Carla Mariela Teglia

Carla Mariela Teglia
Universidad Nacional del Litoral | UNL · Faculty of Biochemistry and Biological Sciences FBCB

PhD. in biological sciences

About

28
Publications
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366
Citations
Introduction
Carla Mariela Teglia currently works at the Faculty of Biochemistry and Biological Sciences FBCB, Universidad Nacional del Litoral. Carla does research in Environmental Chemistry, Biochemistry and Analytical Chemistry. Their most recent publication is 'Determination of six veterinary pharmaceuticals in egg by liquid chromatography: Chemometric optimization of a novel air assisted-dispersive liquid-liquid microextraction by solid floating organic drop'.

Publications

Publications (28)
Article
This work reports for the first time the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of multi-wall carboxylated carbon nanotubes (MWCNTs–COOH) using a mixture of a natural deep eutectic solvent (NADES - LGH/lactic acid-glucose-water), ethylene glycol (EG) and water (GCE/MWCNT–LGH–EG) for the determination and...
Article
The present tutorial aims to review the most frequently reported criteria for the calculation of the limits of detection (LOD) and quantification (LOQ) in univariate calibration, summarizing their fundamentals, advantages, and limitations. The current criteria for estimating LOD and LOQ are based on diverse theoretical and/or empirical assumptions...
Article
Six veterinary active ingredients (imidacloprid, albendazole, fenbendazole, praziquantel, fipronil and permethrin) were extracted and quantified by liquid chromatography with diode array detection in water samples from a wetland system used for the treatment of waste from a dog breeding plant. Response surface methodology, based on least-squares an...
Article
The use of the antibiotic enrofloxacin (ENR) in poultry is controversial. A high‐performance liquid chromatography coupled to fast‐scanning fluorescence detection (HPLC-FSFD) method for the determination of ENR in egg white, egg yolk, and lyophilized samples was developed. In a first analysis, the long-term administration of ENR (100 days) to layin...
Article
Full-text available
The aim of this study was to analyze whether dermal exposure to benzophenone 3 (BP-3) during pregnancy affects critical parameters of pregnancy, and whether this exposure may affect the outcome of a second pregnancy in mice. Pregnant mice were exposed to 50-mg BP-3/kg body weight/day or olive oil (vehicle) from gestation day (gd) 0 to gd6 by dermal...
Article
A novel extraction strategy for the determination of imidacloprid, thiamethoxam and clothianidin in soy cotyledons by liquid chromatography was developed based on the implementation of an in-syringe-dispersive liquid-liquid microextraction system, optimized through successive experimental designs. First, a fractional factorial design was built to s...
Article
In the last years, regulatory agencies in biopharmaceutical industry have promoted the design and implementation of Process Analytical Technology (PAT), which aims to develop rapid and high-throughput strategies for real-time monitoring of bioprocesses key variables, in order to improve their quality control lines. In this context, spectroscopic te...
Article
Full-text available
This review presents applications of liquid phase microextraction (LPME) for extracting analytes in complex samples. This process has been introduced to simplify the extraction methods, and enhance the selectivity, sample cleanup and efficiency, allowing the extraction of a wide variety of analytes. The revision was focused on those works in which...
Article
In this work, the use of design of experiments and posterior data modelling by artificial neural network (ANN) and least squares (LS) is presented as a suitable analytical tool for the performance optimization of a tandem mass spectrometric detector coupled to ultra-high performance liquid chromatography for the analysis of seventeen veterinary dru...
Article
Full-text available
The use of fluoroquinolones for the treatment of infections in humans and animals has increased in Argentina, concurrently with the possibility of finding them in large amount in water bodies. In the present work, the occurrence and associated ecological risk of five fluoroquinolones were investigated in rivers and farm wastewaters of San Luis, San...
Article
This work presents the development of a strategy for the quantitation of 2-hydroxy-4-methoxybenzophenone (BP-3) in mice serum and human plasma. The instrumental determination only lasts 2 min and is based on ultra-high-performance liquid chromatography (UHPLC) coupled to second-order data modeling with multivariate curve resolution-alternating leas...
Article
