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Introduction
Skills and Expertise
Publications
Publications (622)
Rationale
Biologics are becoming increasingly important in the management of severe asthma. However, little is known about the systemic immunometabolic consequences of Th2 response blockage.
Objectives
To provide a better immunometabolic understanding of the effects of mepolizumab and omalizumab treatments by identifying potential biomarkers for m...
Importance
While access to psychotherapy has recently increased in the US, concern exists that recent gains may be unevenly distributed despite teletherapy expansion.
Objective
To characterize recent trends and patterns in outpatient psychotherapy by US adults.
Design, Setting, and Participants
This is a repeated cross-sectional study of psychoth...
Objective: The prevalence of depressive and anxiety disorders is higher in women than in men. In contrast, there is still no clear consensus on the existence of sex-related differences in the effectiveness of antidepressant treatments for these disorders. This real-world study used filled prescription sequences to compare antidepressant medications...
We examined the prospective associations between nicotine dependence and the likelihood of psychiatric and substance use disorders in the general adult population. Participants came from a nationally representative sample of US adults aged 18 years or older, who were interviewed 3 years apart in the National Epidemiologic Survey on Alcohol and Rela...
Optically dense clouds in the interstellar medium composed predominantly of molecular hydrogen, known as molecular clouds, are sensitive to energy injection in the form of photon absorption, cosmic-ray scattering, and dark matter (DM) scattering. The ionization rates in dense molecular clouds are heavily constrained by observations of abundances of...
Importance
Recognizing and providing services to individuals at highest risk for drug overdose are paramount to addressing the drug overdose crisis.
Objective
To examine receipt of medications for opioid use disorder (MOUD), naloxone, and behavioral health services in the 12 months after an index nonfatal drug overdose and the association between...
This cohort study investigates the risk of alcohol-related death among US health care workers compared with non–health care workers.
We tested how 5 simple variables, routinely collected in primary care (i.e., the 3 AUDIT-C items, age, and sex), could constitute a clinician-friendly risk calculator tool of the 3-year risk of several alcohol-related adverse outcomes (i.e., alcohol use disorder, withdrawal symptoms, occurrence of tremors or seizures, and alcohol related interperso...
Importance
Despite a federal declaration of a national child and adolescent mental health crisis in 2021, little is known about recent national trends in mental health impairment and outpatient mental health treatment of US children and adolescents.
Objective
To characterize trends in mental health impairment and outpatient mental health care amon...
Importance
Not all people who die by suicide have a psychiatric diagnosis; yet, little is known about the percentage and demographics of individuals with lifetime suicide attempts who are apparently psychiatrically healthy. If such suicide attempts are common, there are implications for suicide risk screening, research, policy, and nosology.
Objec...
Background:
In addition to the physical disease burden of the COVID-19 pandemic, concern exists over its adverse mental health effects.
Objective:
To characterize trends in psychological distress and outpatient mental health care among U.S. adults from 2018 to 2021 and to describe patterns of in-person, telephone, and video outpatient mental hea...
Introduction:
We examined the association between tobacco product use and health-related quality of life (HRQoL) among individuals with chronic obstructive pulmonary disease (COPD) in Waves 1-5 of the Population Assessment of Tobacco and Health (PATH) Study.
Methods:
Adults ≥40 years with an ever COPD diagnosis were included in cross-sectional (...
We outline the unique opportunities and challenges in the search for “ultraheavy” dark matter candidates with masses between roughly 10 TeV and the Planck scale m_{\rm pl} ≈ 10^{16} TeV. This mass range presents a wide and relatively unexplored dark matter parameter space, with a rich space of possible models and cosmic histories. We emphasize that...
Importance
Historically elevated risks of suicide among physicians may have declined in recent decades. Yet there remains a paucity of information concerning suicide risks among other health care workers.
Objective
To estimate risks of death by suicide among US health care workers.
Design, Setting, and Participants
Cohort study of a nationally re...
We demonstrate that ionization of H2 by dark matter in dense molecular clouds can provide strong constraints on the scattering strength of dark matter with electrons. Molecular clouds have high UV-optical attenuation, shielding them from ultraviolet and x-ray photons. Their chemical and thermal evolution are governed by low-energy cosmic rays. Dark...
Launched in 2018, the National Institutes of Health (NIH) Helping to End Addiction Long-term Initiative®, or NIH HEAL Initiative, is an aggressive effort to speed scientific solutions to stem this national public health crisis. Investments in new strategies to prevent opioid misuse are a key component of this comprehensive response to the opioid ep...
