Can Çokçalışkan

• PhD
• Senior Researcher at Republic of Turkey Ministry of Agriculture and Forestry

Abstract Inactivated conventional vaccines against foot-and-mouth disease (FMD) are used routinely in endemic countries and are effective against clinical disease. Increased systemic IgG levels can be obtained with these vaccines whereas local response at the mucosal sites where the virus primarily enters the organism and replicates remains very li...

Purpose: One of the most important tools against foot-and-mouth disease, a highly contagious and variable viral disease of cloven-hoofed animals, is vaccination. However, the effectiveness of foot-and-mouth disease vaccines on slowing the spread of the disease is questionable. In contrast, high potency vaccines providing early protection may solve...

Foot-and-mouth disease is one of the most important viral diseases of cloven-hoofed animals. Mass vaccination is an effective method to control the disease and is frequently utilized in endemic regions. Sufficient protection of young animals is important in mass vaccination campaigns. Maternal antibodies negatively affect the success of vaccination...

Purpose: Foot-and-mouth disease (FMD) and anthrax are important diseases in sheep. Vaccination is a favorable strategy against both infections. Simultaneous administration of vaccines does generally not impede the immune responses of each other, although there are some exceptions, and it may help reduce the labor and costs of vaccination as well a...

Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease of cloven-hoofed animals. Routine vaccination is one of the preferred methods of protection against this disease in endemic countries. For protective immunity against FMD, repeated immunizations with frequent administration are required. Intradermal immuniz...

Foot-and-mouth disease is a significant viral disease affecting cloven-hoofed domestic and wild animals. One of the most effective measures for combating this disease is vaccination. However, sheep are often excluded from vaccination campaigns because of vaccine shortages. Intradermal vaccination can significantly reduce the quantity of antigens an...

An organizational culture of biosafety and biosecurity is critical for effective management of transboundary animal diseases. One essential aspect of this work is keeping important pathogens studied in veterinary laboratories under control. Türkiye is among the countries that are both endemic and disease-free for foot-and-mouth disease (FMD) virus,...

Foot and mouth disease (FMD) and Lumpy skin disease (LSD) are contagious viral diseases that cause significant economic damage in the livestock industry of countries. Cattle are vaccinated two times a year with FMD and sheep pox and goat pox vaccines (SGP) within 30-day intervals to combat both diseases in Türkiye. However, vaccinations in differen...

Foot-and-mouth disease (FMD) is a highly contagious viral disease which affects cloven-hooved animals causing serious economic losses. FMD virus belongs to the family Picornaviridae. It has an approximately 8 kB RNA genome encoding a single polyprotein that is cleaved into 12 different proteins (structural-SPs and nonstructural proteins-NSPs) with...

Vaccination is one of the basic strategies in the fight against foot-and-mouth disease (FMD) in endemic regions. Today, commercially available FMD vaccines are prepared with inactive whole virion, which has low immunogenicity. Therefore, considerable effort has been devoted to finding novel adjuvants. Although mineral oils are among the most common...

Foot-and-mouth disease (FMD) is a highly contagious animal disease that causes devastating economic losses. The trade of live animals and derived products is only possible if the exporting country is free from disease, according to the World Organisation for Animal Health (OIE) code for FMD. One of the most important ways to prove freedom from dise...

Fighting against infectious diseases with almost 18 million cattle spread over a wide geographical area is troublesome economically and physically. The administration of different vaccines simultaneously during the foot-and-mouth disease (FMD) vaccination campaign will help reduce both the vaccine stress of animals and the field veterinarians’ work...

There are many infectious animal diseases in Turkey and generally vaccination is the prime control strategy to combat them. However, it is difficult to apply all vaccines in a definite period in the field due to limitations of the labor and finance. The rapid vaccination and effective use of labor can be possible with the help of simultaneous vacci...

Aim: In this study on guinea pigs, the relationships between neutralizing antibody titers produced by the addition of powder of Horse Chestnut seed and powder of Mistletoe dried leaves to the vaccines against Foot- and- Mouth Disease (FMD) were investigated and Quasi-Least Squares Regression (QLS) method in data analysis was introduced for the vete...

Giriş Ardıçlar özellikle kuzey yarımkürede geniş yayılış gösterirler. Toplam tür sayısı ise her kaynakta farklılıklar göstermektedir. Türkiye’de yakın zamana kadar yayılış gösteren tür sayısı 7 olarak kabul edilmekteydi: Juniperus drupacea (andız), J. oxycedrus (katran ardıcı), J. communis (adi ardıç), J. excelsa (boylu ardıç), J. foetidissima (kok...

Türkiye’nin ardıçları üzerine hazırlanmış en kapsamlı yayın özelliğindeki bu kitap ardıçların evriminden jeolojik devirlerde Anadolu’daki ardıç varlığına, ardıç türlerinden ardıç ormanlarına, ardıçlar ile ilişkili mantar ve likenlerden tarihî yapılarda ardıç kullanımına kadar ardıçlara dair hemen hemen her konuyu içinde barındırmakla kalmayıp başlı...

