Catharina SchollBundesinstitut für Arzneimittel und Medizinprodukte · Research
Catharina Scholl
Dr. rer. nat
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72
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Introduction
Skills and Expertise
Additional affiliations
January 2004 - November 2012
Publications
Publications (72)
Hormonal contraception is one of the most commonly used methods for preventing unintended pregnancies, but its potential link to an increased risk of depression remains controversial. Clinical and epidemiological studies provide conflicting evidence, often influenced by group-related biases. To address these uncertainties, our research examines the...
Background
Pharmacogenetic testing in routine care could provide benefits for patients, doctors and statutory health insurances. Therefore, the aim of the retrospective, observational study Einfluss metabolischer Profile auf die Arzneimitteltherapiesicherheit in der Routineversorgung (EMPAR) was to analyze the relationship between pharmacogenetic p...
Cytochrome P450 mediated substrate metabolism is generally characterized by the formation of reactive intermediates. In vitro and in vivo reaction uncoupling, results in the accumulation and dissociation of reactive intermediates, leading to increased ROS formation. The susceptibility towards uncoupling and altered metabolic activity is partly modu...
Since its introduction to the market in 1960, hormonal contraception has been heralded as a groundbreaking advancement in women's sexual autonomy, swiftly emerging as a cornerstone in the prevention of unintended pregnancies. Even today, after over six decades, oral hormonal contraception remains a pivotal contraceptive method in many Western natio...
A variety of Alzheimer’s disease (AD) mouse models has been established and characterized within the last decades. To get an integrative view of the sophisticated etiopathogenesis of AD, whole genome transcriptome studies turned out to be indispensable. Here we carried out microarray data collection based on RNA extracted from the retrosplenial cor...
Background
Analytical validity is a prerequisite to use a next generation sequencing (NGS)-based application as an in vitro diagnostic test or a companion diagnostic in clinical practice. Currently, in the United States and the European Union, the intended use of such NGS-based tests does not refer to guided drug therapy on the basis of pharmacogen...
A variety of Alzheimer disease (AD) mouse models has been established and characterized within the last decades. These models are generated to meet the principal criteria of AD isomorphism, homology and predictability to a maximum extent. To get an integrative view of the sophisticated etiopathogenesis of AD, whole genome transcriptome data analysi...
Purpose
Drug intake might be a modifiable factor for the individual fall-risk of older adults, and anticholinergic properties of drugs need to be considered. This study is aimed at analyzing the association of older adults’ individual anticholinergic load with particular focus on use of overactive bladder anticholinergic medications with falls in m...
Hormonal contraception is a widely adopted method for preventing unintended pregnancies, giving women effective control over their reproductiveness. However, a concerning association has been observed between hormonal contraception and an increased risk of mental illness, particularly depression. The evidence for this association primarily relies o...
Depressionen sind laut der Weltgesundheitsorganisation (WHO) eine weit verbreitete Erkrankung mit einer weltweiten Prävalenz von 3,8 Prozent. Über die Risikofaktoren für die Entwicklung einer Depression ist wenig bekannt. Es scheint jedoch klar zu sein, dass sie multifaktoriell bedingt ist und ein komplexes Zusammenspiel von sozialen, psychischen u...
Steroid hormone use is still popular among athletes; according to the 2021 testing figures of the World Anti-Doping Agency (WADA), almost 900 samples tested positive for steroids. Steroids are also widely used for medical reasons, e.g., hormonal contraception, hormone replacement therapy, or cancer treatment.
In addition to the desired therapeutic...
Purpose
Inhaled drugs have been cornerstones in the treatment of chronic obstructive pulmonary disease (COPD) for decades and show a high prescription volume. Due to the local application, drug safety issues of these therapies are often underestimated by professionals and patients. Data about adverse drug reactions (ADRs) caused by inhaled therapy...
Depression is a common disorder with a worldwide prevalence of 3.8 %, according to the World Health Organization (WHO). Little is known about the risk factors for the development of depression. However, it seems clear that it is multifactorial and requires a complex interaction of social, psychological, and biological factors. A possible influence...
Objectives:
Preclinical, epidemiological and small clinical studies suggest that green tea extract (GTE) and its major active component epigallocatechingallate (EGCG) have antineoplastic effects in the colorectum.
