Carla Magda Allan S Domingues

• Doctor of Public Health
• Ministério da Saúde do Brasil

Plain Language Summary Understanding the characteristics of multiple infections is critical in the era of HPV multivalent vaccines for the prevention of cervical carcinomas. Therefore, in this cross-sectional study, we aimed to investigate the pattern of multiple HPV infections and associated factors in 5,268 sexually active unvaccinated women (16–...

For Brazil, there are no nationwide data on HPV prevalence against which the impact of the HPV immunization program can be measured in the future. Therefore, we aim to evaluate the prevalence of genital HPV infection among adolescents and young adults in Brazil. A cross-sectional, multicentric, nationwide survey was conducted between September 2016...

Objectives This study aimed to estimate the prevalence of genital, anal and oral HPV infection in Brazil through systematic review and meta-analysis. Methods We searched EMBASE, LILACS, MEDLINE, Web of Science and SciELO from inception to December 2018. Original research articles that assessed the prevalence of genital (i.e., cervical, penile), an...

Introduction Human papillomavirus (HPV) infection is transmitted through skin-to-skin contact, and vaginal and anal sex are the most common transmission routes. Sex workers and men who have sex with men (MSM) are more exposed to the virus, and therefore, a higher frequency of this infection would be expected. The prevalence of HPV infection types a...

Objectives To analyse factors associated with genital human papillomavirus (HPV) and other self-reported sexually transmitted infection (STI) coinfections among women and men aged 16–25 years from Brazil. Design A cross-sectional, nationwide, multicentre study. Setting 119 primary healthcare centres between September 2016 and November 2017. Part...

Background In addition to screening by Pap smears, vaccination against human papillomavirus (HPV) can dramatically reduce cervical cancers caused by the virus. The acceptance of HPV vaccination is directly related to HPV knowledge. This research aimed to evaluate knowledge about HPV and vaccination among men and women aged 16–25 years who use the p...

The sexual behaviors of 15- to 24-year-olds increase the risk of this population to acquire sexually transmitted infections (STIs). The present study aimed to describe the sexual behavior in the transition to adulthood Brazilian population and its association with STI history. We analyzed cross-sectional data collected from 8562 sexually active wom...

Introduction Human papillomavirus (HPV) is associated with the development of genital warts and different types of cancer, including virtually all cervical cancers and a considerable number of penile, anal and oropharyngeal cancers. Data regarding the prevalence of HPV infection in Brazil are limited and fragmented. We aim to determine HPV prevalen...

The study aimed to describe cases and verify the frequency of anaphylaxis related to measles, mumps, and rubella (MMR) vaccine produced by manufacturer A and to assess associated risk factors. This was a case-control study (1:4) in Santa Catarina State, Brazil, from July 14, 2014, to January 12, 2015, in children from one year to less than five yea...

RESUMO Objetivo Descrever as características das notificações de eventos adversos pós-vacinação (EAPV) no Sistema de Informação da Vigilância de EAPV (SI-EAPV) on-line nos primeiros 2 anos de operação do sistema. Método Foi realizado um estudo descritivo dos registros de EAPV notificados no SI-EAPV entre julho de 2014 e junho de 2016. Resultados...

Objective: To propose and test a model for analyzing municipalities' level of risk of reintroduction and transmission of the measles virus in the post-elimination period in the Americas. Methods: An ecological-analytical study was conducted using data on the measles epidemic that occurred in 2013-2015 in northeastern Brazil. The variables for an...

Background: Varicella vaccine was introduced into the Brazilian Immunization Program in October 2013, as a single-dose schedule administered at 15 months of age. Its effectiveness had not yet been assessed in the country. Methods: A matched case-control study was carried out in São Paulo and Goiânia (Southeast and Midwest regions, respectively),...

Ten-valent pneumococcal conjugate vaccine (PCV10) was introduced in the National Immunization Program of Brazil in March/2010. Although there are recent reports of PCV10 impact on pneumonia hospitalizations, there is still uncertainty regarding the indirect impact in individuals non-targeted by vaccination. We assessed both direct and indirect effe...

