Casper da Costa-Luis

University College London | UCL · Centre for Medical Image Computing

Current PET datasets are becoming larger, thereby increasing the demand for fast and reproducible processing pipelines. This paper presents a freely available, open source, Python-based software package called NiftyPAD, for versatile analyses of static, full or dual-time window dynamic brain PET data. The key novelties of NiftyPAD are the analyses...

Purpose: A novel phantom-imaging platform, a set of software tools, for automated and high precision imaging of the American College of Radiology (ACR) PET phantom for PET/MR and PET/CT systems is proposed. Methods: The key feature of this platform is the vector graphics design which facilitates the automated measurement of the knife-edge respon...

SIRF is a powerful PET/MR image reconstruction research tool for processing data and developing new algorithms. In this research, new developments to SIRF are presented, with focus on motion estimation and correction. SIRF’s recent inclusion of the adjoint of the resampling operator allows gradient propagation through resampling, enabling the MCIR...

Accurate regional brain quantitative PET measurements, particularly when using partial volume correction, rely on robust image registration between PET and MR images. We argue here that the precision, and hence the uncertainty, of MR-PET image registration is mainly driven by the registration implementation and the quality of PET images due to thei...

Unifying Python/C++/CUDA memory: Python buffered array <-> C++11 ``std::vector`` <-> CUDA managed memory.

This article reviews the use of a sub-discipline of artificial intelligence (AI), deep learning, for the reconstruction of images in positron emission tomography (PET). Deep learning can be used either directly or as a component of conventional reconstruction, in order to reconstruct images from noisy PET data. The review starts with an overview of...

Noise suppression is particularly important in low count PET imaging. Post smoothing (PS) and regularisation methods which aim to reduce noise also tend to reduce resolution and introduce bias. Alternatively, anatomical information from another modality such as magnetic resonance (MR) imaging can be used to improve image quality. Convolutional neur...

The combination of positron emission tomography (PET) with magnetic resonance (MR) imaging opens the way to more accurate diagnosis and improved patient management. At present, the data acquired by PET-MR scanners are essentially processed separately, but the opportunity to improve accuracy of the tomographic reconstruction via synergy of the two i...

Purpose: Numerous image reconstruction methodologies for positron emission tomography (PET) have been developed that incorporate magnetic resonance (MR) imaging structural information, producing reconstructed images with improved suppression of noise and reduced partial volume effects. However, the influence of MR structural information also incre...

Caches data to `~/.brainweb/` (raw data source http://brainweb.bic.mni.mcgill.ca/brainweb/anatomic_normal_20.html `uint16(362, 434, 362)`). Transforms to Siemens Biograph mMR volume dimensions `float32(127, 344, 344)`. Modifies to have FDG, T1, T2 and attenuation map intensities. Adds non-piecewise-constant randomised structure for more realistic g...

The combination of positron emission tomography (PET) with magnetic resonance (MR) imaging opens the way to more accurate diagnosis and improved patient management. At present, the data acquired by PET and MR scanners are essentially processed separately, and the search for ways to improve accuracy of the tomographic reconstruction via synergy of t...