex interactions (adamantyl group with cyclodextrin cavity) and...

Interactions in semidilute solutions of a hydrophobically modified alginate (HM-alginate) in the presence of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) monomer or a beta-cyclodextrin polymer (poly(beta-CD)) have been characterized at different temperatures with the aid of rheology and small-angle neutron scattering (SANS). The viscosity results f...

We show here, for the first time, that two neutral polymers may completely associate together in water to spontaneously form supramolecular nanoassemblies (nanogels) of spherical shape. The cohesion of these stable structures of about 200 nm is based upon a "lock and key" mechanism: inclusion complexes are formed between the hydrophobic alkyl chain...

The ability of DNA to bind polycation yielding polyplexes is widely used in nonviral gene delivery. The aim of the present study was to evaluate the DNA compaction with a new DNA vector using Raman spectroscopy. The polyplexes result from an association of a beta-cyclodextrin polymer (polybeta-CD), an amphiphilic cationic connector (DC-Chol or adam...

Surface plasmon resonance (SPR) technique is used to follow, both in real time and in situ, the association between a physically adsorbed polymer of beta-cyclodextrin (pbetaCD) and different hydrophobically modified poly(N-isopropylacrylamide) (PNIPAM) copolymers containing either adamantyl or dodecyl groups. This association is due to the complex...

Polyelectrolyte complexes have been elaborated by mixing in water neutral poly(beta-CD), a cationic surfactant (DTAC) and herring sperm DNA fragments. The driving forces for the poly(beta-CD)/DTAC/DNA association in aqueous solution are, on the one hand, reversible inclusion interactions between the CD cavities of poly(beta-CD) and the alkyl group...

Hydrophobically modified poly( N ‐isopropylacrylamide) (PNIPAM) containing either an adamantyl or a dodecyl group were prepared and characterized. Self‐association in aqueous solutions was evidenced by fluorescence measurements using pyrene as a probe. The lower critical solution temperatures (LCST) were determined from cloud point measurements. Th...

A new model of polyelectrolyte has been elaborated by mixing in water a neutral polymer of β-cyclodextrin (poly(β-CD)) and a cationic dodecyltrimethylammonium chloride surfactant (DTAC). The driving forces for the poly(β-CD)/DTAC association in aqueous solution are reversible inclusion interactions between the CD cavities of the polymer and the alk...

Novel monoalkyl end-capped poly(2-methyl-2-oxazoline) (POXZ-C12 and POXZ-C18), with molecular weights varying from 5500 to 8500, were synthesized by the use of the “initiator method”. The micellar behavior of these polymers in water was investigated by the fluorescence technique. Critical micelle concentrations are in the range of 0.007−0.4 g L-1 a...

New associative pH sensitive systems composed of a modified dextran bearing 2‐carboxycyclohexyl carboxyl groups and neutral (p β CD) or positively charged (p β CDN ⁺ ) β ‐cyclodextrin‐ co ‐epichlorhydrin copolymers have been synthesized and their properties were investigated as a function of pH by phase diagrams and viscosimetry. The affinity betwe...

Tamoxifen represents the endocrine treatment of choice for hormone-dependent breast cancer. However, undesirable side effects appeared after long-term therapy. Therefore, the concept of a drug delivery system at the tumour site is an interesting alternative. The aim of this work was to evaluate the potential of an original in situ forming gel to al...

A novel linear water-soluble β-cyclodextrin polymer has been prepared by grafting β-cyclodextrin on poly[(methyl vinyl ether)-alt-(maleic anhydride)]. First, lithium hydride was used to obtain the mono-alkoxide β-CD. Grafting of β-CD derivatives to the polymer backbone was then carried out by an esterification method. Using this method, polymers co...

The synthesis and photophysical behaviour of a series of 4-amino-N-alkylphthalimides have been described. The complexation between β-cyclodextrin and the different phthalimides has been studied by steady-state fluorescence. The association constant K depends strongly on the hydrophobicity of the alkyl substituent, and the K values vary between 115M...

The interactions between an adamantane end-capped poly(ethylene oxide) (PEO) and a cationic polymer of β-cyclodextrin to build polymer bilayers on negatively charged surfaces are discussed. The association of this system in solution was studied by rheology, light scattering and fluorescence measurements. It was found that the adamantane-terminated...

Formation of polyelectrolyte complexes using cyclodextrin polymers was investigated. Polyanions of different natures such as sodium polystyrene sulfate (NaPSS) and sodium dextran sulfate (NaDxS) were associated with a β-cyclodextrin polymer and a cationic surfactant, dodecyltrimethylammonium chloride (DTAC), to produce ternary complexes. It was fou...

Diblock copolymers of poly(isobutyl vinyl ether-b-2-methyl-2-oxazoline) (PIBVE–POXZ) were synthesized by cationic polymerization. Copolymers with molecular weight from 1,000 to 4,000 g mol−1> had a composition of 20–50% of the IBVE block. They were adsorbed on porous silica particles from three different solvents:dichloromethane, which is a solvent...

Interpolyelectrolyte complexes have been prepared by mixing in aqueous solutions an anionic polymer, a neutral β-cyclodextrin polymer and a cationic surfactant dodecyltrimethylammonium chloride. In this ternary system, electrostatic interactions are involved between the opposite charges of the surfactant and the anionic polymer, whereas inclusion c...

The aim of this work was the design of a pH-sensitive system consisting of an amphiphilic polymer and a β-cyclodextrin coepichlorhydrin water-soluble polymer (pβCD/EP). Different modified dextrans were synthesized from reaction of dextran (M w =40,000) with phthalic anhydride, 2-phenylglutaric anhydride and 1,2-cyclohexane dicarboxylic anhydride wi...

Novel amphiphilic diblock copolymers, poly(isobutylvinyl ether-b-2-methyl-2-oxazoline) (PIBVE-b-POXZ), were synthesized by cationic polymerization. The molar ratio of IBVE in the copolymers was varied from 20% to 50%. Their molecular weights were over the range from 1000 to 4000. The associations of these copolymers have been studied by small-angle...