Number of predicted, observed and averted cases, cost per case, and estimated averted costs of hospitalized pneumonia following PCV10 introduction, by age-group. Brazil, 2011–2015. (DOCX)

R modeling scripts. (DOCX)

Trends in observed (black lines), fit curve (red lines in the pre-vaccination period), and predicted (red lines in the post-vaccination period) hospitalization monthly rates per 100,000 population for the comparison group by age-groups in Brazil. Pre-vaccination period: 2005–2009; Transition period (year of PCV10 introduction): 2010; Post-vaccinati...

The dataset generated / analyzed during the current study. (XLSX)

ICD10 codes for comparison groups according to age-groups. (DOCX)

Annual number for pneumonia and comparison group hospitalization, and mid-year population estimates by age-group. Brazil, 2005–2015. (DOCX)

Mean percentage error of fitting models of time-series analyses for pneumonia and comparison group hospitalizations rates by age-group. (DOCX)

Background: Routine infant immunization with meningococcal C conjugate (MCC) vaccination started in Brazil in November 2010, scheduled at three and five months plus a booster at 12-15months of age. No catch-up was implemented. We assessed the impact of vaccination on meningococcal C disease (MenC) four years after vaccination start in the National...

OBJECTIVE: to describe the transmission risk classification of vaccine-preventable diseases in Brazilian municipalities. METHODS: this was a descriptive epidemiologic study using 2014 data of the Brazilian National Immunization Program Information System; the vaccine coverage indicators were used to classify the transmission risk of vaccine-prevent...

Introduction Human papillomavirus (HPV) infection is a cause of premalignant and malignant cancer in the lower genital and digestive tracts. In Brazil, there have been no prevalence studies that included a nationwide sample, and the prevalence of HPV has not been determined in many regions. Methods We will search the EMBASE, LILACS, MEDLINE, Web o...

Objective: to describe the transmission risk classification of vaccine-preventable diseases in Brazilian municipalities. Methods: this was a descriptive epidemiologic study using 2014 data of the Brazilian National Immunization Program Information System; the vaccine coverage indicators were used to classify the transmission risk of vaccine-prev...

Objetivos: Analisar criticamente as recentes informações sobre riscos e benefícios da vacina influenza em mulheres grávidas. Métodos: Foram analisadas as informações disponíveis nas bases de dados do PUBMED, SCIELO, Organização Mundial da Saúde (OMS), Organização Pan-americana de Saúde (OPAS), Centro de Controle de Doenças (CDC) e Ministério da Saú...

Routine infant immunization with 10-valent pneumococcal conjugate vaccine (PCV-10) began in Brazil in 2010. The impact of the PCV-10 on rates of invasive pneumococcal disease (IPD) at the population level was not yet evaluated. Serotype-specific IPD changes after PCV-10 introduction is still to be determined. Data from national surveillance system...

We applied the indirect cohort method to estimate effectiveness of 10-valent pneumococcal conjugate vaccine (PCV10) among young children in Brazil. Cases of invasive pneumococcal disease (IPD), i.e., Streptococcus pneumoniae, detected in normally sterile fluid identified through laboratory-based surveillance and previously enrolled in a matched cas...

Streszczenie Wprowadzenie W marcu 2010 r. wprowadzono do stosowania w Brazylii 10-walentną skoniugowaną szczepionkę przeciwko pneumokokom (pneumococcal conjugate vaccine; PCV10). Podstawą dopuszczenia jej do obrotu było wykazanie, że w zakresie wskaźników immunologicznych dotyczących skuteczności w zapobieganiu zakażeniom pneumokokowym nie była on...

Introdução: A influenza é uma doença infecciosa altamente transmissível, de distribuição global e que tem alto impacto na saúde pública. De acordo com a OMS, anualmente são registrados de três a cinco milhões de casos graves, que resultam em, aproximadamente, 0,25 a 0,5 milhão de mortes em todo o mundo. Indivíduos com doenças crônicas apresentam al...

A single vaccination of Yellow Fever vaccines is believed to confer life-long protection. In this study, results of vaccinees who received a single dose of 17DD-YF immunization followed over 10 years challenge this premise. YF-neutralizing antibodies, subsets of memory T and B cells as well as cytokine-producing lymphocytes were evaluated in groups...

