Camilo José Morado-Díaz

Universidad de Sevilla | US · Departamento de Fisiología

Transplants of neural progenitor cells (NPCs) into the injured CNS constitute a powerful tool for brain repair. However the effects of these implants on the firing pattern and synaptology of lesioned neurons have not been extensively evaluated. In this study, we analyzed whether NPCs implanted at the site of lesion are able to restore the altered d...

Auditory deviance detection is a function of the auditory system that allows reduction of the processing demand for repetitive stimuli while stressing unpredictable ones, which are potentially more informative. Deviance detection has been extensively studied in humans using the oddball paradigm, which evokes an event-related potential known as mism...

How the brain deals with the conflict between what is likely to happen and what is behaviorally relevant remains unknown. In previous works, we have used oddball paradigm to study stimulus-specific adaptation to assess neuronal responses to standard and deviant stimuli in the auditory brain. Thus, in order to evaluate SSA modulation during an atten...

The oddball paradigm has been widely exploited to study deviance detection. It serves to evaluate expectation, as it provokes an enhancement of the representation of a low-probability stimulus randomly intermingled in a sequence of frequent stimuli. We have previously used this paradigm to study stimulus-specific adaptation (SSA) in single unit rec...

Deviance detection is the automatic capacity to detect salient or novel stimuli within an otherwise monotonous acoustic environment. The neuronal substrate of deviance detection has been widely studied using the oddball paradigm, consisting on a sequence of repeated tones, referred to as standards, randomly interrupted by a low probability tone (th...

Talaverón R. y Morado-Díaz C. J. La glía, las otras células del sistema nervioso. Elementos 115 (2019) 39-44. www.elementos.buap.mx Gracias al despertar de la divulgación científica la sociedad se ha familiarizado con muchos términos básicos relacionados con distintas disciplinas. Sin embargo, en el campo de la neurociencia, mientras que es común o...

Introduction: Medial rectus motoneurons (MRMns) receive inputs from abducens internuclear neurons (ABD Ints), whose axons contact MRMn through the medial longitudinal fascicle (MLF) and are responsible for conjugate horizontal gaze, and neurons in the lateral vestibular nucleus (LVN), whose axons project through the ascending tract of Deiters (ATD)...

Medial rectus motoneurons receive two main pontine inputs: abducens internuclear neurons, whose axons course through the medial longitudinal fasciculus (MLF), and neurons in the lateral vestibular nucleus, whose axons project through the ascending tract of Deiters (ATD). Abducens internuclear neurons are responsible for conjugate gaze in the horizo...

Aims: Horizontal gaze coordination relays on abducens internuclear neurons (ABD-INTs), whose axons contact contralateral medial rectus motoneurons (MRMn) through the medial longitudinal fascicle (MLF). Also, MRMn receive inputs from the lateral vestibular nucleus (LVN) through the ascending tract of Deiters (ATD). The consequences of disconnecting...

Aims: Horizontal gaze coordination relays on abducens internuclear neurons (ABD INTs), whose axons contact contralateral medial rectus motoneurons (MRMn) through the medial longitudinal fascicle (MLF). Also, MRMn receive a major input from the lateral vestibular nucleus (LVN) through the ascending tract of Deiters (ATD). The effects of MLF transect...

Transplants of neural progenitor cells (NPCs) into the injured CNS have been proposed as a powerful tool for brain repair, but, to date, few studies on the physiological response of host neurons have been reported. Therefore, we explored the effects of NPC implants on the discharge characteristics and synaptology of axotomized abducens internuclear...

Palisade endings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primates. They have long been postulated to be proprioceptors. It was recently demonstrated that palisade endings are cholinergic and that in monkeys they originate from the EOM motor nuclei. Nevertheless, there is considerable difference of opi...

We aimed to predict the firing rate of abducens internuclear neurons (Abd Ints) based on regression analysis models that used eye movements, medial/lateral rectus muscle force, or both. Since our group already showed that abducens neurons encode characteristics of eye movement and lateral/medial rectus tension during spontaneous eye movements (Davi...

The abducens nucleus has a central role in control of bilateral horizontal eye movements. In addition to motoneurons, this nucleus contains a group of premotor cells, the abducens internuclear neurons. We previously showed that abducens motoneurons encode characteristics of both the eye movement and lateral rectus muscle tension during spontaneous...

Axotomy leads to deafferentation and changes in the discharge characteristics of lesioned cells. We tested the effects of neural progenitor cells (NPC) implanted at the site of lesion immediately after transection of the medial longitudinal fascicle (MLF) on the synaptology and discharge characteristics of abducens internuclear neurons. The NPCs we...

El NMOE contiene dos tipos neuronales: motoneuronas, que producen la contracción del músculo recto lateral (RL) homolateral y neuronas premotoras (internucleares) que contactan con las motoneuronas del núcleo motor ocular común contralateral. Ambas reciben información de diferentes áreas premotoras relacionadas con los componentes tónico y fásico d...

La axotomía produce deaferentación y alteraciones en las características de disparo de las células lesionadas. En este trabajo hemos estudiado la sinaptología y distintas propiedades electrofisiológicas de las neuronas internucleares del núcleo motor ocular externo (NMOE) tras el implante de progenitores neurales en el fascículo longitudinal medial...

Extraocular muscle tension associated with spontaneous eye movements has a pulse-slide-step profile similar to that of motoneuron firing rate. Existing models only relate motoneuron firing to eye position, velocity and acceleration. We measured and quantitatively compared lateral rectus muscle force and eye position with the firing of abducens moto...

Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation of different forms of synaptic plasticity. Target disconnection produces a profound synaptic stripping due to the lack of trophic support. Consequently, target reinnervation leads to synaptic remodeling and restoration of cellula...

Neurotrophins, as target-derived factors, are essential for neuronal survival during development, but during adulthood, their scope of actions widens to become also mediators of synaptic and morphological plasticity. Target disconnection by axotomy produces an initial synaptic stripping ensued by synaptic rearrangement upon target reinnervation. Us...

We describe the use of an implantable device for peripheral nerves that allows chronic simultaneous delivery of small volumes of solution, recording of both field and multiunit potentials, and electrical stimulation. This custom-made multifunctional device was attached to the cut end of the abducens (VIth) nerve for stimulation, recording and injec...