Camilla Cerutti

Camilla Cerutti
IEO - Istituto Europeo di Oncologia | IEO · Department of Experimental Oncology

BSc, MSc, PhD
iCARE 2Marie Skłodowska-Curie H2020 Fellow at European Institute of Oncology

About

34
Publications
5,203
Reads
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618
Citations
Introduction
Currently, I am recipient of 3-years iCARE-2 Fellowship awarded by AIRC/EU H2020 Marie Skłodowska-Curie with the research project `Single-cell epigenetic and molecular signatures in human breast cancer metastasis formation` at IEO. We will investigate breast cancer metastasis with a human 3D in vitro model with shear stress mimicking blood flow to study breast cancer cells involved in metastasis at single-cell level.
Additional affiliations
May 2018 - May 2020
University of Bristol
Position
  • Research Associate
Description
  • RhoGTPases in cancer cell:endothelial cell interaction in cancer progression and metastasis formation in vitro and in vivo
January 2016 - March 2017
King's College London
Position
  • Tutor
Description
  • 5BBY0202 Cell Biology B tutorials.
October 2014 - May 2018
King's College London
Position
  • Research Associate
Description
  • Role of Rho GTPase in metastasis formation
Education
December 2009
The Open University (UK)
Field of study
  • Endothelial microRNAs in leukocyte adhesion to human blood brain barrier.
November 2005 - April 2009
October 2000 - November 2005

