Carina R Oehrn

Carina R Oehrn
University of California, San Francisco | UCSF

MD, MSc

About

25
Publications
3,548
Reads
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292
Citations
Citations since 2016
20 Research Items
270 Citations
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20162017201820192020202120220204060
Introduction
I am interested in the functional role of cortical and subcortical oscillations for physiological and pathological brain function. Currently, my resesearch focuses on the oscillatory patterns underlying Parkinson's disease and their modulation by deep brain stimulation (DBS).
Additional affiliations
April 2021 - present
University of California, San Francisco
Position
  • PostDoc Position
November 2016 - May 2021
Universitätsklinikum Gießen und Marburg
Position
  • Group Leader
May 2016 - October 2016
University of Cologne
Position
  • Research Associate
Education
October 2010 - February 2016
University of Bonn
Field of study
  • Neuroscience
October 2009 - November 2015
University of Cologne
Field of study
  • Medicine
October 2007 - October 2008
University College London
Field of study
  • Brain and Mind Sciences

Publications

Publications (25)
Article
Besides its relevance for declarative memory functions [1-5], hippocampal activation has been observed during disambiguation of uncertainty and conflict [6, 7]. Uncertainty and conflict may arise on various levels. On the perceptual level, the hippocampus has been associated with signaling of contextual deviance [8-10] and disambiguation of similar...
Article
In an ever-changing environment, selecting appropriate responses in conflicting situations is essential for biological survival and social success and requires cognitive control, which is mediated by dorsomedial prefrontal cortex (DMPFC) and dorsolateral prefrontal cortex (DLPFC). How these brain regions communicate during conflict processing (dete...
Article
Flavour perception derives from an interplay of the senses that conveys information about the odour, taste, texture, or spiciness of ingested foods. Although interactions between smell and taste have been investigated extensively, we do not know a lot about the effect of oral chemical irritation on odour perception. Therefore, the impact of capsaic...
Article
Whilst dysfunction of basal ganglia-thalamic circuitry is implicated in the genesis of parkinsonian symptomatology, few studies have examined the effects of lesioning the motor thalamus in the context of parkinsonism. Forty rats were therefore subdivided into four lesion groups each of 10 rats with lesions or sham surgery targeting (1) the medial f...
Article
Full-text available
Memory for aversive events is central to survival but can become maladaptive in psychiatric disorders. Memory enhancement for emotional events is thought to depend on amygdala modulation of hippocampal activity. However, the neural dynamics of amygdala-hippocampal communication during emotional memory encoding remain unknown. Using simultaneous int...
Article
Full-text available
The vagus nerve constitutes a key link between the autonomic and the central nervous system. Previous studies provide evidence for the impact of vagal activity on distinct cognitive processes including functions related to social cognition. Recent studies in animals and humans show that vagus nerve stimulation is associated with enhanced reward-see...
Article
Full-text available
In many scientific fields including neuroscience, climatology or physics, complex relationships can be described most parsimoniously by non-linear mechanics. Despite their relevance, many neuroscientists still apply linear estimates in order to evaluate complex interactions. This is partially due to the lack of a comprehensive compilation of non-li...
Article
Full-text available
Bimanual coordination is impaired in Parkinson’s disease affecting patients’ ability to perform activities of daily living and to maintain independence. Conveyance of information between cortical and subcortical areas is essential for bimanual coordination and relies on the integrity of cerebral microstructure. As pathological deposition of alpha-s...
Article
Full-text available
Rhythmic neural activity, so-called oscillations, plays a key role in neural information transmission, processing, and storage. Neural oscillations in distinct frequency bands are central to physiological brain function, and alterations thereof have been associated with several neurological and psychiatric disorders. The most common methods to anal...
Article
Full-text available
Successful forgetting of unwanted memories is crucial for goal-directed behavior and mental wellbeing. While memory retention strengthens memory traces, it is unclear what happens to memory traces of events that are actively forgotten. Using intracranial EEG recordings from lateral temporal cortex, we find that memory traces for actively forgotten...
Preprint
Full-text available
