• Home
  • Carsten M. Philipp
Carsten M. Philipp

Carsten M. Philipp
Evangelische Elisabeth Klinik · Lasermedicine

MD

About

183
Publications
85,396
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,124
Citations
Citations since 2016
10 Research Items
172 Citations
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530

Publications

Publications (183)
Poster
MAL-PDT is an established treatment for epithelial skin tumors (AK, MB, sBCC). MAL-PDT is painful and usually requires regional or local anesthesia and sometimes further medication as pain accompanies the patient not only during but also some hours after exposure. During the last PDT-PDD update conference in Kochel 2018, a dosimetry concept for pai...
Article
Purpose Evaluation of MR feasibility and real-time control of an innovative thermoablative applicator for intradiscal thermotherapy and histological analysis of laser annuloplasty in human ex vivo intervertebral discs. Materials and Methods We evaluated a new MR-compatible applicator system for MR-guided percutaneous intradiscal thermotherapy (MRg...
Article
Flashlamp-pumped dye-lasers and near-infrared lasers are applied in the treatment of hypertrophic scars and keloids to reduce hypervasculansation. C02- und Er-YAG-lasers are used to treat atrophic scars. However, they all have in common that scars cannot be removed completely. Functional and aesthetic improvement is possible, though. Today, lasers...
Article
With the term "hemangioma" different vascular anomalies are described. Here one has to discriminate the congenital vascular tumours from the vascular anomalies. But for a clear indication a definite classification is necessary. Basis is the actual ISSVA classification. In the latest version they have incorporated the embryological aspects of the Ha...
Article
Contrary to the more thermal surgical laser applications the photodynamic therapy represent a physical therapy. Basic is the production of reactive cytotoxic singlet oxygen with light by photosensitizers. These photosensitizer itself have pharmacologic no effect, but have a high tumor specifity. This means that any effect happens only on the region...
Article
Full-text available
Pyogenic granuloma (PG) also known as “eruptive hemangioma”, “granulation tissue-type hemangioma”, “ Before therapy, PGs of skin were initially rated in size and vascularization using color-coded duplex sonography. Usually the Nd:YAG laser (1064 nm) was employed. Laser settings and techniques were adjusted appropriately; i.e. pulsed, chopped or con...
Chapter
Congenital vascular tumors have a wide variety of origins. The most common congenital vascular tumor is the GLUT-1-positive infantile hemangioma. This has to be differentiated from the congenital hemangioendothelioma and is not part of the infantile hemangiomas and is GLUT-1-negative. Both have to be differentiated from arterial, venous, lymphatic,...
Chapter
Skin is the largest organ of the human body. Usually, it is easy accessible for topical application of drugs and light dosimetry is easy due to the rather flat appearance in a first approximation. On the other hand a larger number of skin diseases cover a larger area or show multifocal appearance, which favors regional or large field therapies and...
Article
To assess the feasibility of guidance and thermometry by open 1.0 T magnetic resonance (MR) imaging during percutaneous laser disc decompression (PLDD). A fluoroscopic proton-density-weighted turbo spin echo sequence was used for positioning a laser fiber and a reference thermosensor within the targeted spinal disc. In 30 lumbar discs from human do...
Article
Lasers are currently used in diagnostics, for example in metabolic monitoring (fluorescence diagnosis, laser Doppler) and optical imaging (laser scanning microscopy, optical coherence tomography, infrared diaphanoscopy). One main research focus remains therapeutic applications — on one hand using lasers as a surgical instrument, on the other as a c...
Poster
Purpose: Optical coherence tomography (OCT) is able to produce two-dimensional images of living skin in situ with good correlation between histological samples and healthy and diseased skin layers. Therefore we were curious if the method could be extended for displaying dermal vessels in normal skin and CM/CVM of different ages and locations, prior...
Poster
Treatment with pulsed dye laser and pulsed Nd:YAG-laser is the gold standard for the treatment of CM/CVM. Nevertheless, some patients show a better, some a lesser response with residuals and recurrences. Structural differences may be one reason. Optical coherence tomography (OCT) is able to produce two-dimensional images of living skin in situ with...
Conference Paper
Purpose: Optical coherence tomography (OCT) is able to produce two-dimensional images of living skin in situ with good correlation between histological samples and healthy and diseased skin layers. In this investigation we studied the OCT for vascular imaging. Material and methods: We investigated normal skin and PWS before and after pulsed dye- /...
Article
Objective: Hemangioma is a well-recognized cause of airway obstruction in infants with stridor. In former times tracheostomy was the only way in treating these life-threatening hemangiomas of the trachea. Due, to the possibility to transmit laser light with flexible fibres to the trachea, an early treatment of airway hemangiomas became possible. Ma...
Article
Full-text available
Non-invasive two-photon microscopy (TPM) provides a new technique which could become in the future a substitute for hematoxylin and eosin (HE) staining of tissue sections of the epidermis and upper and middle dermis as well. High-resolution imaging, in combination with false-colour representation, allows an accurate reproduction of standard microsc...
Article
Full-text available
Two-photon microscopy (TPM) generates high definition images from biological samples such as human skin in a non-invasive way. The focus of an ultrashort pulsed laser is scanned through the tissue and the fluorescence photons induced by two-photon excitation of endogeneous fluorophores are collected, measured and displayed as a scanning image. So f...
Article
Full-text available
