Camino de Juan Romero

Camino de Juan Romero
FISABIO · Hospital Universitario de Elche

PhD

About

39
Publications
7,215
Reads
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2,127
Citations
Citations since 2016
18 Research Items
1521 Citations
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
Additional affiliations
January 2014 - present
Universidad Miguel Hernández de Elche
Position
  • PostDoc Position

Publications

Publications (39)
Article
Full-text available
The anatomical wiring of the brain is a central focus in network neuroscience. Diffusion MRI tractography offers the unique opportunity to investigate the brain fiber architecture in vivo and non invasively. However, its reliability is still highly debated. Here, we explored the ability of diffusion MRI tractography to match invasive anatomical tra...
Article
Full-text available
The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors1 that delaminate and settle in the subventricular zone in enlarged brain regions2. Th...
Preprint
Full-text available
The anatomical wiring of the brain is a central focus in network neuroscience. Diffusion MRI tractography offers the unique opportunity to investigate the brain fiber architecture in vivo and non invasively. However, its reliability is still highly debated. Here, we explored the ability of diffusion MRI tractography to match invasive anatomical tra...
Preprint
Full-text available
Intrinsic coupling modes (ICMs) reflect the patterns of functional connectivity or synchronization between neuronal ensembles during spontaneous brain activity. These coupling modes represent a widely used concept in modern cognitive neuroscience for probing the connectional organization of intact or damaged brains. However, the principles that sha...
Data
Video S1. RGC Amplification in Rostral NCx at E12.5, Example 1, Related to Figure 2 Videomicroscopy of the lineage of a single RGC in an organotypic slice culture from the rostral neocortex near the mouse OB. Apical surface is down. The slice was prepared 20hr after in utero electroporation, and imaging started 4hrs after slice preparation. Total...
Data
Video S2. RGC Amplification in Rostral NCx at E12.5, Example 2, Related to Figure 2 Videomicroscopy of the lineage of a single RGC in an organotypic slice culture from the rostral neocortex near the mouse OB. Apical surface is down. Total time elapsed is 26hrs. Colored arrowheads follow the same RGC and its progeny through the movie. The initial R...
Data
Videomicroscopy of the lineage of a single RGC in an organotypic slice culture from the rostral neocortex near the mouse OB. Apical surface is down. Total time elapsed is 26hrs. Colored arrowheads follow the same RGC and its progeny through the movie. The initial RGC undergoes interkinetic nuclear migration (INM) to divide apically and produce 1 IP...
Data
Videomicroscopy of the lineage of a single RGC in an organotypic slice culture from the mouse OB. Apical surface is down. Total time elapsed is 9hrs. Colored arrowheads follow the same RGC and its progeny through the movie. The initial RGC divides at the apical surface to produce 1 RGC (red arrowhead) plus 1 neuron (green arrowhead).
Data
Table S1. Sequences for Oligonucleotides Used in This Study, Related to STAR Methods
Data
Videomicroscopy of the lineage of a single RGC in an organotypic slice culture from the mouse OB. Apical surface is down. Total time elapsed is 13hrs. The initial RGC undergoes interkinetic nuclear migration to divide in the apical surface to produce 1 RGC (top cell) plus 1 neuron (bottom cell).
Article
Full-text available
Cerebral cortex size differs dramatically between reptiles, birds, and mammals, owing to developmental differences in neuron production. In mammals, signaling pathways regulating neurogenesis have been identified, but genetic differences behind their evolution across amniotes remain unknown. We show that direct neurogenesis from radial glia cells,...
Article
Folding of the cerebral cortex during brain development is a complex process that depends on the orchestrated action of a number of factors, including generation and proliferation of basal progenitor cells, and the radial migration of neurons. Patterns of primary cortical folding are stereotyped between individuals and across phylogeny, reflecting...
Article
Development of the cerebral cortex depends critically on the regulation of progenitor cell proliferation and fate. Cortical progenitor cells are remarkably diverse with regard to their morphology as well as laminar and areal position. Extrinsic factors, such as thalamic axons, have been proposed to play key roles in progenitor cell regulation, but...
Article
Full-text available
The outer subventricular zone (OSVZ) is a germinal layer playing key roles in the development of the neocortex, with particular relevance in gyrencephalic species such as human and ferret, where it contains abundant basal radial glia cells (bRGCs) that promote cortical expansion. Here we identify a brief period in ferret embryonic development when...
Data
Supplementary Figures 1 - 5, Supplementary Tables 1 - 4, Supplementary Note 1 and Supplementary References
Article
Full-text available
Gyrencephalic species develop folds in the cerebral cortex in a stereotypic manner, but the genetic mechanisms underlying this patterning process are unknown. We present a large-scale transcriptomic analysis of individual germinal layers in the developing cortex of the gyrencephalic ferret, comparing between regions prospective of fold and fissure....
Article
Full-text available
Radial glia cells play fundamental roles in the development of the cerebral cortex, acting both as the primary stem and progenitor cells, as well as the guides for neuronal migration and lamination. These critical functions of radial glia cells in cortical development have been discovered mostly during the last 15 years and, more recently, seminal...
Article
Full-text available
Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen HeCo mice display this phenoty...
Article
Evolution of the mammalian brain encompassed a remarkable increase in size of the cerebral cortex, which includes tangential and radial expansion. However, the mechanisms underlying these key features are still largely unknown. Here, we identified the DNA-associated protein Trnp1 as a regulator of cerebral cortex expansion in both of these dimensio...
Article
Full-text available
Kv10.1 (Eag1), member of the Kv10 family of voltage-gated potassium channels, is preferentially expressed in adult brain. The aim of the present study was to unravel the functional role of Kv10.1 in the brain by generating knockout mice, where the voltage sensor and pore region of Kv10.1 were removed to render non-functional proteins through deleti...
Article
Full-text available
The cerebral cortex of large mammals undergoes massive surface area expansion and folding during development. Specific mechanisms to orchestrate the growth of the cortex in surface area rather than in thickness are likely to exist, but they have not been identified. Analyzing multiple species, we have identified a specialized type of progenitor cel...
Article
Coordinated transfer of information between the brain hemispheres is essential for function and occurs via three axonal commissures in the telencephalon: the corpus callosum (CC), hippocampal commissure (HC), and anterior commissure (AC). Commissural malformations occur in over 50 human congenital syndromes causing mild to severe cognitive impairme...
Article
During our search for developmental regulators of neuronal differentiation, we identified special AT-rich sequence-binding protein (SATB)2 that is specifically expressed in the developing rat neocortex and binds to AT-rich DNA elements. Here we investigated whether the regulatory function of SATB2 involves chromatin remodeling at the AT-rich DNA si...
Article
Full-text available
Pyramidal neurons of the neocortex can be subdivided into two major groups: deep- (DL) and upper-layer (UL) neurons. Here we report that the expression of the AT-rich DNA-binding protein Satb2 defines two subclasses of UL neurons: UL1 (Satb2 positive) and UL2 (Satb2 negative). In the absence of Satb2, UL1 neurons lose their identity and activate DL...

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