Carlos L Pérez

• MD. MSc.
• Universidad de Ciencias Médicas de la Habana

The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16...

Objectives: ABCB1 gene polymorphisms can modify P-glycoprotein function with clinical consequences. Methods: The 3435C>T polymorphism prevalence was analyzed using oligonucleotide probes and next-generation sequencing in 421 unrelated healthy individuals living in Cuba. Data were stratified by gender, ethnic background and residence. The genotyp...

Introduction: NeuroEPO is a non-hematopoietic variant of human recombinant erythropoietin, which may have a hypoglycemic effect. Objectives: To evaluate the influence of NeuroEPO on glycemia in diabetic and non-diabetic rats. Material and Methods: The experiments were conducted in Wistar rats with streptozotocin-induced diabetes with and without in...

Clinical applications of glucocorticoids (GC) in Oncology are dependent on their pro-apoptotic action to treat lymphoproliferative cancers, and to alleviate side effects induced by chemotherapy and/or radiotherapy. However, the mechanism(s) by which GC may also promote tumor progression remains unclear. GC receptor (GR) knockdown decreases the anti...

Background: In recent years, cancer has become a noncommunicable disease with a high mortality in the world, constituting the second cause of death. Although it has a predominance of genetic abnormalities, molecular studies have shown that epigenetic alterations share a leading role in its development. Among the epigenetic drugs inhibiting deacetyl...

Introduction Neuroprotection is an essential purpose in the treatment of neurological disorders and several investigations have evaluated the usefulness of NeuroEPO in preclinical studies and clinical trials. Objective To evaluate the neuroprotective potential of NeuroEPO in neurological disorders. Material and Methods A systematic review of origin...

Introduction: Neuroprotection is an essential purpose in the treatment of neurological disorders and several investigations have evaluated the usefulness of NeuroEPO in preclinical studies and clinical trials. Objective: To evaluate the neuroprotective potential of NeuroEPO in neurological disorders. Material and Methods: A systematic review of ori...

Introduction: Extranodal Natural Killers/T Cell´s lymphomas are uncommon diseases with a higher incidence in the regions of East Asia and Central and South America and are associated with the Epstein-Barr virus. These neoplasms have a tendency to affect the facial midline, mainly the nasal and paranasal regions. These diseases develop an angiocentr...

Background Extranodal Natural Killers/T Cell´s lymphomas are uncommon diseases with tendency to affect the facial midline. Theses neoplasms develops an angiocentric grow patron with necrosis. It is endemic to East Asia and Central and South America and is associated with Epstein-Barr Virus. Case Here we present an Extranodal Natural Killers/T Cell...

Introduction: Strokes and neurodegenerative diseases are major global health problems. Not only because they cause high mortality and disability, but to the lack of effective therapies. NeuroEPO, a variant of recombinant human erythropoietin (rHu-EPO) with a low sialic acid content, has shown encouraging results as a potential neuroprotective agent...

Introducción: En Cuba antes de registrarse casos de la Covid-19 se elaboró un Plan de Prevención y Control y se conformó un Grupo de Trabajo para asesorar al Gobierno en el enfrentamiento a la pandemia con una participación crucial y cohesionada de la comunidad, los trabajadores de la salud y la comunidad científica del país. Objetivo: Explorar la...

Introduction: Strokes and neurodegenerative diseases are major global health problems, not only because they cause high mortality and disability, but due to the lack of effective therapies. NeuroEPO, a variant of recombinant human erythropoietin (rHu-EPO) with a low sialic acid content, has shown encouraging results as a potential neuroprotective a...

Introduction: Pregestational diabetes constitutes a reproductive risk which requires new treatment strategies. NeuroEPO, a variant of the recombinant human erythropoietin produced in Cuba, has neuroprotective and hypoglycemic effects which can be considered for the treatment of this entity. Objective: To evaluate the protective effect of NeuroEPO...

Introduction: pregestational diabetes constitutes a reproductive risk, which requires new treatment strategies. Considering that NeuroEPO, a variant of the recombinant human erythropoietin produced in Cuba, has neuroprotective and hypoglycemic effects, the aim was to evaluate the protective effect of NeuroEPO on the reproduction of diabetic rats. M...

Introduction: pregestational diabetes constitutes a reproductive risk, which requires new treatment strategies. Considering that NeuroEPO, a variant of the recombinant human erythropoietin produced in Cuba, has neuroprotective and hypoglycemic effects, the aim was to evaluate the protective effect of NeuroEPO on the reproduction of diabetic rats. M...

