Carlos E. Medina-De la Garza

• Dr. med.
• Autonomous University of Nuevo León

Ticks and tick-borne diseases affect livestock productivity and cause significant economic losses. Therefore, surveillance of these pathogens and vectors is paramount to reducing these effects in livestock. This study aimed to identify Anaplasma marginale and Borrelia burgdorferi sensu lato in ticks collected from cattle. Molecular biology techniqu...

Diethylcarbamazine, the antiparasitic drug, also possesses anti-inflammatory and immunomodulatory activities. The anti-fibrotic activity of diethylcarbamazine makes it a potential candidate to treat coronavirus disease 2019 (COVID-19)-related pulmonary fibrosis. Experimental and clinical studies should assess this possible effect.

Simple Summary Mexico’s mosquito control program requires better tools for effective mosquito surveillance in dengue-endemic areas. Additionally, technology must be more available in order to gain a better understanding of the factors that condition the presence of mosquitoes in residential settings. This study is the first to report on the use of...

Some HIV-infection diagnostic guidelines and health care providers still rely on the ELISA-Western blot diagnostic algorithm. We present a near misdiagnosis case with discordant test results and a lack of proper counseling. We point out the need for an assertive update of health care providers on diagnostic HIV-tests

Lactobacillus reuteri is a Gram-positive bacterium and can convert glycerol into reuterin, a metabolite in hydrated form (3-hydroxypropionaldehyde) or dehydrated (acrolein) 1. Reuterin is a peptid with acidic-pH, water-soluble and produced by the biotransformation of glycerol to 1,3-propanodiol, catalyzed by coenzyme-B12 dependent dehydrate. This m...

Dr. Eusebio Guajardo Zambrano (1870-1938) graduated in Monterrey, Mexico in 1895 and received pediatrics training in the USA. He was professor of the School of Medicine of Nuevo León, and its director. He actively prevented the closing of the school and with his innovative view of medicine and medical education, provided a vision for the establishm...

It is esential to perform routine vaccination in this pandemic times, and be able to further create trust in vaccines by keeping ourselves informed about real adventages and possible issues in vaccination. We must also learn how to deal with vaccination hesitancy and consider it a real threat to global health.

Alzheimer’s Disease (AD) is the main cause of dementia worldwide. Inflammatory cytokines and chemokines are related to different stages of AD and may be related to the progression of the disease. A Case-control study of AD patients healthy, age and sex-matched controls was carried out at the University Hospital “Dr. José E. Gonzalez”, UANL. Cytokin...

Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans occurring in more than half of men aged over 50 years. Hormonal and genetic factors trigger AGA. Although genomic studies in follicle biopsies and cell cultures have suggested the involvement of BMP2, EphrinA3, PTGDS, PGD2, and AR, no integrative ana...

Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in th...

Mrs. A. was a 55-years-old woman with breast cancer and a history of adverse childhood experiences. She participated in a study with 30 sessions of hypnotherapy before and during medical treatment. The results showed clinical improvement in sleep quality, a decrease in depression and stress symptoms, as well as an increase in self-esteem and percei...

Background. Cancer is a chronic disease that significantly affects the quality of life of patients who suffer from it, because they must face stressful situations, including their diagnosis, surgical procedures, and the adverse effects of chemotherapy and radiotherapy. Objective. To evaluate the effects of hypnotherapy on breast cancer patients’...

This study evaluated the potential antimicrobial properties of a polyguanidine (CatDex) on two oral bacteria. Chlorhexidine gluconate 1340 μmoL L−1 (CHX 0.12%) was used as control. Streptococcus mutans (S. mutans) and Porphyromonas gingivalis (P. gingivalis) were grown in BHI media. Bacterial sensitivity and antimicrobial activity were determined b...

Introducción El Consentimiento Informado es un requisito indispensable de la Ética de la Investigación. Es un proceso porque se mantiene vigente y abierto durante todo el tiempo en una investigación y es una de las garantías del respeto a la autonomía de los participantes en un estudio clínico. Por su gran difusión, se acepta que la obligatoriedad...

Use of formaldehyde for tissue fixation is a worldwide standard. The evergrowing use of flurochrome-conjugated antibodies for diagnostic immunofluorescence of autoimmune and neoplastic diseases demands high levels of sensibility and specificity, for histopathological analysis will determine not only diagnosis but staging and further therapeutics. I...

