Cássio Machado de Campos Bottino

Cássio Machado de Campos Bottino
University of São Paulo | USP · Faculty of Medicine (FM)

MD, PhD

About

214
Publications
42,667
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5,214
Citations
Additional affiliations
January 1994 - March 1996
Hospital do Servidor Público Estadual "Francisco Morato de Oliveira"
Position
  • Medical Doctor
January 1994 - present
University of São Paulo
Position
  • Professor (Associate)

Publications

Publications (214)
Article
Background Evidences indicate that physically active older individuals maintain healthy functioning longer than do sedentary peers. Some lifestyle could impact the risk of dementia including Alzheimer’s. In spite of this, the effect of physical activity on the relationship between age and the risk of dementia is unknown. This is a two‐phase study t...
Poster
Full-text available
Background Neuropsychiatric symptoms (NPS) are significant manifestations of dementia, with important consequences for patients and caregivers. Despite the established genetic link between Down syndrome (DS) and Alzheimer’s disease (AD), studies investigating NPS in individuals with DS and dementia are scarce. The Neuropsychiatric Inventory (NPI) w...
Article
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Abstract Introduction: Mnemonic strategy training (MST) has been shown to improve cognitive performance and increase brain activation in those with mild cognitive impairment (MCI). However, little is known regarding the effects of MST on functional connectivity (FC) at rest. The aim of the present study was to investigate the MST focused on face-na...
Article
Prior work has revealed that mnemonic strategy training (MST)can enhance memory for specific content and engages regions in the frontoparietal cognitive control network. Evidence of transfer to novel content is less clear. Here, we provide secondary analysis of functional magnetic resonance imaging (fMRI)data acquired during a randomized controlled...
Article
Full-text available
Background With the growth of the elderly population in Brazil and the increasing impact of depression and anxiety, the importance of preventing these disorders has been highlighted. Studies have shown an inverse relationship between rates of depression/anxiety and physical activity, pointing out its role as a possible protective factor. Objectives...
Article
Full-text available
Background: Mnemonic strategy training (MST) has been shown to improve cognitive performance in amnestic mild cognitive impairment (a-MCI), however, several questions remain unresolved. The goal of the present study was to replicate earlier pilot study findings using a randomized controlled design and to evaluate transfer effects and changes in bra...
Article
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Objective: Alzheimer's disease occurs at a higher prevalence and an earlier age in individuals with Down syndrome (DS) than typically developing individuals. However, diagnosing dementia in individuals with intellectual disability remains a challenge due to pre-existing cognitive deficits. The aim of this study was to investigate the validity and...
Article
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Objective: To conduct the first support vector machine (SVM)-based study comparing the diagnostic accuracy of T1-weighted magnetic resonance imaging (T1-MRI), F-fluorodeoxyglucose-positron emission tomography (FDG-PET) and regional cerebral blood flow single-photon emission computed tomography (rCBF-SPECT) in Alzheimer's disease (AD). Method: Br...
Article
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New research on assessing neuropsychiatric manifestations of Alzheimer´s Disease (AD) involves grouping neuropsychiatric symptoms into syndromes. Yet this approach is limited by high inter-subject variability in neuropsychiatric symptoms and a relatively low degree of concordance across studies attempting to cluster neuropsychiatric symptoms into s...
Data
Demographic and clinical data from subjects. AD = Alzheimer´s Disease; MMSE = Mini Mental State Examination; CAMCOG = Cognitive Section of the CAMDEX; CDR = Clinical Dementia Rating Scale; NPI = Neuropsychiatric Inventory; Number_of_nps = number of neuropsychiatric symptoms that were present in the subject. *For each symptom presence variable, 1 me...
Data
Distribution and combination of neuropsychiatric symptoms in the Alzheimer´s disease (AD) group. (DOCX)
Article
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Objective: To assess depression, domestic violence and the use of substances in women with recurrent miscarriages. Methods: The Abuse Assessment Screen (AAS), the Edinburgh Postnatal Depression Scale (EPDS) and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) were used to assess violence, depression and the use of substances...
