Carmen Wheatley

Carmen Wheatley
University of Oxford St Catherine's College

D.Phil OXON

About

20
Publications
10,425
Reads
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107
Citations
Introduction
Current projects: 1. The effects of cobalamin in sepsis. Collaborating with Mauro Perretti's Biochemical Pharmacology lab, at The William Harvey institute, London, UK, with a view to conducting clinical trials. 2. Developing and trialling a novel eczema cream. 3. Completing a review of cobalamin and cancer, and a related theory paper. 4. Future collaboration on cobalamin and malaria planned with Dr Robyn van Zyl, University of Witwatersrand.

Publications

Publications (20)
Poster
Full-text available
This is a link to a recent interview arguing the case -in language aimed as much at the general public- for the use of both liposomal and parenteral high dose methylcobalamin for Covid prophylaxis and ARDS ttreatment.
Article
Full-text available
High dose parenteral Cobalamin as prophylaxis and treatment for Covid19 and Sepsis/ARDS. This is a pop article, not a paper.
Preprint
Full-text available
A SAFE AND EFFICACIOUS PROPHYLACTIC /TREATMENT FOR COVID19, TO PREVENT AND TREAT ACUTE RESPIRATORY DISTRESS SYNDROME, ALREADY EXISTS: RESPECTIVELY using HIGH DOSE IM AND IV METHYLCOBALAMIN FORM OF VITAMIN B12. The hydroxocobalamin form of B12 has been used in ICUs in France, Italy and China for nearly 70 years, as the anti-CN antidote of choice. I...
Research Proposal
Full-text available
Corona Virus/ Covid19/ SARS-2-Covid has ground the world to a halt and is showing up the deficiencies of our health care systems everywhere, and the vulnerability of the global population. When Covid/19 kills, it kills through Acute Respiratory Distress Syndrome/ ARDS which, in effect, kills by a sepsis related process. Thus ARDS is fuelled by the...
Preprint
Full-text available
CORONA VIRUS/Covid/19 ADULT RESPIRATORY DISTRESS SYNDROME ************************************************* HIGH DOSE IV METHYLCOBALAMIN IS A SAFE & COST EFFECTIVE RESCUE TREATMENT for ARDS.
Research
THIS IS A DRAFT CLINICAL TRIAL PROTOCOL[WORK IN PROGRESS ]BUT APPLICABLE NOW, FOR ARDS IN COVID.19, ON ACCOUNT OF THE EXCEPTIONAL PHARMACOLOGICAL CLINICAL SAFETY PROFILE OF HIGH DOSE IV COBALAMIN, ALREADY USED IN THE CLINIC IN DIVERSE EXTREME SCENARIOS -CN, H2S, N2O POISONING, REFRACTORY VASOPLEGIC SYNDROME IN CARDIAC AND LIVER SURGERY. FROM THE RE...
Research Proposal
Full-text available
Corona Virus/ Covid-19/ SARS-Cov-2 has ground the world to a halt and is showing up the deficiencies of our health care systems everywhere, and the vulnerability of the global population. When Covid-19 kills, it kills through Acute Respiratory Distress Syndrome/ ARDS which, in effect, kills by a sepsis related process. Thus ARDS is fuelled by the p...
Data
The Supplementary Data contains material, which casts further light on the immune response effects of treatment with HOCbl, and/or the thiol Cbls, during in vivo, experimental endotoxaemia. This material comprises blood analyses of circulating neutrophils/PMN, and of the adhesion molecule/complement receptor, CD11b, a marker of neutrophil activatio...
Article
Full-text available
Background. NOS/•NO inhibitors are potential therapeutics for sepsis, yet they increase clinical mortality. However, there has been no in vivo investigation of the (in vitro) •NO scavenger, cobalamin's (Cbl) endogenous effects on NOS/•NO/inflammatory mediators during the immune response to sepsis. Methods. We used quantitative polymerase chain reac...
Article
Full-text available
Mammalian nitric oxide synthases (NOS) are a source of the universal second messenger, and pivotal biochemical molecule, nitric oxide (. NO). NOS are assumed to function catalytically in a haem-centred manner, by analogy with cytochrome P450. Yet, they differ significantly. Cobalamin, vitamin B12, is believed to function almost solely as an . NO sc...
Patent
The present invention provides methods of treatment and uses of thiolatocobalamin compounds for diseases characterised by NOS depression, malfunction, or dysregulation, for example inflammation, the inflammatory phase of the immune response, SIRS/sepsis/septic, traumatic, anaphylactic shock, a bacterial, viral or parasitidal disease, cancer, sp...
Article
Full-text available
The up-regulation of transcobalamins [hitherto posited as indicating a central need for cobalamin (Cbl) in inflammation], whose expression, like inducible nitric oxide synthase (iNOS), is Sp1- and interferondependent, together with increased intracellular formation of glutathionylcobalamin (GSCbl), adenosylcobalamin (AdoCbl), methylcobalamin (MeCbl...
Article
Full-text available
Several mysteries surround the structure and function of the nitric oxide synthases (NOS). The NOS oxygenase domain structure is unusually open with a large area of solvent that could accommodate an unidentified ligand. The exact mechanism of the two-step five-electron monoxygenation of arginine to N(G)-hydroxy-L-arginine, thence to citrulline and...
Chapter
Full-text available
NO ABSTRACT: Case History of an exceptional survival of untreated Multiple Myeloma Stage 1.
Article
Full-text available
NO ABSTRACT: Introduction The aetiology of Multiple Myeloma is generally acknowledged as obscure. (1) The epidemiology presents a number of puzzles. Most cancers are the affliction of age. Myeloma is more remarkably so, with few cases under the age of 40, (0.3% under 30), 98% above this demarcation line and a median incidence age of 65 years. (2)...
Article
Full-text available
The adverse and contradictory results of recent intervention trials are little understood. The reason for this may be that the trials were designed on mistaken premises. The drugs-testing paradigm was adopted, and no consideration was given to the nature of nutrients. Nutrients do not act in isolation, unlike drugs. They are dependent on synthetic...
Article
Full-text available
Results from intervention trials of β-carotene, α-tocopherol, and vitamin A (eg, CARET and ATBC 1) have brought much adverse publicity for vitamins and nutritional supplements. Parties with a vested interest have jumped on board, clamouring for bans and legislation. But no one has questioned the fundamental premise of these trials—namely, that v...

Questions

Question (1)
Question
What is the genetic aberration in familial, paroxysmal atrial tachycardia, and who is undertaking (gene therapy) research in this area??

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Projects

Projects (7)
Project
To interest clinicians in using this safe, cheap and effective non-drug treatment to radically change the course of Covid and prevent ICU admissions and rescue patinets with Covid sepsis/ARDS. Please see my interview discussion of the subject at Lifesitenews.com "A promising treatment for COVID you've likely never heard of Cancer researcher Dr. Carmen Wheatley joins John-Henry Westen to discuss a safe and novel treatment for COVID: vitamin B-12."
Project
THE EFFECTS OF COBALAMIN ON THE IMMUNE RESPONSE I am currently completing a monograph length review, which includes much unknown in English material, the forgotten, or overlooked and "lost" -in foreign medical journals- divers nonstandard clinical uses of cobalamin, including the antiviral uses of parenteral cobalamin. This, incidentally, also makes a very strong case for the use of cobalamin not only in sepsis, but for Covid-19 sepsis/ARDS.