
Carlos Cabal MirabalUniversity of Havana · Facultad de Física
Carlos Cabal Mirabal
Professor
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20
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Introduction
MRI physics, hardware and applications
Publications
Publications (20)
The Three Sites Exchange Model (3SEM) was properly used to describe Proton (¹H) Magnetic Relaxation Dispersion (¹HMRD) in intracellular samples of hemoglobin A (HbA) and hemoglobin S (HbS) at 310 K. The HbA and HbS samples were obtained from whole blood of voluntary donors and patients, respectively, and processed by classical methods (centrifugati...
Palabras clave física; medicina; tercera revolución en la biología; convergencia tecnológica R E S U M E N Las razones por las que la medicina y la biotecnología son de importancia fundamental en Cuba constituyen objeto de debate. Las causas sociales, económicas e históricas se pre-sentan divididas en los períodos colonial, neocolonial y revolucion...
This chapter sets out the most promising modern directions of research in the field of magnetic resonance imaging. These include multinuclear studies aimed at the exploration of magnetic resonance (MR) image contrast induced by exogeneous (fluorine-19, hyperpolarized noble gases) and “built-in” (phosphorus-31, sodium-23) contrast agents for potenti...
Previous works showed a significant increase in the rotational correlation time of the water bound to the hemoglobin S during the aggregation process under sickle cell disease. In this case, the contribution of "Curie-Spin" relaxation mechanism to proton relaxation may be expected. The Curie-Spin relaxation mechanism has been well described theoret...
In the present work the model of the dynamics insulin-glucose is indicated for both a healthy person and a patient who has already contracted diabetes; the different types of diabetes are indicated as well as the symptoms that characterize it. It presents the model corresponding to the process of regeneration of diabetic foot tissues, distinguishin...
The contemporary set of biophysical and biochemical tools posses a lot of possible ways to study protein aggregation. The magnetic resonance methods such as NMR and EPR are prominent techniques that allow the determination of parameters of structure and dynamics of biomolecular systems under native solution conditions. They usually utilize signals...
The potentials of the magnetic resonance (MR) methods in the research of biomedical systems have been demonstrated during the 70 years of its existence. It is presented that the Cuban experience in quantitative magnetic resonance associated with molecular, preclinical and clinical studies of significant diseases and drugs development. MR "in vitro"...
Nature. This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 mo...
This study aims to assess serial and transverse quantitative Magnetic Resonance Imaging (MRI) in four rat groups using different doses of a formulation based on the combinations of IFN alpha 2b and gamma. Axial and coronal T1, T2 and Diffusion MRI images have been performed in order to follow up morphological and tissue texture changes in the rat b...
Previous works showed a significant increase in the rotational correlation time of the water bound to the hemoglobin S during the aggregation process under sickle cell disease. In this case, the contribution of “Curie-Spin” relaxation mechanism to proton relaxation may be expected. The Curie-Spin relaxation mechanism has been well described theoret...
Background:
Imaging the lower extremity reproducibly and accurately remains an elusive goal. This is particularly true in the high risk diabetic foot, where tissue loss, edema, and color changes are often concomitant. The purpose of this study was to evaluate the reproducibility of a novel and inexpensive stereotaxic frame in assessment of wound h...
Sickle cell disease (SCD) is a blood disorder, which has been studied using different research methods including linear birefringence, electronic microscopy, viscosity determination, Electron Paramagnetic Resonance and Nuclear Magnetic Resonance. We summarized in this paper the contribution of proton magnetic relaxation, to the study of the behavio...
Los peligros no se han de ver cuando se les tiene encima, sino cuando se pueden evitar. Lo primero en política es aclarar y prever.. . Ver después no vale, lo que vale es ver antes y estar preparados..." José Martí Pérez, 1889. Los desafíos que enfrentan la Física y los físicos cubanos, son parte de los retos que tienen la Ciencia y la sociedad cub...
Background: CIGB 814 is an Altered Peptide Ligand (APL) from a CD4 + T-cell epitope of human heat shock protein 60 (HSP60), an auto-antigen involved in the pathogenesis of rheumatoid arthritis (RA). It induced mechanisms associated with restoration of peripheral tolerance in preclinical studies. This clinical trial was conducted to assess safety an...
In this article, it is proposed to revise research approaches in the field of biological sciences in Cuba, according to the international trends of technological convergence. New views are debated concerning to the Third Revolution in Biology and advantages of its implementations. Fundamental aspects of the Cuban higher education system for scienti...
Se presenta la llamada Tercera Revolución en la Biología, consistente en la convergencia visceral entre las ciencias de la vida, la medicina, las ciencias básicas, las ingenierías y la computación. Se plantea la tesis de que las organizaciones que rigen la ciencia en Cuba, así como las instituciones de la Educación deben modificar su visión (incluy...