Article
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Recent studies have demonstrated that lithium (Li) exerts neuronal protective and regenerative effects both in vitro and in vivo. However, the effects of long-term Li treatment in the brain areas associated with memory impairment of elderly bipolar patients are still unknown. The aim of this study was to compare the hippocampal volumes of elderly b...
Article
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Objective: The aim of this study was to examine the psychometric properties of the Brazilian version of the Multifactorial Memory Questionnaire (MMQ), which evaluates different dimensions of subjective memory functioning, such as Feelings, Abilities and Strategies used in everyday life. Methods: The MMQ was translated into Portuguese and administe...
Article
Full-text available
Objectives To access possible differences of the findings in [18F]FDG-PET and the NAA/mI ratio in the Posterior Cingulate Cortex (PCC) while evaluating subjects with AD, MCI and cognitively normal volunteers, and also to evaluate possible correlations between both methods in the PCC of these subjects. Methods Subjects with the clinical diagnosis o...
Article
Full-text available
Background: There is a proven link between Down syndrome and the early development of the neuropathological features of Alzheimer's disease (AD). Changes in the personality and behavior of adults with Down syndrome might indicate the early stages of dementia or of frontotemporal lobar degeneration. The objective of this study was to investigate th...
Article
Aim: To investigate the effects of the Staff Training for Assisted Living Residences administered to formal caregivers of older adults with behavioral and psychological symptoms of dementia in the institutional environment. Methods: The project was developed in two long-term care institutions in Belo Horizonte, Brazil, with 25 formal caregivers...
Article
Full-text available
Objective This study aims to present normative data for Fuld Object Memory Evaluation test stratified by sex, gender, age, and education for the Brazilian elderly population. Method We evaluated 2.132 healthy elderly both genders, with a mean age of 70.30 years (± 7.28) from two community-based samples in Brazil drawn from different economic areas...
Article
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À medida que a população idosa aumenta no mundo, as doenças relacionadas ao envelhecimento, particularmente a demência, tornam-se mais frequentes. Tendo em vista que o Brasil segue essa tendência global do envelhecimento populacional, deve apresentar, também, aumento da prevalência de demência em sua população. Objetivos: os objetivos desse estudo...
Article
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Reduction of regional brain glucose metabolism (rBGM) measured by [18F]FDG-PET in the posterior cingulate cortex (PCC) has been associated with a higher conversion rate from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). Magnetic Resonance Spectroscopy (MRS) is a potential biomarker that has disclosed Naa/mI reductions within the PCC...
Research
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Case report: That is a case of a 67 year-old-man with partial response after treatment with a Selective Serotonin Receptors Inhibitor, and severe autonomic adverse effects with other antidepressants. The addition of rivastigmine to citalopram resulted in a therapeutic success, with a reduction of 23 to 7 points on the Hamilton Depressive Scale (HAM...
Article
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Inter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in healthy elders. Magnetic resonance imaging data we...
Conference Paper
Full-text available
There is evidence on the genetic relationship between Alzheimer’s disease and Down syndrome (DS). However the precursors that hasten cognitive decline and trigger the clinical symptoms of dementia in these individuals are still uncertain. Bereavement is considered a predictor of mental health problems in individuals with intellectual disability. Ob...
Article
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Background: There is a close genetic relationship between Alzheimer's disease (AD) and Down syndrome (DS), AD being the most severe mental disorder affecting ageing individuals with DS. The objective of the present study was to evaluate the efficacy of cognitive rehabilitation interventions in DS patients with AD by means of a critical literature...
Article
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We aimed to compare caregiver burden and distress in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) and to investigate which factors contribute to caregivers' burden and distress. Fifty patients and their caregivers were invited to participate. Among the patients, 20 had a diagnosis of bvFTD and 30 had AD. Caregiver...
Poster
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In this work we carried out a meta-analysis with to evaluate the prevalence of clinically significant depressive symptoms (SDCS) in elderly Brazilians assisted or hospitalized in health facilities.
