Camille Aupiais

Hôpital Jean-Verdier – Hôpitaux Universitaires Paris-Seine-Saint-Denis

Importance Mental disorders among the pediatric population are a major area of public health concern. Little is known regarding changes in pediatric hospital resource use related to mental health (MH) long after the onset of the COVID-19 pandemic in March 2020. Objective To assess rates and trends of hospitalizations and emergency department (ED)...

Background Respiratory syncytial virus (RSV) is the leading cause of lower-respiratory-tract infection in children. Nirsevimab, a monoclonal antibody against RSV, was implemented in a few countries in September 2023. However, its post-license effectiveness in ambulatory care settings is unknown. We aimed to assess the effectiveness of nirsevimab ag...

Background: Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis, resulting in 3 million hospitalizations each year worldwide. Nirsevimab is a monoclonal antibody against RSV that has an extended half-life. Its postlicensure real-world effectiveness against RSV-associated bronchiolitis is unclear. Methods: We conducted a prosp...

( Lancet. 2022;400:592–604) Antenatal corticosteroids are recommended worldwide to help premature fetus lung maturity. However, the current recommended dose may be too high, based on some neurological, mental, and behavioral side effects. This study compared a half-dose (12 mg) of antenatal betamethasone to the typical full dose (24 mg) to determin...

Antenatal corticosteroid administration to women at risk of preterm delivery is recommended worldwide because of their effectiveness in preventing respiratory distress syndrome, as well as in reducing the rate of necrotizing enterocolitis, intraventricular hemorrhage, and neonatal death in preterm infants. However, the current usual dosage regimen...

This cohort study uses COVID-19 Pediatric Observatory study data to analyze the vaccination status of parents with young children hospitalized for SARS-CoV-2 variants Delta and Omicron.

Background Bronchiolitis is a major source of morbimortality among young children worldwide. Non-pharmaceutical interventions (NPIs) implemented to reduce the spread of SARS-CoV-2 may have had an important impact on bronchiolitis outbreaks, as well as major societal consequences. Discriminating between their respective impacts would help define opt...

Testing for SARS-CoV-2 is central to COVID-19 management. Rapid antigen test from self-collected anterior nasal swabs (SCANS-RAT) are often used in children but their performance have not been assessed in real-life. We aimed to compare this testing method to the two methods usually used: reverse transcription polymerase chain reaction from nasophar...

Background During the initial phase of the Coronavirus Disease 2019 (COVID-19) pandemic, reduced numbers of acutely ill or injured children presented to emergency departments (EDs). Concerns were raised about the potential for delayed and more severe presentations and an increase in diagnoses such as diabetic ketoacidosis and mental health issues....

Background Antenatal betamethasone is recommended before preterm delivery to accelerate fetal lung maturation. However, reports of growth and neurodevelopmental dose-related side-effects suggest that the current dose (12 mg plus 12 mg, 24 h apart) might be too high. We therefore investigated whether a half dose would be non-inferior to the current...

Background: Infants with COVID-19 can often present with fever without source, which is a challenging situation in infants <90 days old. The "step-by-step" algorithm has been proposed to identify children at high risk of bacterial infection. In the context of the COVID-19 pandemic, we aimed to reassess the diagnostic performance of this algorithm....

Background To investigate the impact of the COVID-19 pandemic and infection prevention measures on children visiting emergency departments across Europe. Methods Routine health data were extracted retrospectively from electronic patient records of children aged <16 years, presenting to 38 emergency departments (ED) in 16 European countries for the...

Background Infants with COVID-19 can often present with fever without source which is a challenging situation in infants < 90 days old. The “step-by-step” algorithm has been proposed to identify children at high risk of bacterial infection. In the context of the COVID-19 pandemic, we aimed to reassess the diagnostic performance of this algorithm. M...

To compensate for the poor initial knowledge about pediatric SARS-CoV-2 infections and the limited access to non-urgent medical care during lockdown, a local telephone follow-up program was set up to remotely monitor children with confirmed or suspected SARS-CoV-2 infection at the pediatric emergency department of a French tertiary hospital. We ret...

Abstract Acute arthritis is a common cause of consultation in pediatric emergency wards. Arthritis can be caused by juvenile idiopathic arthritis (JIA), septic (SA) or remain undetermined (UA). In young children, SA is mainly caused by Kingella kingae (KK), a hard to grow bacteria leading generally to a mild clinical and biological form of SA. An e...

