Can Erzik

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Verified

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• MD, PhD
• PhD at Marmara University

Background and Objective: Circadian rhythm hormones melatonin (MEL) and 5-Methoxytryptophol (5-MTX) have antioxidant and anti-inflammatory effects on the biological systems. The aim of this study was the investigation of Cyclooxygenase-1 (COX-1), Cyclooxygenase-2 (COX-2), Rapid Accelerated Fibrosarcoma-1 (Raf-1) and Signal Transducer and Activator...

Objectives Behçet disease (BD) has heterogeneous presentations, mainly mucocutaneous, vascular, and ocular manifestations. The mechanisms associated with different phenotypes have not been clarified. We aimed to investigate the expression of innate and adaptive immunity–related cytokines in these 3 main BD phenotypes in active and untreated states...

Radiographic progression in Ankylosing spondylitis (AS) is driven by mechanical strain. A well-balanced spine provides a favorable weight distribution across the entheses. Pelvic parameters are useful in assessing the shape of the spine. The present study aimed to prospectively investigate the predictive value of pelvic parameters for radiographic...

The shape of the spine is critical in maintaining posture on the vertical axis, and the morphology of the pelvis affects the distribution and dynamics of mechanical stress along the spine. Pelvis and spine angulations, called spinopelvic parameters, vary individually, hence, the site of mechanical load in individuals. Particular types of spino-pelv...

Capecitabine is recommended as one of the first-line chemotherapy treatments for advanced or metastatic colorectal cancer. Researches have been conducted on capecitabine’s impact on the viability of human colon cancer cells and its potential to induce apoptosis. However, even in cases initially responsive to treatment, the development of acquired r...

Ankylosing spondylitis (AS) is a chronic inflammatory disorder affecting the axial skeleton and often associated with Human Leukocyte Antigen-B*27 (HLA-B*27) positivity. HLA-B*27 and its role in AS pathogenesis remain unclear despite the identification of multiple susceptibility alleles. As the most frequent subtype related to AS, HLA-B*27:05 diffe...

Precision/personalized medicine in oncology has two key pillars: molecular profiling of the tumors and personalized reporting of the results in ways that are clinically contextualized and triangulated. Moreover, neurosurgery as a field stands to benefit from precision/personalized medicine and new tools for reporting of the molecular findings. In t...

Ankylosing Spondylitis is an autoimmune disease leading to inflammation in the joints and ligaments of the spine. ERAP1 is a major risk factor for AS and ERAP1 mutations may result in structural changes that alter the trimming efficiency, thereby altering the immune response. The underlying structural mechanisms of AS pathogenesis have not yet been...

Aim: Niacin is a water-soluble vitamin. The effects of niacin on inflammation, oxidative stress and apoptotic processes observed after mild traumatic brain injury (TBI) were studied in this study. Material and methods: Wistar albino male rats were randomly divided into control (n=9), TBI + Placebo group (n=9), TBI + niacin (500 mg/kg; n=7) group...

Phoenixin-14 (PNX) is a neuropeptide that has been shown to prevent oxidative damage and stimulates insulin secretion. We investigated the effects of PNX on pancreatic injury induced by streptozotocin (STZ), and nicotinamide (NAD). Male Sprague-Dawley rats, in control (C) and diabetic (STZ) groups, were treated with either saline, or PNX (0.45 nmol...

Plasminogen activator inhibitor-1 (PAI-1) antagonists are known for their neuroprotective effects. In this study, it was aimed to investigate the possible protective effects of PAI-1 antagonists in a rat mild traumatic brain injury (TBI) model. Sprague-Dawley male rats were grouped as sham (n = 7), TBI (n = 9), and TBI + PAI-1 antagonist (5 and 10...

Ankylosing spondylitis (AS) is an autoimmune disease affecting the axial skeleton. Several studies have found out the association between AS and HLA-B27. As an MHC-I, HLA-B27 is responsible for antigen presentation and involved in immune responses. Although HLA-B*27:05 and HLA-B*27:09 differ in only one amino acid, HLA-B*27:05 is implicated in the...

