Carina Nicu

Carina Nicu
Wellcome MRC Cambridge Stem Cell Institute · Haematology

Phd

About

22
Publications
2,689
Reads
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154
Citations
Additional affiliations
September 2017 - present
The University of Manchester
Position
  • Research Assistant
September 2016 - July 2018
The University of Manchester
Position
  • Placement student supervisor
Description
  • Supervisor for undergraduate placement students within our lab
March 2016 - April 2016
Yale University
Position
  • Visiting Student
Description
  • Visiting student in Prof. Valerie Horsley's lab https://horsley.yale.edu/news/welcome-carina-visiting-student-horsley-lab
Education
September 2011 - June 2015
The University of Manchester
Field of study
  • Genetics

Publications

Publications (22)
Article
Traditionally, facial adipose tissue has been perceived and treated as a homogenous volume-occupying subcutaneous depot. However, recent research from across disciplines is converging to reveal a far more anatomically organized and functionally dynamic role of facial adipose tissue. In this narrative review, we will discuss new insights into adipoc...
Article
Full-text available
Hair greying (canities) is one of the earliest, most visible ageing-associated phenomena, whose modulation by genetic, psychoemotional, oxidative, senescence-associated, metabolic and nutritional factors has long attracted skin biologists, dermatologists, and industry. Greying is of profound psychological and commercial relevance in increasingly ag...
Article
The molecular nature of the hair cycle clock (HCC), i.e. the intrinsic oscillator system that drives hair follicle (HF) cycling, remains incompletely understood; therefore, all relevant key players need to be identified. Here, we present evidence that implicates myelin protein zero‐ like 3 (MPZL3), a multifunctional nuclear‐encoded mitochondrial pr...
Article
Hair follicles (HFs) are immersed within dermal white adipose tissue (dWAT), yet human adipocyte-HF communication remains unexplored. Therefore, we investigated how perifollicular adipocytes affect the physiology of organ-cultured human anagen scalp HFs. Quantitative (immuno-)histomorphometry, microCT and transmission electron microscopy showed tha...
Article
Adiponectin reportedly stimulates proliferation and elongation of human scalp hair follicles (HFs) ex vivo. In the current study, we investigated how adiponectin oligomers produced by perifollicular dermal white adipose tissue (dWAT), a potent source of adiponectin isoforms, influence human HF proliferation and pigmentation. To do so, we treated mi...
Article
MPZL3 is a nuclear‐encoded, mitochondrially localized, immunoglobulin‐like V‐type protein that functions as a key regulator of epithelial cell differentiation, lipid metabolism, ROS production, glycemic control, and energy expenditure. Recently, MPZL3 has surfaced as an important modulator of sebaceous gland function and of hair follicle cycling, a...
Poster
Full-text available
The poster explains our hypothesis regarding the metabolic switch within scalp perifollicular dermal adipocytes from lipogenesis in anagen, to lipophagy and lipolysis in catagen. Our preliminary results are followed by extensive advice on future experimental options to further test and confirm this work.
Article
In murine skin dermal white adipose tissue (DWAT) undergoes fluctuations in size across the hair cycle, whereas changes in size, function and metabolism of dermal adipocytes (DAs) during the human scalp hair cycle remain unexplored. Transmission electron microscopy results suggest that, during anagen‐catagen transition, human DAs co‐opt the autopha...
Article
Full-text available
In murine skin, dermal white adipose tissue (DWAT) undergoes major changes in thickness in synchrony with the hair cycle (HC); however, the underlying mechanisms remain unclear. We sought to elucidate whether increased DWAT thickness during anagen is mediated by adipocyte hypertrophy or adipogenesis, and whether lipolysis or apoptosis can explain t...
Article
一直以来的假设是汗腺分布于皮肤,未与毛囊相连(毛发“根部”)。与其相关的脂肪腺以及其他专用腺和使毛发站立的肌肉被统称为毛囊皮脂腺。换句话说,汗腺和毛囊皮脂腺一直被视为单独的结构,汗腺通向毛发之间(而不是毛发旁边)的皮肤表面。手掌和脚底的汗腺发育方式不同,因此不在本研究范围内。这项来自西班牙和英国曼彻斯特的研究使用多种技术,包括通过显微镜观察在毛发移植期间从头皮采集的毛囊剖面以及通过人工和计算机辅助3D方式重建头皮皮肤剖面,最后展现出,在生长毛发的区域,汗腺最深的部位(螺旋结构)实际上在脂肪腺和毛发肌肉连接点下方紧靠毛囊皮脂腺最深的部位,位于毛囊鞘旁。此外,这些结构聚集在从下层脂肪向上延伸至最低层皮肤(网状真皮层)的脂肪的锥形突出内。作者们推断,汗腺、毛囊皮脂腺和这种特殊的脂肪组织(统称为“附...
Article
It has always been assumed that sweat glands are distributed throughout the skin unconnected with hair follicles (hair “roots”) and their associated sebaceous (or “grease”) glands, which, together with other specialised glands and the muscles that make hairs stand up, are known as pilosebaceous units. Sweat glands and pilosebaceous units, in other...
Article
Background: Eccrine sweat glands (ESGs) are critical for thermoregulation and involved in wound healing. ESGs have traditionally been considered as separate skin appendages without connection to the pilosebaceous unit (PSU). However, recent preliminary evidence has encouraged the hypothesis that PSU and ESG are more interconnected than previously...
Poster
Full-text available
This project aimed to characterize markers specific to human dermal white adipose tissue in scalp skin in order to allow for further study of this noteworthy depot.

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