Poster
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Neuropsychiatric Symptoms (NPS) are common in dementia and in pre-dementia syndromes such as Mild Cognitive Impairment (MCI). Mild Behavioral Impairment (MBI) has been proposed as a diagnostic construct aimed to identify early, patients with an increased risk of developing dementia, but who may or may not have manifested cognitive symptoms. Apathy,...
Article
Background: The Cognitive Abilities Screening Instrument - Short (CASI-S) is a brief cognitive screening test. However, there is limited information regarding its applicability in primary care. Objectives: To ascertain whether the CASI-S differentiates between dementia patients and normal controls in primary care; to examine its correlation with...
Article
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Cyberbullying is a new form of violence that is expressed through electronic media and has given rise to concern for parents, educators and researchers. In this paper, an association between cyberbullying and adolescent mental health will be assessed through a systematic review of two databases: PubMed and Virtual Health Library (BVS). The prevalen...
Article
Objectives The objective of this study is to investigate the effectiveness of cognitive behavioral therapies (CBTs) in improving depressive symptoms, disability, and cognition in older adults with depression and cognitive deficits.DesignIt was performed a systematic search for articles published between 1994 and February 2014 in the MEDLINE/Pubmed,...
Article
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Background Cognitive decline and Alzheimer’s disease often affect older adults with Down syndrome (DS) much earlier than those in the general population. There is also growing evidence of the effects of negative life events on the mental health and behavior of individuals with intellectual disability. However, to our knowledge, this is the first st...
Article
Full-text available
The purpose of our study was to evaluate vascular risk factors and other clinical variables as predictors of cognitive and functional decline in elderly patients with mild to moderate dementia. The clinical characteristics of 82 elderly patients (mean age 79.0 ± 5.9 years; 67.1% females) with mild to moderate dementia were obtained at baseline, inc...
Article
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OBJECTIVE: The aim of this study was to assess the evolution of the Brazilian scientific publications on dementia and related conditions from 1999 to 2013. METHODS: Articles published during the analysis period were searched on three electronic databases: Scopus, Medline (via PubMed) and Lilacs (via BVS). The keywords used were Alzheimer's disease...
Article
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Background: Limited data are available in the literature comparing brain SPECT, PET and volumetric MRI in the same cohort of patients with Alzheimer’s disease. Objectives: The main goal was to show a correlation between two different functional imaging substrates, as determined by FDG-PET and SPECT, with structural MRI findings as defined by voxel-...
Conference Paper
Full-text available
Prevalence of Amnestic Mild Cognitive Impairment in depressed and non depressed elderly community Brazilian residents INTRODUCTION: Epidemiological studies have linked depression to development of Mild Cognitive Impairment (MCI) and Alzheimer’s disease. In spite of this relationship is not fully known, Amnestic Mild Cognitive Impairment (aMCI) has...
Article
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Background: Identifying dementia in primary care could minimize the impact of a late intervention; however, it shows high rates of misdiagnosis. One of the reasons seems to be the lack of knowledge of adequate cognitive screening instruments. This is a systematic review of the available instruments for the primary care context. Method: For this...
Article
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Background: There is limited information about the functional profile of behavioral variant frontotemporal dementia (bvFTD). Objective: To compare direct and indirect assessments of activities of daily living (ADLs) in bvFTD and Alzheimer disease (AD) and their relationship with cognitive performance. Methods: In all, 20 patients with bvFTD, 3...
Article
Background The international prevalence of psychotic symptoms in older subjects without dementia varies from 0.9% to 8.0%. However, an analysis of these symptoms in developing countries has not been undertaken.AimsTo determine the prevalence and to correlate these symptoms with socioeconomic and clinical characteristics.MethodA community-based samp...
Article
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Unlabelled: The effects of galantamine (GAL) on quality of life (QoL) and cognitive speed, as well its effects combined with nimodipine (NIM) in Alzheimer disease (AD) with cerebrovascular disease (mixed dementia), have not been explored. Method: Double-blind, placebo-controlled, multicenter Brazilian trial, studying the effects of GAL/NIM vs. G...