In many scientific fields like e.g. neuroscience, climatology or physics, complex relationships can be described most parsimoniously by nonlinear mechanics. Despite their relevance, many scientists still apply linear estimates in order to evaluate complex interactions. This is partially due to the lack of a comprehensive compilation of nonlinear me...
Preprint
Full-text available
Rhythmic neural activity, so called oscillations, play a key role for neural information transmission, processing and storage. Neural oscillations in distinct frequency bands are central to physiological brain function and alterations thereof have been associated with several neurological and psychiatric disorders. The most common methods to analys...
Preprint
Full-text available
Memory for aversive events is central to survival, but can also become maladaptive in psychiatric disorders. Emotional memory relies on the amygdala and hippocampus, but the neural dynamics of their communication during emotional memory encoding remain unknown. Using simultaneous intracranial recordings from both structures in human patients, we sh...
Article
Full-text available
Timed picture naming is a common psycholinguistic paradigm. In this task, participants are asked to label visually depicted objects or actions. Naming performance can be influenced by several picture and verb characteristics which demands fully characterized normative data. In this study, we provide a first German normative data set of picture and...
Article
Full-text available
Bimanual motor control declines during ageing, affecting the ability of older adults to maintain independence. An important underlying factor is cortical atrophy, particularly affecting frontal and parietal areas in older adults. As these regions and their interplay are highly involved in bimanual motor preparation, we investigated age-related conn...
Article
Full-text available
Whereas the effect of vagal nerve stimulation on emotional states is well established, its effect on cognitive functions is still unclear. Recent rodent studies show that vagal activation enhances reinforcement learning and neuronal dopamine release. The influence of vagal nerve stimulation on reinforcement learning in humans is still unknown. Here...
Article
Full-text available
Psychosis is the most common neuropsychiatric side-effect of dopaminergic therapy in Parkinson’s disease (PD). It is still unknown which factors determine individual proneness to psychotic symptoms. Schizotypy is a multifaceted personality trait related to psychosis-proneness and dopaminergic neurotransmission in healthy subjects. We investigated w...
Preprint
Full-text available
Bimanual motor control declines during healthy ageing, affecting the ability of older adults to maintain independence. Age-related changes in neural dynamics of movement preparation that underlie reduced bimanual motor control, however, remain largely elusive. Here, we assessed effective connectivity within a prefrontal-premotor network of 19 young...
Article
Full-text available
Objective: To investigate whether functional sweetspots of deep brain stimulation (DBS) in the subthalamic nucleus (STN) can predict motor improvement in PD patients. Methods: Stimulation effects of 449 DBS settings in 21 PD patients were clinically and quantitatively assessed through standardized monopolar reviews and mapped into standard space...
Article
Objective Deep brain stimulation (DBS) is an effective treatment for movement disorders. Stereotactic electrode placement can be guided by intraoperative imaging, which also allows for immediate intraoperative quality control. This article is about implementation and refining a workflow applying intraoperative computed tomography (iCT) for DBS. Me...
Article
Forgetting does not necessarily reflect failure to encode information but can, to some extent, also be voluntarily controlled. Previous studies have suggested that voluntary forgetting relies on active inhibition of encoding processes in the hippocampus by the dorsolateral prefrontal cortex (DLPFC) [1-4]. During attentional and sensorimotor process...
Article
Introduction Hippocampal sclerosis (HS) frequently underlies temporal lobe epilepsy. Patients often suffer from refractory epileptic seizures, but episodic memory deficits, depressive syndromes or impaired special navigation are also common symptoms. Much less is known about the role of the hippocampus for conflict processing. Patients with impaire...
Article
Natural stimuli consist of multiple properties. However, not all of these properties are equally relevant in a given situation. In this study, we applied multivariate classification algorithms to intracranial electroencephalography data of human epilepsy patients performing an auditory Stroop task. This allowed us to identify neuronal representatio...
Article
Recent findings suggest that repetition effects interact with episodic memory processes that are putatively supported by the hippocampus. Thus, the formation or refinement of episodic memories may be related to a modulating signal from the hippocampus to the neocortex which leads to sparser or more extended stimulus representations (repetition supp...

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