Introduction: Epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) play an important role in extracellular matrix mineralization, a complex process required for proper bone regeneration, one of the biggest challenges in dentistry. The purpose of this study was to evaluate the osteogenic potential of EGF and bFGF on dental pulp s...

Objective To describe the blood feeding behavior of mosquitoes in Mexico, in order to understand host–vector relationships and dynamics of disease transmission.Methods From September 2012 to November 2012 and in November 2013, 911 blood fed Cx. quinquefasciatus mosquitoes were collected with aspirators inside houses in Chetumal and Cancun. Blood me...

Lactic acid bacteria (LAB) are well known for their beneficial effects on human health in the intestine and immune system; however, there are few studies on the impact they can generate in oral health. The aim of this study was to test and compare in vitro antimicrobial activity of L. reuteri on pathogenic bacteria involved in the formation of dent...

Dengue cases occur frequently at Nuevo Leon, Mexico, where Aedes aegypti (L.) and Ae. albopictus (Skuse) are present. Ae. albopictus is considered the second vector of dengue. Because it bites humans outdoors during the day, the mosquito plays an important role in transmission of dengue virus (DENV). However, no previous studies at Nuevo Leon indic...

We tested whether diethylcarbamazine (DEC) or ivermectin (IVM), both antiparasitic drugs with reported immunomodulatory properties, were able to affect the immune system to potentiate host defense mechanisms and protect against actinomycetoma in a mouse model. Male BALB/c mice of 10-12weeks of age were injected with either Nocardia brasiliensis or...

Objective: To determine biofilm formation of Streptococcus mutans UA 159 in the presence of Lactobacillus acidophilus CO14919 on hydroxyapatite discs and tooth enamel. Method: Streptococcus mutans was cultured on BHI 159 AU (Brain Heart Infusion) and Lactobacillus acidophilus in infusion CO14919 MRS. Artificial saliva was prepared to mount the...

Sensitivity of monitoring Aedes aegypti (L.) populations was determined to identify the distribution of dengue virus (DENV) during epidemics in Quintana Roo. From September to November 2012, we used a motorized aspirator to collect 2,144 female Ae. aegypti from 569 homes. These were grouped into 220 to use semi-nested RT-PCR for DENV, and positive...

Objective: The human dental pulp is a major reservoir of stem cells (DPSCs) often are isolated using plastic adherence, however, the purity of the population is low, affecting its differentiation potential. The aim of the study was to isolate and cultivate a homogeneous population of DPSCs premolar tooth using Endoglin CD105 magnetic microbeads and...

Objective: The antigen SSEA-4 (Specific Stage Embryonic Antigen) is present primarily in embryonic stem cells and also during the blastocyst stage, and can be identified in certain populations of adult stem cells as is the case of the dental pulp from human deciduous teeth. The goal of this study is the use of magnetic cell separation technology...

Objective: The study was made in order to compare and evaluate "in vitro" antimicrobial effect of the lactic acid bacterium Lactobacillus reuteri as a probiotic, it is used in various products of daily life. The principal goal of this work was to determine the optimal concentration of L. reuteri capable of inhibiting the growth of bacteria select...

Progressive hemifacial atrophy or Parry-Romberg Syndrome (PRS) is a rare, acquired, progressive dysplasia of subcutaneous tissue and bone characterized by unilateral facial involvement. Its etiology is unknown, but theories about its pathogenesis include infectious, degenerative, autoimmune, and traumatic causes among others. The causal relationshi...

Traditionally the major risk environment for transmission of dengue virus has been assumed to be households. In Mexico, dengue outbreaks continue year after year despite intense control efforts. Nonresidential sites (public and private spaces) infested with Aedes aegypti (L.) were evaluated. In total, 141 nonresidential sites were sampled for the p...

SUMMARY Weekly data from 7 years (2004-2010) of primary-care counts of acute respiratory illnesses (ARIs) and local weather readings were used to adjust a multivariate time-series vector error correction model with covariates (VECMX). Weather variables were included through a partial least squares index that consisted of weekly minimum temperature...

Serology of West Nile virus vectors and non-human reservoirs was surveyed at Acapulco, Jose Azueta, and Ometepec, three Pacific Coast localities of Guerrero State, Mexico. The objectives of this study were to use enzyme-linked immnosorbent assay (ELISA) to assess West Nile virus antibodies of bird and equine serum samples and use reverse transcript...

Objective: Potent cytotoxic properties of CatDex, a poly-cationic macro molecule, has previously been demonstrated in tumor cell cultures. The present study investigates the antimicrobial properties of CatDex tested on two oral bacteria, S. mutans UA130 and P. gingivalis W83. Method: CatDex was prepared as described previously. The antimicrob...

