Carmen Patino-Alonso

• PhD Applied Multivariate Statistics
• Professor (Associate) at University of Salamanca

Effective leak detection in water distribution networks is essential to minimize water loss, reduce maintenance costs, and ensure sustainable resource management. This study introduces the Stochastic Early Leakage Detection System (SHIELDS), an innovative methodology employing Bayesian Networks (BNs) for probabilistic leak identification and locali...

Rainfall is probably the most uncertain natural variable. This research is mainly aimed to design an intelligent data-driven tool called Bayesian Stochastic Rainfall Generator (BSRG) for improving the rainfall forecast. There are several previous stochastic generators for rainfall data generation. However, there is not any designed through a Bayesi...

Sediment deposition at the bottom of artificial reservoirs has become a worldwide problem. This comprises a dual issue that is, in the first place, associated with the reduction in storage capacity and lifetime of large reservoirs. The second aspect comprises the threat that the sediment represents for the dam structure. This research is mainly aim...

Floods are probably the most hazardous global natural event as well as the main cause of human losses and economic damage. They are often hard to predict, but their consequences may be reduced by taking the right precautions. In this sense, hydraulic infrastructures, such as dams, are generally the most widely used management elements to significan...

Background Behavioral and substance addictions are prevalent health problems that, alongside obesity, are linked to reduced physical activity and increased sedentary time. Similarly, arterial stiffness and vascular aging are processes that begin gradually at an early age and are closely associated with morbidity and mortality from cardiovascular di...

Post-pregnancy breast cancer often carries a poor prognosis, posing a major clinical challenge. The increasing trend of later-life pregnancies exacerbates this risk, highlighting the need for effective chemoprevention strategies. Current options, limited to selective estrogen receptor modulators, aromatase inhibitors, or surgical procedures, offer...

Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex trait with a polygenic component that is mainly unidentified. We propose that levels of intermediate molecular phenotypes (IMPs) in the myocardium associated with histopathological damage could explain CD...

Given the increasing non-stationarity of hydrological processes largely due to Climate Change (CC), it is essential to create more accurate methods. The inherent spatiotemporal variability of hydrological processes reaches its maximum when it comes to rainfall process. Rainfall is typically divided up into events in hydrological studies, but this d...

The world currently faces significant hydrologic changes associated with global climate change, such as changes in precipitation patterns, rising surface temperature, and increases in the frequency and intensity of floods and droughts, which will affect the design capacity and operating characteristics of dams/reservoirs. This brings new challenges...

People living with dementia (PLWD) and their family caregivers report higher rates of having a sedentary lifestyle than their non-disabled peers do. This study analyzed the effectiveness of an intervention designed to increase physical activity among PLWD and their family caregivers in primary health care settings. A cluster-randomized multicenter...

The influence of dietary components on vascular dysfunction and aging is unclear. This study therefore aims to propose a model to predict the influence of macro and micronutrients on accelerated vascular aging in a Spanish population without previous cardiovascular disease. This cross-sectional study involved a total of 501 individuals aged between...

Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex disease whose polygenic component is mainly unidentified. We propose that levels of intermediate molecular phenotypes in the myocardium associated with histopathological damage could explain CDA susceptib...

Background The aim of this study was to analyze the association of physical activity and its intensity with arterial stiffness and vascular aging and differences by sex in a Spanish population with intermediate cardiovascular risk. Methods Cross-sectional study. A total of 2475 individuals aged 35–75 years participated in the study. Brachial–ankle...

Purpose This study examined the existence of different groups of attitudes toward sex trafficking in students from a bachelor’s degree programs in Social Education, Law, Psychology and Social Work of the University of Salamanca. Method It was investigated whether these groups could be characterized according to the age, sex, nationality, and acade...

Purpose To assess whether subjects with Philadelphia negative myeloproliferative neoplasms (Ph-MPNs) show differences in the presence of vascular, cardiac or renal target organ damage (TOD) and other vascular function parameters as compared to individuals without this condition. Methods An observational study was conducted. Fifty-seven subjects di...