Ziel In dieser retrospektiven Studie wurde die Effektivität eines 532 nm-Lasers (IDAS; Quantel Derma GmbH) in der Behandlung von Dellwarzen (Molluscum contagiosum) untersucht. Material und Methoden Es wurden die Behandlungsdokumentationen von 32 Patienten, die in unserer Klinik zwischen 09/2005 und 04/2011 wegen Molluscum contagiosum behandelt wur...
Article
To evaluate the feasibility and safety of a novel LITT applicator for thermal ablation of liver malignancies in 1.0-T high-field open MRI. A miniaturised 6-F double-tubed protective catheter with a closed cooling circuit was used with a flexible laser fibre, connected to a 1,064-nm Nd:YAG laser and evaluated in non-perfused porcine livers (18-30 W...
Article
Full-text available
Objective: Optical coherence tomography (OCT) is able to produce two-dimensional images of living skin in situ. We evaluated a frequency-domain OCT system (SR-OCT Imaging System, Thorlabs) with regard to its clinical impact. Material and methods: Seven healthy volunteers and 10 patients were recruited who had been referred for local photodynamic th...
Article
Full-text available
Objective The lichen sclerosus is an inflammatory chronic disease most probably with autoimmunological genesis. Different conservative therapies exist, but the clinical presentation and the subjective complaints in some cases are not effectively improved by these conservative methods. Laser skin ectomy has been used in our department as an alternat...
Article
Full-text available
Lymphatic vascular malformations occur with a large variety of different characteristics. Color-coded duplex sonography is the most effective preoperative and intra-operative diagnosis method. According to different manifestations, suitable laser procedures can be performed with minor side effects and a noticeable stabilization of the clinical situ...
Article
Full-text available
Objective The lichen sclerosus is a non-inflammatory, chronic disease most probably with auto-immunological genesis. Different conservative therapies exist: the local or systemic treatment with estrogens, corticosteroids and immunomodulators. The clinical presentation and the subjective complaints are not persistently improved by these conservative...
Article
Objective Loss of fluorescence is used to determine the endpoint of irradiation in PDT with 5-ALA of non-melanoma skin cancers (NMSC) as actinic keratosis (AK) and superficial basal cell carcinomas (sBCC). Based on earlier research, we investigated the appearance of recovery fluorescence (recurrence of any fluorescence after initial therapeutic irr...
Article
Laparoscopic liver surgery is a safe and feasible technique for the treatment of benign and malignant liver tumors and has been well established at many specialized centers. Many different techniques of tissue dissection have been developed. As an alternative various lasers have been applied to conventional liver resections. Laser surgery is potent...
Article
Introduction Eyelid-hemangioma occupies an exceptional position in the broad range of infantile hemangiomas. In many cases they show a rapid progression resulting in a high risk of amblyopia, and a large number of treatments are needed to achieve a regression. Surgical resection is not an appropriate therapy due to the high degree of vascularizatio...
Article
Objective For the differentiation between healthy skin and actinic and BCC lesions two-dimensional images of the skin structure in situ might be of certain value. Optical coherence tomography (OCT) was used to assess whether the OCT images be of particular value or could act as a projection frame of further information obtained by various other met...
Article
Full-text available
Introduction With an incidence of 1.3%, vascular malformations (VM) cannot be called rare diseases. Only a fraction of them occur with the symptoms of a lymphatic malformation, either in pure form such as Hygroma colli, or in combination with malformed blood vessels. The prognosis is good; a malignant transformation is unknown. The degree of the im...
Article
Full-text available
Hemangiomas in infancy and vascular malformations (VM) such as port-wine stains, venous, arteriovenous, lymphatic or mixed malformations of the anogenital region may present considerable problem for patients at different stages of their individual development. A clear differentiation between the different entities is important for the choice of the...
Article
Computed tomography is the standard imaging modality to minimize the extent of surgical or ablative treatment in osteoid osteomas. In the last 15 years, since a description of thermal ablation of osteoid osteomas was first published, this technique has become a treatment of choice for this tumor. We report the case of a 20-year-old man with an oste...
Article
Full-text available
The existence of scars may present considerable problems for patients. As well as being sometimes disfiguring and having an influence on a person's perception of him or herself, hypertrophic scars and keloids can often also cause pruritus, dysesthesia and pain, and can form strictures.Since the first attempts to influence hypertrophic scars and kel...
Article
Full-text available
Usually systemic photosensitizers (PS) require a long period of incubation (48-96h) after systemic admission. On the other hand clearing from healthy skin needs weeks or months. Severe side effects on skin are possible in case of uncontrolled light exposure. Topical PDT may solve this problem, but deep portions may not be sufficiently sensitized, r...
Article
In future, it will be necessary to bring together the wide spectrum of possibilities offered by biophotonics in conjunction with all other medical techniques. Laser systems as we know them today will always be just one possible form of implementation, light-emitting nanostructures another. Whether used for diagnosis or therapy, whether absorption o...
Article
Full-text available
In the assessment of haemangioma, the colour coded duplex sonography (CCDS) is the only diagnostic tool to rate the activity of proliferating vessels. By use of empirical acquired data, five clearly distinguished stages from progression to regression can be described. So besides control of the clinical course, CCDS is significant for fixing an indi...