In October 2011, the State Health Department announced that several laboratory-confirmed cases of dengue had occurred among residents in two neighborhoods of Benito Juarez, Quintana Roo State, Mexico. To identify the dengue virus serotype(s) temporally and spatially associated with the cases, entomologic-based virus surveillance was initiated i...

Secondary dengue virus infections are a major risk for developing dengue hemorrhagic fever. Recent exposure to infectious bites of Aedes aegypti (L.) females in previously diagnosed dengue cases fulfills the epidemiological model of dengue hemorrhagic fever. A study was comprised of 357 (89.2%) dengue and 43 (10.8%) dengue hemorrhagic fever cases c...

Este artículo está dedicado a la memoria de nuestro colega Prof. Dr. José Wilfrido Bustos Aldana (1933-1999). Recipiendario de la medalla Bernhard Nocht y la venera Gonzalitos. Médico, Parasitólogo, Maestro y Amigo. PALABRAS CLAVE: Fritz Schaudinn, proto-zoología, protistología, Treponema pallidum, México. Resumen Fritz Schaudinn fue un protozoolog...

Diethylcarbamazine (DEC) is an anthelmintic piperazine derivative drug with putative immunomodulating properties, including increased platelet and granulocyte adhesion to parasites and enhanced production of cytokines. To further analyse these properties in a well-established animal model, we evaluated the effect of DEC on antibody, cellular cytoki...

Como consecuencia del crecimiento poblacional mundial y del aumento de la expectativa de vida, el mundo enfrenta ahora el nuevo reto demográfico del envejecimiento global, donde poblaciones y comunidades aumentan el número de sus miembros que alcanzan una mayor edad. Este fenómeno no es nuevo, pero es ahora cuando muestra su significado y posibles...

La historia de la medicina: asignatura interdependiente Desde los inicios de la educación médica formal, existe cierta controversia acerca de si la historia de ésta ciencia, deba ser enseñada en el ámbito de las escuelas y facultades...

Resumen La resistencia a los antibióticos se ha convertido en uno de los principales problemas de salud. El combatir a los organismos patógenos con terapias combinadas que involucren la participación del sistema inmune y de fármacos antimicrobianos, representa un modelo exitoso para el tratamiento de enfermedades infecciosas agudas y crónicas. La p...

Resumen La resistencia a los antibióticos se ha convertido en uno de los principales problemas de salud. El combatir a los organismos patógenos con terapias combinadas que involu-cren la participación del sistema inmune y de fármacos antimicrobianos, representa un modelo exitoso para el tratamiento de enfermedades infecciosas agudas y crónicas. La...

La Facultad de Medicina de la Universidad Autónoma de Nuevo León tiene su origen en la Escuela de Medicina y Farmacia, anexa al Colegio Civil, fundada el 30 de octubre de 1859 por el doctor José Eleuterio González Mendoza, forjador de las instituciones médicas de Nuevo León durante el siglo XIX. El archivo histórico de la Facultad resguarda entre s...

The purpose of this study was to identify the effect of pentoxifylline on the urinary protein excretion profile in type 2 diabetic patients. 40 type 2 nonhypertensive diabetic patients were randomly allocated to receive either pentoxifylline 400 mg t.i.d. or placebo daily for 16 weeks. Eligible subjects were those with urinary albumin excretion bet...

Aims: The purpose of this study was to identify the effect of pentoxifylline on the urinary protein excretion profile in type 2 diabetic patients. Methods: 40 type 2 nonhypertensive diabetic patients were randomly allocated to receive either pentoxifylline 400 mg t.i.d. or placebo daily for 16 weeks. Eligible subjects were those with urinary albumi...

Durante las últimas tres décadas el surgimiento de agentes patógenos desconocidos, como el virus de Ébola, que tiene letalidad incluso del 90%, o el Coronavirus, causante del síndrome respiratorio agudo severo (SARS), ha dado lugar al concepto de las enfermeda-des infecciosas emergentes, el cual ilustra una faceta de la repercusión de todas las act...

Jesús Malacara Muñiz. Introducción a la medicina. Manual de teoría. México: El manual moderno, 2005. 180 pp. ISBN 970-729-181-8 Para aquellos que desean iniciarse en el estudio de la medicina, son escasos los textos introductorios que expliquen, de forma sencilla y breve, algunos de los aspectos más importantes a considerar y que describan también...

