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Canbolat Gürses

Canbolat Gürses
İnönü University · Molecular Biology and Genetics

PhD
www.canbolatgurses.com

About

23
Publications
4,869
Reads
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644
Citations
Citations since 2017
22 Research Items
644 Citations
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2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Introduction
I have been working in İnönü University on the department of Molecular Biology and Genetics as a research assistant for more than 10 years. My research fields are Genotoxicity including Comet, Micronucleus and Sister Chromatid Exchange assays, Cytotoxicity using MTT & WST-8 assays, DNA Binding & Cleavage Studies of organometallic complexes via agarose gel electrophoresis and ctDNA, Antimicrobial Activity such as Zone of Inhibition and MIC and in vitro Endoplasmic Reticulum Stress investigation.
Additional affiliations
July 2022 - September 2022
Max Planck Institute for Intelligent Systems
Position
  • Guest Researcher
August 2013 - April 2023
İnönü University
Position
  • Research Assistant
Education
September 2014 - June 2021
İnönü University
Field of study
  • Chemistry, Biochemistry
September 2014 - April 2023
İnönü University
Field of study
  • Biology, Molecular Biology
September 2009 - March 2012
University of Washington Seattle
Field of study
  • Materials Science and Engineering

Publications

Publications (23)
Article
Full-text available
New seven Au‐N‐heterocyclic carbene (NHC) complexes have been synthesized via transmetalation from Ag‐NHC complexes. NHC salts, Ag‐NHC, and Au‐NHC complexes were fully characterized by widely used spectroscopic techniques. The molecular and crystal structures of 3b and 3f Au‐NHC complexes were clarified through the single‐crystal X‐ray diffraction...
Article
Full-text available
The present study aimed to determine the cytotoxicity of chromium(III) oxide micro particles (Cr2O3-Ps) in rainbow trout (Oncorhynchus mykiss) spermatozoa. Firstly, Cr2O3-Ps were synthesized and structurally characterized the surface, morphological for particle size and thermal properties. In addition, its structural and elemental purity was determ...
Article
Antibacterial polyurethanes as wound-dressing material with high biocompatibility and thermal stability were developed from polyethylene glycol-200 (PEG200), 4,4′-methylenebis(cyclohexyl isocyanate) (HMDI) and β-cyclodextrin (βCD). βCD was preferred in this material because of providing biocompatibility and supporting the absorption/desorption char...
Article
Today, polyurethanes are widely used in our daily lives from the textile industry to medical applications. In this study, we prepared a biocompatible and transparent coating from PEG containing linear polyurethanes including one type of saccharide (xylose, sucrose, or starch). For the characterization of the polyurethanes, FT-IR, TGA, DTA, DSC, and...
Article
Full-text available
In our research, the antibacterial properties of tear which protect our eyes from many infections have been investigated by using Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus haemolyticus and Staphylococcus epidermidis bacteria. In addition, the antibacterial effect of creams in different formulations containing vaseline, also known as...
Article
Hard or soft tissue adhesives have been presented as a promising candidate to replace traditional wound closure methods. A series of hard tissue bioadhesive formulations based on natural polymers have recently been designed and investigated in our laboratory. In current work, we produced an UV-curable polyurethane-acrylate formulations as a bioadhe...
Article
Full-text available
Here, we present a study on the synthesis and biological properties of the ruthenium complexes having naphthyl substituted NHC ligands, which are of great importance for drug development studies. For this purpose, in our study, imidazolidine-functionalized Ru(II)NHC complexes containing naphthyl substitute group were synthesized and in vitro antica...
Preprint
Full-text available
The present study aimed to determine the cytotoxicity of Chromium (III) oxide micro particles (Cr 2 O 3 -Ps) in rainbow trout ( Oncorhynchus mykiss ) spermatozoa. Firstly, Cr 2 O 3 -Ps were synthesized and structurally characterized the surface, morphological for particle size and thermal properties. In addition, its structural and elemental purity...
