Carmen Infante Garcia

Universidad de Cádiz | UCA · Department of Biomedicine, Biotechnology and Public Health

Background While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have described a close relationship between AD and T2D with clinical evidence showing that both diseases coexist. A hallmark pathologica...

Germinal matrix-intraventricular hemorrhage (GM-IVH) is the most frequent intracranial hemorrhage in the preterm infant (PT). Long-term GM-IVH-associated sequelae include cerebral palsy, sensory and motor impairment, learning disabilities, or neuropsychiatric disorders. The societal and health burden associated with GM-IVH is worsened by the fact t...

Alzheimer’s disease is the most common form of dementia, and epidemiological studies support that type 2 diabetes (T2D) is a major contributor. The relationship between both diseases and the fact that Alzheimer’s disease (AD) does not have a successful treatment support the study on antidiabetic drugs limiting or slowing down brain complications in...

Alzheimer’s disease (AD) is the most common cause of dementia. Epidemiological studies show the association between AD and type 2 diabetes (T2DM), although the mechanisms are not fully understood. Dietary habits and lifestyle, that are risk factors in both diseases, strongly modulate gut microbiota composition. Also, the brain-gut axis plays a rele...

The germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most devastating complications of prematurity. The short- and long-term neurodevelopmental consequences after severe GM-IVH are a major concern for neonatologists. These kids are at high risk of psychomotor alterations and cerebral palsy; however, therapeutic approaches are limi...

Background: Both Alzheimer's disease (AD) and type 2 diabetes (T2D) share common pathological features including inflammation, insulin signaling alterations, or vascular damage. AD has no successful treatment, and the close relationship between both diseases supports the study of antidiabetic drugs to limit or slow down brain pathology in AD. Empa...

The classic neuropathological features of Alzheimer's disease (AD) are accompanied by other complications, including alterations in adult cell proliferation and neurogenesis. Moreover, recent studies have shown that traditional markers of the neurogenic process, such as doublecortin (DCX), may also be expressed in CD8+ T cells and ionized calcium b...

Background: Diabetes is a risk factor for developing Alzheimer's disease (AD); however, the mechanism by which diabetes can promote AD pathology remains unknown. Diabetes results in diverse molecular changes in the brain, including dysregulation of glucose metabolism and loss of cerebrovascular homeostasis. Although these changes have been associa...

Diabetes mellitus is a chronic metabolic disease with a high prevalence in the Western population. It is characterized by pancreas failure to produce insulin, which involves high blood glucose levels. The two main forms of diabetes are type 1 and type 2 diabetes, which correspond with >85% of the cases. Diabetes shows several associated alterations...

Type 2 diabetes (T2D) is an important risk factor to suffer dementia, being Alzheimer’s disease (AD) as the most common form. Both AD and T2D are closely related to aging and with a growing elderly population it might be of relevance to explore new therapeutic approaches that may slow or prevent central complications associated with metabolic disor...

Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) remains a serious complication in the preterm newborn. The significant increase of survival rates in extremelye preterm newborns has also contributed to increase the absolute number of patients developing GMH-IVH. However, there are relatively few available animal models to understand...

Hypoxic-ischemic encephalopathy (HIE) is a severe neonatal complication responsible for ∼23% of all neonatal deaths. Also, 30–70% of these patients will suffer lifetime disabilities, including learning impairment, epilepsy or cerebral palsy. However, biomarkers for HIE screening, or monitoring disease progression are limited. Herein, we sought to e...

Background Adverse effects in diabetic mothers offspring (DMO) are a major concern of increasing incidence. Among these, chronic central complications in DMO remain poorly understood, and in extreme cases, diabetes can essentially function as a gestational brain insult. Nevertheless, therapeutic alternatives for DMO are limited. Methods Therefore,...

Alzheimer’s disease (AD) is the most common cause of dementia; however, available treatments have had limited success. Therefore AD patients are in tremendous need of new pharmacological approaches that may delay or slow the progression of the disease. In addition to the classical neuropathological features, immunological and inflammatory processes...