Background:
Despite an unprecedented increase in drug overdose deaths in the United States, the risks faced by U.S. health care workers, who often have access to controlled prescription drugs, are not known.
Objective:
To estimate risks for drug overdose death among health care workers relative to non-health care workers.
Design:
Prospective c...
Background
Allergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may precede or exacerbate other pathologies. In this regard, allergy has been associated to metabolic disorders and with a higher risk of cardiovascular disease, but the underlying mechanisms remain incompletely understood.
Method...
Introduction
To reduce Coronavirus Disease 2019 (COVID-19)-related mortality and morbidity, widely available oral COVID-19 treatments are urgently needed. Certain antidepressants, such as fluvoxamine or fluoxetine, may be beneficial against COVID-19.
Objectives
The main objective was two-fold: (i) to test the hypothesis that the prevalence of anti...
IceCube has recently reported the detection of $\sim 1-10 \,{\rm TeV}$ neutrinos from the nearby active galaxy, NGC 1068. The lack of TeV-scale emission from this source suggests that these neutrinos are generated in the dense corona that surrounds NGC 1068's supermassive black hole. In this paper, we present a physical model for this source, inclu...
Purpose
Depression is among the most common comorbid psychiatric disorders for patients with breast cancer. Depression can decrease patient quality of life and adversely affect cancer treatment if untreated. We sought to identify treatment barriers to women with breast cancer treated with psychotherapy for depression. Findings may help policy maker...
Importance:
Borderline personality disorder (BPD) is often accompanied by a history of high-risk sexual behavior and somatic comorbidities. Yet, these features are most often considered in isolation and little is known about their underlying developmental pathways. Life history theory, a leading framework in evolutionary developmental biology, can...
This cohort study examines the risk of drug overdose death in individuals who live alone.
Objective:
To estimate the prevalence of current DSM-5 disorders in children, ages 9 to 10 years, and their associations with sociodemographic and physical characteristics.
Method:
In this analysis of the Adolescent Brain Cognitive Development (ABCD) first wave study data, current child mental disorders were based on the computerized parent vers...
Importance:
Characterizing the extent and pattern of unmet needs for treatment of children with attention-deficit/hyperactivity disorder (ADHD) could help target efforts to improve access to ADHD medications and outpatient mental health care.
Objective:
To describe current ADHD medication use and lifetime outpatient mental health care among a la...
Importance
Federal emergency authorities were invoked during the COVID-19 pandemic to expand clinical telehealth for opioid use disorder (OUD).
Objective
To examine the association of the receipt of telehealth services and medications for OUD (MOUD) with fatal drug overdoses before and during the pandemic.
Design, Setting, and Participants
This c...
Objective:
Prior studies report conflicting results about the association between lithium use and all-cause mortality. In addition, data are scarce on this association among older adults with psychiatric disorders. In this report, we sought to examine the associations of lithium use with all-cause mortality and specific causes of death (i.e., due...
Background:
Smoking cannabis using a tobacco-derived cigar shell or wrap, called blunt smoking, exposes individuals to non-trivial amounts of nicotine. The extent smoking blunts impact the risk of initiating other tobacco products is not well understood. We investigated if past-year blunt smoking is related to the risk of initiating cigarettes, e-...
Importance:
Adults with psychotic disorders have high premature mortality, partly due to the high prevalence of smoking in this population. Yet recent data are lacking on tobacco product use among US adults with a history of psychosis.
Objective:
To examine the sociodemographic characteristics and behavioral health status; types of tobacco produ...
Background
Research on cigarettes and adult asthma offers mixed findings, perhaps due to overlap with chronic obstructive pulmonary disease (COPD) and inadequate adjustment for other smoke exposures. Associations between other tobacco products, including e-cigarettes, and asthma are also understudied.
Research question
Using Population Assessment...
The total extragalactic γ -ray flux provides a powerful probe into the origin and evolution of the highest energy processes in our universe. An important component of this emission is the isotropic γ -ray background (IGRB), composed of sources that cannot be individually resolved by current experiments. Previous studies have determined that the IGR...
Despite the clinical relevance of defense mechanisms, there are no published studies in nationally representative samples of their prevalence, correlates, and association with psychosocial functioning. We sought to estimate the prevalence and correlates of 12 defense mechanisms in the general adult population by approximating from items used to ass...
Purpose: Depression is one of the most common comorbid psychiatric disorders for patients with breast cancer and can decrease patient’s quality of life and negatively affect cancer treatment results if untreated Our goal was to identify treatment barriers to women with breast cancer who sought psychotherapy for depression Such findings may help pol...