Ankylosing Spondylitis (AS) is a chronic inflammatory autoimmune disease manifesting as arthritis and can lead to bone fusion in severe cases. Endoplasmic Reticulum associated Aminopeptidase-I (ERAP1) and -II (ERAP2) were implicated in AS pathogenesis as risk factors along with HLA-B27. ERAP1 and ERAP2 are homologous proteins involved in antigen pr...

Background: Plasminogen activator inhibitor-1 (PAI-1) antagonists are known for their neuroprotective effects. In this study, it was aimed to investigate the possible protective effects of PAI-1 antagonists in a rat mild traumatic brain injury (TBI) model. Method: Sprague Dawley male rats were grouped as sham (n=7), TBI (n=9), TBI + PAI-1 antagonis...

Cancer as the leading cause of death worldwide has many issues that still need to be addressed. Since the alterations on the glycan compositions or/and structures (i.e., glycosylation, sialylation, and fucosylation) are common features of tumorigenesis, glycomics becomes an emerging field examining the structure and function of glycans. In the past...

Aims: This study aims to evaluate medical students’ knowledge, thoughts, and awareness of the COVID-19 pandemic. Metho- ds: A questionnaire consisting of 31 questions was prepared for this descriptive study. In the questionnaire, medical students’ knowledge, attitudes and behaviors during the COVID-19 pandemic were investigated. Categorical variabl...

Although physiologic and neurologic consequences of micronutrient deficiencies have been addressed extensively, less is known about their impact on developing gut microbiota. Vitamin B12 deficiency is a common micronutrient deficiency in infants. We aimed to analyze the gut microbial composition of exclusively breastfed infants aged between 4 and 6...

Background Cells detaching from primary tumor site are metastasis initiator cells, and detection of CTC, known as liquid biopsy, is one of the important biomarkers of cancer progression. We aimed to investigate molecular characterization of circulating tumor cells (CTC), to profile plasma microRNA content, and to analyze the relation with clinical...

Objectives: In the present study, it was aimed to study the antioxidant effects of spironolactone (SPL) to determine its possible protective effects in hepatic ischemia reperfusion injury. Material and methods: Hepatic artery, portal vein, and bile duct of Wistar albino rats were clamped for 45 minutes under anesthesia to form an ischemia period...

Aim: We aimed to identify copy number variations that are specific to myxopapillary ependymomas (MPEs) of the cauda equina. Material and methods: The patient cohort included five patients who underwent resection of histologically confirmed MPEs. Tumor samples collected during surgery and stored in liquid nitrogen as well as corresponding blood s...

New findings: • What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inflammatory effects? • What...

Objectives: The purpose of this study was to investigate possible protective effects of St. John's wort in the hepatic ischemia/reperfusion injury. Material and methods: The hepatic artery, portal vein, and bile duct were all clamped for 45 minutes to induce ischemia in rats, and after that reperfusion for 1 hour. SJW was administrated orally, o...

Background Radiographic severity of ankylosing spondylitis (AS) shows such great variance that some patients never develop syndesmophytes throughout the entire disease span, whereas some develop bamboo spine relatively early. Objective To study the association between ERAP1, IL23R and PTGER4 single nucleotide polymorphisms (SNPs) and radiographic...

Obstructive jaundice (OJ) can be defined as cessation of bile flow into the small intestine due to benign or malignant changes. Nesfatin-1, recently discovered anorexigenic peptide derived from nucleobindin-2 in hypothalamic nuclei, was shown to have anti-inflammatory and antiapoptotic effects. This study is aimed to investigate the therapeutic eff...

Background: The insulin-like growth factor binding protein5 (IGFBP5) is often dysregulated in human cancers and considered neither a tumor suppressor nor an oncogene. Objective: We aim to examine the reason of the changeable gene regulation of IGFBP5 in the case of methylation in breast cancer. Methods: We used methyl-specific polymerase (MSP)...

