
Caroline KardebyAston University · School of Biosciences
Caroline Kardeby
Doctor of Philosophy
About
20
Publications
1,672
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148
Citations
Introduction
Caroline Kardeby is a researcher in the field of platelet receptor signalling and the role of platelets in inflammation and immunity. Caroline is currently investigating the connection between platelet reactivity and neurodegenerative disease.
Additional affiliations
October 2022 - March 2023
Position
- EU and International Research Funding Officer
Description
- Research Funding Officer for EU and International grants. Supporting with grant feedback, budgeting, and all other aspects of submitting proposals to EU and International funding bodies like the European Comission, the European Research Council, the US Department of Defense and many others.
October 2020 - September 2022
Position
- Research Fellow
Description
- Maria Skłodowska-Curie Actions Individual Fellowship #893262 Title: PAELLA. ' I'm on a two year project funded by the European Commission and Horizon 2020 to study the role of Platelet Endothelial Aggregation Receptor 1 (PEAR1) in thrombosis and thromboinflammation.
Education
November 2014 - May 2019
Örebro University
Field of study
- Medicine
Publications
Publications (20)
Background
Platelet endothelial aggregation receptor 1 (PEAR1) is a single-transmembrane orphan receptor primarily expressed on platelets and endothelial cells. Genetic variants of PEAR1 have repeatedly and independently been identified to be associated with cardiovascular diseases, including coronary artery disease.
Objectives
We have identified...
Purine analogues bearing a nitrate ester motif were previously discovered as cardioprotective and anti-inflammatory agents, but the anti-inflammatory mechanism remains to be established. We therefore investigated the anti-inflammatory effect of two purine analogues, MK118 bearing a nitrate ester moiety and the methyl-substituted analogue MK196 in A...
Charge interactions play a critical role in the activation of the innate immune system by damage- and pathogen-associated molecular pattern receptors. The ability of these receptors to recognize a wide spectrum of ligands through a common mechanism is critical in host defense. In this article, we argue that platelet glycoprotein receptors that sign...
Background
The novel coronavirus SARS-CoV-2 has caused a global pandemic. Vaccines are an important part of the response. Although rare, unusual thrombotic events and thrombocytopenia in recipients 4–16 days after vaccination with the AstraZeneca AZD1222 have been reported. This syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT)...
Background
Arterial and venous thrombosis are both common in antiphospholipid syndrome (APS). Recent studies have shown that anti‐FXa therapy in APS patients leads to a greater number of patients with arterial thrombosis than with warfarin. We hypothesise that this may be due to the lowering of prothrombin levels by warfarin.
Objectives
To investi...
Platelet Endothelial Aggregation Receptor 1 (PEAR1) is an orphan receptor of unknown function which mediates powerful activation of platelets and endothelial cells in response to crosslinking by antibodies and sulfated polysaccharides belonging to the dextran and fucoidan families. PEAR1 is a single transmembrane protein composed of 15 epidermal gr...
In X-linked thrombocytopenia with thalassemia (XLTT; OMIM 314050), caused by the mutation p.R216Q in exon 4 of the GATA1 gene, male hemizygous patients display macrothrombocytopenia, bleeding diathesis and a β-thalassemia trait. Herein, we describe findings in two unrelated Swedish XLTT families with a bleeding tendency exceeding what is expected f...
Supplementary Table 1 – Top 25 Up- and down regulated genes induced by IL6 knockdown in human endothelial cells.
Supplementary Table 2 – Top 25 Up- and down regulated genes induced by IL6 knockdown in presence of soluble IL6-receptor α in human endothelial cells
Supplementary Table 3 – Differentially regulated genes induced by soluble IL6-recepto...
Background:
Interleukin 6 (IL6) is a multifunctional cytokine produced by various cells, including vascular endothelial cells. IL6 has both pro- and non-/anti-inflammatory functions, and the response to IL6 is dependent on whether it acts via the membrane-bound IL6 receptor α (IL6Rα) (classic signaling) or the soluble form of the receptor (transsi...
Natural purines like ATP, ADP and adenosine have crucial roles in platelet physiology. This knowledge has been significant in drug development and today ADP receptor antagonists are widely used for prevention of thrombotic events following myocardial infarction and ischaemic stroke.
Recent studies have shown that a purine analogue bearing nitrate e...
The healthy vascular endothelium constantly releases autacoids which cause an increase of intracellular cyclic nucleotides to tame platelets from inappropriate activation. Elevating cGMP and cAMP, in line with previous reports, cooperated in the inhibition of isolated human platelet intracellular calcium-mobilization, dense granules secretion, and...
Fucoidans are sulfated fucose-based polysaccharides that activate platelets and have pro- and anticoagulant effects; thus, they may have therapeutic value. In the present study, we show that 2 synthetic sulfated α-l-fucoside-pendant glycopolymers (with average monomeric units of 13 and 329) and natural fucoidans activate human platelets through a S...
The marine sulfated polysaccharide fucoidan displays superior ability to induce platelet aggregation compared to other sulfated polysaccharides. As such, it is an attractive tool for studying molecular and cellular responses in activated platelets. The heterogeneous structure, however, poses a problem in such applications. This study describes the...
Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. We previously showed that interleukin-1 (IL-1α) counteracts TGF-β-stimulated CTGF mRNA and prote...