Cascia Day

Cascia Day
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Cascia verified their affiliation via an institutional email.
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Cascia verified their affiliation via an institutional email.
University of Cape Town | UCT · Department of Medicine

Allergist Cert Allergy (Phys) MBBCh FCP(SA) MMed(Med) HIV Dip Man

About

22
Publications
1,589
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71
Citations

Publications

Publications (22)
Article
Full-text available
Purpose of Review Despite global incidence, considerable morbidity, and diverse triggers, CU is poorly characterized amongst diverse African populations. This systematic review aims to describe available African CU studies and unmet needs. Recent Findings Overall 221 publications were screened and 29 were eligible for full review. These publicatio...
Preprint
Full-text available
Background Angiotensin-converting enzyme inhibitor-induced angioedema (AE-ACEI) is a life-threatening adverse event and, globally, the commonest cause of emergency presentations with angioedema. Several large genome-wide association studies (GWAS) have found genomic associations with AE-ACEI. However, despite African Americans having a 5-fold incre...
Preprint
n=254/250 words) Background: The Janssen-Ad26.COV2.S vaccine is authorised for use in several countries with more than 30 million doses administered. Mild and severe allergic adverse events following immunisation(AEFI) have been reported. The aim of this report is to detail allergic reactions reported during the Sisonke phase 3B study in South Afri...
Article
Background: Concerns about disease exacerbations and fear of reactions following COVID-19 vaccinations are common in chronic urticaria (CU) patients and may lead to vaccine hesitancy. Objective: We assessed the frequency and risk factors of CU exacerbation and adverse reactions in CU patients after COVID-19-vaccinations. Methods: COVAC-CU is a...
Article
Full-text available
Background. Angioedema is the most common acute allergic presentation to emergency centres (EC), with hospitalisation rates increasing in high-income countries. Angioedema can complicate with life-threatening laryngeal obstruction. There are no local data; therefore, we aimed to characterise acute angioedema cases presenting to ECs and develop a si...
Article
Full-text available
Background Chronic spontaneous urticaria (CSU) is defined as the spontaneous occurrence of hives, angioedema, or both for more than 6 weeks; several inciting triggers including vaccines have been implicated. Coronavirus disease 2019 (COVID-19) vaccinations have been well tolerated by patients with CSU. However, reports have emerged of CSU triggered...
Article
Full-text available
Objectives In high-income countries, up to 25% of inpatients have a self-reported penicillin allergy (PA). After testing, 95% of these self-reported PAs are incorrect. These incorrectly labelled PAs increase the use of broad-spectrum antibiotics, and drive bacterial resistance. The epidemiology of PA in low- and middle-income countries is unknown....
Article
Full-text available
Background: Up to a quarter of inpatients in high-income countries (HICs) self-report beta-lactam allergy (BLA), which if incorrect,increases the use of alternative antibiotics, worsening individual health outcomes and driving bacterial resistance. In HICs, up to 95% ofself-reported BLAs are incorrect. The epidemiology of BLA in low- and middle-in...
Article
Full-text available
Cold urticaria is a rare but potentially life-threatening disease that is part of the chronic inducible urticarias. Unfortunately, the diagnosis is often delayed as clinicians need to have a high level of suspicion in order to diagnose and test for this condition. In this article we provide a brief overview of the topic and discuss patients in a So...
Preprint
Full-text available
Background Up to a quarter of inpatients in high-income countries self-report beta-lactam allergy (BLA), which if incorrect, can increase use of alternative antibiotics that impact on bacterial resistance.. The epidemiology of BLA in low- and middle-income African countries is unknown. Methods Point-prevalence surveys were conducted at seven hospit...
Article
Background The Janssen-Ad26.COV2.S vaccine is authorised for use in several countries with over 30 million doses administered. Mild and severe allergic adverse events following immunisation(AEFI) have been reported. The aim of this report is to detail allergic reactions reported during the Sisonke phase 3B study in South Africa. Methods A single-d...
Article
Full-text available
Background: Delirium is associated with increased mortality and length of hospital stay. Limited data are available from HIV-infected acute hospital admissions in developing countries. We conducted a prospective study of delirium among acute medical admissions in South Africa (SA), a developing country with universal antiretroviral therapy (ART) a...
Article
The SARS-COV-2 infection has already claimed the lives of more than 150 000 South Africans. In order to combat ongoing infections and fatalities, South Africa has commenced its largest adult mass vaccination roll-out ever. Roll-out commences against a backdrop of emerging science, increased anti-vaccine sentiments and much public anxiety about vacc...
Article
Full-text available
Background: Delirium is a common, serious, underdiagnosed condition in medical and surgical inpatients with acute conditions. It is associated with increased risk of mortality and morbidity. Data of geriatric cohorts are largely limited to developed countries. Objectives: To describe prevalence, risk factors and outcomes of delirium among genera...
Article
Full-text available
Abstract Background Timely identification of people who are at risk of dying is an important first component of end-of-life care. Clinicians often fail to identify such patients, thus trigger tools have been developed to assist in this process. We aimed to evaluate the performance of a identification tool (based on the Gold Standards Framework Prog...
Preprint
Full-text available
Background: Timely identification of people who are at risk of dying is an important first component of end-of-life care. Clinicians often fail to identify such patients, thus trigger tools have been developed to assist in this process. We aimed to evaluate the performance of a identification tool (based on the Gold Standards FrameworkPrognostic In...
Preprint
Full-text available
Background: Timely identification of people who are at risk of dying is an important first component of end-of-life care. Clinicians often fail to identify such patients, thus trigger tools have been developed to assist in this process. We aimed to evaluate the performance of a identification tool (based on the Gold Standards FrameworkPrognostic In...
Preprint
Full-text available
Background: Timely identification of people who are at risk of dying is an important first component of end-of-life care. Clinicians often fail to identify such patients, thus trigger tools have been developed to assist in this process.Aim: To evaluate the performance of a screening tool (based on the Gold Standards Framework Prognostic Indicator G...
Preprint
Full-text available
Background Timely identification of people who are at risk of dying is an important first component of end-of-life care. Clinicians often fail to identify such patients, thus trigger tools have been developed to assist in this process. Aim To evaluate the performance of a screening tool (based on the Gold Standards Framework Prognostic Indicator Gu...
Article
Full-text available
Background: South Africa, ranked as the world's second most stressful country to live in, has an estimated 7 million smokers. A dedicated smoking cessation clinic established at Groote Schuur Hospital, Cape Town, provides the only clinical service and training centre in the country. Objectives: To evaluate the smokers attending the clinic, in or...

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