AMAÇ: Tıkanma sarılığı, safra yollarında meydana gelen tıkanıklık sonucu ortaya çıkan safra retansiyonu sonucu sarılık oluşmasına sebep olan ve sebat etmesi durumunda orga yetmezliğine kadar götürebilen bir hastalık tablosudur. Nesfatin-1 ilk kez 2006’da Oh ve arkadaşları tarafından tanımlanmış hipotalamusta bulunan bir tokluk molekülüdür. Bu çalış...

Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease affecting spine which may lead to new bone formation and disability. However, the radiographic severity of AS shows great variance. The genetic determinants for the new bone formation and for this great variance have not been fully understood yet. By using a well-categorized...

Background Ankylosing spondylitis (AS) is an inflammatory disease predominantly affecting spine which may lead to syndesmophyte formation and disability. However, the new bone formation and the radiographic severity of AS shows great variance that some patients never develop syndesmophytes throughout the entire disease duration, whereas some develo...

The functional role of IGFBP5 in breast cancer is complicated. Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b, although this has not yet been proven in clinical samples. The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue a...

Purpose: The present study was conducted to characterize the possible therapeutic effects of glucagon-like peptide (GLP)-1 and GLP-2 against oxidative damage in the ileum and colon of irradiated rats. Methods and materials: Sprague-Dawley rats of both sexes received either a single dose of GLP-1 (0.1 nmol/kg, intraperitoneally, ip; n = 6) 10 min be...

Objective Observed low prevalence of SLE among familial Mediterranean fever (FMF) patients in several large cohorts suggests a possible protective effect of the MEFV mutations from SLE. In contrast, SLE patient carriers for the common MEFV mutations had rather complex disease expression with an increased frequency of febrile episodes and pleurisy a...

Coccydynia is defined as pain in or around the tail bone area. The most common cause of coccydynia is either a trauma such as a fall directly on to the coccyx or repetitive minor trauma. The etiology remains obscure in up to 30% of patients. The literature on the contribution of rheumatic diseases to coccydynia is scarce. Our objective was to inves...

Objective: Previous studies have demonstrated a higher incidence of ulcerative colitis in non-smokers. We investigated the beneficial effects of nicotine treatment on colitis-induced anxiety and oxidative colonic damage on rats. Materials and Methods: Wistar Albino (250-300 g) rats (n=40) were randomly divided into 5 groups as saline-treated coliti...

Aim: As the population ages, it is important to recognize the health problems of the elderly in relation to individual and public health issues. Our aim was to determine the daily habits and health-related behaviours of an aging population concerning factors such as nutritional status, physical and social activity levels and chronic health problems...

J13.07 Congenital Right Tibia Diaphysis Amputation and Bilateral Nephrolithiasis in a 6-Months-old child M. A. SOYLEMEZ, K. Delil, H. Simsek, A. Tafazzoli, P. Gultepe, M. Avsar, S. Ergunsu, N. Haklıgur, G. Girgin, H. Kazan, G. Koc, T. Avcılar, C. Erzik, M. jovaroq, A. I. Guney; MARMARA UNIVERSITY MEDICAL SCHOOL, ISTANBUL, Turkey. Objective: We repo...

Background: Recent studies have analyzed the efficacy of various agents in experimental chemoprevention trials. In our study, the effects of melatonin (Mel) and its antagonist Luzindole (Luz) on Heme oxygenase-1 (HO-1) in a NMU (N-methyl-N-nitrosourea)-induced rat mammary carcinoma model are investigated. We aim to demonstrate the relationship bet...

Spinal cord injury (SCI) leads to an inflammatory response that generates substantial secondary damage within the tissue besides the primary damage. Ghrelin, 28 amino-acid peptide, has been shown to modulate the release of proinflammatory cytokines and exert antiinflammatory effects. The aim of the current study was to investigate the anti-inflamma...

