Carlo Mosci

Carlo Mosci
Galliera Hospital | galliera · ocular oncology center

MD

About

48
Publications
4,510
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675
Citations
Citations since 2017
8 Research Items
504 Citations
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2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100

Publications

Publications (48)
Article
Background and aim of the study Mutations in the Gα-genes GNAQ and GNA11 are found in 85–90% of uveal melanomas (UM). Aim of the study is to understand whether the mutations in both genes differentially affect tumor characteristics and outcome and if so, to identify potential mechanisms. Methods We analyzed the association between GNAQ and GNA11 m...
Article
Full-text available
Uveal melanoma (UM) is a rare tumor of the eye that leads to deadly metastases in about half of the patients. ADAM10 correlates with c-Met expression in UM and high levels of both molecules are related to the development of metastases. MiR122 and miR144 modulate ADAM10 and c-Met expression in different settings. We hypothesized a potential onco-sup...
Article
Purpose: The aim of this study was to compare the functional and anatomical effectiveness of photodynamic therapy (PDT) versus proton beam therapy (PBT) in a real-life setting for the treatment of circumscribed choroidal hemangioma. Methods: A total of 191 patients with a diagnosis of circumscribed choroidal hemangioma and treated by PBT or PDT...
Article
Full-text available
Uveal melanoma (UM) is fatal in ~50% of patients as a result of disseminated disease. This study aims to externally validate the Liverpool Uveal Melanoma Prognosticator Online V3 (LUMPO3) to determine its reliability in predicting survival after treatment for choroidal melanoma when utilizing external data from other ocular oncology centers. Anonym...
Article
Full-text available
Relatively little is known about the genetic aberrations of conjunctival melanomas (CoM) and their correlation with clinical and histomorphological features as well as prognosis. The aim of this large collaborative multicentre study was to determine potential key biomarkers for metastatic risk and any druggable targets for high metastatic risk CoM....
Article
Full-text available
The most frequent site of ocular metastasis is the choroid. The occurrence of choroidal metastases has increased steadily due to the longer survival of metastatic patients and the improvement of diagnostic tools. Fundoscopy, ultrasonography, and fluorescein angiography are now complemented by indocyanine green angiography and optical coherence tomo...
Article
Uveal melanoma (UM) exhibits recurring chromosomal abnormalities and gene driver mutations, which are related to tumor evolution/progression. Almost half of the patients with UM develop distant metastases, predominantly to the liver, and so far there are no effective adjuvant therapies. An accurate UM genetic profile could assess the individual pat...
Article
Purpose: To report on the clinical characteristics and outcomes for patients with iris melanoma using proton therapy. Design: Retrospective study. Participants: One hundred seven patients with iris melanoma from 3 regional ophthalmologic centers. Methods: A retrospective study was conducted for iris melanoma patients from 3 regional ophthalm...
Article
Full-text available
Importance: Chromosome 6p amplification is associated with more benign behavior for uveal melanomas (UMs) with an otherwise high risk of metastasis conferred by chromosome 3 monosomy. Chromosome 6p contains several members of the B7 family of immune regulator genes, including butyrophilin-like 2 (BTNL2; OMIM, 606000), which is associated with pros...
Article
Purpose: In parapapillary melanoma patients, radiation-induced optic complications are frequent and visual acuity is often compromised. We investigated dose-effect relationships for the optic nerve with respect to visual acuity after proton therapy. Methods and materials: Of 5205 patients treated between 1991 and 2014, those treated using comput...
Article
Conventional melanoma serum biomarkers (S100 and lactate dehydrogenase [LDH]) perform poorly in patients with uveal melanoma, and the search for new biomarkers is needed. A high expression of the oncoprotein c-Met in primary uveal melanoma is associated with metastatic progression, and c-Met is released as a soluble ectodomain through ADAM10- and A...
Article
Background: Choroidal metastases (CM) are the most common malignant intraocular lesion observed in up to 4-12% of necropsy series of patients with solid cancer. The spectrum of presentations varies from prevalent CM in disseminated cancer to isolated CM. CM are responsible for visual deterioration. Depending on the primary cancer, estimated life e...
Article
Uveal melanoma is the most frequent primary tumor of the eye. It is molecularly clearly distinct from cutaneous melanoma and shows a different pattern of driver mutations. The influence of sunlight UV-exposure on the etiology of uveal melanoma is matter of debate. The recent identification of driver mutations in the promoter of the telomerase rever...
Article
Uveal melanoma (UM) is a rare ocular tumor that may lead to deadly metastases in 50% of patients. ADAM (a disintegrin and metalloproteinase)10, ADAM17 and the HGF receptor c-Met support invasiveness in different tumors. Here, we report that high ADAM10, MET and, to a lesser extent, ADAM17 gene expression correlate with poor progression-free surviva...
Article