Article
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Background: Staging scales for dementia have been devised for grading Alzheimer's disease (AD) but do not include the specific symptoms of frontotemporal lobar degeneration (FTLD). Objective: To translate and adapt the Frontotemporal Dementia Rating Scale (FTD-FRS) to Brazilian Portuguese. Methods: The cross-cultural adaptation process consisted...
Article
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The relationship between structural changes in grey matter and treatment response in patients with late-life depression remains an intriguing area of research. This magnetic resonance imaging (MRI) study compares the baseline grey matter volume of elderly people with and without major depression (according to the DSM-IV-TR criteria) and assesses it...
Data
Full-text available
INTRODUCTION Longitudinal studies have found that some lifestyle could impact the risk of dementia including Alzheimer Disease. There are considerable evidences indicating that physically active older individuals maintain healthy functioning longer than do sedentary peers The evaluation of these conditions associated to the risk of cognitive and fu...
Article
Background: Amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) are believed to be a continuum of the same process, in which aMCI is a symptomatic pre-dementia stage. There is a growing need to early diagnosis and neuroimaging methods may help it. Nevertheless, there is a relative lack of studies which correlate findings in magne...
Article
Full-text available
The objective of this critical review of the literature was to reveal the neural circuits involved in the occurrence of neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) patients through the association of these symptoms with neuroimaging findings. The search for articles was performed on PUBMED from January 2000 to May 2013, using the ke...
Article
Full-text available
Cognitive deficits in cancer patients can be related to depression, anxiety, and the side effects of treatments such as fatigue. In this case report, we described an elderly patient with rectal adenocarcinoma, which presented depressive symptoms and memory complaints after treatment with 5-Fluoracil and Leucovorin. Depressive symptoms improved afte...
Article
Full-text available
Methods: A total of 1,563 randomly-selected subjects were assessed by the Mini-Mental State Examination, Fuld Object Memory Evaluation, Informant Questionnaire on Cognitive Decline in the Elderly and Bayer - Activities of Daily Living Scale. Subjects considered screen-positives were submitted to a dementia workup and diagnosis was determined accord...
Article
Objective: The aim of this study was to investigate the effectiveness of a modified version of the Duke Somatic Algorithm Treatment for Geriatric Depression (STAGED) in a Brazilian sample of older patients with major depression. Besides, we aimed to investigate possible baseline predictive factors for remission in this sample. Methods: Sixty-sev...
Article
Full-text available
Objectives: i) To investigate studies published between 1991 and 2010 on the prevalence of depressive morbidity (major depressive disorder [MDD], dysthymia and clinically significant depressive symptoms [CSDS]) among elderly Brazilians assisted at healthcare facilities; ii) to establish the prevalence of depression and identify its related factors...
Data
Full-text available
a b s t r a c t Background: Studies investigating major depression and associated factors in older people from develop-ing countries are scarce. Methods: Cross-sectional study of a community-based sample of 1563 elderly subjects aged 60 years or older from Sao Paulo, Brazil. The frequency of major depression (MD) and the relationship with sociodemo...
Article
Full-text available
Objective: The aim of the present investigation was to characterize the functional profile of patients previously diagnosed with bvFTD. Methods: The sample consisted of 31 patients diagnosed with bvFTD, who were compared to patients with Alzheimer's disease (AD) (n=31) and to healthy control subjects (NC) (n=34), matched for schooling and age. bvF...
Article
Mild Cognitive Impairment (MCI) represents a transitional state between normal aging and early dementia and is commonly associated with memory impairment (Amnestic-MCI or A-MCI). Several studies have investigated therapeutic approaches to A-MCI, including cholinestherase inhibitors (I-ChEs), although this practice is still controversial. Thus, ther...
Article
Full-text available
Introduction: The Cambridge Cognitive Examination (CAMCOG) is a brief tool for cognitive assessment. It is composed of subscales that represent various cognitive domains (orientation, language, memory, attention, praxis, perception, calculation and abstract thinking). Appropriate total scores permit to define impairment in the dementia level. Howev...