Despite the widespread use of the conventional inactivated foot-and-mouth disease (FMD)vaccine, its immunogenicity is poor and the duration of its protection is short. In this study, humoral response to commercial ready-to-use MontanideTM ISA 201 VG and MontanideTMISA 61 VG oil adjuvants and a common adjuvant MontanideTM ISA 206 VG developed by Sep...

The national program for foot‐and‐mouth disease (FMD) eradication includes the use of vaccination; Turkey is endemic to FMD virus (FMDV) (except for the Thrace region) and there is a risk of incursion of exotic strains from eastern borders. In 2015 a devastating outbreak was caused by the A/ASIA/G‐VII lineage, which led to the inclusion of a new va...

Purpose: The success of foot-and-mouth disease (FMD) serological serosurveillance greatly depends on the FMD vaccine which does not include any non-structural proteins (NSPs) of the FMD virus. Since pure FMD vaccines from NSPs are used with the FMD eradication programs using DIVA (Differentiating Infected from Vaccinated Animals) tests. Apart from...

Foot and Mouth Disease (FMD) is a highly contagious viral disease of cloven-hoofed animals with huge economic losses because of a significant decrease of yield. One of the most basic methods in the fight against FMD is vaccination in many countries. Trivalent or tetravalent inactivated FMD vaccines are used in the fight against FMD extensively. Alt...

This study aims to investigate and compare the effects of insulin and embryonic stem-cell (ESC) loaded liposomes (LPs) and nanocochleate formulations and their PEGylated forms on the glucose levels. All formulations were characterized considering particle size, zeta potential, polydispersity index and encapsulation efficiencies. In-vitro insulin th...

İç Anadolu Bölgesi’nin Kalıntı Ormanları Projesi, Kırsal Çevre ve Ormancılık Sorunları Araştırma Derneği üyesi ve gönüllüleri için heyecan verici bir çalışmanın başlangıcı oldu. Projeye 30’un üzerinde gönüllü katıldı. Önce işin kavramsal çerçevesini tartışmaya başladık. “Kalıntı orman” ve “orman kalıntısı” hakkında eldeki yazılı kaynakların sınırlı...

The present study, aims to investigate and compare the effect of insulin and embryonic stem cells (ESC) loaded nanoparticle formulations (NPs) on pancreatic-beta-TC-cell regeneration. Characterization studies of NPs were performed. Permeability of insulin and the effect of ESC on pancreatic beta cells were investigated. Insulin or glucose levels we...

Relict forest, remnant forest and forest remnant terms are often mentioned in the literature to refer certain forest ecosystems that used to cover larger areas in the past and presently sustain its existence in a restricted area at certain locations. In botany field,“relict” and “remnant” terms are sometimes used interchangeably. However, typically...

The first vaccination against foot and mouth disease (FMD) has long been carried out when the calves reach 4 months of age in Turkey. But, it is believed that this strategy creates a gap in herd immunity because almost fifteen percent of the cattle population consists of animals younger than 4 months old. Fifty-four calves aged 9 to 114 days were u...

Foot and Mouth Disease is a highly contagiouse viral disease of clowen hoofed animals with milk and meat loss, and economic consequences because of international trade sanctions. The one of the most important method to combat with the disease is vaccination. Vaccination takes an important part of the control measures in Turkey for a long time. Impl...

Mouse parvoviruses are one of the most important pathogens of mouse colonies. Minute Virus of Mice (MVM) is a parvovirus of murine. Unenveloped spherical small particles contain DNA It was found that BHK-21 suspension cells can be infected with a virus serologically related to MVM. The virus isolated from large scale cultures as well as storage tan...

Two genotypes of foot-and-mouth disease virus serotype A were identified as the cause of disease outbreaks in Turkey during 1996-2004, while serotype O strains, identified during the same period, seem to represent an evolutionary continuum, and Asia1 strains were only rarely identified. The data presented are concordant with the conclusion that ser...

The present report adds years to the monitoring since 1964 of FMDV strains causing disease outbreaks in Turkey. Full-length VP1 sequencing confirms a significant discrepancy in epidemiological dynamics of serotype A versus serotype O strains where distinct A genotypes are repeatedly introduced from exogenous sources while serotype O strains re-emer...

Bu calismada, bir ticari asi (ScourGuard(K),Pfizer) ile asilanan sigirlarda BRV ve BCV spesifik bagisikligin duzeyi ile yeni doganlarin enfeksiyonunda pasif bagisikligin rolu incelendi. Bu amacla gebeliginin 3. trimesterinde bulunan 41 sigirdan 2 grup olusturuldu. Grup I'de bulunan sigirlara ticari asi prospektusune gore asi uygulandi. Grup II ise...

Peste des petits ruminants virus (PPRV, genus Morbillivirus), which causes a severe disease in sheep and goats, has only recently been officially declared to be present in Turkey. We carried out a study to determine the prevalence, distribution, and host range of PPRV in Turkey. A total of 1,607 animals, reared in 18 different locations, were monit...