Chronic exposure to toxicants alters immune function that can affect the ability of the host to mount a response to infection. Giardiasis is a gastrointestinal disease in which subtle alteration in immunity of the host can transform the normal acute infection into a chronic one. In this work we used a murine giardiasis model to evaluate the effect...

ABSTRACT Background: Demodex folliculorum and Demodex brevis are the most pervasive ectoparasites of man. Its prevalence is described ranging from 0 to 100% in different human populations. Objective: To determine prevalence of infestation by Demodex in our community. Material and methods: We conducted in Monterrey a survey in 315 individuals, with...

La creación artística y literaria parece lejana del arte médico y del ejercicio de la medicina. Sin embargo, es interesante observar y disfrutar la abundante obra literaria de colegas del pasado y contemporáneos. Médicos que en el arte de la escritura encontraron no sólo una forma de expresar sus más íntimos pensamientos sino también la manera de g...

Fernando Martínez Cortés. Ciencia y humanismo al servicio del enfermo. 2ª ed. México: El Manual Moderno, 2003, 86 pp. ISBN: 68-426-025-0. Este libro muestra la brevedad de un texto escrito por alguien que sabe lo que quiere decir, y lo dice. Esto último no es una perogrullada: en esta época posmoderna, en que el redescubrimiento del hilo negro pas...

Human toxoplasmosis has worldwide distribution and its prevalence depends upon climatic, geographic, hygienic and cultural factors. Objectives: To know the toxoplasmosis seroprevalence among adult population from 18 to 45 years old and to know and to analyze by a questionnaire the ranking of risk factors of toxoplasmosis acquisition among those peo...

La toxoplasmosis humana es una infección de distribución mundial, cuya prevalencia es variable dependiendo de factores climatológicos higiénicos y culturales. Objetivos: conocer la seroprevalencia de toxoplasmosis en población adulta del rango muestral de 18 a 45 años de edad y conocer mediante la aplicación de un análisis de un cuestionario de jer...

Enhanced in vitro cytokine production by Diethylcarbamazine: proposal for a mechanism of action. EditRe-order section IV Latin American Congress of Immunology. XI Mexican Congress of Immunology. March 3-7, 1996 Zacatecas, Zac, México. (Abstract).

Extravasation of host's leukocytes from blood vessels into inflammatory tissues represents a prerequisite for a subsequent interaction with invaded parasites. The migratory responses of eosinophilic and neutrophilic granulocytes in the polar forms of the filarial infection onchocerciasis were investigated. The hyporeactive, generalized form, the ch...

Identification and quantification of eosinophilic granulocytes are commonly performed indirectly by total leukocyte count and white cell differentiation in smears or cytocentrifuge preparations. Using a combination of four dyes, phloxine, Biebrich scarlet, methylene blue, and crystal violet, at 50-800 micrograms/ml, we have substantially improved a...

Three recently introduced anthelmintic agents, the macrocyclic lactone, ivermectin, the amoscanate derivative CGP 6140 and the benzothiazole compound CGP 20376, were investigated for their in vitro modulatory effects on eosinophilic effector cells. The investigation comprised studies on the generation of the toxic oxygen intermediates superoxide an...

Adherence of eosinophilic granulocytes from patients with onchocerciasis to microfilariae (Mf), third (L3) and fourth (L4) stage larvae of Onchocerca volvulus was studied in vitro. Native and heat-inactivated sera from patients with onchocerciasis (OS), from endemic controls without signs of the disease (ECS), from healthy Caucasians (NS) or foetal...

The adherence and cytotoxicity of granulocytes to microfilariae of Onchocerca volvulus were examined in vitro. Reactivity and modulation by diethylcarbamazine of isolated eosinophilic and neutrophilic granulocytes from patients with generalized and chronic hyper-reactive onchocerciasis (sowda or localized form) from endemic foci in Liberia were eva...

Studies on the metabolism of human eosinophils and their interaction with helminthic parasites have been hampered by the difficulty in obtaining these granulocytes in sufficient purity and quantity. In this report, we describe for the first time the application of the density medium Nycodenz for the purification of eosinophils from peripheral blood...

Microfilariae of O. volvulus were purified from dissected nodules by centrifugation on discontinuous Percoll density gradients. Nodules were used freshly or after cryopreservation in liquid nitrogen. Highly purified and motile microfilariae were recovered from a layer of a density of 1.090 g/ml. The isolated microfilariae retained their motility up...