The objectives of this study were to analyse the capacity of different anthropometric indices to predict vascular ageing and this association in Spanish adult population without cardiovascular disease. A total of 501 individuals without cardiovascular disease residing in the capital of Salamanca (Spain) were selected (mean age: 55.9 years, 50.3% wo...

Background: Vitamin D deficiency affects the general population and is very common among elderly Europeans. This study compared different supervised learning algorithms in a cohort of Spanish individuals aged 35–75 years to predict which anthropometric parameter was most strongly associated with vitamin D deficiency. Methods: A total of 501 partici...

Organizational excellence is critical towards the development of organizations and, considering organizations’ role in the modern world, for societies’ economic and social development. The ability of organizations to adapt and adjust to the contingencies of the change and recover the stability of organizational systems through organizations’ own dy...

Este trabajo examina la relación entre burnout y apoyo social percibido en una muestra de 801 maestros de Educación Primaria. Para ello se usa el Maslach Burnout Inventory (MBI) y el cuestionario Duke-UNC-11. El método estadístico empleado fue el análisis canónico de correspondencias, donde se seleccionó la combinación lineal de los factores del ap...

The aim of this study was to validate and analyze the psychometric properties of a Spanish version of the Sexual Trafficking Attitudes Scale towards women and girls (STAS). A sample of 204 students from the University of Salamanca (Spain) was used. The exploratory factor analysis and confirmatory factor analysis confirmed a multifactorial structure...

Aim: To evaluate the effectiveness of an intervention in primary health care designed to increase physical activity in people with dementia and their family caregivers. Methods: A cluster-randomized multicentre clinical trial was carried out. Participants: 140 people with dementia (median age 82 years;63.6% women) and 176 caregivers (median age 62...

Introduction: The aim of this work was to analyse the association of the retinal arteriolar calibre and the arteriole/venule index (AV index) with vascular ageing in a general population without previous cardiovascular disease. Materials and methods: Descriptive cross-sectional study. A total of 482 individuals without cardiovascular disease (me...

Objectives: Central blood pressure (BP) predicts mortality independent of office brachial BP. The aim was to describe reference values for central blood pressure and pulsatile hemodynamic parameters, and their relationship with cardiovascular risk factors in an adult Spanish population without cardiovascular disease. Methods: Cross-sectional stu...

Purpose To assess whether subjects with Philadelphia negative myeloproliferative neoplasms (Ph-MPNs) show differences in the presence of vascular, cardiac or renal target organ damage (TOD) and other vascular function parameters as compared to individuals without this condition. Methods An observational study was conducted. Fifty-seven subjects di...

Governments serve a variety of purposes, and where governments spend their money has always been of concern to society. In particular, spending on public education is of great interest. However, the volume of this information can be difficult to manage. Therefore, the purpose of this work is to compare the COSTATIS method and generalized Procrustes...

This contibution proposes a novel methodological framework for assessing temporal behaviour of a river basin at annual scale This is done through a hybrid approach by means of Bayeasian Causality and a Multivariate Linear Model This is mainly aimed to improve the analysis capacity and the knowledge over temporal hydrological records behaviour of a...

In recent decades, progress has been made in the ability to develop accurate hydrological models Among the various conceptual models developed in this period, Multivariate Statistical Analysis and Artificial Intelligence based models have been the most promising for simulating hydrologic processes The present work focuses on the application of gene...

This paper describes the joint development of two different methods for temporal riveŕs runoff assessment. This is performed through a hybrid approach by means of Multivariate General Linear Models (MGLM; inspired by MLR as a statistical method), and Causal Reasoning (CR; as non-linear ones). This innovative methodological approach, named Hybrid Ca...

Learning approaches are factors that contribute to sustainability education. Academic stress negatively affects students’ performances in the context of sustainability teaching. This study analyzed how deep and surface approaches could be related to coping with academic stress and gender. An online survey was completed by 1012 university students....

Introduction Little is known about the relationship between arterial stiffness and cardiovascular target organ damage (TOD) in the general population. The aim was to analyse the relationship between different measurements of arterial stiffness and TOD, in a general Spanish population without a history of cardiovascular event. Materials and methods...