Diabetes mellitus (DM) is one of the most common chronic diseases nowadays, with a prevalence of 387 million diabetics worldwide. Type I diabetes (T1D) is the second most common cause of diabetes and it is characterized by the selective destruction of pancreatic β-cells, in most cases due to an autoimmune mechanism, causing an insulin deficit. Prev...

Prematurity is a worldwide health problem, with an increasing incidence of up to 10% around the world. In recent years we have improved the survival of premature infants, although the incidence of related diseases has also raised, including bronchopulmonary dysplasia or central nervous system related disorders. Among these, one of the most feared c...

Epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common causes of dementia. Due to the limited success of available treatments, AD patients are in a tremendous need of new therapeutic options. Natural p...

Metabolic disorders, including prediabetes and type 2 diabetes (T2D) are considered risk factors to suffer Alzheimer’s Disease (AD), the most common cause of dementia. In order to further understand this relationship, we have induced: 1) prediabetes in an Alzheimer’s mouse model (APP/PS1) by long-term high fat diet and 2) T2D by crossing APP/PS1 an...

Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Metabolic disorders and concretely type 2 diabetes mellitus (T2D) are risks factors to develop AD. Both, AD and T2D are chronic, age-related diseases. Therefore we have explored this relationship in an aged (36 weeks) mixed mouse, by crossing an AD model (APP/PS1 mice) and a T2D m...

Preterm birth (PTB) is defined as birth prior to 37 weeks of gestational age and affects over 10% of births worldwide. Also, the increase in the survival of the tiniest premature infants, has also raised the incidence of preterm-related pathologies. One of the most feared complications in PTB is the germinal matrix-intraventricular hemorrhage (IVH)...

Alzheimer’s disease (AD) and vascular dementia (VaD) are the most common forms of dementia, clinically characterized by cognitive decline. Whereas the ultimate causes remain largely unknown, many studies support the relationship between AD-VaD and metabolic disorders. Among these, diabetes mellitus (DM) seems to be of special relevance and it is a...

Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Neuropathological features include: 1) neurofibrillary tangles with abnormally phosphorylated tau protein, 2) senile plaques (SP), mainly composed of amyloid-beta peptide (Aβ), and 3)neuronal loss. Whereas aging remains the main risk factor to suffer dementia, hyperinsulinemia and...

Aging remains the main risk factor to suffer Alzheimer's disease (AD), though epidemiological studies also support that type 2 diabetes (T2D) is a major contributor. In order to explore the close relationship between both pathologies we have developed an animal model presenting both AD and T2D, by crossing APP/PS1 mice (AD model) with db/db mice (T...

Alzheimer's disease (AD) and vascular dementia (VaD) are the most common causes of dementia, and borderlines are blurred in many cases. Aging remains the main risk factor to suffer dementia; however, epidemiological studies reveal that diabetes may also predispose to suffer AD. In order to further study this relationship, we have induced hypoinsuli...

Type 2 diabetes (T2D) is an important risk factor for developing dementias, including Alzheimer's disease (AD). Hyperinsulinemia and glucose intolerance, as features of T2D, might increase the neurodegeneration process, synaptic loss and brain atrophy, leading to cognitive impairment observed in AD. Also, adult neurogenesis seems to be impaired in...

Diabetes mellitus (DM) is characterized by hiperglycemia, due insulin-producing β-cell loss or dysfunction within the pancreatic islets of Langerhans. Diabetes is established when glucose blood levels surpass ~250mg/dL. DM is a well known risk factor to develop some types of dementia, such as Alzheimer’s disease (AD) or vascular dementia, and exten...

Alzheimer’s disease (AD) is the most common cause of dementia worldwide and type 2 diabetes mellitus (T2D) increases the risk to develop AD in elderly people since both AD and T2D are closely related with aging. Among others, chronic inflammation and vascular injury associated with T2D, may contribute to AD pathogenesis. In order to further explore...

Alzheimer’s disease (AD) is the most common cause of dementia worldwide and whereas age remains the main risk facto to suffer AD, type 2 diabetes (T2D) is also a relevant risk factor to develop AD (Luchsinger et al, 2004). Besides it has also been pointed out that hyperinsulinemia and insulin resistance, observed before T2D onset, might be the init...