Objective:
The authors aimed to compare national rates and patterns of use of outpatient mental health care among Hispanic, non-Hispanic Black, and non-Hispanic White individuals.
Methods:
Data from the 2018-2019 Medical Expenditure Panel Survey, a nationally representative survey of U.S. households, were analyzed, focusing on use of any outpati...
Importance:
Information about national substance use trends among youths and adults after mid-March 2020 is limited due to constraints on surveillance during the COVID-19 pandemic.
Objective:
To evaluate whether substance use prevalence in the early part of the pandemic (2020) differed from the prepandemic periods of 2018 to 2019 and 2016 to 201...
Objective: Sleep alterations have been suggested as a cause and consequence of psychiatric disorders. In this context, we evaluated the incidence of psychiatric disorders following sleep complaints in adults with major depressive episode (MDE). Methods: In a large, nationally representative 3-year prospective survey, the National Epidemiologic Surv...
Nuclear scattering events with large momentum transfer in atomic, molecular, or solid-state systems may result in electronic excitations. In the context of atomic scattering by dark matter (DM), this is known as the Migdal effect, but the same effect has also been studied in molecules in the chemistry and neutron scattering literature. Here we pres...
Importance
Evolving tobacco use patterns, including increasing electronic nicotine delivery systems (ENDS) use, warrant re-examination of the associations between tobacco use and oral health.
Objective
To examine associations between tobacco product use and incidence of adverse oral health outcomes.
Design, Setting, and Participants
This cohort s...
Objectives. To evaluate the association between living alone and suicide and how it varies across sociodemographic characteristics.
Methods. A nationally representative sample of adults from the 2008 American Community Survey (n = 3 310 000) was followed through 2019 for mortality. Cox models estimated hazard ratios of suicide across living arrange...
We demonstrate that ionization of $\text{H}_2$ by dark matter in dense molecular clouds can provide strong constraints on the scattering strength of dark matter with electrons. Molecular clouds have high UV-optical attenuation, shielding them from ultraviolet and X-ray photons. Their chemical and thermal evolution are governed by low-energy cosmic...
This Viewpoint discusses overlapping challenges to multiple stakeholders as telepsychiatry continues to expand.
Background: Although about half of patients do not respond to a first-line antidepressant medication, there is no consensus on the best second-line option. The aim of this nationwide population-based study was to rank antidepressants according to their relative acceptability (ie, efficacy and tolerability) using filled prescription sequences after...
To reduce Coronavirus Disease 2019 (COVID-19)-related mortality and morbidity, widely available oral COVID-19 treatments are urgently needed. Certain antidepressants, such as fluvoxamine or fluoxetine, may be beneficial against COVID-19. We included 388,945 adult inpatients who tested positive for SARS-CoV-2 at 36 AP–HP (Assistance Publique–Hôpitau...
Background:
We examined the association of non-cigarette tobacco use on chronic obstructive pulmonary disease (COPD) risk in the Population Assessment of Tobacco and Health (PATH) Study.
Methods:
There were 13,752 participants ≥ 40 years with Wave 1 (W1) data for prevalence analyses, including 6945 adults without COPD for incidence analyses; W1-...
Importance:
Federal emergency authorities were invoked during the COVID-19 pandemic to expand use of telehealth for new and continued care, including provision of medications for opioid use disorder (MOUD).
Objective:
To examine receipt of telehealth services, MOUD (methadone, buprenorphine, and extended-release [ER] naltrexone) receipt and rete...
Nuclear scattering events with large momentum transfer in atomic, molecular, or solid-state systems may result in electronic excitations. In the context of atomic scattering by dark matter (DM), this is known as the Migdal effect, but the same effect has also been studied in molecules in the chemistry and neutron scattering literature. Here we pres...
Objective: Multiple factors may influence the risk of recurrence or persistence of panic disorder, suggesting the need to combine them into an integrative model to develop more effective prevention strategies. In this report, we sought to build a comprehensive model of the 3-year risk of recurrence or persistence in individuals with panic disorder...
Allergic diseases are allergen-induced immunological disorders characterized by the development of type 2 immunity and IgE responses. The prevalence of allergic diseases has been on the rise alike cardiovascular disease (CVD), which affects arteries of different organs such as the heart, the kidney and the brain. The underlying cause of CVD is ofte...
Objective
Prior studies support that younger age of onset would be associated with poorer psychiatric and mental health outcomes for many psychiatric disorders. However, such relationship has never been examined for social anxiety disorder (SAD) in a nationally representative sample.
