Can Justin Kiessling
Can Justin Kiessling
PhD (Bachelor of Biomedical Sciences with Honours)
About
13
Publications
99,119
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102
Citations
Introduction
Molecular biologist & bioinformatic specialist. I worked in variety of areas spanning diverse topics such as NIPT (noninvasive prenatal testing), cardiac aging and solid tumor testing.
Additional affiliations
September 2022 - May 2023
GaziGen
Position
- Senior Bioinformatic Scientist
February 2018 - September 2022
January 2010 - January 2011
Publications
Publications (13)
Cardioprotective interventions such as ischemic
preconditioning as well as numerous pharmacological approaches are reliant on the
presence of caveolae and present a novel therapeutic target as enhanced expression of caveolae has been shown to be protective against variety of stressors such as I-R injury in the aged heart. The unique morphology of...
Phenotypic and transcriptomic evidence of early cardiac aging, and associated mechanisms, were investigated in young to middle-aged male mice (C57Bl/6; ages 8, 16, 32, 48 wks). Left ventricular gene expression (profiled via Illumina MouseWG-6 BeadChips), contractile and coronary function, and stress-resistance were assessed in Langendorff perfused...
Cardioprotection is a promising novel therapeutic for the treatment of ischemic heart disease (IHD). Various cardioprotective methods such as ischemic, anesthetic and G-protein-coupled-receptor (GPCR) based preconditioning have been shown to be reliant on the presence of unique regions in the sarcolemma termed caveolae. Caveolae compartmentalize an...
Mildly elevated circulating unconjugated bilirubin (UCB) is associated with protection against hypertension and ischemic heart disease. We assessed whether endogenously elevated bilirubin in Gunn rats modifies cardiovascular function and resistance to ischemic insult. Hearts were assessed ex vivo (Langendorff perfusion) and in vivo (Millar catheter...
Cholesterol-rich caveolar microdomains and associated caveolins influence sarcolemmal ion channel and receptor function, and protective stress-signaling. However, the importance of membrane cholesterol content to cardiovascular function, and myocardial responses to ischemia-reperfusion (IR) and cardioprotective stimuli are unclear. We assessed effe...
Cardioprotection against infarction and dysfunction in the myocardium involves G-protein-coupled receptor signalling orchestrated by specialised membrane microdomains termed caveolae. The caveolin protein family consist of three subtypes: caveolin-1, −2 and −3 (Cav1-3) and are responsible for the formation of caveolae and hypothesized to orchestrat...
Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3-5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct from conventional preconditioning responses. We thus applied unbiased gene-array interrogation to identify...
Functional gene groupings sensitive to SLP induction in normoxic myocardium.
(XLSX)
Genes significantly modified during SLP induction in normoxic myocardium.
(DOCX)
Effects of SLP on post-ischemic gene expression.
(DOCX)
Functional gene groupings sensitive to SLP in post-ischemic myocardium.
(XLSX)
RT-qPCR primer sequences for validated targets.
(DOCX)