Los conflictos armados, la pobreza, los altos índices de violencia y el desempleo incrementan los flujos migratorios a nivel mundial y con ello, la proliferación de las redes criminales. En este estudio teórico se discute la relación entre la trata sexual, el racismo y el colonialismo español, desde la óptica de los derechos humanos y de género. Es...

Aim This study assesses the effect of an intervention to reduce the disruptive behaviours (DB) presented by care recipient users of adult day care centres (ADCC), thereby reducing caregiver overload. While ADCC offer beneficial respite for family caregivers, the DB that many care recipients show promote resistance to attending these centres, which...

Introduction and objectives Our objective was to study the relationship of healthy vascular aging (HVA) with lifestyle and the components of metabolic syndrome. We also analyzed the differences between chronological age and heart age (HA) and vascular age (VA) in the Spanish adult population without cardiovascular disease. Methods This descriptive...

Resumen Introducción y objetivos Estudiar la relación del envejecimiento vascular saludable (EVS) con estilos de vida y componentes del síndrome metabólico y analizar las diferencias entre la edad del corazón (EC) y la edad vascular (EV) con la edad cronológica en población adulta española sin enfermedad cardiovascular. Métodos Estudio descriptiv...

Numerosos estudios han contribuido a impulsar la investigación sobre enfoques de aprendizaje en el ámbito universitario. El enfoque adoptado por los estudiantes frente a la realización de la tarea puede ser superficial o profundo y tiende a cambiar en función de diferentes variables contextuales. El objetivo principal de este trabajo fue estudiar e...

The objective of this study is to analyze the influence of adherence to the Mediterranean diet (MDA) and its components on early vascular aging (EVA) in a Spanish population sample free of cardiovascular disease and to analyze the differences by sex. Methods: We recruited 501 individuals aged 35-75 without cardiovascular disease by random samplin...

Nomophobia is a situational phobia leading to a deep, irrational, and disproportionate fear of not being able to use the smartphone. An instrumental study on the Spanish version of the Nomophobia Questionnaire (NMP-Q) was carried out. The objectives were: 1) To analyse its factor structure and reliability; 2) to test for the invariance of sex and a...

Objectives: To describe the prevalence of healthy vascular aging (HVA), normal vascular aging and early vascular aging (EVA) in a sample of Spanish population without cardiovascular disease. The relationship of vascular aging with lifestyle, cardiovascular risk factors, psychological and inflammatory risk factors is also analyzed. Methods: A tot...

The influence of vitamin intake on vascular function parameters in the Spanish general population has not been studied. The main objective of this study is to analyze the influence of vitamin intake on vascular function and as a secondary objective the adequacy of vitamin intake in a sample of the Spanish population without previous cardiovascular...

The concept of sustainability is assumed for this research from a temporal perspective. Rivers represent natural systems with an inherent internal memory on their runoff and, by extension, to their hydrological behavior, that should be identified, characterized and quantified. This memory is formally called temporal dependence and allows quantifyin...

Background and objectives: The examination of the fundus allows to evaluate retinal the microcirculation in vivo. We assess the reliability and validity of ALTAIR software, and to evaluate its clinical relevance by the association of thickness, area and length of the retinal vessels with other measures of vascular structure and function, target or...

Background and objective The estimation of cardiovascular risk (CVR) with scores at 30 years old has a special interest in reclassifying in a suitable way <60 year subjects with intermediate CVR. This study analyzes what percentage of patients with intermediate CVR included in the MARK study is reclassified by applying the 30-year Framingham score...

Objectives: To determine the association between home enteral nutrition (HEN) administration modality and its complications in patients. Methods: This is a prospective multicenter longitudinal study including 15 Spanish hospitals, from April 2015 to March 2017. A 4-month follow-up period was conducted for each patient by home visit. The study su...

Introduction and objectives: To describe, for the first time, reference values for the cardio-ankle vascular index (CAVI), brachial-ankle pulse wave velocity (BA-PWV), carotid-femoral pulse wave velocity (CF-PWV), and the central augmentation index and to establish their association with cardiovascular risk factors in the Spanish adult population...