Article
This study presents a more extensive report on the experimental and theoretical characterization of the Ce-doped hydroxyapatite (HAp) samples additionally doped with Pr at varying amounts. To achieve this goal, four Ce-containing (a constant amount of 0.35 at.%) HAps additionally doped with Pr at various amounts (0.35, 0.70, 1.05, and 1.40 at.%) we...
Article
Researchers have recently focused on the advancement of new materials from biorenewable and sustainable sources because of great concerns about the environment, waste accumulation and destruction, and the inevitable depletion of fossil resources. Biorenewable materials have been extensively used as a matrix or reinforcement in many applications. In...
Article
In the present study, coumarin‐bearing three pyridinium and three tetra‐alkyl ammonium salts were synthesized. The compounds were fully characterized by 1H and 13C NMR, LC‐MS and IR spectroscopic methods and elemental analyses. The cytotoxic properties of all compounds were tested against human liver cancer (HepG2), human colorectal cancer (Caco‐2)...
Article
Five different samples of Sr-based Er-doped hydroxyapatites (HAps) in the dissimilar quantities like 0, 0.35,0.70, 1.05 and 1.40 at% were produced via a wet chemical process. The prepared samples were investigatedexperimentally by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray(EDX), Fourier transform inf...
Article
In recent years, the preparation of metal complexes and the introduction of biologically active organometalic compounds are new strategies in drug development. For this purpose, generally N-heterocyclic pharmaceutical agents have been used as promising nuclei. Au-containing N-heterocyclic carbene (Au-NHC) derivatives are among the compounds used fo...
Article
Recently, the medical applications of organoruthenium complexes have attention attracted to organometallic chemists and biochemists. In this study, 4-vinylbenzyl and 2-morpholinoethyl substituted (NHC)Ru(II)(η⁶-p-cymene) complexes were synthesized and in vitro DNA binding, cell cytotoxicity (anticancer activity) and genotoxicity properties were det...
Article
A series of the morpholine‐liganded palladium(II) complexes (1a–e) bearing N‐heterocyclic carbene (NHC) functionalized by benzonitrile were synthesized. These complexes were synthesized from (NHC)Pd(II)(pyridine) complexes (PEPPSI) and morpholine. The new complexes were fully characterized by using 1H NMR, 13C NMR, Fourier‐transform infrared spectr...
Article
In the present study, four palladium and four ruthenium complexes were synthesized with benzotriazole substituted N-heterocyclic carbene ligands. The structures of complexes were established by appropriate spectroscopic methods and elemental analyses. In addition, the crystal structure of a Pd–]NHC complex (1c) was reported. Anticancer, antimicrobi...
Article
In this study, six [Ag(NHC)2]⁺[AgCl2]⁻ type silver complexes were synthesized by the reaction of corresponding carbene precursor and Ag2O. One [Ag(NHC)2]⁺NO3⁻ type complex was synthesized by the anion exchange reaction of corresponding silver–NHC and NaNO3. The synthesized complexes were characterized by ¹H NMR, ¹³C NMR and IR spectroscopic methods...
Article
New benzimidazolium salts 1a-d having methylpyridine group on the side chain, have been synthesized and reacted with Ag2O to produce Ag(I)-N-heterocyclic carbene (NHC) complexes 2a-d. Ag(I)-N-heterocyclic carbene (NHC) complexes were used as a carben transfer agents to synthesize water-soluble ruthenium(II)-NHC complexes 4a-d. All synthesized compo...
Article
The aim of this study was to characterize and investigate the effects of the Mobil Composition of Matter No. 41 (MCM‐41) concentrations (0.5, 1, 3, 5 and 10 wt%) on structural, thermal, wettability, water content, oxygen (O2) permeability and swelling properties as well as morphological characteristics of chitosan/polyvinylpyrrolidone/MCM‐41 (CH/PV...
Chapter
Hybrid materials are composites consisting of organic and inorganic species connected each other with physical and chemical interactions at the nanometer or molecular level. In hybrid polymer composite materials, interactions of components in microscale dimensions lead to a more homogeneous material that either shows characteristics in between the...

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