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Publications (22)
Aloin, an anthraquinone-C-glycoside found in Aloes, exhibits antimalarial activity; however, its development into therapeutic drugs is hindered by its intrinsic chemical instability. Herein, we synthesized a novel and stabilized chitosan-Schiff base of aloin (ALCSB) through superficial Schiff condensation of chitosan's amino groups with 2-chloroqui...
Consumption of algae has been historically practiced, especially in East Asia and the Pacific region cultures. However, sporadic events and empirical studies have suggested that some compounds could be triggering intoxications, allergic reactions and mortalities in humans who consumed algae. This chapter is an effort to explore with in-depth attent...
Metal fabrication workshops (MFWs) are common businesses in Ugandan cities, and especially those producing metallic security gates, window and door frames (burglar-proof), and balcony and staircase rails. The objective of this study was to comparatively assess the pollution levels and potential health risks of manganese (Mn), chromium (Cr), cadmium...
With increased resistant pests and low crop yields, farmers especially in sub-saharan Africa have greatly embraced usage of chemicals. These chemicals include pesticides used in gardens for better yields and also in the stalls for longer shelf life by sellers of farm products especially fresh perishables like tomatoes, cabbages, carrots, and green...
Pollution of water resources is one of the major impediments to the realization of Sustainable Development Goals, especially in developing countries. The aim of this study was to investigate the physicochemical quality and potentially toxic element (lead and cadmium) concentrations in surface water sampled from Pager River, a tributary of the Nile...
Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the molecular mechanism of Colocasia esculenta(CE) as a novel agent for BPH chemotherapy. In vivo, we assigned 45 male Wistar albino r...
Lake Victoria (L. Victoria) is the largest African tropical and freshwater lake, with one of the highest pollution levels, globally. It is shared among Uganda, Kenya and Tanzania, but it is drained only by the river Nile, the longest river in Africa. Though environmental studies have been conducted in the lake, investigations of the heavy metals (H...
Benign Prostatic Hyperplasia (BPH) is a major cause of lower urinary tract infections and erectile dysfunction thus a major contributor to lowering the quality of life among older men. In this study, we investigated the molecular mechanism of Colocasia esculenta ( CE ) as a novel agent for BPH chemotherapy. In Vivo, we assigned 45 male Wistar albin...
Aloe barbadensis Miller (A. barbadensis) has been reported for use in the traditional management of malaria in Kenya. Aloin (an anthraquinone-C-gly-coside) is one of the therapeutic molecules in Aloe species that is responsible for their antimalarial effect. However, there is no report on the aloin content of A. barbadensis leaves latex and gel fro...
Aims: Aloe barbadensis Miller (A. barbadensis) is one of the most treasured species from the Aloe genus that has been used in management of various ailments. However, there are few reports on the secondary metabolites, total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activities of its leaf latex and gel. This study aimed...
In the current study, water from Chuho springs used as the main water source in Kisoro municipality, Uganda were assessed for their suitability as drinking water. The temperature, turbidity, conductivity, total dissolved solids, dissolved oxygen, biological oxygen demand, total hardness, total alkalinity, calcium, magnesium, phosphates, iron, coppe...
Aflatoxins are endemic in Kenya. The 2004 outbreak of acute aflatoxicosis in the country was one of the unprecedented epidemics of human aflatoxin poisoning recorded in mycotoxin history. In this study, an elaborate review was performed to synthesize Kenya’s major findings in relation to aflatoxins, their prevalence, detection, quantification, expo...
Background: Poisonous snake envenomation is a complex neglected health problem implicated for the mortality, disability, psychological morbidity and socio-economic losses recorded worldwide. Antivenin sera, the only medically recommended treatment for snakebites has several drawbacks such as hypersensitivity, inability to prevent local tissue damag...
The effect of sewage sludge amendment (5-25% w/w) on the potential of maize (MM3 variety) to phytoextract trace metals from chromated copper arsenate (CCA) contaminated soils was investigated. The metal content of fresh soils, and soils, maize roots and shoots after 80 days of planting were determined by atomic absorption spectroscopy. The concentr...
Aim: The use of copper-based preservatives such as chromated copper arsenate (CCA) and creosote to prolong the life of lumber present environmental concerns because they contain heavy metals and polycyclic aromatic hydrocarbons which are toxic to humans. The aim of this study was to investigate the effects of sewage sludge biosolid amendment on the...
The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21, 829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the invent...
Many science-based institutions in most developing countries use heavy metal containing salts in practical teaching sessions. The commonly used chemicals are the salts of lead (II) and copper (II) and the wastes generated end up into the environment when untreated. Thus, a study was done to remove lead (II) and copper (II) ions from mono synthetic...
River Rwizi originates from the Buhweju hills. It is a major source of water for the inhabitants of Mbarara Municipality and surrounding environment. In this study, spatial variation of water quality in River Rwizi section within Mbarara Municipality was determined using cluster analysis. Laboratory analysis was conducted on water samples from five...
River Rwizi originates from the Buhweju hills. It is a major source of water for the inhabitants of Mbarara Municipality and surrounding environment.In this study, spatial variation of water quality in River Rwizi section within Mbarara Municipality was determined using cluster analysis. Laboratory analysis was conducted on water samples from five...