Water quality is a sensitive topic of worldwide concern that is defined by a series of physical, chemical and biological characteristics. The complex nature for studying water quality requires finding simple models to identify the variables that influence it the most. Therefore, the use of multivariate analysis techniques will be of immense help to...

Resumen Introducción y objetivos Describir por primera vez valores de referencia del índice vascular corazón-tobillo (ICT), la velocidad de la onda de pulso brazo-tobillo (VOP-BT), la velocidad de la onda de pulso carótida-femoral (VOP-CF) y el índice de aumento central y establecer relación con factores de riesgo cardiovascular en población adult...

Introduction and objectives Certain lifestyle habits may influence aspects of sleep quality, such as insomnia. The main objective of the present study was to analyze the relationship of the presence of insomnia, with walking physical activity and diet quality in an adult population. Patients and methods A cross-sectional descriptive study was perf...

Background: Daily aerobic exercise such as healthy walking could have an immediate effect on parameters of arterial stiffness; however, there is little evidence in the diabetic population. Our aim, therefore, is to evaluate the association between healthy walking and acute effects on the parameters of arterial stiffness in subjects with type 2 dia...

Background and objective: The estimation of cardiovascular risk (CVR) with scores at 30 years old has a special interest in reclassifying in a suitable way <60 year subjects with intermediate CVR. This study analyzes what percentage of patients with intermediate CVR included in the MARK study is reclassified by applying the 30-year Framingham scor...

Background:: Regular physical activity is essential for metabolic control in type 2 diabetes mellitus. Aims:: The aim of this study was to assess the short and long-term impact of a multifactorial intervention on physical activity and clinically relevant biochemical parameters in patients with type 2 diabetes mellitus. Methods:: This randomise...

Show the learning results obtained by a simulation tool used by students of an online course on anesthesia techniques and regional analgesia guided by ultrasound. A satisfaction survey generated with a form of Google Forms was carried out in September 2018 with 14 questions related to the quality, ease and capacity of the learning obtained after th...

Background Obesity increases mortality, and is linked to cardiovascular diseases and metabolic syndrome (MetS). Therefore, the purpose of this study was to analyze the ability of different adiposity indices to identify subjects with MetS among people with intermediate cariovascular risk. Materials and methods The cross-sectional study involved 247...

Degree of agreement between the adiposity indices to identify subjects with MetS. Kappa index. (DOC)

The Mediterranean diet (MD) is recognized as one of the healthiest dietary patterns and has benefits such as improving glycaemic control among patients with type 2 diabetes (T2DM). Our aim is to assess the effectiveness of a multifactorial intervention to improve adherence to the MD, diet quality and biomedical parameters. The EMID study is a rando...

A body shape index (ABSI) has been introduced as a marker of the relationship between body composition and all-cause mortality. However, until now, the relationships between ABSI and vascular structure and function have not been evaluated. The aim of this study was to investigate the association of ABSI with vascular structure and function in Spani...

Introduction and objectives: Certain lifestyle habits may influence aspects of sleep quality, such as insomnia. The main objective of the present study was to analyze the relationship of the presence of insomnia, with walking physical activity and diet quality in an adult population. Patients and methods: A cross-sectional descriptive study was...

Several classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be...

This edited volume is composed of twenty-one chapters and covers topics such as digital skills, teaching-learning methodologies, innovative projects and proposals, and reflections on the Spanish University context.

Background: The validation of new blood pressure devices with easier use and more rapid data collection may facilitate the incorporation of these measures into clinical practice. We analyze the reliability and validity of Pulse Wave Analysis as reported by a novel wrist-worn device, easy and quick to use, comparing central and peripheral augmentat...

Background: Information and communication technologies are currently among the supporting elements that may contribute to improving health and changing lifestyles. Objective: The aim of this study was to evaluate the long-term effectiveness of adding an app to standardized counseling in order to increase physical activity (PA) and adherence to t...

