Caroline Quoilin

Caroline Quoilin
Université Catholique de Louvain - UCLouvain | UCLouvain · Institute of Neuroscience

PhD

About

40
Publications
2,340
Reads
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347
Citations
Additional affiliations
June 2014 - present
Université Catholique de Louvain - UCLouvain
Position
  • PostDoc Position
February 2013 - June 2014
Indiana University-Purdue University Indianapolis
Position
  • PostDoc Position
October 2008 - October 2012
University of Liège
Position
  • PhD Student

Publications

Publications (40)
Article
Background: In Parkinson's disease (PD), neurophysiological abnormalities within the primary motor cortex (M1) have been shown to contribute to bradykinesia, but exact modalities are still uncertain. We propose that such motor slowness could involve alterations in mechanisms underlying movement preparation, especially the suppression of corticospi...
Preprint
In Parkinson’s disease, neurophysiological abnormalities within the primary motor cortex have been shown to contribute to cardinal symptoms such as bradykinesia, but the exact modalities are still uncertain. Here, we propose that such impairment could involve alterations of mechanisms shaping motor activity specifically during voluntary movement pr...
Article
Full-text available
Action preparation relies on the operation of control processes that modulate the excitability of the corticospinal tract. On the one hand, excitatory processes prepare the motor system for the forthcoming response; the stronger these influences, the stronger the tendency to act. On the other hand, inhibitory influences allow to suppress inappropri...
Article
Full-text available
Inhibitory control underlies the ability to inhibit inappropriate responses and involves processes that suppress motor excitability. Such motor modulatory effect has been largely described during action preparation but very little is known about the neural circuit responsible for its implementation. Here, we addressed this point by studying the deg...
Article
Full-text available
Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and social impairments. The gut microbiota has been recently shown to regulate brain functions and behavior but convincing evidence of its role in AUD is lacking. Here, we show that gut dysbiosis is associated with metabolic alterations that affect behavioral (dep...
Article
Full-text available
A lack of inhibitory control appears to contribute to the development and maintenance of addictive disorders. Among the mechanisms thought to assist inhibitory control, an increasing focus has been drawn on the so-called preparatory suppression, which refers to the drastic suppression observed in the motor system during action preparation. Interest...
Article
By applying transcranial magnetic stimulation (TMS) over primary motor cortex (M1) to elicit motor-evoked potentials (MEPs) in muscles of the contralateral hand during reaction time (RT) tasks, many studies have reported a strong global suppression of motor excitability during action preparation, a phenomenon called preparatory inhibition. Several...
Preprint
Full-text available
By applying transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) to elicit motor-evoked potentials (MEPs) in muscles of the contralateral hand during reaction time (RT) tasks, many studies have reported a strong suppression of MEPs during action preparation, a phenomenon called preparatory inhibition. Several hypotheses have b...
Article
Objectives Motor-evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) show a profound suppression when elicited during the instructed-delay of reaction time (RT) tasks. One predominant hypothesis is that this phenomenon, called “preparatory inhibition”, reflects the operation of processes that suppress motor activity to withhold prep...
Article
Full-text available
Impaired inhibitory control contributes to the development, maintenance, and relapse of alcohol-dependence, but the neural correlates of this deficit are still unclear. Because inhibitory control has been labeled as an executive function, most studies have focused on prefrontal areas, overlooking the contribution of more “primary” structures, such...
Article
Full-text available
Using instructed-delay choice reaction time (RT) paradigms, many previous studies have shown that the motor system is transiently inhibited during response preparation: motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) over the primary motor cortex are typically suppressed during the delay period. This effect has be...
Article
Full-text available
Background: Binge co-consumption of highly caffeinated energy drinks with alcohol (ethanol [EtOH]) has become a common practice among adolescents/young adults and has been associated with an increased incidence of hazardous behaviors. Animal models are critical in advancing our understanding the neurobehavioral consequences of this form of binge d...
Article
Full-text available
Background: Many previous transcranial magnetic stimulation (TMS) studies have investigated corticospinal excitability changes occurring when choosing which hand to use for an action, one of the most frequent decision people make in daily life. So far, these studies have applied single-pulse TMS eliciting motor-evoked potential (MEP) in one hand w...
Article
Full-text available
