Carlos Eduardo Sequeiros Borja

Carlos Eduardo Sequeiros Borja
Adam Mickiewicz University | UAM · Institute of Molecular Biology and Biotechnology

Master of Science

About

13
Publications
1,542
Reads
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50
Citations
Introduction
Carlos Eduardo Sequeiros Borja currently works at the laboratory of Biomolecular Interactions and Transport (BIT), at the Faculty of Biology, Adam Mickiewicz University in Poznan. Carlos does research in Structural Biology and Bioinformatics. His most recent publication is 'Observed crowding effects on Mycobacterium tuberculosis 2-trans-enoyl-ACP (CoA) reductase enzyme activity are not due to excluded volume only.' http://labbit.eu/
Additional affiliations
February 2011 - February 2012
Fundacion Proinpa
Position
  • Research Assistant
Description
  • My job consisted in microbe's identification by PCR on soil and plant samples, detection of plant pathogens on soil and plant samples, plant tissue culture of Solanum commersonii and I also conducted a phylogeny research of Ralstonia solanacearum strains
Education
March 2015 - February 2017
Pontifícia Universidade Católica do Rio Grande do Sul
Field of study
  • Molecular and Cellular Biology
February 2005 - February 2011
University of San Simón
Field of study
  • Biology

Publications

Publications (13)
Article
Full-text available
Computational prediction has become an indispensable aid in the processes of engineering and designing proteins for various biotechnological applications. With the tremendous progress in more powerful computer hardware and more efficient algorithms, some of in silico tools and methods have started to apply the more realistic description of proteins...
Poster
Brief outline of the methodology to systematically detect transport events through tunnels and benchmark with different water models. Poster also explains how water can squeeze into narrow tunnels to reach the active site and vice versa. Also some results included from TransportTools.
Preprint
Full-text available
ABCG46 of the legume Medicago truncatula is an ABC-type plasma membrane transporter that selectively translocates endogenous phenylpropanoids from the biosynthetic pathway of the phytoalexin, medicarpin, namely 4-coumarate and liquiritigenin. To investigate molecular determinants of the observed substrate selectivity, we applied a combination of ph...
Preprint
Full-text available
ABCG46 of the legume Medicago truncatula is an ABC-type plasma membrane transporter that selectively translocates endogenous phenylpropanoids from the biosynthetic pathway of the phytoalexin, medicarpin, namely 4-coumarate and liquiritigenin. To investigate molecular determinants of the observed substrate selectivity, we applied a combination of ph...
Article
Full-text available
Information regarding pathways through voids in biomolecules and their roles in ligand transport is critical to our understanding of the function of many biomolecules. Recently, the advent of high-throughput molecular dynamics simulations has enabled the study of these pathways, and of rare transport events. However, the scale and intricacy of the...
Preprint
Full-text available
Information regarding pathways through voids in biomolecules and their roles in ligand transport is critical to our understanding of the function of many biomolecules. Recently, the advent of high-throughput molecular dynamics simulations has enabled the study of these pathways, and of rare transport events. However, the scale and intricacy of the...
Article
Full-text available
Progress in technology and algorithms throughout the past decade has transformed the field of protein design and engineering. Computational approaches have become well-engrained in the processes of tailoring proteins for various biotechnological applications. Many tools and methods are developed and upgraded each year to satisfy the increasing dema...
Article
Full-text available
Flexibility is a feature intimately related to protein function, since conformational changes can be used to describe environmental changes, chemical modifications, protein-protein and protein-ligand interactions. In this study, we have investigated the influence of the quaternary structure of 2-trans-enoyl-ACP (CoA) reductase or InhA, from Mycobac...
Article
Full-text available
The cellular milieu is a complex and crowded aqueous solution. Macromolecular crowding effects are commonly studied in vitro using crowding agents. The aim of the present study was to evaluate the effects, if any, of macromolecular synthetic crowding agents on the apparent steady-state kinetic parameters (Km, kcat, and kcat/Km) of Mycobacterium tub...
Conference Paper
Full-text available
Los microorganismos del suelo son los componentes vivos más importantes de este y son los responsables de mantener el suelo saludable y de sustentar la vida de plantas y animales. Un suelo fértil es aquel que contiene una reserva adecuada de compuestos orgánicos y minerales disponibles para la planta y una población microbiana que libere nutrientes...
Conference Paper
Full-text available
Situation of bacterial wilt in Bolivia and an alternative strategy to fight against this disease.

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