Objective: To evaluate the postprandial effects of high and low glycaemic index (GI) breakfasts on cognitive performance in young, healthy adults. Methods: A crossover clinical trial including 40 young, healthy adults (aged 20–40 years, 50% females) recruited from primary healthcare centres in Salamanca, Spain. Verbal memory, phonological fluency,...

The data presented in this article are related to the research paper entitled “The biological age linked to oxidative stress modifies breast cancer aggressiveness” (M.M. Sáez-Freire, A. Blanco-Gómez, S. Castillo-Lluva, A. Gómez-Vecino, J.M. Galvis-Jiménez, C. Martín-Seisdedos, M. Isidoro-García, L. Hontecillas-Prieto, M.B. García-Cenador, F.J. Garc...

The new European training model has led to innovations in Higher Education as the incorporation of Information and Communication Technology (ICT) to learning processes. Each student learns in a different way and therefore the ways of studying are very relevant in the academic development. This fact has revealed the need for the use of ICT in the un...

The incidence of breast cancer increases with age until menopause, and breast cancer is more aggressive in younger women. The existence of epidemiological links between breast cancer and aging indicates that both processes share some common mechanisms of development. Oxidative stress is associated with both cancer susceptibility and aging. Here we...

Background: Evidence on the efficacy of smartphone applications (apps) for reducing body weight and other measurements of adiposity sustainably is not conclusive. Objective: To evaluate the effect of adding an app for 3 months to traditional counselling on physical activity (PA) and a heart-healthy diet for the modification of measurements of ad...

Aim: This study evaluates the effectiveness of a behavioural intervention program aimed at reducing the reluctance of dependent people to attend Adult Day Care Centres. We hope that reducing resistance will have a positive influence on the mental health of caregivers. Background: Care centres offer important relief and rest services for family c...

Recent studies have revealed that emotional competences are relevant to the student’s learning process and, more specifically, in the use of learning strategies (LSs). The aim of this study is twofold. First, we aim to analyze the relationship between perceived emotional intelligence (PEI) and LSs applying the scales TMMS-24 and Abridged ACRA to a...

Abstract Objective: Leucocyte count has been proposed as a marker for predicting cardiovascular risk and appearance of metabolic syndrome. However, few prospective studies have evaluated the relationship between these cells and earlier, subclinical, stages of disease. The aim of this study is to evaluate de relation between monocytes counts and...

Introduction New information and communication technologies (ICTs) may promote lifestyle changes, but no adequate evidence is available on their combined effect of ICTs with multifactorial interventions aimed at improving diet and increasing physical activity in patients with type 2 diabetes mellitus (DM2). The primary objective of this study is to...

Background The cardiovascular risk of obesity is potentially increased by arterial stiffness. Objective To assess the relationship of adiposity measures with arterial stiffness in Caucasian adults with intermediate cardiovascular risk. Setting Six Spanish health centres. Participants We enrolled 2354 adults (age range, 35–74 years; mean age, 61....

During the last years, the concept of learning styles has generated numerous questions in academic field. In spite of the great variety of instruments that exist, the Honey-Alonso Learning Styles Questionnaire (CHAEA) has been consolidated as one of the most used to know learning styles of Spanish-speaking students. In this paper, we analyse CHAEA...

This study aimed to evaluate the postprandial effects of high and low glycemic index (GI) breakfasts on vascular function. It was a crossover trial that included 40 young healthy adults (50% women), aged 20-40 years, who were recruited at primary care settings. They consumed three experimental breakfasts in randomized order, each one separated by a...

Background: Diet quality indices address the diet's complexity and are calculated by a combination of foods and/ or nutrients which together represent a dietary pattern. The current study analysed the relationship between the common carotid artery intima media thickness (cIMT), the presence of plaque and the carotid target organ damage (cTOD) with...

Background Effect of prediabetes and normal glucose on arterial stiffness remains controversial. The primary aim of this study was to investigate the relationship of fasting plasma glucose (FPG), postprandial glucose (PG) and glycosylated haemoglobin (HbA1c) with brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) in C...