Carlos. Alberto. Rinaldi

Instituto Antártico Argentino | IAA · geologia

Thrombotic thrombocytopenic purpura (TTP) is a severe, life-threatening disease that needs urgent diagnosis and prompt therapeutic intervention. In pregnant women TTP may complicate the course of gestation putting mother and child at vital risk. Differential diagnosis with other obstetric and medical disorders may be difficult due to the overlap of...

Aims and methods: This study assessed incidence, predictive factors, and outcome of Epstein-Barr virus (EBV) DNAemia in 100 recipients of allogeneic hematopoietic stem cell transplant. A total of 68 patients received anti-thymocyte globulin before unrelated grafts. Results: Cumulative incidence of high-load EBV DNAemia defined by levels >10,000...

BACKGROUND: In the past two decades peripheral blood stem cells (PBSCs) have increasingly replaced marrow as stem cells source for allogeneic transplantation. The PBSC donation initially applied only to related donors; later, due to the safety of the procedure, it was extended to unrelated donors. STUDY DESIGN AND METHODS: We have retrospectively c...

Most of the adult patients with primary systemic CD30 (Ki-1)-positive anaplastic large cell lymphoma (ALCL) reported in the literature have been treated with combination chemotherapy (CHT), with only an occasional patient being autotransplanted, mostly after relapse. Here we report a series of 19 patients treated at our Institution with a sequentia...

El calentamiento clim ático que afectó a la Patagonia en el Pleistoceno tardío-Holoceno temprano produjo cambios en la morfología del paisaje, incluyendo la génesis, desarrollo y desintegración de grandes lagos al este de los Andes. Hasta entonces, los glaciares y sus morenas formaban diques naturales que embalsaron las aguas de deshielo y mantenía...

The climate warming that affected Patagonia region during late Pleistocene-early Holocene times produced changes in landscape morphology, including the formation, development, breakdown and disintegration of big lakes at the eastern side of Andes. Before these times, glaciers and their moraines formed natural dams that maintained a high water level...

Umbilical cord blood (UCB) is a source of hematopoietic progenitor cells and is used as an alternative to the bone marrow or peripheral blood for treatment of several onco-hematological diseases. Because of the limited number of CD34+ hematopoietic stem cells present in UCB units and of the elevated costs of cryopreservation, it is of paramount imp...

This report describes the development of a one-tube multiplex reverse transcriptase (RT)-PCR assay for the simultaneous detection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) in plasma samples. The assay was evaluated with two panels of HCV- and HIV-1-positive samples, as well as negative plasma specimens. Extraction and amplif...

Autologous stem cell transplantation (ASCT) is largely employed in primary resistant or recurrent Hodgkin's Lymphoma (HL), while its role early in the course of the disease is still controversial. Our purpose was to analyse the results of 51 high-risk HL patients autografted at our Institution and the role of possible prognostic risk factors for th...

Regardless the mobilization procedure used there is a great variability from patient to patient in the yield of CD34 collections for autologous transplantation. We analyzed retrospectively our non-Hodgkin's lymphoma survey of 60 patients harvested with G-CSF alone after a unique first line chemotherapy; 67% of patients harvested a sufficient number...

New outcrops of Hope Bay Formation and Larsen Basin rocks have been exposed by recent ice-retreat on Tabarin Peninsula, northern Antarctic Peninsula. Quartzose, very low-grade metasedimentary rocks, cropping out at Balegno Nunatak (63°2831[double prime or second]W) are assigned to the Permian52[double prime or second]S, 57°07W) closely resemble Low...

To obtain long-term engraftment and hematopoiesis in myeloablated patients, the cell population used for hematopoietic reconstitution should include a sufficient number of early pluripotent hematopoietic stem cells (HSCs), along with committed cells from the various lineages. For this purpose, the small subset of CD34+ cells purified from different...

A paleomagnetic study in Jurassic and Cretaceous rocks from the Cañadón Asfalto basin, central Patagonia, indicates the occurrence of about 25–30° clockwise rotation in Upper Jurassic–lowermost Cretaceous rocks, whereas the overlying mid-Cretaceous rocks do not show evidence of rotation. This constrains the tectonic rotation to be related to a majo...