Background: Sickle Cell Disease (SCD) children are frequent travellers to countries where Yellow Fever (YF) is endemic, but there are no data regarding the safety and immunogenicity of the vaccine in such children treated with hydroxyurea (HU). The main objective of this study was to compare the tolerance and immune response to YF vaccination in SC...

Background The extent to which very young children contribute to the transmission of SARS-CoV-2 is unclear. We aimed to estimate the seroprevalence of antibodies against SARS-CoV-2 in daycare centres that remained open for key workers' children during a nationwide lockdown in France. Methods Children and staff who attended one of 22 daycare centre...

Background: Initial reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in children suggested that very young age and comorbidities may increase risk of severe evolution, but these findings remained to be confirmed. We aimed to analyze the clinical spectrum of hospitalized pediatric SARS-CoV-2 infection and predictor...

Objective: Infliximab (IFX) is a frequent therapeutic option for Crohn disease (CD) patients. Early detection of responders to IFX is critical for the management of CD in order to avoid long-term exposure to the drug without benefit. This retrospective study aimed at analysing which early parameters recorded during the induction period are able to...

Background: When conducing Phase-III trial, regulatory agencies and investigators might want to get reliable information about rare but serious safety outcomes during the trial. Bayesian non-inferiority approaches have been developed, but commonly utilize historical placebo-controlled data to define the margin, depend on a single final analysis, a...

Introduction Le vaccin de la fièvre jaune (FJ) est contre-indiqué chez les patients ayant une immunosuppression. Malgré l’absence de données, les recommandations sanitaires pour le voyageur autorisent cette vaccination chez les patients drépanocytaires traités par hydroxycarbamide (HC). L’objectif de cette étude était d’évaluer la tolérance et l’ef...

Introduction Les essais de non-infériorité (NI) sont de plus en plus utilisés lorsque l’on souhaite démontrer qu’un nouveau traitement - dont le bénéfice potentiel réside dans son coût, sa facilité d’utilisation et/ou sa tolérance - est aussi efficace qu’un traitement standard. Un des enjeux méthodologiques est la détermination de la marge de NI, q...

Objectives: In adult inflammatory bowel disease (IBD) treated by anti-TNF antibodies, paradoxical psoriasis has an estimated prevalence of 1.6 to 22%, especially in infliximab (IFX)-treated patients. Little is known in the pediatric IBD (PIBD) populations. Methods: All patients aged from 2 to 18 years with Crohn's disease (CD) or Ulcerative coli...

Background Although antenatal betamethasone is recommended worldwide for women at risk of preterm delivery, concerns persist regarding the long-term effects associated with this treatment. Indeed, adverse events, mainly dose-related, have been reported. The current recommended dose of antenatal betamethasone directly derives from sheep experiments...

Introduction: Emergency services are faced with people over the age of 75 whose frailty leads to states of agitation. Objective: To improve the quality of the care of this situation through the invention of an advanced practice nurse. Method: A phenomenological and monocentric study from interviews with professionals intervening in emergencies...

Aim Studies on bone and joint infections (BJI) in infants under three months are rare. We described the clinical and paraclinical features and outcomes of infants hospitalised with BJI under three months of age. Methods The French National Hospital Discharge Database provided data on BJIs in infants under three months of age from January 2004 to 2...

Objective To review characteristics, methodology and reporting of non-inferiority and equivalence trials in the specific context of paediatrics. Design PubMed and Cochrane databases were searched (up to September 2016) for non-inferiority/equivalence randomised controlled trials conducted in children published in high-impact-factor journals (>5.0...

Objectif L’objectif de cette étude était d’étudier l’agrégation familiale du syndrome d’apnées obstructives du sommeil et de l’hypertrophie amygdalienne. Méthodes Étude de cohorte monocentrique incluant des enfants non obèses adressés dans notre centre du sommeil pour suspicion de SAOS. À l’inclusion, les parents remplissaient un questionnaire de...

We investigated the knowledge of female genital mutilation (FGM) among 60 general and 52 specialized travel medicine practitioners. Less than 50% of these practitioners had adequate knowledge of FGM. Only 42.9% declared having encountered FGM. FGM is likely underestimated in health facilities. Medical education and supporting information should be...

Primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) both entail bronchiectasis and pulmonary impairment as measured using spirometry, during childhood. We aimed at looking whether blood gas exchanges progressed differently between CF and PCD children in a retrospective study of repeated measurements. Comparisons between groups (Wilcoxon-Mann-...

Context GH therapy may improve statural growth outcomes in patients with severe juvenile idiopathic arthritis (JIA). Objectives To evaluate the effect of GH treatment on adult height and to identify determinants of growth outcomes in JIA. Design and patients Data from 58 JIA patients, including 53 given GH, enrolled in three prospective clinical...

Context: Very few studies have evaluated the role of procalcitonin (PCT) in infants with bronchiolitis. Aims: To describe infants who had both a diagnosis of bronchiolitis at the emergency department and a blood test including PCT, and to compare the characteristics of children according to the PCT value. Methods: Infants admitted to the Pedia...

Introduction Les essais de non-inferiorite (NI) et d’equivalence (EQ) sont de plus en plus utilises en recherche clinique lorsque l’on souhaite demontrer qu’un nouveau traitement–dont le benefice potentiel reside dans son cout, sa facilite d’utilisation et/ou sa tolerance–est aussi efficace qu’un traitement standard. Une revue systematique a ete me...

Background: Migraine is a common cause of headache in childhood. Several studies have investigated the association between migraine and atopic diseases, mostly in the adult population. Objective: This study aimed to investigate this association in children. Methods: A case-control study was conducted across 3 European tertiary care hospitals b...

Background Increasing numbers of young people with perinatally acquired HIV are surviving to adulthood. When they come of age, they leave pediatric services in which they were followed and have to be transferred to the adult health care system. Difficulties in adaptation to adult care and the numbers of young people lost to follow up after transfer...

Consolidated criteria for reporting qualitative studies (COREQ)–Checklist. (DOCX)

Objectifs Décrire les infections ostéoarticulaires (IOA) des nourrissons de moins de 3 mois. Matériels et méthodes Les données ont été collectées rétrospectivement chez tous les enfants âgés de moins de 3 mois hospitalisés pour une IOA sur une période de 11 ans (2004–2015) dans les CHU Debré, Trousseau et Necker (Paris). Résultats Au total, 71 en...

Objectif Décrire les infections ostéo-articulaires (IOA) des nourrissons de moins de 3 mois. Patients et méthodes Les données ont été collectées rétrospectivement chez tous les enfants âgés de moins de 3 mois hospitalisés pour une IOA sur une période de 11 ans (2004–2015) dans les CHU Debré, Trousseau et Necker (Paris). Résultats Au total, 71 enf...

Aim: Childhood arthritis arises from several causes. The aim of this observational study is to compare the clinical and biological features and short-term outcome of different types of arthritis because they have different treatment and prognoses. Methods: Children <16 years of age hospitalised in a French tertiary care centre for a first episod...

Arthritis in children has many causes and includes septic and viral arthritis, reactive arthritis and juvenile idiopathic arthritis (JIA). We aimed to describe the different types of arthritis among children hospitalised for a first episode of arthritis. Retrospective, descriptive case series study. A French tertiary care centre. Children under 16...

Chez l’enfant, un épanchement articulaire fébrile doit faire suspecter le diagnostic d’arthrite septique (AS) et réaliser une ponction articulaire pour confirmer le diagnostic et effectuer un lavage articulaire. La protéine C-réactive (CRP) est une aide diagnostique mais dans les AS son élévation peut être modérée ou nulle. Dans une étude précédent...

Septic arthritis has to be suspected in children with joint effusion and fever so as to perform joint aspiration, which will confirm the diagnosis by bacteriological methods, and to perform surgical treatment by joint lavage. Since development of current molecular methods, such as real-time PCR, Kingella kingae has become the first microbial agent...

Background: Antiretroviral treatment interruption (TI) is not recommended in HIV-infected children. We aimed to evaluate the context and consequences of TI in clinical practice. Methods: We investigated the probability and risk factors of a first TI in the 483 children treated with combined ART (cART) in the ANRS French national pediatric cohort...

Group A rotaviruses are the main viral causative agent of acute diarrhea, and cause considerable morbidity in children. G9 rotaviruses have recently emerged all over the world and are thought to give more severe symptoms because of a lack of previous exposure and the absence of maternal antibodies in patients. To determine the clinical severity of...