Methods
Using data from the second Wave of the National Epidemio...
In recent years, the sensitivity of optomechanical force sensors has improved leading to increased interest in using these devices as particle detectors. In this study we consider scenarios where dark matter with mass close to the Planck scale may be probed by a large array of optomechanical accelerometers. We motivate a macroscopic mechanical sear...
Prior research suggests that certain psychiatric symptoms could be associated with increased risk of death. However, it remains unclear whether this association could rely on all or specific symptoms. In this report, we used data from a multicenter 5-year prospective study (N = 641) of older adults with an ICD-10 diagnosis of schizophrenia, bipolar...
Allergic diseases are allergen-induced immunological disorders characterized by the development of type 2 immunity and IgE responses. The prevalence of allergic diseases has been on the rise alike cardiovascular disease (CVD), which affects arteries of different organs such as the heart, the kidney and the brain. The underlying cause of CVD is ofte...
Importance:
Tobacco use is highly concentrated in persons with mental illness.
Objectives:
To assess trends in past-month prevalence of cigarette smoking among adults with vs without past-year depression, substance use disorders (SUDs), or both, using nationally representative data.
Design, setting, and participants:
Exploratory, serial, cross...
Background:
Prior studies have not clearly established risk of cardiovascular disease (CVD) among smokers who switch to exclusive use of electronic nicotine delivery systems (ENDS). We compared cardiovascular disease incidence in combustible-tobacco users, those who transitioned to ENDS use, and those who quit tobacco with never tobacco users.
Me...
Aims
To examine the association between benzodiazepine receptor agonist (BZRA) use and mortality in patients hospitalised for coronavirus disease 2019 (COVID-19).
Methods
A multicentre observational study was performed at Greater Paris University hospitals. The sample involved 14 381 patients hospitalised for COVID-19. A total of 686 (4.8%) inpati...
The absence of clear signals from particle dark matter in direct detection experiments motivates new approaches in disparate regions of viable parameter space. In this Snowmass white paper, we outline the Windchime project, a program to build a large array of quantum-enhanced mechanical sensors. The ultimate aim is to build a detector capable of se...
We outline the unique opportunities and challenges in the search for "ultraheavy" dark matter candidates with masses between roughly $10~{\rm TeV}$ and the Planck scale $m_{\rm pl} \approx 10^{16}~{\rm TeV}$. This mass range presents a wide and relatively unexplored dark matter parameter space, with a rich space of possible models and cosmic histor...
Background
Most psychiatric disorders are associated with several risk factors, but a few underlying psychopathological dimensions account for the common co-occurrence of disorders. If these underlying psychopathological dimensions mediate associations of the risk factors with psychiatric disorders, it would support a trans-diagnostic orientation t...
Aim
To examine prevalence of mental health conditions and receipt of mental health care (MHC) by illicit lysergic acid diethylamide (LSD) use status (past-year; lifetime without-past-year; never) among young adults.
Design
Cross-sectional, annual survey data from 2015–2019 National Surveys on Drug Use and Health (NSDUH).
Setting
United States.
P...
Background
Prior research suggests that psychiatric disorders could be linked to increased mortality among patients with COVID-19. However, whether all or specific psychiatric disorders are intrinsic risk factors of death in COVID-19, or whether these associations reflect the greater prevalence of medical risk factors in people with psychiatric dis...
In recent years, the sensitivity of opto-mechanical force sensors has improved leading to increased interest in using these devices as particle detectors. In this study we consider scenarios where dark matter with mass close to the Planck scale may be probed by a large array of opto-mechanical accelerometers. We motivate a macroscopic mechanical se...
Importance
Cigarette smokers not planning to quit are often overlooked in population studies evaluating the risk-benefit potential of electronic nicotine delivery products (e-cigarettes).
Objective
To evaluate whether e-cigarette use is associated with discontinuing cigarette smoking among smokers who were initially never planning to quit.
Design...
(1) Background: Based on its antiviral activity, anti-inflammatory properties, and functional inhibition effects on the acid sphingomyelinase/ceramide system (FIASMA), we sought to examine the potential usefulness of the H1 antihistamine hydroxyzine in patients hospitalized for COVID-19. (2) Methods: In a multicenter observational study, we include...
Introduction
It remains unclear whether specific clinical factors contribute to heterogeneity in the timing of the onset of major depression.
Methods
Using a nationally representative US adult sample, the second wave of the National Epidemiologic Survey on Alcohol and Related Conditions, we compared the characteristics of 5 different groups of pat...