A low-level data fusion strategy was developed and implemented for data processing of second-order liquid chromatographic data with dual detection, i.e. absorbance and fluorescence monitoring. The synergistic effect of coupling individual information provided by two different detectors was evaluated by analyzing the results gathered after the appli...
Article
Two extraction strategies for albendazole, chloramphenicol, trimethoprim, enrofloxacin, oxitetracycline and nicarbazin in egg were optimized for its quantitation by liquid chromatography. First, two designs were built to find out the optimized condition for the air assisted-dispersive liquid-liquid microextraction based on solidification of organic...
Article
The potential of front-face fluorescence spectroscopy along with chemometric algorithms was investigated for the non-destructive evaluation of mayonnaise spoilage stored at 5 °C and 37 °C during six days. Fluorescence excitation spectra on homemade and commercial mayonnaise samples were recorded between 230 and 400 nm, and emission wavelengths from...
Article
A method for the simultaneous investigation of twenty one veterinary active ingredients in poultry litter based on MCR-ALS modeling of three-way liquid chromatography with fluorescence and UV detection data is presented. The chromatographic procedure was optimized in terms of both the nature of the organic solvent and the pH of the mobile phase to...
Article
The ecological risks posed by two β-diketone antibiotics (DKAs, enrofloxacin, ENR and ciprofloxacin, CPX), characterized by their long persistence in aqueous environments and known deleterious effect on model organisms such as zebrafish were analysed using Rhinella arenarum larvae. Sublethal tests were conducted using environmentally relevant conce...
Article
In the previously published part of this study, we detailed a novel strategy based on dispersive liquid-liquid microextraction to extract and preconcentrate nine fluoroquinolones in porcine blood. Moreover, we presented the optimized experimental conditions to obtain complete CE separation between target analytes. Consequently, this second part rep...
Article
This paper proposes a multiway calibration strategy implementing the modeling with MCR-ALS and U-PLS/RBL of second-order chromatographic data for quantitation of six analytes: gliclazide, glibenclamide, glimepiride, atenolol, enalapril and amlodipine in serum samples, in an analysis time of 3. min.The performance of both algorithms was compared in...
Article
A dispersive liquid-liquid microextraction (DLLME) procedure was developed to extract nine fluoroquinolones (FQs) in porcine blood, six of which were quantified using a univariate calibration method. Extraction parameters including type and volume of extraction and dispersive solvent and pH, were optimized using a full-factorial and a central compo...
Article
Full-text available
An efficient generic static headspace gas chromatography (HSGC) method was developed, optimized and validated for the routine determination of several residual solvents (RS) in drug substance, using a strategy with two sets of calibration. Dimethylsulfoxide (DMSO) was selected as the sample diluent and internal standards were used to minimize signa...
Chapter
Full-text available
This chapter includes an overview of current chemometric methodologies using the second-order advantage to solve problems related to the analysis of emergent contaminants in water samples. Discussions are focus on pharmaceuticals and other compounds in tap, river and other sort of water samples. Second-order data generation through several techniqu...
Article
Full-text available
This paper reports the development of a method based on high-performance liquid chromatography (HPLC) coupled to second-order data modeling with multivariate curve resolution-alternating least-squares (MCR–ALS) for quantification of retinoic acid and its main isomers in plasma in only 5.5 min. The compounds retinoic acid (RA), 13-cis-retinoic acid,...
Article
A simple and fast on line spectrophotometric method combined with a hybrid hard-soft modeling multivariate curve resolution (HS-MCR) was proposed for the monitoring of photodegradation reaction of ciprofloxacin under UV radiation. The studied conditions attempt to emulate the effect of sunlight on these antibiotics that could be eventually present...
Article
The development, optimization and validation of an ion-pairing high performance liquid chromatography method for the simultaneous determination of both nicarbazin (NIC) components: 4,4'-dinitrocarbanilide (DNC) and 2-hydroxy-4,6-dimethylpyrimidine (HDP) in bulk materials and feed additives are described. An experimental design was used for the opti...

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