Sedimentary cores from Mascardi Lake, as well as outcrops, have been studied to reconstruct late Pleistocene and Holocene environmental conditions in northern Patagonia, Argentina. The Mascardi Lake sequence is a key-site for understanding such conditions, providing evidences of ice retreat, volcanic activity and important sedimentation changes. A...

This study describes the multilineage differentiation pattern of purified CD34+ stem cells obtained from human umbilical cord blood. CD34+ cells were collected from 49 umbilical cord blood samples. Following immunomagnetic purification, cells were double stained with anti CD34 and CD71, CD61, CD7, CD19, CD33, CD36 and triple stained with anti CD34,...

Thirty-two patients with multiple myeloma (MM) were autografted in our Centre over a 3-year period. Twenty-three patients had a newly diagnosed MM submitted to one induction regimen and 9 had a refractory or relapsing disease treated with at least two different chemotherapy lines: 15 out of 32 patients were sensitive to conventional treatment. In 2...

The aim of the study was to retrospectively evaluate the outcome of patients with aggressive non-Hodgkin's lymphoma (NHL), undergoing autologous stem cell transplantation (ASCT) in first complete (CR) or partial (PR) remission, according to the age-adjusted International Prognostic Index (IPI). Fifty-two consecutive patients, aged less than 60 year...

La Meseta Formation is a discontinuity bounded sedimentary unit which crops out on Marambio (Seymour) and Cockburn islands, approximately 100 km SE of the northern tip of the Antarctic Peninsula. The base of this unit is a diachronous surface which intersects all other older units of the island. Along this surface the hiatus increases towards the W...

Treatment intensification with autologous bone marrow transplantation (ABMT) was administered to 37 cases of Hodgkin's and non-Hodgkin's lymphoma (HL and NHL) who were in complete or partial remission (CR or PR) after chemotherapy (MOPP/ABVD or F-MACHOP respectively) and to 12 cases of HL and NHL who were in relapse. ABMT treatment was BAVC for NHL...

Although a large amount of data is available on the effects of filgrastim (granulocyte colony-stimulating factor [G-CSF]) on the mobilization of stem cells in the circulation, data concerning its effects on bone marrow (BM) harvesting is scarce and controversial. We have designed a randomized trial comparing filgrastim-mobilized peripheral blood st...

Most of the adult patients with primary systemic CD30 (Ki-1)-positive anaplastic large cell lymphoma (ALCL) reported in the literature have been treated with combination chemotherapy (CHT), with only an occasional patient being autotransplanted, mostly after relapse. Here we report a series of 19 patients treated at our Institution with a sequentia...

Few series of adult patients with primary systemic CD30 (Ki-1)-positive anaplastic large cell lymphoma (ALCL) are reported in the literature; most of them have been treated with combination chemotherapy (CHT), with only an occasional patient being autotransplanted, mainly after relapsing. The remission rate ranges from 60% to 90%, but relapses are...

Bone marrow processing requires a first step of filtration to remove small clots, bone fragments, fat cells and fibrin followed by centrifugation to separate mononuclear cells (MNC). These procedures cause a significant loss of cells potentially including hematopoietic stem cells (HSC). We therefore analyzed the cell recovery and phenotype of vario...

We retrospectively analyzed the factors influencing the mononuclear cell (MNC) yield on bone marrow (BM) harvests in a cohort of 15 non-Hodgkin's lymphoma patients undergoing autologous bone marrow transplantation. All the patients were treated with the F-MACHOP regimen and four of them also received radiotherapy on bulky disease. Before harvesting...

During the austral summer of 1986,fieldwork on James Ross Island by the Instituto Antártico Argentino resulted in the discovery of the first remains of dinosaurs from the Antarctic continent. These consist of a partial skeleton and bony plates of an armoured ornithischian belonging to the Ankylosauria. The fossil material was found in marine sandy-...