Methods:
Randomized, double-blind trial of GTE standardized to 150mg EGCG bid versus Placebo over 3 years to prevent colorectal adeno...
Zika virus (ZIKV) is a flavivirus that is mainly transmitted by Aedes mosquitos and normally causes mild symptoms. During the outbreak in the Americas in 2015, it was associated with more severe implications, like microcephaly in new-borns and the Gullain-Barré syndrome. The lack of specific vaccines and cures strengthen the need for a deeper under...
Objective:
Pharmacogenomics (PGx) is a clinically significant factor in the safe and efficacious use of medicines. While PGx knowledge is abundant for other populations, there are scarce PGx data on African populations and is little knowledge on drug-gene interactions for medicines used to treat diseases common in Africa. The aim of this study was...
The impact of genetic variability of pharmacogenes as a possible risk factor for adverse drug reactions is elucidated in the EMPAR (Einfluss metabolischer Profile auf die Arzneimitteltherapiesicherheit in der Routineversorgung/English: influence of metabolic profiles on the safety of drug therapy in routine care) study. EMPAR evaluates possible ass...
On the basis of scientific evidence, information on the option, recommendation or requirement to test for pharmacogenetic or pharmacogenomic biomarkers is incorporated in the Summary of Product Characteristics of an increasing number of drugs in Europe. A screening of the Genetic Testing Registry (GTR) showed that a variety of molecular genetic tes...
The aim of this study was to compare effects of an individualized with a standardized risk assessment for adverse drug reactions to improve drug treatment with antithrombotic drugs in older adults. A randomized controlled trial was conducted in general practitioner (GP) offices. Patients aged 60 years and older, multi-morbid, taking antithrombotic...
Pharmacogenetic studies have shown involvement of cytochrome P450 enzymes in the metabolism of psychotropic drugs. However, expression and activity on endogenous substrates in the brain may underlie a constitutive role of these enzymes beyond drug metabolism. CYP2C19, which is expressed in the human fetal brain during neurodevelopment, shows affini...
For many authorized drugs, accumulating scientific evidence supports testing for predictive biomarkers to apply personalized therapy and support preventive measures regarding adverse drug reactions and treatment failure. Here, we review cytogenetic and biochemical genetic testing methods that are available to guide therapy with drugs centrally appr...
Objective:
Epidermal growth factor receptor inhibitors (EGFRI) are used as targeted cancer therapy. On average 70% of patients treated with EGFRIs suffer from skin toxicity. Studies showed a correlation between overall survival and the appearance of a skin rash, which is used as a biomarker for therapy efficacy. Micro RNAs (miRNA) as tumor or resi...
Cytochrome P450 (CYP) 2D6 is a polymorphic enzyme expressed in the central nervous system (CNS), important in drug metabolism and with a potentially constitutive role in CNS function such as vigilance. This study aimed to analyze variability in CYP2D6 activity linked to vigilance-related adverse drug reactions (ADRs) in the CNS. A dataset of N = 29...
Background and aims
The Hepatitis E virus hijacks the endosomal system for its release. These structures are highly dependent on cholesterol. Hence, this study investigates the impact of HEV on cholesterol-metabolism, the effect of intracellular cholesterol content on HEV-release and the potential of cholesterol-modulators to serve as antivirals....
Pharmacogenetic studies have shown involvement of cytochrome P450 enzymes in the metabolism of psychotropic drugs. However, expression and activity on endogenous substrates in the brain may underlie a constitutive role of these enzymes beyond drug metabolism. CYP2C19, which is expressed in the human fetal brain during neurodevelopment, shows affini...
Zika virus (ZIKV) is a mosquito-borne virus, which can cause brain abnormalities in newborns, including microcephaly. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally regulate gene expression. They are involved in various processes including neurological development and host responses to viral infection, but their potentia...
The polymorphic drug-metabolizing enzyme CYP2D6, which is responsible for the metabolism of most psychoactive compounds, is expressed not only in the liver, but also in the brain. The effects of its marked genetic polymorphism on the individual capacity to metabolize drugs are well known, but its role in metabolism of neural substrates affecting be...