Traumatic injury to the central nervous system results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that neutralize ROS occurs at later time points...

Traumatic injury to the central nervous system results in the delayed dysfunction and neuronal death. Impaired mitochondrial function, generation of reactive oxygen species (ROS), and lipid peroxidation occur soon after traumatic spinal cord injury (SCI), while the activation of compensatory molecules that neutralize ROS occurs at later time points...

Oxidative stress is a mediator of secondary injury to the spinal cord following trauma. To investigate the putative neuroprotective effect of alpha-lipoic acid (LA), a powerful antioxidant, in a rat model of spinal cord injury (SCI). Wistar albino rats were divided as control, vehicle-treated SCI, and LA-treated SCI groups. To induce SCI, a standar...

To elucidate the putative neuroprotective effects of ghrelin in subarachnoid hemorrhage (SAH)-induced brain injury, Wistar albino rats (n = 54) were divided into sham-operated control, saline-treated SAH, and ghrelin-treated (10 microg/kg/d IP) SAH groups. The rats were injected with blood (0.3 mL) into the cisterna magna to induce SAH, and were sa...

To elucidate the putative neuroprotective effects of ghrelin in subarachnoid hemorrhage (SAH)-induced brain injury, Wistar albino rats (n ¼ 54) were divided into sham-operated control, saline-treated SAH, and ghrelin-treated (10 mg/kg/d IP) SAH groups. The rats were injected with blood (0.3 mL) into the cisterna magna to induce SAH, and were sacrif...

The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH groups, which were accompanied with significant increases in the format...

The present study was undertaken to determine whether resveratrol (RVT) could ameliorate ionizing radiation-induced oxidative injury. After a 10-days pre-treatment with RVT (10 mg/kg/day p.o.), rats were exposed to whole-body IR (800 cGy) and the RVT treatment was continued for 10 more days after the irradiation. Irradiation caused a significant de...

Thermal injury may cause distant organ inflammation and multiorgan failure. Oxytocin (OT), a nonapeptide, modulates the immune and inflammatory processes. To investigate the effects of oxytocin on burn-induced tissue injury, Sprague-Dawley rats were subjected to a partial thickness burn. Immediately after burn, half of the burned rats were placed s...

To evaluate the role of ALA treatment on the healing of acetic acid-induced gastric ulcer, rats were given ALA (35 mg/kg/day) or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days (early) or 10 days (late) until they were decapitated. Gastric ulcer index, microscopic score, elevated DNA fragmentat...

Oksidatif stresin subaraknoid kanama (SAK) dahil pekçok nörodejeneratif hastalıktaki patolojik süreçlerden sorumlu olduğu bilinmektedir. Bu amaçla çeşitli antioksidanların tedavi edici etkileri araştırılmaktadır. Mide kaynaklı bir peptit hormon olan ghrelin’in farklı inflamasyon modellerinde anti-inflamatuvar etkileri olduğu gösterilmiş, ancak beyi...

Epidemiyolojik ve klinik çalışmalar nikotinin ülseratif kolit sürecinde olumlu etkiye yol açtığını göstermişse de, nikotinin bu etkisine aracılık eden mekanizmalar henüz aydınlatılamamıştır.Kolitte oluşan oksidan hasar üzerine nikotinin yararlı etki gösterip göstermeyeceğini ortaya koymak amacıyla, Wistar Albino (250-300 g) sıçanlarda intrarektal (...

Purpose: Alpha-Lipoic acid (ALA), which has been intensely investigated as a therapeutic agent for several diseases, is elucidated for its possible protective effect as a potent antioxidant on colonic inflammation.Material and Methods: Following intracolonic administration of trinitrobenzene sulphonic acid, Sprague-Dawley rats were treated orally e...