Introducción: La NeuroEPO es una variante no-hematopoyética de la eritropoyetina recombinante humana, que pudiera tener efecto hipoglicemiante. Objetivo: Evaluar la influencia de la NeuroEPO sobre la glicemia de ratas con diabetes mellitus y ratas no-diabéticas. Material y Métodos: Se realizaron experimentos en ratas Wistar con diabetes inducida...

Introducción: Cualquier estrategia diseñada para aumentar la percepción de riesgo involucra procesos de cambio o modificación de las actitudes subyacentes. Objetivo: Explorar las actitudes y percepciones de la población de La Habana sobre la COVID-19. Métodos: Estudio descriptivo transversal en una población de 2012 habaneros que, de forma anónima...

Introducción: Cualquier estrategia diseñada para aumentar la percepción de riesgo involucra procesos de cambio o modificación de las actitudes subyacentes. Objetivo: Explorar las actitudes y percepciones de la población de La Habana sobre la COVID-19. Métodos: Estudio descriptivo transversal en una población de 2012 habaneros que, de forma anónim...

Objetivo: Explorar sobre las actitudes y percepciones de la población de La Habana sobre la COVID-19. Material y métodos: Se realizó un estudio descriptivo transversal en una población de 2012 ciudadanos habaneros que, de forma anónima y voluntaria, respondieron un cuestionario en línea distribuido en redes sociales entre mayo y junio de 2021. Se e...

The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16...

The protective effect of the supplementation with an aqueous‐ethanolic extract obtained from Ulva lactuca (Delile) green seaweed on benzo[a] pyrene‐induced damage in mice was evaluated. Animals were treated with oral doses of U. lactuca extract (100 and 400 mg/kg) for 9 weeks. They were exposed to 50 mg/kg of oral doses of benzo(a)pyrene starting f...

Several factors could affect physiologic and blood biochemical variables in laboratory animals. Bearing this in mind, it is recommended to characterize the animal´s variables in each laboratory. The aim of this study was to evaluate the effect of diabetes and gestation on blood biochemical variables in Wistar rats. Female Wistar rats were randomly...

Obesity during pregnancy can affect not only women´s health, but also the health of the offspring. We evaluate blood biomarkers, and clinical development of 139 pregnant and their offspring. Obese pregnant shows increased levels of NO3/NO2, proteins and DNA oxidation. Likewise, pregnant with obesity has higher risk of diabetes, abortion, and offspr...

P-glycoprotein (P-gp) is a transmembrane active efflux pump for a variety of drugs and the most extensively studied ATP-binding cassette (ABC) coded by MDR1 gene. The importance of P-gp in drug-drug interactions is being identified. ABCB1 polymorphisms also contribute to variability in P-gp function. Single-nucleotide polymorphisms (SNPs) in MDR1 g...

Background: The aqueous extract of the Allophylus cominia (L) Sw (Sapindaceae) leaves has shown anti-diabetic, anti-obesity and anti-inflammatory properties. In the Caribbean region, it is typically used for the treatment of type-2 diabetes. Methods: Considering the herb–drug interaction, the aim of this study was to evaluate the potential effects...

The chemical composition and biological properties of Ulva fasciata aqueous-ethanolic extract were examined. Five components were identified in one fraction prepared from the extract by gas chromatography-mass spectrometry, and palmitic acid and its ethyl ester accounted for 76% of the total identified components. Furthermore, we assessed the extra...

Xanthium strumarium L. is a member of the Asteraceae commonly used in Cuba, mainly as diuretic. Some toxic properties of this plant have also been reported and, to date, very little is known about its genotoxic properties. The present work aims was to evaluate the potential cytotoxic and genotoxic risk of whole extract from Xanthium strumarium L. w...

Obesity during pregnancy affects both maternal and foetal lipid and lipoprotein levels, but our knowledge on oxidative stress biomarkers is limited. The aim of this study is to determine the redox status in obese and overweight mothers and it relationship with the health of the newborn. Observational, descriptive, prospective and longitudinal study...

One of the difficulties in the comparison of results between laboratories working with the comet assay is the great diversity of parameters used to express DNA damage and the lack of conversion factors between the majority of them. Here we report a scorer-independent conversion curve to transform the values of DNA damage reported in arbitrary units...