Antidepressant therapy is still associated with delays in symptomatic improvement and low response rates. Incomplete understanding of molecular mechanisms underlying antidepressant effects hampered the identification of objective biomarkers for antidepressant response. In this work, we studied transcriptome-wide expression followed by pathway analy...
Individual differences in required drug dosages exist based on the pharmacogenomic (PGx) profiles. This study aimed to assess associations between PGx profiles and adverse drug reactions (ADR) that lead to admissions to the emergency department (ED). ADR cases of the prospective multi-center observational trial in EDs (ADRED study) were analyzed (n...
1551
Background: Prevention of colorectal adenomas (CA) can reduce colorectal cancers (CRC). Epidemiological and experimental data suggest that the green tea catechin epigallocatechingallate has an antineoplastic effect in the large bowel. MIRACLE is the largest trial so far to examine the effect of three-year daily intake of green tea extract (GTE...
The polymorphic drug-metabolizing enzyme CYP2D6, which is responsible for the metabolism of most psychoactive compounds, is expressed not only in the liver, but also in the brain. The effects of its marked genetic polymorphism on the individual capacity to metabolize drugs are well known, but its role in metabolism of neural substrates affecting be...
Background
Prevention of colorectal adenomas (CA) is likely to prevent colorectal cancer (CRC). Nutri- or chemoprevention of CRC is not yet established. NSAIDs show some benefit but also increase the bleeding risk. Agents with a more favourable benefit/risk ratio are desirable. Preclinical and small clinical trials suggest that epigallocatechingall...
Background:
Adverse drug reactions (ADR) are a common reason for emergency room visits and for hospitalization. An ADR is said to have occurred when the patient's symptoms and signs are considered to be possibly, probably, or definitely related to the intake of a drug.
Methods:
In four large hospital emergency departments, one in each of four Ge...
Green tea polyphenols may contribute to the prevention of cancer and other diseases. To learn more about the pharmacokinetics and interindividual variation of green tea polyphenols after oral intake in humans we performed a population nutrikinetic study of standardized green tea extract. 84 healthy participants took green tea extract capsules stand...
Study protocol nutrikinetics (english version).
(PDF)
Blood concentrations of green tea catechins.
(TXT)
Study protocol MIRACLE Study (german version).
(PDF)
Study protocol nutrikinetics (german version).
(PDF)
Epidermal growth factor receptor overexpression in human cancer can be effectively targeted by drugs acting as specific inhibitors of the receptor, like erlotinib, gefitinib, cetuximab and panitumumab. A common adverse effect is a typical papulopustular acneiform rash, whose occurrence and severity are positively correlated with overall survival in...
The neurotrophic hypothesis of depression suggests an association between effects on neuroplasticity and clinical response to antidepressant drug therapy. We studied individual variability in antidepressant drug effects on cell proliferation in lymphoblastoid cell lines (LCLs) from n=25 therapy-resistant patients versus n=25 first-line therapy resp...
The current therapy success of depressive disorders remains in need of improvement due to low response rates and a delay in symptomatic improvement. Reliable functional biomarkers would be necessary to predict the individual treatment outcome. On the basis of the neurotrophic hypothesis of antidepressant’s action, effects of antidepressant drugs on...
Background
Pharmacogenetics are an important component in the individualization of treatment; however, pharmacogenetic diagnostics have so far not been used to any great extent in clinical practice. A consistent consideration of individual patient factors, such as pharmacogenetics may help to improve drug therapy and increase individual safety and...
1Federal Institute for Drugs and Medical Devices (BfArM), Research Division, Bonn, 2Institute of Pharmacology of Natural Products and Clinical Pharmacology, 3Department of Internal Medicine II, University of Ulm, Ulm, 4Pneumology, Thoracic Oncology, Sleep- and Respiratory Critical Care Medicine, Clinics Kempten-Oberallgau, Kempten, and 5Department...
Aim:
To identify genomic variants in the EGFR pathway and in cytokines predisposing to skin toxicity from EGFR inhibitors.
Patients & methods:
In 126 patients with cancer and EGFR inhibitor therapy skin toxicity was quantified and EGFR and inflammatory pathway genes were analyzed by deep sequencing.
Results:
We found 1437 SNPs in the 382-kb ta...