Mechanisms of burn-induced skin and remote organ injury involve oxidant generation and the release of pro-inflammatory cytokines. In this study the possible antioxidant and anti-inflammatory effects of ghrelin were evaluated in a rat model of thermal trauma. Wistar albino rats were exposed to 90 degrees C bath for 10 s to induce thermal trauma. Ghr...

Transient splanchnic vasoconstriction following major burns causes oxidative and/or nitrosative damage in gastrointestinal tissues due to ischemia, which is followed by reperfusion injury. Oxytocin (OT), a hypothalamic nonapeptide, possesses antisecretory and antiulcer effects, facilitates wound healing and is involved in immune and inflammatory pr...

This investigation elucidates the role of free radicals in ethanol-induced gastric mucosal erosion and the protective effect of lipoic acid. After overnight fasting, Wistar albino rats were orally treated with 1 ml of absolute ethanol to induce gastric erosion. Lipoic acid (100 mg/kg) was given orally for 3 days before ethanol administration. Mucos...

There is increasing evidence suggesting that stem cells are susceptive to carcinogenesis and, consequently, can be the origin of many cancers. Recently, the neoplastic potential of stem cells has been supported by many groups showing the existence of subpopulations with stem cell characteristics in tumor biopsies such as brain and breast. Evidence...

Effect of hormone replacement (HRT) therapy on plasma lipoproteins and apolipoproteins, endothelial function and myocardial perfusion in postmenopausal women with estrogen receptor-alpha (ER-alpha) IVS1-397 C/C genotype and established coronary artery disease. Associations between various ER-alpha polymorphisms and clinical phenotypes have been stu...

The objective of this study was to examine the potential radioprotective properties of propylthiouracil (PTU)-induced hypothyroidism against oxidative organ damage induced by irradiation. Sprague-Dawley rats were pre-treated with saline or PTU (10 mg/kg i.p.) for 15 days, and were then exposed to whole-body irradiation (800 cGy). A group of rats we...

The present study was designed to determine the possible protective effects of Ginkgo biloba extract (EGb) against oxidative organ damage induced by irradiation (IR). Sprague-Dawley rats were exposed to whole-body IR (800 cGy) after a 15-day pretreatment with either saline or EGb (50 mg/kg/day), intraperitoneally, and treatments were repeated immed...

A 19-year-old woman presented with pain at the lateral side of the fifth toe of her left foot, which was separated from the adjacent toe. Initial examination suggested dislocation of the fifth metatarsophalangeal joint due to a past fracture. Radiographs showed a mass arising from the proximal phalanx of the little toe, with no medullary and cortic...

The present study was designed to determine the possible protective effects of Ginkgo biloba extract (EGb) against oxidative organ damage induced by irradiation (IR). Sprague–Dawley rats were exposed to whole-body IR (800 cGy) after a 15-day pretreatment with either saline or EGb (50 mg/kg/day), intraperitoneally, and treatments were repeated immed...

The use of human stem cells is controversial today, since human embryos and fetal cadavers seem to be the main source of them. Currently many local and national ethic committees and authorities are handling ethical issues raised by the embryo researches. A 'Working Group' on Ethics in Science and New Technologies established within the European Cou...

Background Mutations in the gene coding for the RNA component of telomerase, hTERC, have been found in autosomal dominant dyskeratosis congenita (DC) and aplastic anemia. Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal blood disorder associated with aplastic anemia and characterized by the presence of one or more clones of blood cells lacking...

Objective: Henoch Schönlein Purpura (HSP) is the most common benign vasculitis occurring during childhood. Morbidity and mortality rates rise when there is organ system involvement. We aimed to retrospectively evaluate HSP cases in our clinic according to organ involvement, clinical and laboratory findings. Material and Methods: Twenty-eight HSP ca...

A 3,5-year-old boy was admitted with febrile convulsion and bronchitis. He had polydactyly, obesity, and micropenis on his physical examination which indicated the Bardet Biedl syndrome. Then further investigations were made to make the definitive diagnosis, in the light of literature. We would like to present this case report.