Publications

Publications (34)
Preprint
Full-text available
The blood–brain barrier (BBB) acquires unique properties for regulation of the neuronal function during development. The genesis of the BBB coupled with angiogenesis is orchestrated by the Wnt/β–catenin signaling pathway. Aside from the importance of Wnt/β–catenin signaling, the molecular mechanisms that regulate these processes are poorly understo...
Article
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): British Heart Foundation Introduction Cardiovascular inflammation is associated with endothelial cell (EC) damage, resulting in leukocyte trafficking and oedema formation. Inflammation disrupts EC junctions, increasing microvascular permeability, and r...
Chapter
Adhesion between leukocytes and brain endothelial cells, which line cerebral blood vessels, is a key event in both physiological and pathological conditions such as neuroinflammatory diseases. Leukocyte recruitment from blood into tissues is described as a multistep process involving leukocyte rolling on endothelial cells, adhesion, crawling, and d...
Article
Glioblastoma multiforme (GBM) is the most common and the most aggressive type of primary brain malignancy. Glioblastoma stem-like cells (GSCs) can migrate in vascular niches within or away from the...
Chapter
Full-text available
Adhesion between cancer cells and endothelial cells, lining the blood vessels, is an important event in tumor progression and metastasis formation. The expression of Rho GTPases is frequently altered in cancers, and they are known to regulate cell migration through their effects on adhesion and cytoskeletal dynamics. Several different types of assa...
Preprint
Full-text available
Glioblastoma multiforme (GBM), is the most common and the most aggressive type of primary brain malignancy. Glioblastoma stem- like cells (GSCs) are able to migrate in vascular niches within or away from the tumour mass, increasing tumour resistance to patient treatments and contributing to relapses. To study individual GSCs migration and their int...
Article
Background/Introduction Cardiovascular inflammation is associated with endothelial damage, resulting in leukocyte trafficking and oedema formation, which results in a positive-feedback loop of inflammatory events. Purpose The phosphoinositide 3-kinase (PI3K) pathway has been shown to be upregulated in vascular disease conditions whereby its inhibi...
Article
Full-text available
Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the activity of cyclooxygenase-1 (COX-1) and COX-2. Aspirin impairs the biosynthesis of all prostanoids through the irreversible inhibition of both COX isoforms. Long-t...
Article
Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the activity of cyclooxygenase-1 (COX-1) and COX-2. Aspirin impairs the biosynthesis of all prostanoids through the irreversible inhibition of both COX isoforms. Long-t...
Data
-Confocal Fluorescent images of RhB cargo released in brain endothelial cells hCMEC/D3 by RhB@ZIP particles -TEM images of AuNP@ZIP nanoparticle released by RhB@ZIP particles into brain endothelial cells hCMEC/D3 .
Data
https://www.rsc.org/suppdata/c5/tb/c5tb01814e/c5tb01814e1.pdf
Article
Evidence from experimental studies and clinical trials has shown that aspirin reduces the incidence of distant metastases. Aspirin inhibits cyclooxygenase (COX)-1 and COX-2, triggering anti-thrombotic and anti-inflammatory effects, respectively. However, the mechanisms underlying the anti-metastatic effect of aspirin are still largely unknown. By e...
Article
Full-text available
Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare the signaling networks that contribute to endothelial permeability and leukocyte transendothelial migration, focusing par...
Article
Full-text available
Leukocyte adhesion to brain endothelial cells, the blood-brain barrier main component, is a critical step in the pathogenesis of neuroinflammatory diseases such as multiple sclerosis (MS). Leukocyte adhesion is mediated mainly by selectins, cell adhesion molecules and chemokines induced by pro-inflammatory cytokines such as TNF? and IFN?, but the r...
Chapter
Full-text available
http://link.springer.com/chapter/10.1007%2F978-3-319-45514-3_7 Blood-brain barrier (BBB) dysfunction, characterised by increased permeability across brain endothelium and/or leukocyte extravasation into CNS tissue, is associated with changes in the gene expression profile of brain endothelium and is therefore potentially controlled by epigenetic fa...
Article
Full-text available
Abstract Background: Increased leukocyte adhesion to brain endothelial cells forming the blood-brain barrier (BBB) precedes extravasation into the central nervous system (CNS) in neuroinflammatory diseases such as multiple sclerosis (MS). Previously, we reported that microRNA-155 (miR-155) is up-regulated in MS and by inflammatory cytokines in hum...
Article
Full-text available
Herein, we report the synthesis and characterization of nanospheres of a biodegradable zinc-imidazolate polymers (ZIP) as a proof-of-concept delivery vehicle into human brain endothelial cells, the main component of the blood-brain barrier (BBB). The ZIP particles can readily encapsulate functional molecules such as fluorophores and inorganic nanop...
Article
Full-text available
Herein, we report the synthesis and characterization of nanospheres of a biodegradable zinc-imidazolate polymers (ZIPs) as a proof-of-concept delivery vehicle into human brain endothelial cells, the main component of the blood-brain barrier (BBB). The ZIP particles can readily encapsulate functional molecules such as fluorophores and inorganic nano...
Article
Full-text available
Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders such as multiple sclerosis (MS). In contrast, microRNA-146a (miR-146a) has emerged as an anti-infla...
Data
Full-text available
Figures S1-S5. Supplemental Figure 1: MMTV-neu mice spontaneously develop breast tumors and lung metastases. Supplemental Figure 2: Cannabinoids inhibit breast tumor growth in vivo Supplemental Figure 3: MMTV-neu-derived tumors express cannabinoid receptors Supplemental Figure 4: Cannabinoids modulate the expression of MMP2 and MMP9 Supplemental Fi...
Article
Full-text available
ErbB2-positive breast cancer is characterized by highly aggressive phenotypes and reduced responsiveness to standard therapies. Although specific ErbB2-targeted therapies have been designed, only a small percentage of patients respond to these treatments and most of them eventually relapse. The existence of this population of particularly aggressiv...
Article
Δελτα⁹-tetrahydrocannabinol (THC), the important cannabinoid in terms of potency and abundance, reduces human breast cancer cell proliferation in vitro by blocking the progression through the cell cycle and by inducing apoptosis. Here we show that cannabinoids have antitumoural properties in an animal model of breast cancer: the MMTV-neu mouse....
Article
Full-text available
It has been recently shown that cannabinoids, the active components of marijuana and their derivatives, inhibit cell cycle progression of human breast cancer cells. Here we studied the mechanism of Delta(9)-tetrahydrocannabinol (THC) antiproliferative action in these cells, and show that it involves the modulation of JunD, a member of the AP-1 tran...

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Projects

Projects (5)
Project
The aim of my project is to understand how the microenvironment regulates the haematogenous dissemination of tumour cells in order to identify metastasis-preventive therapies.