Background: Binge alcohol (ethanol [EtOH]) drinking is common during adolescence, a time characterized by many behavioral and neurobiological changes. Among them, the GABAA receptor system undergoes substantial modifications, including changes in the density, distribution, and subunit composition of the receptor. Based on its demonstrated role in...
Article
Full-text available
Understanding the neural substrates underlying the ability to navigate through continuous sets of action choices in a goal-directed manner represents an intricate challenge for contemporary neuroscience. This human behavior is thought to rely in part on a fine interplay between excitatory and inhibitory neural mechanisms. As such, recent behavioral...
Article
Repeated drug injections lead to sensitization of their stimulant effects in mice, a phenomenon sometimes referred to as drug psychomotor sensitization. Previous studies showed that sensitization to cocaine is context dependent as its expression is reduced in an environment that was not paired with cocaine administration. In contrast, the effects o...
Conference Paper
Impulsivity is thought to play a major role in the development and maintenance of alcohol-dependence. This multifaceted behavioural trait has been associated with poor behavioral inhibition. However, whether this deficit is due to abnormal physiological inhibitory processes is unclear. Recent transcranial magnetic stimulation (TMS) studies have ide...
Conference Paper
Adolescent binge consumption of caffeinated alcoholic beverages is a growing concern. Caffeine may mask alcohol’s sedative effects, increasing risk for continued drinking despite significant intoxication. However, the available human data is equivocal. The goal of the current work was to adapt the Drinking-in-the-Dark paradigm to model adolescent b...
Article
Repeated ethanol injections lead to a sensitization of its stimulant effects in mice. Some recent results argue against a role for ventral tegmental area (VTA) dopamine neurons in ethanol behavioral sensitization. The aim of the present study was to test whether in vivo ethanol locomotor sensitization correlates with changes in either basal- or eth...
Article
Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is a possible consequence of ethanol exposure during adolescence. The aim of this study was to characterize the long-term alterations in the stimulant effects...
Article
The adolescent brain has been suggested to be particularly sensitive to ethanol-induced neuroadaptations, which in turn could increase the risk of youths for alcohol abuse and dependence. Sensitization to the locomotor stimulant effects of ethanol has often been used as an animal model of ethanol-induced neuroadaptations. Previously, we showed that...
Article
Recent studies suggest that the brain histaminergic system and especially the H3 receptors are involved in the regulation of alcohol consumption and alcohol-induced behaviors. Part of this effect might be due to a modulation of ethanol-induced sedation by central histamine. The aim of the present study was to investigate the effects of several hist...
Article
Alcohol exposure during early adolescence is believed to durably alter the behavioral properties of ethanol, increasing the likelihood of later alcohol-related disorders. The aim of the present experiments was to characterize changes in the behavioral effects of ethanol in adult female Swiss mice after a chronic ethanol exposure during adolescence,...
Article
Full-text available
The maturing adolescent brain has been suggested to be more sensitive than the adult brain to ethanol-induced neuroadaptations. In animal studies, sensitization to the stimulant effects of ethanol is used to study the vulnerability to chronic ethanol-induced neurobehavioral alterations. The aim of the present study was to systematically characteriz...
Article
The adolescent period is characterized by a specific sensitivity to the effects of alcohol, which is believed to contribute to the enhanced risks of alcohol dependence when drinking is initiated early during adolescence. In adolescent rodents, while the reduced sensitivity to the sedative effects of ethanol has been well characterized, its stimulan...
Article
Repeated administrations of ethanol induce a progressive and enduring increase in its locomotor stimulant effects, a phenomenon termed behavioral sensitization that has not been systematically characterized. The aim of the present studies was to characterize the development and expression of ethanol sensitization in female Swiss mice by examining (...

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Project
What is the defining property of addiction; what comes first and what follows? In a recent study, Quoilin and Duque (2015) [1] showed deficits in motor inhibition in alcohol-dependent (AD) patients. While this lack of inhibition may represent interesting biological predictors of alcoholism, it is unclear whether these impairments were present before the pathology or resulted exclusively from the brain damage occurring following chronic alcohol exposure; which came first, which followed. This question is the focus of this project. References: [1]C. Quoilin, J. Duque; SY19-4 DEFICIENT MOTOR INHIBITORY MECHANISMS IN ALCOHOL-DEPENDENCE: A TMS STUDY, Alcohol and Alcoholism, Volume 50, Issue suppl_1, 1 September 2015, Pages i22,