O Objetivo deste trabalho foi relatar a implementação do Programa Nacional de Imunizações do SUS e os critérios para a incorporação de novas vacinas. Metodologia: relato de experiência descritivo sobre a implementação do PNI, o histórico de incorporações de novas vacinas e o Calendário Nacional de Vacinação. Resultados: O país apresenta um históric...

In August 2012, the Brazilian Ministry of Health introduced inactivated polio vaccine (IPV) as part of sequential polio vaccination schedule for all infants beginning their primary vaccination series. The revised childhood immunization schedule included 2 doses of IPV at 2 and 4 months of age followed by 2 doses of oral polio vaccine (OPV) at 6 and...

ResumoA influenza afeta pessoas de todas as idades, causando substancial impacto em saúde pública. No Brasil, em 2014, a vacinação de crianças foi ampliada, abrangendo todas as crianças de 6 a 60 meses de idade. O objetivo desta revisão é analisar as informações da literatura que justificam a ampliação da vacinação na faixa etária pediátrica.Método...

OBJETIVO: estimar as chances de adoecimento por coqueluche segundo número de doses de vacinas Pertussis administradas e idade, no Brasil. MÉTODOS: estudo de caso-controle utilizando dados do Sistema de Informação de Agravos de Notificação (Sinan) no período 2007-2011; considerou-se como casos aqueles notificados com coqueluche confirmada, e como c...

Background: In March 2010, Brazil introduced the ten-valent pneumococcal conjugate vaccine (PCV10), which was licensed based on non-inferiority of immunological correlates of protection compared with the seven-valent vaccine. The schedule comprised three primary doses at ages 2 months, 4 months, and 6 months, and a booster dose at age 12 months. A...

OBJECTIVE: describe rapid monitoring of vaccination coverage (RMC) following Measles Mumps Rubella (MMR) (2008-2011) and Multivaccination (2012) vaccination campaigns. METHODS: descriptive study using National Immunization Program administrative data on vaccine coverage as well as RMC data, in addition to data on the grounds for non-vaccination (20...

Pneumonia is most problematic for children in developing countries. In 2010, Brazil introduced a 10-valent pneumococcal conjugate vaccine (PCV10) to its National Immunization Program. To assess the vaccine's effectiveness for preventing pneumonia, we analyzed rates of hospitalization among children 2-24 months of age who had pneumonia from all caus...

Sources of data on vaccination coverage.

OBJETIVE: to describe vaccination coverage (VC) and its homogeneity, dropout rates (DR) and the occurrence of vaccine-preventable diseases in Brazil. METHODS: a descriptive cross-sectional study was conducted based on National Immunization Program (PNI) information systems data for the period 2002-2012 in order to calculate VC, its homogeneity and...

The development of a Brazilian National Surveillance System in 1975 led to a compulsory reporting of selected infectious diseases aiming to reduce the burden of these events in the country. However, shifts in the epidemiology of these diseases associated with modern life style, demand constant revision of surveillance activities. In this manuscript...

Neste artigo, os autores apresentam um resumo historico do Sistema de Informacao de Agravos de Notificacao (Sinan), listam os principais pontos criticos presentes na concepcao do sistema em DOS e apontam as contribuicoes mais importantes geradas em diferentes foruns de discussao para adequacao do sistema de informacoes a vigilância epidemiologica....

In 1992, Brazil adopted the goal of measles elimination by the year 2000; however, in 1997, after a 4‐year period of good control, there was a resurgence of measles in Brazil. In 1999, to achieve the elimination goal, Brazil implemented the Supplementary Emergency Measles Action plan, with one measles surveillance technician designated to each stat...

The successful eradication of the transmission of autochthonous wild poliomyelitis virus in the Americas, encouraged the Ministers of Health of the members States of the Pan-American Health Organization - PAHO - in 1994 to adopt the goal of eliminating measles in the Region by the year 2000. The Measles Elimination Plan consist of four basic strate...

Objetivou caracterizar o processo de construção da identidade do adolescente, a partir de múltiplas identificações que o conformam. Considerando que na adolescência relações de gênero emergentes e manifestações da sexualidade assumemsignificações particulares no processo de formação dessa identidiade, procurou-se, igualmente, reter tais aspectos co...