To describe the dynamics of thickness and internal reflectivity after proton beam therapy (PBT) in uveal melanoma. One hundred and ninety-eight consecutive patients with choroidal or ciliary body melanoma treated by PBT were retrospectively considered. The post-PBT follow-up included ophthalmologic examination, retinography, and B and A modes of st...
Article
Full-text available
Background: Uveal melanoma is the most frequent primary tumour of the eye. It is molecularly clearly distinct from cutaneous melanoma and shows a different pattern of driver mutations. The influence of sunlight ultraviolet (UV) exposure on the aetiology of uveal melanoma is a matter of debate. The recent identification of driver mutations in the pr...
Article
Purpose: To evaluate survival and clinical outcome for patients with a large uveal melanoma treated by either enucleation or proton beam radiotherapy (PBRT). Procedures: This retrospective non-randomized study evaluated 132 consecutive patients with T3 and T4 choroidal melanoma classified according to TNM stage grouping. Results: Cumulative al...
Article
Full-text available
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of the patients, with a high lethality rate. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis of the gene expression profiles of primary human uveal me...
Data
Nuclear and cytoplasmic localization of mda-9/syntenin in uveal melanoma cell lines. Confocal microscopy of 92.1 and OMM2.5 cells stained for anti- mda-9/syntenin (green). Nuclei are stained with propidium iodide (red). Z-Y and Z-X sections through a 3-dimensional stack of confocal images show nuclear localization of mda-9/syntenin. (TIF)
Data
Nuclear and cytoplasmic localization of mda-9/syntenin in primary uveal melanomas. Immunohystochemistry of primary uveal melanoma specimens for mda-9/syntenin showed prevalent nuclear (panel A) or cytoplasmic localization (panel B) in different primary uveal melanomas. (TIF)
Data
Liver metastases develop earlier in NOD/SCIDIL2Rγ null mice (NOG) (upper panels), than in nude mice (lower panels). NOG and NU/NU mice were imaged with IVIS imaging system at different time points (15, 22 and 30 days) following spleen transplantation of 105 92.1 or Mel 270 transduced with a retroviral vector containing the luciferase gene. The sign...
Article
Full-text available
To evaluate the results of 15 years of experience with proton beam radiotherapy in the treatment of intraocular melanoma, and to determine univariate and multivariate risk factors for local failure, eye retention, and survival. A total of 368 cases of intraocular melanoma were treated with proton beam radiotherapy at Centre Lacassagne Cyclotron Bio...
Article
An on-line clinical folder has been optimised in order to manage all the available data coming from eight years of choroidal melanoma treatment with proton beams. The system allows the ophthalmologist, in a very easy way, to record and update, in different display sessions, the required data coming from the usual eye specialised visit, the tumour d...
Article
This paper presents the statistical results of the first nine years of activity on proton beam therapy for ocular melanoma treated by the Genoa Ocular Oncology Group. The sample is composed by 127 patients, coming from all Italy, treated at Centre Antoine Lacassagne of Nice. In the considered follow-up we have an average time of 21 ± 5 months with...
Article
The authors assessed the regression of choroidal tumors, following irradiation treatment, by means of B scan sonography (Sonomed B 3000). Thirty-two patients were studied, 12 of whom underwent brachytherapy with 106Ru plaques and 20 of whom were treated with accelerated protons. After a follow-up period of 12 months, the following was observed: red...
Chapter
Conservative treatment of ocular melanoma is used whenever possible.The Genoa ocular oncology study group (GOOSG) treated small and medium choroidal melanomas (thickness < 5 mm) with ruthenium plaque, except for tumours located near the optic disc. These and medium-large melanomas were treated with proton beam irradiation. We evalueted the results...
Article
We reviewed 55 consecutive cases of rhegmatogenous retinal detachment treated with pneumatic retinopexy as a primary procedure and followed up for a minimum of 1 year. 40 eyes were phakic, 11 aphakic and 4 pseudophakic. 0.6 ml of sulfur hexafluoride were injected into 42 eyes, while 0.3 ml of perfluoropropane were introduced into 13. Transconjuncti...
Article
Since June 1991, a Cyclotron unit with a proton beam of 65 MeV has been working at the Institute Antoine Lacassagne in Nice, France. An international cooperative group has been founded to guarantee the thorough exploitation of the facility through complete cooperation. From June 17 to December 20, 1991, 47 patients with uveal melanoma were treated;...
Article
The authors present a clinical study on the macular recovery test, in a new optimized version, in normal subjects and in diabetic patients. The discriminating thresholds between normals and retinopathic diabetics and between non-retinopathic and retinopathic diabetics were statistically analyzed.
Article
Using panretinal fluorescein angiography, three patterns (A, B, C) of capillary nonperfusion were identified in 308 eyes with proliferative diabetic retinopathy. Statistical analysis showed that there was a significant association with different retinal complications and clinical parameters. Pattern A (83.7%: midperipheral location of capillary non...

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