AIM: The identification of antidepressant drugs (ADs) response biomarkers in depression is of high clinical importance. We explored CHL1 and ITGB3 expression as tentative response biomarkers.
MATERIALS & METHODS: In vitro sensitivity to ADs, as well as gene expression and genetic variants of the candidate genes CHL1, ITGB3 and SLC6A4 were measured...
Aim:
Epidermal growth factor receptor inhibitor (EGFRI) induced skin toxicity has a prognostic value suggesting skin toxicity can be a useful surrogate marker for successful epidermal growth factor receptor (EGFR) inhibition, improved response and survival. But the pathophysiology of EGFRI induced skin toxicity remains elusive. However the involve...
Neural stem cells (NSCs) generate new neurons in vivo and in vitro throughout adulthood and therefore are physiologically and clinically relevant. Unveiling the mechanisms regulating the lineage progression from NSCs to newborn neurons is critical for the transition from basic research to clinical application. However, the direct analysis of NSCs a...
Zonation of metabolic activities within specific structures and cell types is a phenomenon of liver organization and ensures complementarity of variant liver functions like protein production, glucose homeostasis and detoxification. To analyze damage and regeneration of liver tissue in response to a toxic agent, expression of liver specific enzymes...
Oral antidiabetic drugs are mainly metabolized by CYP2C8, CYP2C9 und CYP3A4 and are eliminated under participation of drug transporters. Polymorphisms in genes involved in biotransformation and drug transport influence the pharmacokinetics of oral antidiabetic drugs. As a consequence, the interindividual genetic variability can influence the effica...
Regulatory Smads (R-Smads), Smad1/5/8 and Smad2/3, are the central mediators of TGFβ and BMP signaling pathways. Here, we screened indirubin derivatives, known kinase inhibitors, and observed strong interference with BMP signaling. We found that indirubin derivative E738 inhibited both TGFβ and BMP pathways through ubiquitin-proteasome-mediated dep...
Both bone morphogenetic proteins (BMPs) and histone deacetylases (HDACs) have previously been established to play a role in the development of the three major cell types of the central nervous system: neurons, astrocytes, and oligodendrocytes. We have previously established a connection between these two protein families, showing that HDACs suppres...
Table S1 - S26. Additional file 1 contains tables with additional gene expression data. Table S1-S4 summarize the 25 genes with the strongest regulation of expression after TSA or BMP2 treatment. Table S5-S10 contains the genes regulated in two treatments, which represents the intersections of the Venn Diagrams from Figure 3A-F. Table S11-S21 conta...
In situ hybridization (ISH) is the method of choice for analysis of the local distribution of gene expression in tissue samples at the cellular level. In this study we present a rapid and efficient protocol for the generation of labelled cRNA probes.
The protocol is based on the preparation of DNA in vitro transcription templates using polymerase c...
Real-time response profiles of cellular respiration, glycolysis, and impedance upon MMS or tBHP treatment. MCF-7 breast cancer cells or HT-29 colon carcinoma cells were treated with the strong stress inducing agents methyl methanesulfonate (MMS) and tert-butyl hydroperoxide (tBHP). MMS is a methylating agent which leads to strong intracellular ROS...
Significantly regulated functional groups*.
(XLS)
Genes regulated by cisplatin in MCF-7 cells at change of (i) glycolysis (8–9 h) and (ii) impedance (10–11 h).
(XLS)
Genes regulated by cisplatin in MCF-7 cells at change of (i) glycolysis (8–9 h) and (ii) impedance (10–11 h).
(XLS)
Since the discovery of cisplatin more than 40 years ago and its clinical introduction in the 1970s an enormous amount of research has gone into elucidating the mechanism of action of cisplatin on tumor cells. With a novel cell biosensor chip system allowing continuous monitoring of respiration, glycolysis, and impedance we followed cisplatin treatm...
In den vergangenen Jahren hat sich unser Verständnis von der funktionellen Diversität der RNA erheblich vergrößert. Besonders konnte eine große Anzahl nicht-kodierender RNA (ncRNA) Moleküle identifiziert werden, die entscheidende Schritte in der zellulären Differenzierung steuern. Angesichts der komplexen Natur der neuronalen Entwicklung wächst zun...